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A total of 210 index PLHIV participants (105 intervention, 105 control) and 599 alters were enrolled; assessments were conducted at baseline and 6-, 12-, and 18-months post-baseline. Intention-to-treat repeated measures regressions indicated significant intervention effects on reduced internalized stigma and increased HIV prevention advocacy, prevention advocacy self-efficacy, and disclosure among index participants. In within-intervention group analyses, alters exposed to prevention advocacy showed higher likelihoods of HIV testing and condom use.\n                    <jats:italic>Game Changers<\/jats:italic>\n                    had direct psychosocial benefits for index participants, and indirect benefits for improved HIV prevention behaviors among alters. Implementation research is needed to determine conditions under which\n                    <jats:italic>Game Changers<\/jats:italic>\n                    is most effective.\n                  <\/jats:p>\n                  <jats:p>NCT05098015, Registered 2021-10-18.<\/jats:p>","DOI":"10.1007\/s10461-025-04907-4","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:27:07Z","timestamp":1762831627000},"page":"1007-1021","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Randomized Controlled Trial of Game Changers, a Social Network Intervention for HIV Prevention in Uganda"],"prefix":"10.1007","volume":"30","clinical-trial-number":[{"clinical-trial-number":"nct05098015","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-5542","authenticated-orcid":false,"given":"Laura M.","family":"Bogart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K. 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Study procedures were approved by the RAND Human Subjects Protection Committee (2021-N0155), the Infectious Diseases Institute Research Ethics Committee (IDI REC Ref#009-2021), and the Uganda National Council of Science and Technology (UNCST Reference #HS1896ES). Informed consent was obtained from all individual study participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}