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Yet, anxiety and depression are underdiagnosed and undertreated in this population. Implementing a system for routine anxiety and depression screening may overcome barriers to diagnosis. To improve the identification and management of anxiety and depression within an HIV clinic, we engaged HIV clinicians in the design of the workflow, created electronic health record reminders for screening, and trained medical assistants to deliver the screening questions at clinic visits. We evaluated this 24-month quality improvement project using electronic health record data and clinician surveys. From November 2020 to October 2022, 747 patients had 1166 appointments during which anxiety and\/or depression screening was due. During year one, anxiety and depression screening were completed at 75% (311\/416) and 77% (362\/469) of eligible encounters, respectively. During year two, screening was completed at 85% of encounters for anxiety (425\/502) and depression (446\/524). On average, anxiety screening increased by 2.2% per month (t\u2009=\u20094.24,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and depression screening increased by 1.2% per month (t\u2009=\u20092.82,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) after intervention implementation. Patients who screened positive received follow-up. Clinician satisfaction with screening processes increased from baseline to 6 months. Findings suggest that screening for anxiety and depression can improve detection and management in an HIV clinic, while also being acceptable to HIV clinicians.\n                  <\/jats:p>","DOI":"10.1007\/s10461-026-05102-9","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:25:16Z","timestamp":1774869916000},"page":"3079-3086","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a Clinic-Level Intervention to Increase Anxiety and Depression Screening in an Urban HIV Clinic"],"prefix":"10.1007","volume":"30","author":[{"given":"Daniela","family":"Zimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Staab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica P.","family":"Ridgway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa I.","family":"Franco-Galicia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-4325","authenticated-orcid":false,"given":"Neda","family":"Laiteerapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"5102_CR1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026881900222X","volume":"148","author":"A Camara","year":"2020","unstructured":"Camara A, Sow MS, Tour\u00e9 A, et al. Anxiety and depression among HIV patients of the infectious disease department of Conakry University Hospital in 2018. Epidemiol Infect. 2020;148:e8. https:\/\/doi.org\/10.1017\/S095026881900222X.","journal-title":"Epidemiol Infect"},{"issue":"18","key":"5102_CR2","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1097\/cm9.0000000000003202","volume":"137","author":"J Shi","year":"2024","unstructured":"Shi J, Zhang Z, Zhang J, et al. Mental health disparities in people living with human immunodeficiency virus: a cross-sectional study on physician-patient concordance and treatment regimens. Chin Med J. 2024;137(18):2223\u201332. https:\/\/doi.org\/10.1097\/cm9.0000000000003202.","journal-title":"Chin Med J"},{"issue":"1","key":"5102_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10461-020-02948-5","volume":"25","author":"AB Algarin","year":"2021","unstructured":"Algarin AB, Sheehan DM, Varas-Diaz N, et al. Enacted HIV-related stigma\u2019s association with anxiety & depression among people living with HIV (PLWH) in Florida. AIDS Behav. 2021;25(1):93\u2013103. https:\/\/doi.org\/10.1007\/s10461-020-02948-5.","journal-title":"AIDS Behav"},{"issue":"9","key":"5102_CR4","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1093\/cid\/ciy309","volume":"67","author":"MS Rane","year":"2018","unstructured":"Rane MS, Hong T, Govere S, et al. Depression and anxiety as risk factors for delayed care-seeking behavior in human immunodeficiency virus-infected individuals in South Africa. Clin Infect Dis. 2018;67(9):1411\u20138. https:\/\/doi.org\/10.1093\/cid\/ciy309.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"5102_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/13548500124807","volume":"6","author":"SL Catz","year":"2001","unstructured":"Catz SL, Heckman TG, Kochman A, Dimarco M. 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