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We developed and conducted a preliminary evaluation of a proposed composite outcome measure, \u201cprevention effective practice,\u201d integrating behavioral and biomedical prevention practices into a single binary outcome. Using longitudinal data from 392 transgender women not living with HIV in S\u00e3o Paulo, Brazil, we assessed whether prevention effective practice predicted subsequent HIV seroconversion. Prevention effective practice incorporated sufficient PrEP use, condom use, abstinence from sex, and absence of injection risk. Despite the small number of seroconversions (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911), prevention effective practice demonstrated preliminary predictive utility, with a Brier score of 0.0030, sensitivity of 0.59 (95%CI 0.56, 0.62), and specificity of 0.70 (95%CI 0.41, 0.99). These findings support further evaluation of prevention effective practice as a proposed status-neutral outcome measure, including validation among people living with HIV.\n                  <\/jats:p>","DOI":"10.1007\/s10461-026-05290-4","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:14:35Z","timestamp":1790759675000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention Effective Practice: Development and Preliminary Evaluation of a Proposed Composite Outcome for Status-Neutral HIV Prevention Research"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-038X","authenticated-orcid":false,"given":"Jae M.","family":"Sevelius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-7928","authenticated-orcid":false,"given":"A. 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