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Participants completed surveys on PrEP, and were screened for HIV, syphilis,\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    , and\n                    <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                    . PrEP eligibility was determined using Chinese PrEP guidelines, and participants\u2019 self-perceived HIV risk was documented. Multivariable logistic regression Analysed factors influencing PrEP-related outcomes And the discrepancy between perceived and actual risk. Among 1,085 participants (median age: 32 years), 54.4% resided in urban areas, 71.1% identified as homosexual, And 60.8% held a college degree or higher. Although 87.0% were PrEP-eligible, only 28.5% were identified as high risk. PrEP awareness was 82.0%, yet only 8.8% had used it, And 3.3% currently used it. Despite 72.9% expressing willingness, uptake was hindered by high costs. Rural residence and lower education correlated with reduced awareness and acceptance, while greater income, more male partners, and recent STI testing predicted higher acceptance. Prior PEP use was strongly associated with PrEP use. Targeted efforts to improve affordability, accessibility, and education are crucial for better prevention results.\n                  <\/jats:p>","DOI":"10.1007\/s10461-025-04884-8","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T23:42:37Z","timestamp":1759102957000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Awareness, Acceptance, and Uptake of HIV Pre-Exposure Prophylaxis among Men Who Have Sex with Men (MSM) in Northwestern China: A Cross-Sectional Study"],"prefix":"10.1007","volume":"30","author":[{"given":"Rui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-084X","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"issue":"10013","key":"4884_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0140-6736(15)00056-2","volume":"387","author":"S McCormack","year":"2016","unstructured":"McCormack S, Dunn DT, Desai M, et al. 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All participants signed an informed consent that included details of the on-site surveys, screening tests for HIV, syphilis, chlamydia and gonorrhoea.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The participant has consented to the submission of the case report to the journal.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}}]}}