{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:03:04Z","timestamp":1768611784409,"version":"3.49.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Medical Research Project Fund of Yancheng Health Commission","award":["YK2024126"],"award-info":[{"award-number":["YK2024126"]}]},{"name":"Jiaxing Key Discipline of Medicine\u2010Clinical Diagnostics","award":["2023\u2010ZC\u2010002"],"award-info":[{"award-number":["2023\u2010ZC\u2010002"]}]},{"name":"the \u201cVenus\u201d Talent Training Program of the Jiaxing First Hospital","award":["2022-QXM-019"],"award-info":[{"award-number":["2022-QXM-019"]}]},{"name":"Zhejiang Provincial Medical and Health Technology Program","award":["2025KY354"],"award-info":[{"award-number":["2025KY354"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10482-025-02238-x","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:16:11Z","timestamp":1766837771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Codon usage bias of low-risk human papillomavirus types 6 and 11"],"prefix":"10.1007","volume":"119","author":[{"given":"Jiani","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunyou","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"2238_CR1","doi-asserted-by":"publisher","first-page":"1567209","DOI":"10.3389\/fvets.2025.1567209","volume":"12","author":"Y Akt\u00fcrk Dizman","year":"2025","unstructured":"Akt\u00fcrk Dizman Y (2025a) Comprehensive analysis of the codon usage patterns in the polyprotein coding sequences of the honeybee viruses. Front Vet Sci 12:1567209. https:\/\/doi.org\/10.3389\/fvets.2025.1567209","journal-title":"Front Vet Sci"},{"key":"2238_CR2","doi-asserted-by":"publisher","first-page":"107892","DOI":"10.1016\/j.micpath.2025.107892","volume":"207","author":"Y Akt\u00fcrk Dizman","year":"2025","unstructured":"Akt\u00fcrk Dizman Y (2025b) Genome-wide analysis of codon usage bias in Ascovirus: insights into viral evolution and host adaptation. Microb Pathog 207:107892. https:\/\/doi.org\/10.1016\/j.micpath.2025.107892","journal-title":"Microb Pathog"},{"issue":"4","key":"2238_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/s1470-2045(09)70096-8","volume":"10","author":"V Bouvard","year":"2009","unstructured":"Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V, WHO International Agency for Research on Cancer Monograph Working Group (2009) A review of human carcinogens\u2014Part B: biological agents. Lancet Oncol 10(4):321\u2013322. https:\/\/doi.org\/10.1016\/s1470-2045(09)70096-8","journal-title":"Lancet Oncol"},{"issue":"19","key":"2238_CR4","doi-asserted-by":"publisher","first-page":"9957","DOI":"10.1128\/JVI.00508-09","volume":"83","author":"CC Burns","year":"2009","unstructured":"Burns CC, Campagnoli R, Shaw J, Vincent A, Jorba J, Kew O (2009) Genetic inactivation of poliovirus infectivity by increasing the frequencies of CpG and UpA dinucleotides within and across synonymous capsid region codons. J Virol 83(19):9957\u20139969. https:\/\/doi.org\/10.1128\/JVI.00508-09. (Epub 2009 Jul 15)","journal-title":"J Virol"},{"issue":"3","key":"2238_CR5","doi-asserted-by":"publisher","first-page":"e90905","DOI":"10.1371\/journal.pone.0090905","volume":"9","author":"AM Butt","year":"2014","unstructured":"Butt AM, Nasrullah I, Tong Y (2014) Genome-wide analysis of codon usage and influencing factors in chikungunya viruses. PLoS ONE 9(3):e90905. https:\/\/doi.org\/10.1371\/journal.pone.0090905","journal-title":"PLoS ONE"},{"key":"2238_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.virusres.2019.01.011","volume":"263","author":"S Chakraborty","year":"2019","unstructured":"Chakraborty S, Deb B, Barbhuiya PA, Uddin A (2019) Analysis of codon usage patterns and influencing factors in Nipah virus. Virus Res 263:129\u2013138. https:\/\/doi.org\/10.1016\/j.virusres.2019.01.011","journal-title":"Virus Res"},{"issue":"1","key":"2238_CR7","doi-asserted-by":"publisher","first-page":"e85631","DOI":"10.1371\/journal.pone.0085631","volume":"9","author":"H Chen","year":"2014","unstructured":"Chen H, Sun S, Norenburg JL, Sundberg P (2014) Mutation and selection cause codon usage and bias in mitochondrial genomes of ribbon worms (Nemertea). PLoS ONE 9(1):e85631. https:\/\/doi.org\/10.1371\/journal.pone.0085631","journal-title":"PLoS ONE"},{"issue":"11","key":"2238_CR8","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1097\/OLQ.0000000000000193","volume":"41","author":"HW Chesson","year":"2014","unstructured":"Chesson HW, Dunne EF, Hariri S, Markowitz LE (2014) The estimated lifetime probability of acquiring human papillomavirus in the United States. Sex Transm Dis 41(11):660\u2013664. https:\/\/doi.org\/10.1097\/OLQ.0000000000000193","journal-title":"Sex Transm Dis"},{"key":"2238_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.virusres.2016.06.022","volume":"223","author":"J Cristina","year":"2016","unstructured":"Cristina J, Fajardo A, So\u00f1ora M, Moratorio G, Musto H (2016) A detailed comparative analysis of codon usage bias in Zika virus. Virus Res 223:147\u2013152. https:\/\/doi.org\/10.1016\/j.virusres.2016.06.022","journal-title":"Virus Res"},{"issue":"1","key":"2238_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.virol.2004.03.033","volume":"324","author":"EM de Villiers","year":"2004","unstructured":"de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H (2004) Classification of papillomaviruses. Virology 324(1):17\u201327. https:\/\/doi.org\/10.1016\/j.virol.2004.03.033","journal-title":"Virology"},{"issue":"5","key":"2238_CR11","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/v12050498","volume":"12","author":"M Dilucca","year":"2020","unstructured":"Dilucca M, Forcelloni S, Georgakilas AG, Giansanti A, Pavlopoulou A (2020) Codon usage and phenotypic divergences of SARS-CoV-2 genes. Viruses 12(5):498. https:\/\/doi.org\/10.3390\/v12050498","journal-title":"Viruses"},{"issue":"2","key":"2238_CR12","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1073\/pnas.80.2.560","volume":"80","author":"L Gissmann","year":"1983","unstructured":"Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schn\u00fcrch HG, zur Hausen H (1983) Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci USA 80(2):560\u2013563. https:\/\/doi.org\/10.1073\/pnas.80.2.560","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"2238_CR13","doi-asserted-by":"publisher","first-page":"108872","DOI":"10.1016\/j.celrep.2021.108872","volume":"34","author":"X Hernandez-Alias","year":"2021","unstructured":"Hernandez-Alias X, Benisty H, Schaefer MH, Serrano L (2021) Translational adaptation of human viruses to the tissues they infect. Cell Rep 34(11):108872. https:\/\/doi.org\/10.1016\/j.celrep.2021.108872","journal-title":"Cell Rep"},{"key":"2238_CR14","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1146\/annurev.genet.42.110807.091442","volume":"42","author":"R Hershberg","year":"2008","unstructured":"Hershberg R, Petrov DA (2008) Selection on codon bias. Annu Rev Genet 42:287\u2013299. https:\/\/doi.org\/10.1146\/annurev.genet.42.110807.091442","journal-title":"Annu Rev Genet"},{"issue":"1","key":"2238_CR15","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12985-020-01395-x","volume":"17","author":"W Hou","year":"2020","unstructured":"Hou W (2020) Characterization of codon usage pattern in SARS-CoV-2. Virol J 17(1):138. https:\/\/doi.org\/10.1186\/s12985-020-01395-x","journal-title":"Virol J"},{"issue":"1","key":"2238_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0168-1702(02)00309-x","volume":"92","author":"GM Jenkins","year":"2003","unstructured":"Jenkins GM, Holmes EC (2003) The extent of codon usage bias in human RNA viruses and its evolutionary origin. Virus Res 92(1):1\u20137. https:\/\/doi.org\/10.1016\/s0168-1702(02)00309-x","journal-title":"Virus Res"},{"issue":"7","key":"2238_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/s0168-9525(00)89076-9","volume":"11","author":"S Karlin","year":"1995","unstructured":"Karlin S, Burge C (1995) Dinucleotide relative abundance extremes: a genomic signature. Trends Genet 11(7):283\u2013290. https:\/\/doi.org\/10.1016\/s0168-9525(00)89076-9","journal-title":"Trends Genet"},{"key":"2238_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-1-0716-0872-2_4","volume":"2197","author":"N Kayraklioglu","year":"2021","unstructured":"Kayraklioglu N, Horuluoglu B, Klinman DM (2021) Cpg oligonucleotides as vaccine adjuvants. Methods Mol Biol 2197:51\u201385. https:\/\/doi.org\/10.1007\/978-1-0716-0872-2_4","journal-title":"Methods Mol Biol"},{"key":"2238_CR19","doi-asserted-by":"publisher","first-page":"886","DOI":"10.3389\/fmicb.2019.00886","volume":"10","author":"R Khandia","year":"2019","unstructured":"Khandia R, Singhal S, Kumar U, Ansari A, Tiwari R, Dhama K, Das J, Munjal A, Singh RK (2019) Analysis of Nipah virus codon usage and adaptation to hosts. Front Microbiol 10:886. https:\/\/doi.org\/10.3389\/fmicb.2019.00886","journal-title":"Front Microbiol"},{"issue":"5","key":"2238_CR20","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.chom.2012.10.008","volume":"12","author":"AS Lauring","year":"2012","unstructured":"Lauring AS, Acevedo A, Cooper SB, Andino R (2012) Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virus. Cell Host Microbe 12(5):623\u2013632. https:\/\/doi.org\/10.1016\/j.chom.2012.10.008","journal-title":"Cell Host Microbe"},{"key":"2238_CR21","doi-asserted-by":"publisher","first-page":"938651","DOI":"10.3389\/fmicb.2022.938651","volume":"13","author":"B Li","year":"2022","unstructured":"Li B, Wu H, Miao Z, Hu L, Zhou L, Lu Y (2022) Codon usage of hepatitis E viruses: a comprehensive analysis. Front Microbiol 13:938651. https:\/\/doi.org\/10.3389\/fmicb.2022.938651","journal-title":"Front Microbiol"},{"issue":"7","key":"2238_CR22","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3390\/v13071281","volume":"13","author":"W Liu","year":"2021","unstructured":"Liu W, Li J, Du H, Ou Z (2021) Mutation profiles, glycosylation site distribution and codon usage bias of human papillomavirus type 16. Viruses 13(7):1281. https:\/\/doi.org\/10.3390\/v13071281","journal-title":"Viruses"},{"key":"2238_CR23","doi-asserted-by":"publisher","first-page":"570131","DOI":"10.3389\/fmicb.2020.570131","volume":"11","author":"W Luo","year":"2020","unstructured":"Luo W, Roy A, Guo F, Irwin DM, Shen X, Pan J, Shen Y (2020) Host adaptation and evolutionary analysis of Zaire ebolavirus: insights from codon usage based investigations. Front Microbiol 11:570131. https:\/\/doi.org\/10.3389\/fmicb.2020.570131","journal-title":"Front Microbiol"},{"issue":"2","key":"2238_CR24","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1093\/bib\/bbaa383","volume":"22","author":"YS Malik","year":"2021","unstructured":"Malik YS, Ansari MI, Kattoor JJ, Kaushik R, Sircar S, Subbaiyan A, Tiwari R, Dhama K, Ghosh S, Tomar S, Zhang KYJ (2021) Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2. Brief Bioinform 22(2):1006\u20131022. https:\/\/doi.org\/10.1093\/bib\/bbaa383","journal-title":"Brief Bioinform"},{"issue":"8","key":"2238_CR25","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1515\/hsz-2017-0113","volume":"398","author":"AA McBride","year":"2017","unstructured":"McBride AA (2017) Mechanisms and strategies of papillomavirus replication. Biol Chem 398(8):919\u2013927. https:\/\/doi.org\/10.1515\/hsz-2017-0113","journal-title":"Biol Chem"},{"issue":"2","key":"2238_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s10709-022-00155-9","volume":"150","author":"K Nambou","year":"2022","unstructured":"Nambou K, Anakpa M, Tong YS (2022) Human genes with codon usage bias similar to that of the nonstructural protein 1 gene of influenza A viruses are conjointly involved in the infectious pathogenesis of influenza A viruses. Genetica 150(2):97\u2013115. https:\/\/doi.org\/10.1007\/s10709-022-00155-9. (Epub 2022 Apr 8)","journal-title":"Genetica"},{"issue":"1","key":"2238_CR27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrg2899","volume":"12","author":"JB Plotkin","year":"2011","unstructured":"Plotkin JB, Kudla G (2011) Synonymous but not the same: the causes and consequences of codon bias. Nat Rev Genet 12(1):32\u201342. https:\/\/doi.org\/10.1038\/nrg2899. (Epub 2010 Nov 23)","journal-title":"Nat Rev Genet"},{"key":"2238_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1745-6150-3-38","volume":"3","author":"P Puigb\u00f2","year":"2008","unstructured":"Puigb\u00f2 P, Bravo IG, Garcia-Vallve S (2008) CAIcal: a combined set of tools to assess codon usage adaptation. Biol Direct 3:38. https:\/\/doi.org\/10.1186\/1745-6150-3-38","journal-title":"Biol Direct"},{"key":"2238_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1756-0500-3-87","volume":"3","author":"P Puigb\u00f2","year":"2010","unstructured":"Puigb\u00f2 P, Aragon\u00e8s L, Garcia-Vallv\u00e9 S (2010) RCDI\/eRCDI: a web-server to estimate codon usage deoptimization. BMC Res Notes 3:87. https:\/\/doi.org\/10.1186\/1756-0500-3-87","journal-title":"BMC Res Notes"},{"issue":"2","key":"2238_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.molcel.2015.05.035","volume":"59","author":"TE Quax","year":"2015","unstructured":"Quax TE, Claassens NJ, S\u00f6ll D, van der Oost J (2015) Codon bias as a means to fine-tune gene expression. Mol Cell 59(2):149\u2013161. https:\/\/doi.org\/10.1016\/j.molcel.2015.05.035","journal-title":"Mol Cell"},{"issue":"4","key":"2238_CR31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00284-025-04131-2","volume":"82","author":"J Ren","year":"2025","unstructured":"Ren J, Li Q, Shen W, Tan X (2025) Decoding codon usage patterns in high-risk human papillomavirus genomes: a comprehensive analysis. Curr Microbiol 82(4):148. https:\/\/doi.org\/10.1007\/s00284-025-04131-2","journal-title":"Curr Microbiol"},{"issue":"11","key":"2238_CR32","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1099\/0022-1317-78-11-2859","volume":"78","author":"BK Rima","year":"1997","unstructured":"Rima BK, McFerran NV (1997) Dinucleotide and stop codon frequencies in single-stranded RNA viruses. J Gen Virol 78(11):2859\u20132870. https:\/\/doi.org\/10.1099\/0022-1317-78-11-2859","journal-title":"J Gen Virol"},{"issue":"3","key":"2238_CR34","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/BF00163236","volume":"40","author":"N Sueoka","year":"1995","unstructured":"Sueoka N (1995) Intrastrand parity rules of DNA base composition and usage biases of synonymous codons. J Mol Evol 40(3):318\u2013325. https:\/\/doi.org\/10.1007\/BF00163236","journal-title":"J Mol Evol"},{"issue":"5","key":"2238_CR35","doi-asserted-by":"publisher","first-page":"e2300636","DOI":"10.1002\/jobm.202300636","volume":"64","author":"X Tan","year":"2024","unstructured":"Tan X, Xie Y, Jiang C, Li H, Lu Y, Shen W, Chen J (2024a) Codon usage bias of human papillomavirus type 33 and 58: a comprehensive analysis. J Basic Microbiol 64(5):e2300636. https:\/\/doi.org\/10.1002\/jobm.202300636","journal-title":"J Basic Microbiol"},{"issue":"4","key":"2238_CR36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.33073\/pjm-2024-036","volume":"73","author":"X Tan","year":"2024","unstructured":"Tan X, Bao S, Lu X, Lu B, Shen W, Jiang C (2024b) Comprehensive analysis of codon usage bias in human Papillomavirus type 51. Pol J Microbiol 73(4):455\u2013465. https:\/\/doi.org\/10.33073\/pjm-2024-036","journal-title":"Pol J Microbiol"},{"issue":"3","key":"2238_CR37","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1089\/AID.2015.0320","volume":"33","author":"KK Vidyavijayan","year":"2017","unstructured":"Vidyavijayan KK, Hassan S, Precilla LK, Ashokkumar M, Chandrasekeran P, Swaminathan S, Hanna LE (2017) Biased nucleotide composition and differential codon usage pattern in HIV-1 and HIV-2. AIDS Res Hum Retroviruses 33(3):298\u2013307. https:\/\/doi.org\/10.1089\/AID.2015.0320","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"2238_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0378-1119(90)90491-9","volume":"87","author":"F Wright","year":"1990","unstructured":"Wright F (1990) The \u201ceffective number of codons\u201d used in a gene. Gene 87(1):23\u201329. https:\/\/doi.org\/10.1016\/0378-1119(90)90491-9","journal-title":"Gene"},{"issue":"1-2","key":"2238_CR39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/s0014-5793(98)00955-7","volume":"434","author":"T Xie","year":"1998","unstructured":"Xie T, Ding D (1998) The relationship between synonymous codon usage and protein structure. FEBS Lett 434(1\u20132):93\u201396. https:\/\/doi.org\/10.1016\/s0014-5793(98)00955-7","journal-title":"FEBS Lett"},{"issue":"2","key":"2238_CR40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/v11020167","volume":"11","author":"W Zhang","year":"2019","unstructured":"Zhang W, Zhang L, He W, Zhang X, Wen B, Wang C, Xu Q, Li G, Zhou J, Veit M, Su S (2019) Genetic evolution and molecular selection of the HE gene of influenza C virus. Viruses 11(2):167. https:\/\/doi.org\/10.3390\/v11020167","journal-title":"Viruses"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-025-02238-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10482-025-02238-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-025-02238-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:38:03Z","timestamp":1768473483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10482-025-02238-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,27]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2238"],"URL":"https:\/\/doi.org\/10.1007\/s10482-025-02238-x","relation":{},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,27]]},"assertion":[{"value":"5 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declaration"}}],"article-number":"23"}}