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Using a mixed-method single-group, pre-post design, we assessed the intervention\u2019s feasibility, acceptability, and intended effects on health-related quality of life (HRQOL) and psychological distress. Fifteen Hispanic men participated in the study. Baseline assessments revealed low HRQOL, high levels of stress, and cancer-related PTSD symptoms. On average, participants attended seven of 10 sessions, with a 100% completion rate for pre- and post-intervention assessments. Most found the program relevant to their health needs, easy to navigate, and would recommend it. Participants demonstrated significant improvements in emotional well-being and on the PTSD avoidance subscale. Our findings emphasize the acceptability and feasibility of CBSM interventions for this population. However, recruitment challenges highlight the necessity for more inclusive and flexible strategies in future research.<\/jats:p>","DOI":"10.1007\/s10461-025-04945-y","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:19:02Z","timestamp":1761664742000},"page":"928-941","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cultural Adaptation of a Web-Based Cognitive Behavioral Stress and Self-Management Intervention for Hispanic Sexual Minority Men Living with HIV and Cancer: A Mixed-Methods Feasibility Study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-4408","authenticated-orcid":false,"given":"Blanca","family":"Noriega Esquives","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Pavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Puccinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-0417","authenticated-orcid":false,"given":"Frank J.","family":"Penedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-4609","authenticated-orcid":false,"given":"Sara","family":"St. George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"4945_CR1","unstructured":"Centers for Disease Control and Prevention (CDC). 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