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Long-acting injectable cabotegravir (CAB-LA) offers a new form of effective prevention, but maximizing uptake requires co-designing implementation strategies with impacted populations. In Chicago, where HIV disproportionately impacts sexual minority men (SMM), a community-focused innovation tournament identified home-based CAB-LA delivery as the top strategy. Through a partnership with key constituents, this research aimed to operationalize this strategy for SMM (\n                    <jats:italic>\u2265<\/jats:italic>\n                    \u200913 years) in Chicago, with particular attention to Black SMM and Latino SMM populations, through human-centered design (HCD). A four-hour, in-person workshop convened 19 transdisciplinary participants (e.g., SMM, clinicians, public health leadership, community-based organization leadership, implementation scientists) to co-create a preliminary blueprint for home-based delivery. Virtual follow-up semi-structured interviews with 10 workshop participants elicited feedback on the blueprint. Rapid qualitative analysis refined the blueprint, and final materials were produced in English and Spanish. Key phases of the home-based delivery strategy included: pre-implementation (e.g., outreach; procurement of shots), implementation (e.g., identification of staffing; administration in homes), and maintenance (e.g., post-administration and re-engagement). Patient actions focused on indicating preferences for visit, preparing home for visit, and scheduling follow-up care. Clinician actions emphasized prescribing CAB-LA, sharing financing information, and administration procedures. This research produced a blueprint for a co-designed strategy of \u201clow-barrier PrEP.\u201d Future efforts will develop complementary implementation strategies and will test the success of home-based delivery on increasing the uptake of CAB-LA among SMM. The HCD approach can also provide a framework for co-design approaches across the HIV care continuum.\n                  <\/jats:p>","DOI":"10.1007\/s10461-026-05316-x","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:46:52Z","timestamp":1790693212000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co-designing a Blueprint for Home Delivery of Long-Acting Injectable Pre-exposure Prophylaxis for Sexual Minority Men in Chicago"],"prefix":"10.1007","author":[{"given":"Amelia E.","family":"Van Pelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Casline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byrd G. M.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B. L.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Gregory","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cestou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Mustanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinad S.","family":"Beidas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"5316_CR1","unstructured":"Getting to Zerio Illinois. HIV prevalence. 2023. Accessed January 30, 2025. Available from: https:\/\/dashboard.gtzillinois.hiv\/graphs\/hiv-prevalence\/"},{"key":"5316_CR2","unstructured":"Getting to Zerio Illinois. 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Dr. Beidas is principal at Implementation Science & Practice, LLC and serves as co-Editor-In-Chief for Implementation Science. She is currently an appointed member of the National Advisory Mental Health Council and serves on the scientific advisory board for AIM Youth Mental Health Foundation, Klingenstein Third Generation Foundation, and the American Foundation for Suicide Prevention. She was previously an appointed member of the NASEM study, \u201cBlueprint for a national prevention infrastructure for behavioral health disorders,\u201d served on the scientific and advisory board for Optum Behavioral Health, received consulting fees from United Behavioral Health and OptumLabs, and received royalties from Oxford University Press. All activities are outside of the submitted work.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was obtained from the Institutional Review Board at Northwestern University.","order":2,"name":"Ethics","label":"Ethical Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All individuals provided informed consent to participant in the workshop and interviews.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}