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Participants completed the WHOQOL-HIV-BREF and EQ-5D-5\u00a0L questionnaires. Clinical and immunological data were provided by the CoRIS at enrollment and on questionnaire completion. Linear repeated measures analyses assessed the evolution of immunological markers. Partial least squares structural equation modeling showed the longitudinal impact of baseline immunological markers on HRQoL. High baseline CD4 counts predicted higher WHOQOL-HIV-BREF independence scores (<jats:italic>p<\/jats:italic>\u2009=\u20090.021) and a marginally higher EQ-5D-5\u00a0L index value (<jats:italic>p<\/jats:italic>\u2009=\u20090.058), which was also associated with CD8 (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). A higher CD4\/CD8 ratio predicted lower scores on the WHOQOL-HIV-BREF \u2018spirituality, religion and personal belief\u2019 dimension (<jats:italic>p<\/jats:italic>\u2009=\u20090.006). Currently, PLH who present with advanced HIV disease achieve a moderate long-term HRQoL, with room for improvement.<\/jats:p>","DOI":"10.1007\/s10461-025-04730-x","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T19:47:28Z","timestamp":1747252048000},"page":"2729-2741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Health-Related Quality of Life in People Living with HIV Who Present to Care with AIDS or Severe Immunodeficiency: The CoRIS AIDS Survivors Study"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-9646","authenticated-orcid":false,"given":"Julia","family":"Portilla-Tamarit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-7194","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Fuster-RuizdeApodaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-8731","authenticated-orcid":false,"given":"Irene","family":"Portilla-Tamarit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-9754","authenticated-orcid":false,"given":"Sergio","family":"Reus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0887-8710","authenticated-orcid":false,"given":"Melchor","family":"Riera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2249-2352","authenticated-orcid":false,"given":"Nuria","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-1147","authenticated-orcid":false,"given":"Juan","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-0579","authenticated-orcid":false,"given":"Enrique","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9878-2458","authenticated-orcid":false,"given":"Mar","family":"Masia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-6448","authenticated-orcid":false,"given":"Sonia","family":"Calzado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3676-9511","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Portilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"4730_CR1","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1177\/0956462418778705","volume":"29","author":"HB Krentz","year":"2018","unstructured":"Krentz HB, John Gill M. 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