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LaBMicrA B280, isolated from the rhizosphere of\n                    <jats:italic>Inga edulis<\/jats:italic>\n                    (Mart.). Our approach combined a phylogenomic approach, annotation of metabolic subsystems and biosynthetic gene clusters (BGCs), biological assays to assess antifungal, antimalarial, cytotoxic, and larvicidal activities, classical molecular networking analysis, and characterization of the major compound in the most active fraction (FR3). The digital DNA\u2013DNA hybridization values, using the d2 (GGDC) and d4 (TYGS) formulas, average nucleotide identity, and average amino acid identity (&lt;\u200970% and\u2009\u2264\u200995\u201396%, respectively) revealed LaBMicrA B280 as a novel species within the\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    genus. Our genomic analysis revealed 39 BGCs, including the cluster responsible for pentamycin biosynthesis, 314 metabolic subsystems, and 24 gene categories. In the molecular networking analysis, pentamycin was the only compound identified. Biological assays with fraction FR3 at a concentration of 50\u00a0\u00b5g\/mL showed 96.59%\u2009\u00b1\u20090.03 and 72.39%\u2009\u00b1\u20090.18 inhibition against\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    strains W2 and 3D7, respectively, as well as 91.45%\u2009\u00b1\u20090.55 cytotoxicity against the HEp-2 cancer cell line. Larvicidal activity assays demonstrated 100% efficacy against\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    (FO) at 250\u00a0\u00b5g\/mL after 48\u00a0h. Pentamycin, a known antifungal compound, was successfully isolated from the highly active FR3 fraction. These findings highlight that LaBMicrA B280 exhibits a broad biotechnological potential and represents a promising source of important secondary metabolites for future application.\n                  <\/jats:p>","DOI":"10.1007\/s10482-026-02268-z","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:14:06Z","timestamp":1772964846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic, biological, and chemical studies of Streptomyces sp. LaBMicrA B280 isolated from the rhizosphere of Inga edulis Martius in the Amazon"],"prefix":"10.1007","volume":"119","author":[{"given":"Rafael","family":"de Souza Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia Queiroz Lima","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jania Lilia","family":"da Silva Bentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila Rangel Primo","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Moura Ara\u00fajo","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima Oliveira","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Pinto e Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Nogueira","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio C\u00e9sar Sousa","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Reis Alves","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"de Melo Katak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanildes","family":"dos Santos Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Puccinelli","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeferson Chagas","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilvan Ferreira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afonso Duarte Le\u00e3o","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"2268_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0022-1759(94)90396-4","volume":"170","author":"SA Ahmed","year":"1994","unstructured":"Ahmed SA, Gogal RM, Walsh JE (1994) A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H] thymidine incorporation assay. 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