{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:07:46Z","timestamp":1772881666481,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Beijing Innovation Consortium of Agriculture Research System","award":["BAIC02-2016"],"award-info":[{"award-number":["BAIC02-2016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10482-018-1057-1","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T22:52:15Z","timestamp":1519858335000},"page":"1673-1685","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Differences in gut microbiota composition in finishing Landrace pigs with low and high feed conversion ratios"],"prefix":"10.1007","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-1916","authenticated-orcid":false,"given":"Zhen","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaokang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xitong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuduan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"1057_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2323\/jgam.60.140","volume":"60","author":"BPE Alain","year":"2014","unstructured":"Alain BPE, Chae JP, Balolong MP, Bum KH, Kang DK (2014) Assessment of fecal bacterial diversity among healthy piglets during the weaning transition. J Gen Appl Microbiol 60:140\u2013146","journal-title":"J Gen Appl Microbiol"},{"key":"1057_CR2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1264\/jsme2.ME12157","volume":"28","author":"E Avershina","year":"2013","unstructured":"Avershina E, Frisli T, Rudi K (2013) De novo semi-alignment of 16S rRNA gene sequences for deep phylogenetic characterization of next generation sequencing data. Microbes Environ 28:211\u2013216","journal-title":"Microbes Environ"},{"key":"1057_CR3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R (2010) QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7:335\u2013336","journal-title":"Nat Methods"},{"key":"1057_CR4","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"RC Edgar","year":"2013","unstructured":"Edgar RC (2013) UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods 10:996","journal-title":"Nat Methods"},{"key":"1057_CR5","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.2527\/jas.2011-4515","volume":"90","author":"H Gilbert","year":"2012","unstructured":"Gilbert H, Bidanel JP, Billon Y, Lagant H, Guillouet P, Sellier P, Noblet J, Hermesch S (2012) Correlated responses in sow appetite, residual feed intake, body composition, and reproduction after divergent selection for residual feed intake in the growing pig. J Anim Sci 90:1046\u20131097","journal-title":"J Anim Sci"},{"key":"1057_CR6","doi-asserted-by":"publisher","first-page":"11953","DOI":"10.1038\/srep11953","volume":"5","author":"L Jing","year":"2015","unstructured":"Jing L, Hou Y, Wu H, Miao Y, Li X, Cao J, Michael Brameld J, Parr T, Zhao S (2015) Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential residual feed intake in pigs. Sci Rep 5:11953","journal-title":"Sci Rep"},{"key":"1057_CR7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.vetmic.2015.03.014","volume":"177","author":"HB Kim","year":"2015","unstructured":"Kim HB, Isaacson RE (2015) The pig gut microbial diversity: understanding the pig gut microbial ecology through the next generation high throughput sequencing. Vet Microbiol 177:242\u2013251","journal-title":"Vet Microbiol"},{"key":"1057_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.vetmic.2011.05.021","volume":"153","author":"HB Kim","year":"2011","unstructured":"Kim HB, Borewicz K, White BA, Singer RS, Sreevatsan S, Tu ZJ, Isaacson RE (2011) Longitudinal investigation of the age-related bacterial diversity in the feces of commercial pigs. Vet Microbiol 153:124\u2013133","journal-title":"Vet Microbiol"},{"key":"1057_CR9","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00203-015-1108-1","volume":"197","author":"J Kim","year":"2015","unstructured":"Kim J, Nguyen SG, Guevarra RB, Lee I, Unno T (2015) Analysis of swine fecal microbiota at various growth stages. Arch Microbiol 197:753\u2013759","journal-title":"Arch Microbiol"},{"key":"1057_CR10","doi-asserted-by":"publisher","first-page":"5112","DOI":"10.1128\/AEM.01043-13","volume":"79","author":"JJ Kozich","year":"2013","unstructured":"Kozich JJ, Westcott SL, Baxter NT, Highlander SK, Schloss PD (2013) Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl Environ Microbiol 79:5112\u20135120","journal-title":"Appl Environ Microbiol"},{"key":"1057_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/1471-2180-11-103","volume":"11","author":"R Lamendella","year":"2011","unstructured":"Lamendella R, Domingo JW, Ghosh S, Martinson J, Oerther DB (2011) Comparative fecal metagenomics unveils unique functional capacity of the swine gut. BMC Microbiol 11:103","journal-title":"BMC Microbiol"},{"key":"1057_CR12","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nbt.2676","volume":"31","author":"MGI Langille","year":"2013","unstructured":"Langille MGI, Zaneveld J, Caporaso JG, McDonald D, Knights D, Reyes JA, Clemente JC, Burkepile DE, Thurber RLV, Knight R, Beiko RG, Huttenhower C (2013) Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol 31:814","journal-title":"Nat Biotechnol"},{"key":"1057_CR13","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1073\/pnas.1120238109","volume":"109","author":"T Looft","year":"2012","unstructured":"Looft T, Johnson TA, Allen HK, Bayles DO, Alt DP, Stedtfeld RD, Sul WJ, Stedtfeld TM, Chai B, Cole JR, Hashsham SA, Tiedje JM, Stanton TB (2012) In-feed antibiotic effects on the swine intestinal microbiome. Proc Natl Acad Sci USA 109:1691\u20131696","journal-title":"Proc Natl Acad Sci USA"},{"key":"1057_CR14","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/ismej.2014.12","volume":"8","author":"T Looft","year":"2014","unstructured":"Looft T, Allen HK, Cantarel BL, Levine UY, Bayles DO, Alt DP, Henrissat B, Stanton TB (2014) Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations. ISME J 8:1566\u20131576","journal-title":"ISME J"},{"key":"1057_CR15","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1111\/j.1365-2672.2007.03322.x","volume":"102","author":"P Louis","year":"2007","unstructured":"Louis P, Scott KP, Duncan SH, Flint HJ (2007) Understanding the effects of diet on bacterial metabolism in the large intestine. J Appl Microbiol 102:1197\u20131208","journal-title":"J Appl Microbiol"},{"key":"1057_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/ismej.2010.133","volume":"5","author":"C Lozupone","year":"2011","unstructured":"Lozupone C, Lladser ME, Knights D, Stombaugh J, Knight R (2011) UniFrac: an effective distance metric for microbial community comparison. ISME J 5:169\u2013172","journal-title":"ISME J"},{"key":"1057_CR17","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jff.2015.11.017","volume":"20","author":"S Lu","year":"2016","unstructured":"Lu S, Zuo T, Zhang N, Shi H, Liu F, Wu J, Wang Y, Xue C, Tang Q (2016) High throughput sequencing analysis reveals amelioration of intestinal dysbiosis by squid ink polysaccharide. J Funct Foods 20:506\u2013515","journal-title":"J Funct Foods"},{"key":"1057_CR18","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3382\/ps.2010-00747","volume":"89","author":"BS Lumpkins","year":"2010","unstructured":"Lumpkins BS, Batal AB, Lee MD (2010) Evaluation of the bacterial community and intestinal development of different genetic lines of chickens. Poult Sci 89:1614\u20131621","journal-title":"Poult Sci"},{"key":"1057_CR19","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-1-4615-4111-0_9","volume-title":"Ecology and physiology of gastrointestinal microbes","author":"GT Macfarlane","year":"1997","unstructured":"Macfarlane GT, Gibson GR (1997) Carbohydrate fermentation, energy transduction and gas metabolism in the human large intestine. In: Mackie RI, White BA (eds) Ecology and physiology of gastrointestinal microbes. Chapman and Hall, London, pp 269\u2013318"},{"key":"1057_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.anaerobe.2013.02.005","volume":"20","author":"BU Metzler-Zebeli","year":"2013","unstructured":"Metzler-Zebeli BU, Schmitz-Esser S, Klevenhusen F, Podstatzky-Lichtenstein L, Wagner M, Zebeli Q (2013) Grain-rich diets differently alter ruminal and colonic abundance of microbial populations and lipopolysaccharide in goats. Anaerobe 20:65\u201373","journal-title":"Anaerobe"},{"key":"1057_CR21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.micpath.2012.05.007","volume":"53","author":"M Million","year":"2012","unstructured":"Million M, Angelakis E, Paul M, Armougom F, Leibovici L, Raoult D (2012) Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microb Pathog 53:100\u2013108","journal-title":"Microb Pathog"},{"key":"1057_CR22","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.1223813","volume":"336","author":"JK Nicholson","year":"2012","unstructured":"Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S (2012) Host-gut microbiota metabolic interactions. Science 336:1262\u20131267","journal-title":"Science"},{"key":"1057_CR23","doi-asserted-by":"publisher","first-page":"584","DOI":"10.5713\/ajas.14.0651","volume":"28","author":"EAB Pajarillo","year":"2015","unstructured":"Pajarillo EAB, Chae JP, Balolong MP, Kim HB, Seo K, Kang D (2015) Characterization of the fecal microbial communities of duroc pigs using 16S rRNA gene pyrosequencing. Asian Aust J Anim 28:584\u2013591","journal-title":"Asian Aust J Anim"},{"key":"1057_CR24","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1371\/journal.pbio.0050177","volume":"5","author":"C Palmer","year":"2007","unstructured":"Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO (2007) Development of the human infant intestinal microbiota. PLoS Biol 5:e177","journal-title":"PLoS Biol"},{"key":"1057_CR25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.cmet.2012.12.007","volume":"17","author":"BW Parks","year":"2013","unstructured":"Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ (2013) Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab 17:141\u2013152","journal-title":"Cell Metab"},{"key":"1057_CR26","doi-asserted-by":"publisher","first-page":"e56612","DOI":"10.1371\/journal.pone.0056612","volume":"8","author":"R Pedersen","year":"2013","unstructured":"Pedersen R, Ingerslev H, Sturek M, Alloosh M, Cirera S, Christoffersen BO, Moesgaard SG, Larsen N, Boye M (2013) Characterisation of gut microbiota in ossabaw and gottingen minipigs as models of obesity and metabolic syndrome. PLoS ONE 8:e56612","journal-title":"PLoS ONE"},{"key":"1057_CR27","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1038\/ismej.2016.77","volume":"10","author":"Y Ramayo-Caldas","year":"2016","unstructured":"Ramayo-Caldas Y, Mach N, Lepage P, Levenez F, Denis C, Lemonnier G, Leplat J, Billon Y, Berri M, Dore J, Rogel-Gaillard C, Estelle J (2016) Phylogenetic network analysis applied to pig gut microbiota identifies an ecosystem structure linked with growth traits. ISME J 10:2973\u20132977","journal-title":"ISME J"},{"key":"1057_CR28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/oby.2009.167","volume":"18","author":"A Schwiertz","year":"2010","unstructured":"Schwiertz A, Taras D, Schaefer K, Beijer S, Bos NA, Donus C, Hardt PD (2010) Microbiota and SCFA in lean and overweight healthy subjects. Obesity 18:190\u2013195","journal-title":"Obesity"},{"key":"1057_CR29","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12:R60","journal-title":"Genome Biol"},{"key":"1057_CR30","doi-asserted-by":"publisher","first-page":"10595","DOI":"10.1007\/s11033-012-1947-7","volume":"39","author":"KM Singh","year":"2012","unstructured":"Singh KM, Shah T, Deshpande S, Jakhesara SJ, Koringa PG, Rank DN, Joshi CG (2012) High through put 16S rRNA gene-based pyrosequencing analysis of the fecal microbiota of high FCR and low FCR broiler growers. Mol Biol Rep 39:10595\u201310602","journal-title":"Mol Biol Rep"},{"key":"1057_CR31","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s13353-013-0179-4","volume":"55","author":"KM Singh","year":"2014","unstructured":"Singh KM, Shah TM, Reddy B, Deshpande S, Rank DN, Joshi CG (2014) Taxonomic and gene-centric metagenomics of the fecal microbiome of low and high feed conversion ratio (FCR) broilers. J Appl Genet 55:145\u2013154","journal-title":"J Appl Genet"},{"key":"1057_CR32","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.vetmic.2008.10.022","volume":"136","author":"LV Stamm","year":"2009","unstructured":"Stamm LV, Walker RL, Read DH (2009) Genetic diversity of bovine ulcerative mammary dermatitis-associated treponema. Vet Microbiol 136:192\u2013196","journal-title":"Vet Microbiol"},{"key":"1057_CR33","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12866-015-0388-6","volume":"15","author":"D Stanley","year":"2015","unstructured":"Stanley D, Geier MS, Chen H, Hughes RJ, Moore RJ (2015) Comparison of fecal and cecal microbiotas reveals qualitative similarities but quantitative differences. BMC Microbiol 15:51","journal-title":"BMC Microbiol"},{"key":"1057_CR34","doi-asserted-by":"publisher","first-page":"14886","DOI":"10.1038\/s41598-017-14568-6","volume":"7","author":"Z Tan","year":"2017","unstructured":"Tan Z, Wang Y, Yang T, Xing K, Ao H, Chen S, Zhang F, Zhao X, Liu J, Wang C (2017a) Differentially expressed genes in the caecal and colonic mucosa of Landrace finishing pigs with high and low food conversion ratios. Sci Rep 7:14886","journal-title":"Sci Rep"},{"key":"1057_CR35","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.3389\/fmicb.2017.01546","volume":"8","author":"Z Tan","year":"2017","unstructured":"Tan Z, Yang T, Wang Y, Xing K, Zhang F, Zhao X, Ao H, Chen S, Liu J, Wang C (2017b) Metagenomic analysis of cecal microbiome identified microbiota and functional capacities associated with feed efficiency in landrace finishing pigs. Front Microbiol 8:1546","journal-title":"Front Microbiol"},{"key":"1057_CR36","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","volume":"444","author":"PJ Turnbaugh","year":"2006","unstructured":"Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027\u20131031","journal-title":"Nature"},{"key":"1057_CR37","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/ismej.2010.99","volume":"5","author":"PK Wuest","year":"2011","unstructured":"Wuest PK, Horn MA, Drake HL (2011) Clostridiaceae and enterobacteriaceae as active fermenters in earthworm gut content. ISME J 5:92\u2013106","journal-title":"ISME J"},{"key":"1057_CR38","doi-asserted-by":"publisher","first-page":"45308","DOI":"10.1038\/srep45308","volume":"7","author":"W Yan","year":"2017","unstructured":"Yan W, Sun C, Yuan J, Yang N (2017) Gut metagenomic analysis reveals prominent roles of Lactobacillus and cecal microbiota in chicken feed efficiency. Sci Rep 7:45308","journal-title":"Sci Rep"},{"key":"1057_CR39","doi-asserted-by":"publisher","first-page":"898","DOI":"10.5713\/ajas.2013.13621","volume":"27","author":"L Yang","year":"2014","unstructured":"Yang L, Bian G, Su Y, Zhu W (2014) Comparison of faecal microbial community of Lantang, Bama, Erhualian, Meishan, Xiaomeishan, Duroc, Landrace, and Yorkshire Sows. Asian Aust J Anim 27:898\u2013906","journal-title":"Asian Aust J Anim"},{"key":"1057_CR40","doi-asserted-by":"publisher","first-page":"27427","DOI":"10.1038\/srep27427","volume":"6","author":"H Yang","year":"2016","unstructured":"Yang H, Huang X, Fang S, Xin W, Huang L, Chen C (2016) Uncovering the composition of microbial community structure and metagenomics among three gut locations in pigs with distinct fatness. Sci Rep 6:27427","journal-title":"Sci Rep"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10482-018-1057-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-018-1057-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-018-1057-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T11:45:19Z","timestamp":1551959119000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10482-018-1057-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["1057"],"URL":"https:\/\/doi.org\/10.1007\/s10482-018-1057-1","relation":{},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]},"assertion":[{"value":"19 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}