{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:13:11Z","timestamp":1774365191596,"version":"3.50.1"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI117943, P30AI094189, P30MH062294, P30MH058107, P30AI036214, P30AI027767"],"award-info":[{"award-number":["P30AI117943, P30AI094189, P30MH062294, P30MH058107, P30AI036214, P30AI027767"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AIDS Behav"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Same-day pre-exposure prophylaxis (PrEP) for HIV prevention is a novel tool to increase biomedical prevention access and uptake. Although prior research has identified same-day PrEP as feasible and acceptable, improved understanding of key barriers and facilitators to implementation is needed to optimize impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Network for Implementation Science in HIV (NISH) examined the implementation of same-day PrEP across 42 Ryan White Part A-D-funded organizations in seven Ending the U.S. HIV Epidemic Initiative priority jurisdictions. We used crisp-set coincidence analysis with six conditions to identify key barriers explaining delayed implementation of same-day PrEP among 38 clinical organizations representing 137 individual clinics where same-day PrEP services were available currently or in the future.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our final model explained\u2009~\u200967% of clinical organizations not currently implementing same-day PrEP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), with a consistency of 80%. This model identified three pathways to non-implementation of same-day PrEP: (1) insurance coverage as a top barrier\n                      <jats:italic>and<\/jats:italic>\n                      insufficient staffing resources as a top barrier; (2) no onsite pharmacy as a top barrier;\n                      <jats:italic>or<\/jats:italic>\n                      (3) provider reticence with same-day PrEP prescribing and insurance coverage as top barriers,\n                      <jats:italic>and<\/jats:italic>\n                      patient demand\/(dis)interest in same-day PrEP not being ranked as a top barrier.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The three identified pathways to delayed implementation of same-day PrEP aid researchers and providers in reverse mapping strategies to enhance and scale up the implementation of same-day PrEP in federally funded clinics in the U.S. Such strategies may include federal and state-level policy changes to expand funding for PrEP coverage, pharmacist-led same-day PrEP implementation, or mail delivery of PrEP prescriptions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10461-025-04898-2","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:25:43Z","timestamp":1760102743000},"page":"558-570","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Barriers to Same-Day Pre-exposure Prophylaxis (PrEP) Implementation in Federally Funded HIV Clinics Within High-Burden Areas of the U.S.: A Coincidence 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