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DHST\u2019s institution has received investigator-initiated grants from Gilead, and support for participation in clinical research sponsored by Gilead, Glaxo Smith Kline and ViiV. JC and GL report nonfinancial support from the Direction r\u00e9gionale de sant\u00e9 publique, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux Centre-Sud-de-l\u2019Ile-de-Montr\u00e9al. JC reports grants and personal fees from ViiV Healthcare and Gilead Sciences Canada, and personal fees from Merck Canada, outside the submitted work. NL reports grants from the Canadian Institutes of Health Research, the Michael Smith Foundation for Health Research, Canadian Blood Services, the Vancouver Island Health Authority, the Canadian Foundation for AIDS Research, Gilead Sciences Canada, the Vancouver Foundation, the Public Health Agency of Canada, the University of Victoria and Mitacs, outside the submitted work. Other authors declare that they do not have conflicts.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Engage Cohort Study is approved by the Toronto Metropolitan University (#2016\u2009\u2212\u2009113), the University of Toronto (#00033527), St. Michael\u2019s Hospital (#17\u2013043), the University of Windsor (#33443), the University of British Columbia (H16-01226), Providence Health Care (H16-01226), the University of Victoria (H16-01226), Simon Fraser University (H16-01226), and the McGill University Health Centre (15-632-MUHC).","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}