{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:13Z","timestamp":1792783573697,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Guizhou University Young Talents Basic Research Project","award":["GDJQ[2024]25"],"award-info":[{"award-number":["GDJQ[2024]25"]}],"id":[{"id":"https:\/\/ror.org\/02wmsc916","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Guizhou University Laboratory Open Project","award":["SYSKF2024-063"],"award-info":[{"award-number":["SYSKF2024-063"]}],"id":[{"id":"https:\/\/ror.org\/02wmsc916","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Guizhou High-level Innovative Talents Project","award":["Guizhou Science and Technology Cooperation Platform Talented-GCC[2023]013"],"award-info":[{"award-number":["Guizhou Science and Technology Cooperation Platform Talented-GCC[2023]013"]}]},{"name":"Construction of Scientific and Technological Innovation Talents Team for Mining and Utilizing Characteristic Microbial Resources of Fermentation Industry in Guizhou Province","award":["Guizhou Science and Technology Cooperation Platform Talented-CXTD[2023]029"],"award-info":[{"award-number":["Guizhou Science and Technology Cooperation Platform Talented-CXTD[2023]029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10482-025-02243-0","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:12:06Z","timestamp":1770142326000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physiological characterization and safety assessment of thermotolerant Lodderomyces elongisporus in sauce-flavored Daqu: based on genomic insight"],"prefix":"10.1007","volume":"119","author":[{"given":"Xuexue","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-2451","authenticated-orcid":false,"given":"Xiaoye","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"issue":"6","key":"2243_CR1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.cstres.2024.10.006","volume":"29","author":"MJ Alasady","year":"2024","unstructured":"Alasady MJ, Mendillo ML (2024) The heat shock factor code: specifying a diversity of transcriptional regulatory programs broadly promoting stress resilience. Cell Stress Chaperones 29(6):735\u2013749. https:\/\/doi.org\/10.1016\/j.cstres.2024.10.006","journal-title":"Cell Stress Chaperones"},{"issue":"5","key":"2243_CR2","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1751-7915.2012.00343.x","volume":"5","author":"C Anc\u00edn-Azpilicueta","year":"2012","unstructured":"Anc\u00edn-Azpilicueta C, Barriuso-Esteban B, Nieto-Rojo R, Aristiz\u00e1bal-L\u00f3pez N (2012) SO(2) protects the amino nitrogen metabolism of Saccharomyces cerevisiae under thermal stress. Microb Biotechnol 5(5):654\u2013662. https:\/\/doi.org\/10.1111\/j.1751-7915.2012.00343.x","journal-title":"Microb Biotechnol"},{"issue":"2","key":"2243_CR3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jbiosc.2017.03.009","volume":"124","author":"C Auesukaree","year":"2017","unstructured":"Auesukaree C (2017) Molecular mechanisms of the yeast adaptive response and tolerance to stresses encountered during ethanol fermentation. J Biosci Bioeng 124(2):133\u2013142. https:\/\/doi.org\/10.1016\/j.jbiosc.2017.03.009","journal-title":"J Biosci Bioeng"},{"issue":"2","key":"2243_CR4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jbiosc.2012.03.012","volume":"114","author":"C Auesukaree","year":"2012","unstructured":"Auesukaree C, Koedrith P, Saenpayavai P, Asvarak T, Benjaphokee S, Sugiyama M, Boonchird C (2012) Characterization and gene expression profiles of thermotolerant Saccharomyces cerevisiae isolates from Thai fruits. J Biosci Bioeng 114(2):144\u2013149. https:\/\/doi.org\/10.1016\/j.jbiosc.2012.03.012","journal-title":"J Biosci Bioeng"},{"key":"2243_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1259015","author":"AA Bedekar","year":"2023","unstructured":"Bedekar AA, Deewan A, Jagtap SS, Parker DA, Liu P, Mackie RI, Rao CV (2023) Transcriptional and metabolomic responses of Methylococcus capsulatus Bath to nitrogen source and temperature downshift. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2023.1259015","journal-title":"Front Microbiol"},{"key":"2243_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.fm.2015.01.018","volume":"50","author":"NA Bokulich","year":"2015","unstructured":"Bokulich NA, Amiranashvili L, Chitchyan K, Ghazanchyan N, Darbinyan K, Gagelidze N, Mills DA (2015) Microbial biogeography of the transnational fermented milk matsoni. Food Microbiol 50:12\u201319. https:\/\/doi.org\/10.1016\/j.fm.2015.01.018","journal-title":"Food Microbiol"},{"issue":"5102","key":"2243_CR7","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1126\/science.7681220","volume":"259","author":"JL Brewster","year":"1993","unstructured":"Brewster JL, de Valoir T, Dwyer ND, Winter E, Gustin MC (1993) An osmosensing signal transduction pathway in yeast. Science 259(5102):1760\u20131763. https:\/\/doi.org\/10.1126\/science.7681220","journal-title":"Science"},{"key":"2243_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114366","volume":"187","author":"K Cao","year":"2024","unstructured":"Cao K, Wu J, Wan X, Hou Y, Zhang C, Wang Y, Wu R (2024) Impact of non-Saccharomyces yeasts derived from traditional fermented foods on beer aroma: analysis based on HS-SPME-GC\/MS combined with chemometrics. Food Res Int 187:114366. https:\/\/doi.org\/10.1016\/j.foodres.2024.114366","journal-title":"Food Res Int"},{"key":"2243_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.13746\/j.njkj.2020115","volume":"12","author":"Q Chang","year":"2020","unstructured":"Chang Q, Wu Z, Sun W, Ll X, Llu C, Jlang C, Wel X (2020) Production of Nongxiang Baijiu by fortified Daqu. Liquor-Mak Sci Technol 12:44\u201348. https:\/\/doi.org\/10.13746\/j.njkj.2020115","journal-title":"Liquor-Mak Sci Technol"},{"issue":"37","key":"2243_CR10","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.3748\/wjg.v11.i37.5795","volume":"11","author":"L Chen","year":"2005","unstructured":"Chen L, Pan D, Zhou J, Jiang Y (2005) Protective effect of selenium-enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms. World J Gastroenterol 11(37):5795\u20135800. https:\/\/doi.org\/10.3748\/wjg.v11.i37.5795","journal-title":"World J Gastroenterol"},{"key":"2243_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104451","volume":"60","author":"A Chen","year":"2024","unstructured":"Chen A, Qu T, Smith JR, Li J, Du G, Chen J (2024) Osmotic tolerance in saccharomyces cerevisiae: implications for food and bioethanol industries. Food Biosci 60:104451. https:\/\/doi.org\/10.1016\/j.fbio.2024.104451","journal-title":"Food Biosci"},{"key":"2243_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136843","volume":"282","author":"Y Chi","year":"2024","unstructured":"Chi Y, Xiang J, Li H, Shi H, Ning K, Shi C, Chi YY, Xiang JY, Li HM, Shi HY, Xiang H, Xie Q (2024) Schisandra chinensis polysaccharide prevents alcohol-associated liver disease in mice by modulating the gut microbiota-tryptophan metabolism-AHR pathway axis. Int J Biol Macromol 282:136843. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.136843","journal-title":"Int J Biol Macromol"},{"key":"2243_CR13","unstructured":"China, N. H. C. o. t. P. s. R. o. (2016). Microbiological examination of foods:L determination of microbial enzyme activity. China Standard Press, Beijing"},{"issue":"12","key":"2243_CR14","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ncb1070","volume":"5","author":"BT Chua","year":"2003","unstructured":"Chua BT, Volbracht C, Tan KO, Li R, Yu VC, Li P (2003) Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nat Cell Biol 5(12):1083\u20131089. https:\/\/doi.org\/10.1038\/ncb1070","journal-title":"Nat Cell Biol"},{"issue":"03","key":"2243_CR15","first-page":"75","volume":"42","author":"H Cui","year":"2015","unstructured":"Cui H, Meng J (2015) The isolation and performance determination of high temperature resistan yeast strains from Daqu. Liquor Mak 42(03):75\u201377","journal-title":"Liquor Mak"},{"key":"2243_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2023.115064","volume":"184","author":"J Deng","year":"2023","unstructured":"Deng J, Zheng J, Huang D, Huang Z, Ye G, Luo H (2023) Characterization of physicochemical properties, volatile compounds and microbial community structure in four types of Daqu. LWT 184:115064. https:\/\/doi.org\/10.1016\/j.lwt.2023.115064","journal-title":"LWT"},{"issue":"10","key":"2243_CR17","doi-asserted-by":"publisher","first-page":"5968","DOI":"10.1016\/j.biortech.2011.02.015","volume":"102","author":"SS Dhaliwal","year":"2011","unstructured":"Dhaliwal SS, Oberoi HS, Sandhu SK, Nanda D, Kumar D, Uppal SK (2011) Enhanced ethanol production from sugarcane juice by galactose adaptation of a newly isolated thermotolerant strain of Pichia kudriavzevii. Bioresour Technol 102(10):5968\u20135975. https:\/\/doi.org\/10.1016\/j.biortech.2011.02.015","journal-title":"Bioresour Technol"},{"issue":"43","key":"2243_CR18","doi-asserted-by":"publisher","first-page":"32909","DOI":"10.1074\/jbc.M602454200","volume":"281","author":"DL Eastmond","year":"2006","unstructured":"Eastmond DL, Nelson HCM (2006) Genome-wide analysis reveals new roles for the activation domains of the Saccharomyces cerevisiae heat shock transcription factor (Hsf1) during the transient heat shock response*. J Biol Chem 281(43):32909\u201332921. https:\/\/doi.org\/10.1074\/jbc.M602454200","journal-title":"J Biol Chem"},{"issue":"2","key":"2243_CR19","first-page":"143","volume":"1","author":"B Esteve-Zarzoso","year":"1998","unstructured":"Esteve-Zarzoso B, Manzanares P, Ram\u00f3n D, Querol A (1998) The role of non-Saccharomyces yeasts in industrial winemaking. Int Microbiol 1(2):143\u2013148","journal-title":"Int Microbiol"},{"key":"2243_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9010002","author":"C Fang","year":"2018","unstructured":"Fang C, Du H, Jia W, Xu Y (2018) Compositional differences and similarities between typical Chinese Baijiu and Western liquor as revealed by mass spectrometry-based metabolomics. Metabolites. https:\/\/doi.org\/10.3390\/metabo9010002","journal-title":"Metabolites"},{"key":"2243_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105282","volume":"62","author":"NA Fazio","year":"2024","unstructured":"Fazio NA, Pino A, Foti P, Esteve-Zarzoso B, Randazzo CL, Torija M-J, Caggia C (2024) Screening and characterization of indigenous Saccharomyces cerevisiae and non-Saccharomyces yeasts isolated from Sicilian vineyards. Food Biosci 62:105282. https:\/\/doi.org\/10.1016\/j.fbio.2024.105282","journal-title":"Food Biosci"},{"issue":"1","key":"2243_CR22","first-page":"22","volume":"134","author":"NK Ganguly","year":"2011","unstructured":"Ganguly NK, Bhattacharya SK, Sesikeran B, Nair GB, Ramakrishna BS, Sachdev HPS, Kathuria SC (2011) ICMR-DBT guidelines for evaluation of probiotics in food. Indian J Med Res 134(1):22\u201325","journal-title":"Indian J Med Res"},{"key":"2243_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.116895","volume":"219","author":"Y Gao","year":"2025","unstructured":"Gao Y, Wang H, Xiong A, Liu L, Tong R, Pei W, Yang L, Wu X, Wang Z (2025) Baijiu: chemical compositions, biological functions, and endogenous metabolic profiles. Food Res Int 219:116895. https:\/\/doi.org\/10.1016\/j.foodres.2025.116895","journal-title":"Food Res Int"},{"issue":"6","key":"2243_CR24","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s002530000464","volume":"54","author":"G Gellissen","year":"2000","unstructured":"Gellissen G (2000) Heterologous protein production in methylotrophic yeasts. Appl Microbiol Biotechnol 54(6):741\u2013750. https:\/\/doi.org\/10.1007\/s002530000464","journal-title":"Appl Microbiol Biotechnol"},{"issue":"06","key":"2243_CR25","first-page":"51","volume":"41","author":"M He","year":"2022","unstructured":"He M, Ren Y, Xiong L, Xie S, Zhang J, Hu J, Han X (2022) Microbial community structure of different high-temperature Daqu in Maotai area. China Brew 41(06):51\u201357","journal-title":"China Brew"},{"issue":"2","key":"2243_CR26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/mmbr.66.2.300-372.2002","volume":"66","author":"S Hohmann","year":"2002","unstructured":"Hohmann S (2002) Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev 66(2):300\u2013372. https:\/\/doi.org\/10.1128\/mmbr.66.2.300-372.2002","journal-title":"Microbiol Mol Biol Rev"},{"issue":"5","key":"2243_CR27","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1002\/bit.22457","volume":"104","author":"OP Ishchuk","year":"2009","unstructured":"Ishchuk OP, Voronovsky AY, Abbas CA, Sibirny AA (2009) Construction of Hansenula polymorpha strains with improved thermotolerance. Biotechnol Bioeng 104(5):911\u2013919. https:\/\/doi.org\/10.1002\/bit.22457","journal-title":"Biotechnol Bioeng"},{"issue":"5","key":"2243_CR28","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.6133\/apjcn.042018.05","volume":"27","author":"L Javadi","year":"2018","unstructured":"Javadi L, Khoshbaten M, Safaiyan A, Ghavami M, Abbasi MM, Gargari BP (2018) Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease. Asia Pac J Clin Nutr 27(5):1031\u20131039. https:\/\/doi.org\/10.6133\/apjcn.042018.05","journal-title":"Asia Pac J Clin Nutr"},{"issue":"15","key":"2243_CR29","doi-asserted-by":"publisher","first-page":"6755","DOI":"10.3390\/app14156755","volume":"14","author":"K Klimczak","year":"2024","unstructured":"Klimczak K, Cioch-Skoneczny M, Poreda A (2024) Evaluation of non-Saccharomyces yeast for low-alcohol beer production. Appl Sci 14(15):6755. https:\/\/doi.org\/10.3390\/app14156755","journal-title":"Appl Sci"},{"issue":"01","key":"2243_CR30","doi-asserted-by":"publisher","first-page":"266","DOI":"10.16429\/j.1009-7848.2021.01.032","volume":"21","author":"M Kurman","year":"2021","unstructured":"Kurman M, Bao Y (2021) Screening, ldentification of cholesterol-lowering abilities of strains from traditional ferments and analysis of bile salt hydrolase activity. J Chinese Inst Food Sci Technol 21(01):266\u2013275. https:\/\/doi.org\/10.16429\/j.1009-7848.2021.01.032","journal-title":"J Chinese Inst Food Sci Technol"},{"key":"2243_CR31","first-page":"22","volume":"12","author":"J Liang","year":"1991","unstructured":"Liang J, Liu Z, Tian Z (1991) Application of thermotolerant yeast in vinegar production. China Condiment 12:22\u201319+26","journal-title":"China Condiment"},{"issue":"03","key":"2243_CR32","first-page":"38","volume":"36","author":"L Liu","year":"2016","unstructured":"Liu L, Li X, Yang F, Luo J, Zhang Z, Li H (2016) Study on the growth characteristics of saccharomyces cerevisiae. Chin J Herbiv Sci 36(03):38\u201341","journal-title":"Chin J Herbiv Sci"},{"key":"2243_CR33","unstructured":"Madigan M, Sattley W, Aiyer J, Stahl D, Buckley D (2021) Brock biology of microorganisms, Global Edition. In (pp. 1128). Retrieved from https:\/\/elibrary.pearson.de\/book\/99.150005\/9781292405063 DOI"},{"issue":"9","key":"2243_CR34","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/yea.2969","volume":"30","author":"F Martani","year":"2013","unstructured":"Martani F, Fossati T, Posteri R, Signori L, Porro D, Branduardi P (2013) Different response to acetic acid stress in Saccharomyces cerevisiae wild-type and l-ascorbic acid-producing strains. Yeast 30(9):365\u2013378. https:\/\/doi.org\/10.1002\/yea.2969","journal-title":"Yeast"},{"issue":"48","key":"2243_CR35","doi-asserted-by":"publisher","first-page":"45193","DOI":"10.1074\/jbc.M105971200","volume":"276","author":"SC Masters","year":"2001","unstructured":"Masters SC, Fu H (2001) 14\u20133-3 proteins mediate an essential anti-apoptotic signal*. J Biol Chem 276(48):45193\u201345200. https:\/\/doi.org\/10.1074\/jbc.M105971200","journal-title":"J Biol Chem"},{"issue":"5","key":"2243_CR36","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00294-018-0819-7","volume":"64","author":"B Mikolaskova","year":"2018","unstructured":"Mikolaskova B, Jurcik M, Cipakova I, Kretova M, Chovanec M, Cipak L (2018) Maintenance of genome stability: the unifying role of interconnections between the DNA damage response and RNA-processing pathways. Curr Genet 64(5):971\u2013983. https:\/\/doi.org\/10.1007\/s00294-018-0819-7","journal-title":"Curr Genet"},{"issue":"4","key":"2243_CR37","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1534\/genetics.111.128033","volume":"190","author":"KA Morano","year":"2012","unstructured":"Morano KA, Grant CM, Moye-Rowley WS (2012) The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics 190(4):1157\u20131195. https:\/\/doi.org\/10.1534\/genetics.111.128033","journal-title":"Genetics"},{"issue":"3","key":"2243_CR38","doi-asserted-by":"publisher","first-page":"339","DOI":"10.11594\/jtls.11.03.11","volume":"11","author":"HA Oyewusi","year":"2021","unstructured":"Oyewusi HA, Muhammad M, Wahab RA, Huyop F (2021) A Review on enzymatic response to salt stress and genomic\/metagenomic analysis of adaptation protein in hypersaline environment. J Trop Life Sci 11(3):339\u2013360","journal-title":"J Trop Life Sci"},{"key":"2243_CR39","first-page":"113","volume":"05","author":"J Pan","year":"2011","unstructured":"Pan J, Wang C, Li F, Wang Y, Chen M (2011) Breeding and characteristics of Sacchromyces cerevisiae conferred multi-tolerances. China Brew 05:113\u2013116","journal-title":"China Brew"},{"key":"2243_CR40","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/978-1-4020-8292-4_25","volume-title":"Yeast biotechnology: diversity and applications","author":"C Pasha","year":"2009","unstructured":"Pasha C, Rao LV (2009) Thermotolerant yeasts for bioethanol production using lignocellulosic substrates. In: Satyanarayana T, Kunze G (eds) Yeast biotechnology: diversity and applications. Springer, Netherlands, Dordrecht, pp 551\u2013588"},{"key":"2243_CR41","unstructured":"Pei J, Li H, Dong J, Hao F, Luan C, Jin W, Yu J (2024). China patent patent no. CN113980813B"},{"key":"2243_CR42","unstructured":"Qi X, Gan Y, Wang Q (2018) Development of thermotolerant Saccharomyces cerevisiae and its application in ethanol fermentation at high temperature. Biotechnol Bus (4): 84\u201389"},{"key":"2243_CR43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13068-017-0806-0","volume":"10","author":"Z Qiu","year":"2017","unstructured":"Qiu Z, Jiang R (2017) Improving Saccharomyces cerevisiae ethanol production and tolerance via RNA polymerase II subunit Rpb7. Biotechnol Biofuels 10:125. https:\/\/doi.org\/10.1186\/s13068-017-0806-0","journal-title":"Biotechnol Biofuels"},{"issue":"4","key":"2243_CR44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1590\/s0100-879x2003000400001","volume":"36","author":"M Rosenquist","year":"2003","unstructured":"Rosenquist M (2003) 14\u20133-3 proteins in apoptosis. Braz J Med Biol Res 36(4):403\u2013408. https:\/\/doi.org\/10.1590\/s0100-879x2003000400001","journal-title":"Braz J Med Biol Res"},{"key":"2243_CR45","unstructured":"Ruan H, Li X, Lan B, Jiang L (2006) The High Osmolarity Glycerol (HOG) signal transduction pathway. J Cell Biol (05): 651\u2013655"},{"key":"2243_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2019.108255","volume":"305","author":"J Ruiz","year":"2019","unstructured":"Ruiz J, Ortega N, Mart\u00edn-Santamar\u00eda M, Acedo A, Marquina D, Pascual O, Roz\u00e8s N, Zamora F, Santos A, Belda I (2019) Occurrence and enological properties of two new non-conventional yeasts (Nakazawaea ishiwadae and Lodderomyces elongisporus) in wine fermentations. Int J Food Microbiol 305:108255. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2019.108255","journal-title":"Int J Food Microbiol"},{"issue":"2","key":"2243_CR47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1534\/genetics.112.140863","volume":"192","author":"H Saito","year":"2012","unstructured":"Saito H, Posas F (2012) Response to hyperosmotic stress. Genetics 192(2):289\u2013318. https:\/\/doi.org\/10.1534\/genetics.112.140863","journal-title":"Genetics"},{"issue":"05","key":"2243_CR48","first-page":"1","volume":"35","author":"M Shen","year":"2016","unstructured":"Shen M, Zhang C, Wang Y (2016) Research progress on microorganism in Daqu liquor. China Brew 35(05):1\u20135","journal-title":"China Brew"},{"issue":"03","key":"2243_CR49","first-page":"79","volume":"43","author":"H Sixing","year":"2024","unstructured":"Sixing H, Yurong W, Zihao H, Longxin T, Jiaping Z, Juzhen L, Zhuang G (2024) Analysis of the diversity of bacillus flora in high-temperature aqua and identification of its isolated strains. Chinese Brew 43(03):79\u201383","journal-title":"Chinese Brew"},{"issue":"1","key":"2243_CR50","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ajps.2018.06.004","volume":"14","author":"S Song","year":"2019","unstructured":"Song S, Cong W, Zhou S, Shi Y, Dai W, Zhang H, Zhang Q (2019) Small GTPases: structure, biological function and its interaction with nanoparticles. Asian J Pharm Sci 14(1):30\u201339. https:\/\/doi.org\/10.1016\/j.ajps.2018.06.004","journal-title":"Asian J Pharm Sci"},{"issue":"04","key":"2243_CR51","first-page":"44","volume":"37","author":"S Sun","year":"2018","unstructured":"Sun S, Zhai L, Bai F, Yu X, Feng H, Yao S (2018) Identification of strain CICC 33077 and response surface optimization of culture medium components. China Brew 37(04):44\u201350","journal-title":"China Brew"},{"issue":"5","key":"2243_CR52","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1074\/jbc.R100059200","volume":"277","author":"G Tzivion","year":"2002","unstructured":"Tzivion G, Avruch J (2002) 14\u20133-3 proteins: active cofactors in cellular regulation by serine\/threonine phosphorylation. J Biol Chem 277(5):3061\u20133064. https:\/\/doi.org\/10.1074\/jbc.R100059200","journal-title":"J Biol Chem"},{"issue":"15","key":"2243_CR53","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1111\/j.1365-2958.1992.tb01392.x","volume":"6","author":"JC Varela","year":"1992","unstructured":"Varela JC, van Beekvelt C, Planta RJ, Mager WH (1992) Osmostress-induced changes in yeast gene expression. Mol Microbiol 6(15):2183\u20132190. https:\/\/doi.org\/10.1111\/j.1365-2958.1992.tb01392.x","journal-title":"Mol Microbiol"},{"issue":"11","key":"2243_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112963","volume":"9","author":"BJ Walker","year":"2014","unstructured":"Walker BJ, Abeel T, Shea T, Priest M, Abouelliel A, Sakthikumar S, Cuomo CA, Zeng Q, Wortman J, Young SK, Earl AM (2014) Pilon: an integrated tool for comprehensive microbial variant detection and genome assembly improvement. PLoS ONE 9(11):e112963. https:\/\/doi.org\/10.1371\/journal.pone.0112963","journal-title":"PLoS ONE"},{"issue":"09","key":"2243_CR55","doi-asserted-by":"publisher","first-page":"204","DOI":"10.13560\/j.cnki.biotech.bull.1985.2015.09.029","volume":"31","author":"F Wang","year":"2015","unstructured":"Wang F, Ma L (2015) Fermentative characteristics of indigenous WineSaccharomyces cerevisiae lsolated from western area of lnnermongolia. Biotechnol Bull 31(09):204\u2013208. https:\/\/doi.org\/10.13560\/j.cnki.biotech.bull.1985.2015.09.029","journal-title":"Biotechnol Bull"},{"issue":"02","key":"2243_CR56","first-page":"162","volume":"42","author":"X Wang","year":"2021","unstructured":"Wang X, Bai X, Zhu G, Lei A, Ban S, Qiu S (2021) Application of yeast producing polyhydric alcohol in Moutai-flavour liquor and spirits fermentation. Food Ind 42(02):162\u2013166","journal-title":"Food Ind"},{"issue":"16","key":"2243_CR57","doi-asserted-by":"publisher","first-page":"284","DOI":"10.13995\/j.cnki.11-1802\/ts.031716","volume":"48","author":"C Wang","year":"2022","unstructured":"Wang C, Chen Y, Yang J, Chen Q, Wei X (2022) Comprehensive factor analysis of commercialization research on wild yeast. Food Ferment Ind 48(16):284\u2013290. https:\/\/doi.org\/10.13995\/j.cnki.11-1802\/ts.031716","journal-title":"Food Ferment Ind"},{"key":"2243_CR58","unstructured":"Wu X, Liu S, Meng J, Liu S, Bao T (2023) China patent patent no. CN116716193B"},{"key":"2243_CR59","unstructured":"Xiang C (2024) China patent patent no. CN114836353B"},{"issue":"06","key":"2243_CR60","first-page":"119","volume":"39","author":"X Yang","year":"2020","unstructured":"Yang X, Ma G, Wang G, Hu X, Zhang Z, Wang Y, Li B (2020) Analysis of bacterial and fungal community structure inmedium-high temperature Daqu of Baijiu by high-throughput sequencing. China Brewing 39(06):119\u2013123","journal-title":"China Brewing"},{"key":"2243_CR61","doi-asserted-by":"publisher","unstructured":"Yang D (2022) Screening of thermotolerant ester-producing yeasts from Jiang-flavor fermented grains and Daqu and their application in the production of distillers' grains wine. (Master\u2019s thesis ), Retrieved from https:\/\/link.cnki.net\/doi\/https:\/\/doi.org\/10.27047\/d.cnki.ggudu.2022.000736 Available from Cnki","DOI":"10.27047\/d.cnki.ggudu.2022.000736"},{"key":"2243_CR62","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.0254-5071.2011.06.012","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Sun J, Zhang J, Luo Y, Hu J, Liu P (2011) Effect ofdissolved oxygen on nitrite reductase fermentation by Bacillus megaterium MPF-906. China Brew. https:\/\/doi.org\/10.3969\/j.issn.0254-5071.2011.06.012","journal-title":"China Brew"},{"key":"2243_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.103936","volume":"71","author":"J Zhao","year":"2020","unstructured":"Zhao J, Yu L, Zhai Q, Tian F, Zhang H, Chen W (2020) Effects of probiotic administration on hepatic antioxidative parameters depending on oxidative stress models: a meta-analysis of animal experiments. J Funct Foods 71:103936. https:\/\/doi.org\/10.1016\/j.jff.2020.103936","journal-title":"J Funct Foods"},{"key":"2243_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106990","volume":"70","author":"Y Zhou","year":"2025","unstructured":"Zhou Y, Liu N, Li Z, Peng K, Wang C, Xia Y, Huang D, Luo H (2025) The rate of change in temperature and humidity during the temperature increase period determines the microbial community structure and function of medium-high temperature Daqu. Food Biosci 70:106990. https:\/\/doi.org\/10.1016\/j.fbio.2025.106990","journal-title":"Food Biosci"},{"key":"2243_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.110955","volume":"153","author":"M Zhu","year":"2022","unstructured":"Zhu M, Zheng J, Xie J, Zhao D, Qiao Z, Huang D, Luo H (2022) Effects of environmental factors on the microbial community changes during medium-high temperature Daqu manufacturing. Food Res Int 153:110955. https:\/\/doi.org\/10.1016\/j.foodres.2022.110955","journal-title":"Food Res Int"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-025-02243-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10482-025-02243-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-025-02243-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:35:48Z","timestamp":1770453348000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10482-025-02243-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2243"],"URL":"https:\/\/doi.org\/10.1007\/s10482-025-02243-0","relation":{},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"4 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"48"}}