{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:50:06Z","timestamp":1771667406895,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s10482-012-9797-9","type":"journal-article","created":{"date-parts":[[2012,9,3]],"date-time":"2012-09-03T06:33:42Z","timestamp":1346654022000},"page":"163-174","source":"Crossref","is-referenced-by-count":10,"title":["Increased frequency of integrons and \u03b2-lactamase-coding genes among extraintestinal Escherichia coli isolated with a 7-year interval"],"prefix":"10.1007","volume":"103","author":[{"given":"Joanna","family":"Mokracka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Oszy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kaznowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,4]]},"reference":[{"key":"9797_CR1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/jac\/dkn056","volume":"61","author":"ML Arag\u00f3n","year":"2008","unstructured":"Arag\u00f3n ML, Mirelis B, Mir\u00f3 E, G\u00f3mez L, Rivera A, Coll P, Navarro F (2008) Increase in \u03b2-lactam-resistant Proteus mirabilis strains due to CTX-M- and CMY-type as well as new VEB- and inhibitor-resistant TEM-type \u03b2-lactamases. J Antimicrob Chemother 61:1029\u20131032","journal-title":"J Antimicrob Chemother"},{"key":"9797_CR2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-genet-102209-163504","volume":"44","author":"G Cambray","year":"2010","unstructured":"Cambray G, Guerout A, Mazel D (2010) Integrons. Annu Rev Genet 44:141\u2013146","journal-title":"Annu Rev Genet"},{"key":"9797_CR3","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1128\/AAC.48.6.2308-2313.2004","volume":"48","author":"M Cartelle","year":"2004","unstructured":"Cartelle M, del Mar TM, Molina F, Moure R, Villanueva R, Bou G (2004) High-level resistance to ceftazidime conferred by a novel enzyme, CTX-M-32, derived from CTX-M-1 through a single Asp240-Gly substitution. Antimicrob Agents Chemother 48:2308\u20132313","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR4","unstructured":"CLSI (2009) Performance standards for antimicrobial disk susceptibility tests; approved standard, 10th edn. M02-A10. vol 29. No. 1"},{"key":"9797_CR5","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1128\/AAC.00044-07","volume":"51","author":"G Daikos","year":"2007","unstructured":"Daikos G, Kosmidis C, Tassios P, Petrikkos G, Vasilakopoulou A, Psychogiou M, Stefanou I, Avlami A, Katsilambros N (2007) Enterobacteriaceae bloodstream infections: presence of integrons, risk factors and outcome. Antimicrob Agents Chemother 51:2366\u20132372","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR6","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1128\/AAC.46.9.3031-3034.2002","volume":"46","author":"C Champs De","year":"2002","unstructured":"De Champs C, Poirel L, Bonnet R, Sirot D, Chanal C, Sirot J (2002) Prospective survey of \u03b2-lactamases produced by ceftazidime-resistant Pseudomonas aeruginosa isolated in a French hospital in 2000. Antimicrob Agents Chemother 46:3031\u20133034","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mimet.2005.02.007","volume":"62","author":"B Dillon","year":"2005","unstructured":"Dillon B, Thomas L, Mohmand G, Zelynsky A, Iredell J (2005) Multiplex PCR for screening of integrons in bacterial lysates. J Microbiol Methods 62:221\u2013232","journal-title":"J Microbiol Methods"},{"key":"9797_CR8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jac\/dki398","volume":"57","author":"C Eckert","year":"2006","unstructured":"Eckert C, Gautier V, Arlet G (2006) DNA sequence analysis of the genetic environment of various bla CTX-M genes. J Antimicrob Chemother 57:14\u201323","journal-title":"J Antimicrob Chemother"},{"key":"9797_CR9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1472-765X.2010.02926.x","volume":"51","author":"NG El-Najjar","year":"2010","unstructured":"El-Najjar NG, Farah MJ, Hashwa FA, Tokajian ST (2010) Antibiotic resistance patterns and sequencing of class I integron from uropathogenic Escherichia coli in Lebanon. Lett Appl Microbiol 51:456\u2013461","journal-title":"Lett Appl Microbiol"},{"key":"9797_CR10","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1128\/AAC.00043-08","volume":"52","author":"J Empel","year":"2008","unstructured":"Empel J, Baraniak A, Literacka E, Mrowka A, Fiett J, Sadowy E, Hryniewicz W, Gniadkowski M (2008) Molecular survey of \u03b2-lactamasesconferring resistance to newer \u03b2-lactams in Enterobacteriaceae isolates from Polish hospitals. Antimicrob Agents Chemother 52:2449\u20132454","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR11","unstructured":"European Centre for Disease Prevention and Control (2009) EARSS Annual Report 2008. Bilthoven"},{"key":"9797_CR12","unstructured":"European Centre for Disease Prevention and Control (2011) Antimicrobial resistance surveillance in Europe 2010. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm"},{"key":"9797_CR13","doi-asserted-by":"crossref","unstructured":"Gagliotti C, Balode A, Baquero F, Degener J, Grundmann H, G\u00fcr D, Jarlier V, Kahlmeter G, Monen J, Monnet DL, Rossolini GM, Suetens C, Weist K, Heuer O, The EARS Net Participants (Disease Specific Contact Points for AMR) (2011) Escherichia coli and Staphylococcus aureus: bad news and good news from the European Antimicrobial Resistance Surveillance Network (EARS-Net, formerly EARSS), 2002 to 2009. Euro Surveill 16(11):pii=19819. Available online: http:\/\/www.eurosurveillance","DOI":"10.2807\/ese.16.11.19819-en"},{"key":"9797_CR14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1128\/AAC.42.3.514","volume":"42","author":"M Gniadkowski","year":"1998","unstructured":"Gniadkowski M, Schneider I, Jungwirth R, Hryniewicz W, Bauernfeind A (1998a) Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended- spectrum \u03b2-lactamases. Antimicrob Agents Chemother 42:514\u2013520","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR15","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1128\/AAC.42.4.827","volume":"42","author":"M Gniadkowski","year":"1998","unstructured":"Gniadkowski M, Schneider I, Palucha A, Jungwirth R, Mikiewicz B, Bauernfeind A (1998b) Cefotaxime resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland: identification of a new CTX-M-3 cefotaxime-hydrolyzing \u03b2-lactamase that is closely related to the CTX-M-1\/MEN-1 enzyme. Antimicrob Agents Chemother 42:827\u2013832","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2958.1995.tb02368.x","volume":"15","author":"RM Hall","year":"1995","unstructured":"Hall RM, Collis CM (1995) Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol Microbiol 15:593\u2013600","journal-title":"Mol Microbiol"},{"key":"9797_CR17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","volume":"2","author":"JB Kaper","year":"2004","unstructured":"Kaper JB, Nataro JP, Mobley HL (2004) Pathogenic Escherichia coli. Nat Rev Microbiol 2:123\u2013140","journal-title":"Nat Rev Microbiol"},{"key":"9797_CR18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1086\/345880","volume":"187","author":"MA Leverstein-van Hall","year":"2003","unstructured":"Leverstein-van Hall MA, Blok HEM, Rogier A, Donders T, Paauw A, Fluit AC, Verhoef J (2003) Multidrug resistance among Enterobacteriaceae is strongly associated with the presence of integrons and is independent of species or isolate origin. J Infect Dis 187:251\u2013259","journal-title":"J Infect Dis"},{"key":"9797_CR19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/AAC.39.1.185","volume":"39","author":"C L\u00e9vesque","year":"1995","unstructured":"L\u00e9vesque C, Pich\u00e9 L, Larose C, Roy PH (1995) PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob Agents Chemother 39:185\u2013191","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0924-8579(03)00157-2","volume":"22","author":"CR Li","year":"2003","unstructured":"Li CR, Li Y, Zhang PA (2003) Dissemination and spread of CTX-M extended-spectrum \u03b2-lactamases among clinical isolates of Klebsiella pneumoniae in central China. Int J Antimicrob Agents 22:521\u2013525","journal-title":"Int J Antimicrob Agents"},{"key":"9797_CR21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/JCM.00073-07","volume":"46","author":"Y Li","year":"2008","unstructured":"Li Y, Li Q, Du Y, Jiang X, Tang J, Wang J, Li G, Jiang Y (2008) Prevalence of plasmid-mediated AmpC \u03b2-lactamases in a Chinese university hospital from 2003 to 2005: first report of CMY-2-type AmpC \u03b2-lactamase resistance in China. J Clin Microbiol 46:1317\u20131321","journal-title":"J Clin Microbiol"},{"key":"9797_CR22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/jac\/dkl483","volume":"59","author":"DM Livermore","year":"2007","unstructured":"Livermore DM, Canton R, Gniadkowski M, Nordmann P, Rossolini GM, Arlet G, Ayala J, Coque TM, Kern-Zdanowicz I, Luzzaro F, Poirel L, Woodford N (2007) CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother 59:165\u2013174","journal-title":"J Antimicrob Chemother"},{"key":"9797_CR23","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/AAC.49.5.1823-1829.2005","volume":"49","author":"E Machado","year":"2005","unstructured":"Machado E, Cant\u00f3n R, Baquero F, Gal\u00e1n JC, Roll\u00e1n A, Peixe L, Coquel TM (2005) Integron content of extended-spectrum-\u03b2-lactamase-producing Escherichia coli strains over 12\u00a0years in a single hospital in Madrid, Spain. Antimicrob Agents Chemother 49:1823\u20131829","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR24","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nrmicro1462","volume":"4","author":"D Mazel","year":"2006","unstructured":"Mazel D (2006) Integrons: agents of bacterial evolution. Nat Rev Microbiol 4:608\u2013620","journal-title":"Nat Rev Microbiol"},{"key":"9797_CR25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijantimicag.2008.11.014","volume":"34","author":"N Mendon\u00e7a","year":"2008","unstructured":"Mendon\u00e7a N, Ferreira E, Louro D, ARSIP Participants, Cani\u00e7a M (2008) Molecular epidemiology and antimicrobial susceptibility of extended- and broad-spectrum \u03b2-lactamase-producing Klebsiella pneumoniae isolated in Portugal. Int J Antimicrob Agents 34:29\u201337","journal-title":"Int J Antimicrob Agents"},{"key":"9797_CR26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1099\/jmm.0.027979-0","volume":"60","author":"J Mokracka","year":"2011","unstructured":"Mokracka J, Koczura R, Paw\u0142owski K, Kaznowski A (2011) Resistance patterns and integron cassette arrays of Enterobacter cloacae complex strains of human origin. J Med Microbiol 60:737\u2013743","journal-title":"J Med Microbiol"},{"key":"9797_CR27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1574-6976.2011.00277.x","volume":"35","author":"SR Partridge","year":"2011","unstructured":"Partridge SR (2011) Analysis of antibiotic resistance regions in Gram-negative bacteria. FEMS Microbiol Rev 35:820\u2013855","journal-title":"FEMS Microbiol Rev"},{"key":"9797_CR28","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1574-6976.2009.00175.x","volume":"33","author":"SR Partridge","year":"2009","unstructured":"Partridge SR, Tsafnat G, Coiera EJ, Iredell R (2009) Gene cassettes and cassette arrays inmobile resistance integrons. FEMS Microbiol Rev 33:757\u2013784","journal-title":"FEMS Microbiol Rev"},{"key":"9797_CR29","first-page":"9","volume":"3","author":"JDD Pitout","year":"2012","unstructured":"Pitout JDD (2012) Extraintestinal pathogenic Escherichia coli: a combination of virulence with antibiotic resistance. Front Microbiol 3:9","journal-title":"Front Microbiol"},{"key":"9797_CR30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","volume":"8","author":"JD Pitout","year":"2008","unstructured":"Pitout JD, Laupland KB (2008) Extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis 8:159\u2013166","journal-title":"Lancet Infect Dis"},{"key":"9797_CR31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/jac\/dkf240","volume":"50","author":"L Poirel","year":"2002","unstructured":"Poirel L, Gniadkowski M, Nordmann P (2002) Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum b-lactamase CTX-M-15 and of its structurally related b-lactamase CTX-M-3. J Antimicrob Chemother 50:1031\u20131034","journal-title":"J Antimicrob Chemother"},{"key":"9797_CR32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1469-0691.2007.01865.x","volume":"14","author":"L Poirel","year":"2008","unstructured":"Poirel L, Naas T, Nordmann P (2008) Genetic support of extended-spectrum \u03b2-lactamases. Clin Microbiol Infect 14:75\u201381","journal-title":"Clin Microbiol Infect"},{"key":"9797_CR33","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1128\/AAC.00726-07","volume":"51","author":"MP Quiroga","year":"2007","unstructured":"Quiroga MP, Andres P, Petroni A, Soler Bistue AJC, Guerriero L, Vargas LJ, Zorreguieta A, Tokumoto M, Quiroga C, Tolmasky ME, Galas M, Centron D (2007) Complex class 1 integrons with diverse variable regions, including aac(6)-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. Antimicrob Agents Chemother 51:4466\u20134470","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR34","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1086\/315418","volume":"181","author":"T Russo","year":"2000","unstructured":"Russo T, Johnson J (2000) A proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: exPEC. J Infect Dis 181:1753\u20131754","journal-title":"J Infect Dis"},{"key":"9797_CR35","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1128\/AAC.48.10.3996-4001.2004","volume":"48","author":"Y S\u00e1enz","year":"2004","unstructured":"S\u00e1enz Y, Brinas L, Dom\u00ednguez E, Ruiz J, Zarazaga M, Vila J (2004) Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins. Antimicrob Agents Chemother 48:3996\u20134001","journal-title":"Antimicrob Agents Chemother"},{"key":"9797_CR36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.diagmicrobio.2007.09.006","volume":"60","author":"PJ Turner","year":"2008","unstructured":"Turner PJ (2008) Meropenem activity against European isolates: report on the MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) 2006 results. Diagn Microbiol Infect Dis 60:185\u2013192","journal-title":"Diagn Microbiol Infect Dis"},{"key":"9797_CR37","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1093\/nar\/19.24.6823","volume":"19","author":"J Versalovic","year":"1991","unstructured":"Versalovic J, Koeuth T, Lupski JR (1991) Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes. Nucleic Acids Res 19:6823\u20136831","journal-title":"Nucleic Acids Res"},{"key":"9797_CR38","doi-asserted-by":"crossref","unstructured":"Welch RA (2006) The genus Escherichia. In: Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E (eds) The prokaryotes 3rd edn, volume 6: Proteobacteria: gamma subclass. Springer, New York, pp 60\u201371","DOI":"10.1007\/0-387-30746-X_3"},{"key":"9797_CR39","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijantimicag.2004.03.007","volume":"23","author":"G Weldhagen","year":"2004","unstructured":"Weldhagen G (2004) Integron and \u03b2-lactamases: a novel perspective on resistance. Int J Antimicrob Agents 23:556\u2013562","journal-title":"Int J Antimicrob Agents"},{"key":"9797_CR40","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1128\/AAC.45.9.2658-2661.2001","volume":"45","author":"PA White","year":"2001","unstructured":"White PA, McIver CJ, Rawlinson WD (2001) Integrons and gene cassettes in the Enterobacteriaceae. Antimicrob Agents Chemother 45:2561\u20132658","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s10482-012-9797-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T05:41:58Z","timestamp":1562132518000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10482-012-9797-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["9797"],"URL":"https:\/\/doi.org\/10.1007\/s10482-012-9797-9","relation":{},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,4]]}}}