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Limited studies have examined the dyadic effects of HIV-related stigma and resilience on psychological distress for people with HIV (PWH) and their family members. This study aimed to explore the actor-partner effect and the mediation role of resilience in the relationship between internalized stigma and psychological distress among PWH and family members dyads. Between October 2023 and December 2023, a total of 800 PWH-family member dyads were recruited from two urban cities and nine rural counties in Guangxi, China. All participants completed validated questionnaires capturing demographic characteristics, internalized stigma, resilience, and psychological distress. This study employed the actor-partner interdependence mediation model to examine both individual (actor) and dyadic (partner) pathways, along with resilience as a mediator. For actor effects, resilience partially mediated the relationship between internalized stigma and psychological distress in PWH (\u03b2\u2009=\u20090.08, SE\u2009=\u20090.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but not in their family members (\u03b2 = -0.00, SE\u2009=\u20090.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.68). Regarding partner effects, indirect effects were significant in the association between family members\u2019 internalized stigma and PWH\u2019s psychological distress through PWH\u2019s resilience (\u03b2\u2009=\u20090.03, SE\u2009=\u20090.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). This study underscores the complex interplay between internalized stigma, resilience, and psychological distress in PWH-family member dyads. Psychological health promotion programs would benefit from adopting family-centered strategies that attend to stigma reduction and resilience improvement for both PWH and family members.\n                  <\/jats:p>","DOI":"10.1007\/s10461-026-05104-7","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:10:06Z","timestamp":1774516206000},"page":"3113-3123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dyadic Internalized Stigma, Resilience, and Psychological Distress Among People with HIV and their Family Members: An Actor-Partner Interdependence Mediation Model Analysis"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-5398","authenticated-orcid":false,"given":"Fanghui","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk Chi","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"issue":"6","key":"5104_CR1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1017\/S0033291702005949","volume":"32","author":"J Leserman","year":"2002","unstructured":"Leserman J, Petitto JM, Gu H, Gaynes BN, Barroso J, Golden R, et al. 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