{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:05:52Z","timestamp":1792037152966,"version":"4.4.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10482-025-02199-1","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T04:51:23Z","timestamp":1763527883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights into genetic heterogeneity and drug resistance in Leishmania donovani of the Indian sub-continent from genomic data"],"prefix":"10.1007","volume":"118","author":[{"given":"Aroop","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam Nath","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"issue":"5","key":"2199_CR1","doi-asserted-by":"publisher","first-page":"e01368","DOI":"10.1128\/aac.01368-23","volume":"68","author":"C Al Khoury","year":"2024","unstructured":"Al Khoury C, Thoumi S, Tokajian S, Sinno A, Nemer G, El Beyrouthy M, Rahy K (2024) ABC transporter inhibition by beauvericin partially overcomes drug resistance in Leishmania tropica. Antimicrob Agents Chemother 68(5):e01368-e1423","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2199_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10123-022-00259-4","volume":"26","author":"PJ Alcolea","year":"2023","unstructured":"Alcolea PJ, Alonso A, Garc\u00eda-Tabares F, Larraga J, Martins LT, Loayza FJ, Ruiz-Garc\u00eda S, Larraga V (2023) An insight into differential protein abundance throughout Leishmania donovani promastigote growth and differentiation. Int Microbiol 26(1):25\u201342","journal-title":"Int Microbiol"},{"key":"2199_CR3","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1590\/S0037-86822010000200017","volume":"43","author":"DGd Alvarenga","year":"2010","unstructured":"Alvarenga DGd, Escalda PMF, Costa ASVd, Monreal MTFD (2010) Leishmaniose visceral: estudo retrospectivo de fatores associados \u00e0 letalidade. Rev Soc Bras Med Trop 43:194\u2013197","journal-title":"Rev Soc Bras Med Trop"},{"key":"2199_CR4","volume-title":"FastQC: a quality control tool for high throughput sequence data","author":"S Andrews","year":"2010","unstructured":"Andrews S (2010) FastQC: a quality control tool for high throughput sequence data. Babraham Bioinformatics, Babraham Institute, Cambridge"},{"key":"2199_CR5","first-page":"238","volume":"119","author":"A Awasthi","year":"2004","unstructured":"Awasthi A, Mathur RK, Saha B (2004) Immune response to Leishmania infection. Indian J Med Res 119:238\u2013258","journal-title":"Indian J Med Res"},{"issue":"11","key":"2199_CR6","first-page":"12500","volume":"9","author":"K Bharadava","year":"2024","unstructured":"Bharadava K, Upadhyay TK, Kaushal RS, Ahmad I, Alraey Y, Siddiqui S, Saeed M (2024) Genomic insight of Leishmania parasite: in-depth review of drug resistance mechanisms and genetic mutations. ACS Omega 9(11):12500\u201312514","journal-title":"ACS Omega"},{"issue":"3","key":"2199_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/bioinformatics\/btr670","volume":"28","author":"V Boeva","year":"2012","unstructured":"Boeva V, Popova T, Bleakley K, Chiche P, Cappo J, Schleiermacher G, Janoueix-Lerosey I, Delattre O, Barillot E (2012) Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics 28(3):423\u2013425","journal-title":"Bioinformatics"},{"issue":"15","key":"2199_CR8","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B (2014) Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30(15):2114\u20132120","journal-title":"Bioinformatics"},{"issue":"6","key":"2199_CR10","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1111\/cbdd.13502","volume":"93","author":"N Bora","year":"2019","unstructured":"Bora N, Nath Jha A (2019) An integrative approach using systems biology, mutational analysis with molecular dynamics simulation to challenge the functionality of a target protein. Chem Biol Drug Des 93(6):1050\u20131060","journal-title":"Chem Biol Drug Des"},{"key":"2199_CR9","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fgene.2020.00179","volume":"11","author":"N Bora","year":"2020","unstructured":"Bora N, Jha AN (2020) In silico metabolic pathway analysis identifying target against leishmaniasis\u2014a kinetic modeling approach. Front Genet 11:179","journal-title":"Front Genet"},{"key":"2199_CR100","unstructured":"CDC (2018) Leishmania epidemilogy and risk factors. https:\/\/www.cdc.gov\/parasites\/leishmaniasis\/epi.html."},{"issue":"2","key":"2199_CR11","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4161\/fly.19695","volume":"6","author":"P Cingolani","year":"2012","unstructured":"Cingolani P, Platts A, Wang LL, Coon M, Nguyen T, Wang L, Land SJ, Lu X, Ruden DM (2012) A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly 6(2):80\u201392","journal-title":"Fly"},{"issue":"D1","key":"2199_CR12","doi-asserted-by":"publisher","first-page":"D67","DOI":"10.1093\/nar\/gkv1276","volume":"44","author":"K Clark","year":"2016","unstructured":"Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J, Sayers EW (2016) GenBank. Nucleic Acids Res 44(D1):D67\u2013D72","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2199_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008","volume":"10","author":"P Danecek","year":"2021","unstructured":"Danecek P, Bonfield JK, Liddle J, Marshall J, Ohan V, Pollard MO, Whitwham A, Keane T, McCarthy SA, Davies RM (2021) Twelve years of SAMtools and BCFtools. Gigascience 10(2):giab008","journal-title":"Gigascience"},{"issue":"12","key":"2199_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005296","volume":"11","author":"RMC de Paiva","year":"2015","unstructured":"de Paiva RMC, Grazielle-Silva V, Cardoso MS, Nakagaki BN, Mendonca-Neto RP, Canavaci AMC, Souza Melo N, Martinelli PM, Fernandes AP, daRocha WD (2015a) Amastin knockdown in Leishmania braziliensis affects parasite\u2013macrophage interaction and results in impaired viability of intracellular amastigotes. PLoS Pathog 11(12):e1005296","journal-title":"PLoS Pathog"},{"issue":"12","key":"2199_CR16","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1101\/gr.123430.111","volume":"21","author":"T Downing","year":"2011","unstructured":"Downing T, Imamura H, Decuypere S, Clark TG, Coombs GH, Cotton JA, Hilley JD, de Doncker S, Maes I, Mottram JC (2011) Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Genome Res 21(12):2143\u20132156","journal-title":"Genome Res"},{"key":"2199_CR17","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00599-00517","author":"F Dumetz","year":"2017","unstructured":"Dumetz F, Imamura H, Sanders M, Seblova V, Myskova J, Pescher P, Vanaerschot M, Meehan CJ, Cuypers B, De Muylder G (2017) Modulation of aneuploidy in Leishmania donovani during adaptation to different in vitro and in vivo environments and its impact on gene expression. MBio. https:\/\/doi.org\/10.1128\/mbio.00599-00517","journal-title":"MBio"},{"issue":"11","key":"2199_CR18","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.3390\/genes11111362","volume":"11","author":"S Ghosh","year":"2020","unstructured":"Ghosh S, Verma A, Kumar V, Pradhan D, Selvapandiyan A, Salotra P, Singh R (2020) Genomic and transcriptomic analysis for identification of genes and interlinked pathways mediating artemisinin resistance in Leishmania donovani. Genes 11(11):1362","journal-title":"Genes"},{"issue":"11","key":"2199_CR19","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1007\/s00436-022-07645-x","volume":"121","author":"S Ghosh","year":"2022","unstructured":"Ghosh S, Kumar V, Verma A, Sharma T, Pradhan D, Selvapandiyan A, Salotra P, Singh R (2022) Genome-wide analysis reveals allelic variation and chromosome copy number variation in paromomycin-resistant Leishmania donovani. Parasitol Res 121(11):3121\u20133132","journal-title":"Parasitol Res"},{"key":"2199_CR50","doi-asserted-by":"crossref","unstructured":"Hazarika U, Jha AN (2025) Uncovering therapeutic targets in Leishmania donovani through comparative network topology analysis. Archives Microbiol 207(12)","DOI":"10.1007\/s00203-025-04511-z"},{"key":"2199_CR51","doi-asserted-by":"crossref","unstructured":"Hojaisa S, Jha AN (2023) Microbial Technology Databases and Tools for Microbial Genome and Human Microbiome Studies. In: Verma, P. (eds) Industrial Microbiology and Biotechnology. Springer, Singapore: 41\u201367","DOI":"10.1007\/978-981-99-2816-3_3"},{"issue":"1","key":"2199_CR20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4269\/ajtmh.23-0373","volume":"110","author":"AB Joshi","year":"2024","unstructured":"Joshi AB, Banjara MR, Das ML, Ghale P, Pant KR, Pyakurel UR, Dahal G, Paudel KP, Das CL, Kroegerm A, Aseffa A (2024) Epidemiological, serological, and entomological investigation of new visceral leishmaniasis foci in Nepal. Am J Trop Med Hyg 110(1):44","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"2199_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2174\/1389203724666230210123147","volume":"24","author":"I Kumari","year":"2023","unstructured":"Kumari I, Lakhanpal D, Swargam S, Nath Jha A (2023a) Leishmaniasis: omics approaches to understand its biology from molecule to cell level. Curr Protein Pept Sci 24(3):229\u2013239","journal-title":"Curr Protein Pept Sci"},{"issue":"13","key":"2199_CR22","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.2174\/0113894501254585230927100440","volume":"24","author":"P Kumari","year":"2023","unstructured":"Kumari P, Mamud A, Jha AN (2023b) Review on the drug intolerance and vaccine development for the leishmaniasis. Curr Drug Targets 24(13):1023\u20131031","journal-title":"Curr Drug Targets"},{"issue":"16","key":"2199_CR23","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R, Genome Project Data Processing Subgroup (2009) The sequence alignment\/map format and SAMtools. Bioinformatics 25(16):2078\u20132079","journal-title":"Bioinformatics"},{"issue":"2","key":"2199_CR24","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1086\/314896","volume":"180","author":"R Lira","year":"1999","unstructured":"Lira R, Sundar S, Makharia A, Kenney R, Gam A, Saraiva E, Sacks D (1999) Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. J Infect Dis 180(2):564\u2013567","journal-title":"J Infect Dis"},{"key":"2199_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.103802","author":"P Lypaczewski","year":"2022","unstructured":"Lypaczewski P, Thakur L, Jain A, Kumari S, Paulini K, Matlashewski G, Jain M (2022) An intraspecies Leishmania donovani hybrid from the Indian subcontinent is associated with an atypical phenotype of cutaneous disease. iScience. https:\/\/doi.org\/10.1016\/j.isci.2022.103802","journal-title":"iScience"},{"key":"2199_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s40475-021-00232-7","volume":"8","author":"S Mann","year":"2021","unstructured":"Mann S, Frasca K, Scherrer S, Henao-Mart\u00ednez AF, Newman S, Ramanan P, Suarez JA (2021) A review of leishmaniasis: current knowledge and future directions. Curr Trop Med Rep 8:121\u2013132","journal-title":"Curr Trop Med Rep"},{"issue":"4","key":"2199_CR27","first-page":"163","volume":"39","author":"FV Mart\u00ednez","year":"2011","unstructured":"Mart\u00ednez FV, Guerrero ET, Arenas R, Cedillo MQ (2011) Leishmaniasis en M\u00e9xico. Med Cutan Iber-Lat Am 39(4):163\u2013183","journal-title":"Med Cutan Iber-Lat Am"},{"issue":"11","key":"2199_CR28","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1101\/gr.239244.118","volume":"28","author":"A Mayakonda","year":"2018","unstructured":"Mayakonda A, Lin D-C, Assenov Y, Plass C, Koeffler HP (2018) Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res 28(11):1747\u20131756","journal-title":"Genome Res"},{"issue":"1","key":"2199_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S1368-7646(98)80213-6","volume":"1","author":"M Ouellette","year":"1998","unstructured":"Ouellette M, L\u00e9gar\u00e9 D, Haimeur A, Grondin K, Roy G, Brochu C, Papadopoulou B (1998) ABC transporters in Leishmania and their role in drug resistance. Drug Resist Updat 1(1):43\u201348","journal-title":"Drug Resist Updat"},{"key":"2199_CR30","unstructured":"Patil RR, Chatterjee PK (2023). Epidemiology of visceral leishmaniasis in India. In: Leishmania Parasites - Epidemiology, Immunopathology and Hosts"},{"issue":"D1","key":"2199_CR31","doi-asserted-by":"publisher","first-page":"D418","DOI":"10.1093\/nar\/gkac993","volume":"51","author":"T Paysan-Lafosse","year":"2023","unstructured":"Paysan-Lafosse T, Blum M, Chuguransky S, Grego T, Pinto BL, Salazar GA, Bileschi ML, Bork P, Bridge A, Colwell L (2023) InterPro in 2022. Nucleic Acids Res 51(D1):D418\u2013D427","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"2199_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011230","volume":"19","author":"OA Pilling","year":"2023","unstructured":"Pilling OA, Reis-Cunha JL, Grace CA, Berry AS, Mitchell MW, Yu JA, Malekshahi CR, Krespan E, Go CK, Lombana C (2023) Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies. PLoS Pathog 19(3):e1011230","journal-title":"PLoS Pathog"},{"key":"2199_CR101","doi-asserted-by":"crossref","unstructured":"Pinheiro AC,  de Souza MVN (2022) Current leishmaniasis drug discovery. RSC Med Chem 13(9):\n1029\u20131043","DOI":"10.1039\/D1MD00362C"},{"key":"2199_CR52","doi-asserted-by":"crossref","unstructured":"Rajkhowa S, Hazarika Z, Jha AN (2021) Applications of Nanobiotechnology for Neglected Tropical Diseases Systems biology and bioinformatics approaches in leishmaniasis. Elsevier 509\u2013548","DOI":"10.1016\/B978-0-12-821100-7.00018-2"},{"issue":"4","key":"2199_CR33","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.molcel.2015.05.004","volume":"58","author":"JA Reuter","year":"2015","unstructured":"Reuter JA, Spacek DV, Snyder MP (2015) High-throughput sequencing technologies. Mol Cell 58(4):586\u2013597","journal-title":"Mol Cell"},{"issue":"1","key":"2199_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011892","volume":"18","author":"Z Rezaei","year":"2024","unstructured":"Rezaei Z, Tahmasebi A, Pourabbas B (2024) Using meta-analysis and machine learning to investigate the transcriptional response of immune cells to Leishmania infection. PLoS Negl Trop Dis 18(1):e0011892","journal-title":"PLoS Negl Trop Dis"},{"key":"2199_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-019-3305-2","volume":"12","author":"CV Ribeiro","year":"2019","unstructured":"Ribeiro CV, Rocha BFB, Moreira DdS, Peruhype-Magalh\u00e3es V, Murta SMF (2019) Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony. Parasit Vectors 12:1\u20137","journal-title":"Parasit Vectors"},{"issue":"1","key":"2199_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011875","volume":"18","author":"K Riebenbauer","year":"2024","unstructured":"Riebenbauer K, Czerny S, Egg M, Urban N, Kinaciyan T, Hampel A, Fidelsberger L, Karlhofer F, Porkert S, Walochnik J (2024) The changing epidemiology of human leishmaniasis in the non-endemic country of Austria between 2000 to 2021, including a congenital case. PLoS Negl Trop Dis 18(1):e0011875","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"2199_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011920","volume":"18","author":"J S\u00e1dlov\u00e1","year":"2024","unstructured":"S\u00e1dlov\u00e1 J, Yeo M, Mateus DS, Phelan J, Hai LA, Bhattacharyya T, Kurtev S, Sebesta O, Myskova J, Seblova V (2024) Comparative genomics of Leishmania donovani progeny from genetic crosses in two sand fly species and impact on the diversity of diagnostic and vaccine candidates. PLoS Negl Trop Dis 18(1):e0011920","journal-title":"PLoS Negl Trop Dis"},{"key":"2199_CR49","doi-asserted-by":"crossref","unstructured":"Saha D, Jha AN (2024) Integrated subtractive genomics and structure-based approach to unravel the therapeutic drug target of Leishmania species. Archive Microbiol 206(10)","DOI":"10.1007\/s00203-024-04118-w"},{"key":"2199_CR38","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.sajb.2023.08.067","volume":"162","author":"D Saha","year":"2023","unstructured":"Saha D, Borah NJ, Jha AN (2023) Molecular scaffold recognition of drug molecules against essential genes of Leishmania donovani using biocomputing approach. S Afr J Bot 162:52\u201363","journal-title":"S Afr J Bot"},{"key":"2199_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.826287","volume":"12","author":"AMM Santi","year":"2022","unstructured":"Santi AMM, Murta SMF (2022) Impact of genetic diversity and genome plasticity of Leishmania spp. in treatment and the search for novel chemotherapeutic targets. Front Cell Infect Microbiol 12:9","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"2199_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-023-08034-8","volume":"123","author":"SG Sapp","year":"2024","unstructured":"Sapp SG, Low R, Nine G, Nascimento FS, Qvarnstrom Y, Barratt JL (2024) Genetic characterization and description of Leishmania (Leishmania) ellisi sp. nov.: a new human-infecting species from the USA. Parasitol Res 123(1):52","journal-title":"Parasitol Res"},{"issue":"7","key":"2199_CR41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0169-4758(93)90070-V","volume":"9","author":"Y Schlein","year":"1993","unstructured":"Schlein Y (1993) Leishmania and sandflies: interactions in the life cycle and transmission. Parasitol Today 9(7):255\u2013258","journal-title":"Parasitol Today"},{"key":"2199_CR42","doi-asserted-by":"publisher","unstructured":"Shirley MD, Ma Z, Pedersen BS, Wheelan SJ (2015) Efficient pythonic access to FASTA files using pyfaidx. Peer J PrePrints 3:e970v1 https:\/\/doi.org\/10.7287\/peerj.preprints.970v1","DOI":"10.7287\/peerj.preprints.970v1"},{"issue":"3","key":"2199_CR43","doi-asserted-by":"publisher","first-page":"328","DOI":"10.4103\/0972-9062.374037","volume":"60","author":"OMUD Sofi","year":"2023","unstructured":"Sofi OMUD, Godara R, Katoch R, Yadav A (2023) Morphological and molecular evidence of sandfly (Diptera: Psychodidae: Phlebotomine) and its relevance to recent cases of leishmaniasis from Jammu region of North India. J Vector Borne Dis 60(3):328\u2013332","journal-title":"J Vector Borne Dis"},{"key":"2199_CR44","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11120.1","author":"E Torres-Guerrero","year":"2017","unstructured":"Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J, Arenas R (2017) Leishmaniasis: a review. F1000Res. https:\/\/doi.org\/10.12688\/f1000research.11120.1","journal-title":"F1000Res"},{"key":"2199_CR102","doi-asserted-by":"crossref","unstructured":"UniProt Consortium T (2018) UniProt: the universal protein knowledgebase. Nucleic acids res 46(5):2699\u20132699","DOI":"10.1093\/nar\/gky092"},{"key":"2199_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-016-1904-8","volume":"9","author":"P Vacchina","year":"2016","unstructured":"Vacchina P, Norris-Mullins B, Carlson E, Morales M (2016) A mitochondrial HSP70 (HSPA9B) is linked to miltefosine resistance and stress response in Leishmania donovani. Parasit Vectors 9:1\u201315","journal-title":"Parasit Vectors"},{"issue":"1","key":"2199_CR46","doi-asserted-by":"crossref","first-page":"11.10.11","DOI":"10.1002\/0471250953.bi1110s43","volume":"43","author":"GA Van der Auwera","year":"2013","unstructured":"Van der Auwera GA, Carneiro MO, Hartl C, Poplin R, Del Angel G, Levy-Moonshine A, Jordan T, Shakir K, Roazen D, Thibault J (2013) From FastQ data to high-confidence variant calls: the genome analysis toolkit best practices pipeline. Curr Protoc Bioinform 43(1):11.10.11-11.10.33","journal-title":"Curr Protoc Bioinform"},{"issue":"16","key":"2199_CR47","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38(16):e164\u2013e164","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"2199_CR48","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1046\/j.1365-2958.2001.02286.x","volume":"39","author":"WW Zhang","year":"2001","unstructured":"Zhang WW, Matlashewski G (2001) Characterization of the A2\u2013A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection. Mol Microbiol 39(4):935\u2013948","journal-title":"Mol Microbiol"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-025-02199-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10482-025-02199-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-025-02199-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T08:05:53Z","timestamp":1764230753000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10482-025-02199-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2199"],"URL":"https:\/\/doi.org\/10.1007\/s10482-025-02199-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7267613\/v1","asserted-by":"object"}]},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"assertion":[{"value":"1 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}],"article-number":"198"}}