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In recent years we can observe an increasing number of infections caused by multidrug-resistant <jats:italic>Corynebacterium striatum, Corynebacterium jeikeium<\/jats:italic> and <jats:italic>Corynebacterium urealyticum<\/jats:italic>, including wide range of disorders, such as invasive infections. In this study 14 <jats:italic>Corynebacterium<\/jats:italic> spp. isolated from intravenous sites were sequenced and new combinations of mutations in the QRDR of the <jats:italic>gyr<\/jats:italic>A gene were found in <jats:italic>C. jeikeium<\/jats:italic> and <jats:italic>C. urealyticum.<\/jats:italic> Nowadays, no study comparing mutations in this region and the susceptibility to fluoroquinolones in <jats:italic>C. jeikeium<\/jats:italic> and <jats:italic>C. urealyticum<\/jats:italic> has been described. All the isolates that showed double mutation (position 87 and 91) in the QRDR <jats:italic>gyr<\/jats:italic>A gene had high MIC to the fluoroquinolones tested.<\/jats:p>","DOI":"10.1007\/s10482-019-01353-w","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T03:01:26Z","timestamp":1574046086000},"page":"589-592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Novel mutations in the QRDR region gyrA gene in multidrug-resistance Corynebacterium spp. isolates from intravenous sites"],"prefix":"10.1007","volume":"113","author":[{"given":"Juliana Nunes","family":"Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita Bernardo","family":"Valad\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Victor Pereira","family":"Baio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Mattos-Guaraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica Viana","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"issue":"1","key":"1353_CR1","doi-asserted-by":"publisher","first-page":"9704","DOI":"10.1038\/s41598-017-10081-y","volume":"7","author":"S Alibi","year":"2017","unstructured":"Alibi S, Ferjani A, Boukadida J, Cano ME, Fern\u00e1ndez-Mart\u00ednez M, Mart\u00ednez-Mart\u00ednez L, Navas J (2017) Occurrence of Corynebacterium striatum as na emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital. 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Antimicrob Agents Chemother 49:1714\u20131719","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"1353_CR8","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3343\/alm.2015.35.4.472","volume":"35","author":"G Yoo","year":"2015","unstructured":"Yoo G, Kim J, Uh Y, Lee HG, Hwang GY, Yoon KJ (2015) Multidrug-resistant Corynebacterium striatum bacteremia: first case in Korea. 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The consent to participate was not required because all the investigated isolates were taken as a part of standard care (diagnostic purposes). The samples were not collected for research purposes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}