{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:11:23Z","timestamp":1788599483367,"version":"build-2803163510"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10482-026-02412-9","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:36:52Z","timestamp":1787369812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The underexplored mycobiome: insights from Drosophila into human health and disease"],"prefix":"10.1007","volume":"119","author":[{"given":"Rumaisa Ali","family":"Ebrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamprasad Varija","family":"Raghu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar Prasad","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"2412_CR1","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1007\/s00394-020-02324-y","volume":"59","author":"AK Akobeng","year":"2020","unstructured":"Akobeng AK, Singh P, Kumar M, Al Khodor S (2020) Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications. Eur J Nutr 59:3369\u20133390. https:\/\/doi.org\/10.1007\/s00394-020-02324-y","journal-title":"Eur J Nutr"},{"key":"2412_CR2","doi-asserted-by":"publisher","first-page":"5622","DOI":"10.4049\/jimmunol.172.9.5622","volume":"172","author":"A-M Alarco","year":"2004","unstructured":"Alarco A-M, Marcil A, Chen J et al (2004) Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens. J Immunol 172:5622\u20135628. https:\/\/doi.org\/10.4049\/jimmunol.172.9.5622","journal-title":"J Immunol"},{"key":"2412_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.5941\/MYCO.2017.45.4.233","volume":"45","author":"HS AL-Maliki","year":"2017","unstructured":"AL-Maliki HS, Martinez S, Piszczatowski P, Bennett JW (2017) Drosophila melanogaster as a model for studying Aspergillus fumigatus. Mycobiology 45:233\u2013239. https:\/\/doi.org\/10.5941\/MYCO.2017.45.4.233","journal-title":"Mycobiology"},{"key":"2412_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/ffunb.2020.629510","author":"HS Almaliki","year":"2021","unstructured":"Almaliki HS, Angela A, Goraya NJ et al (2021) Volatile organic compounds produced by human pathogenic fungi are toxic to Drosophila melanogaster. Front Fungal Biol. https:\/\/doi.org\/10.3389\/ffunb.2020.629510","journal-title":"Front Fungal Biol"},{"key":"2412_CR5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3233\/JAD-170058","volume":"58","author":"R Alonso","year":"2017","unstructured":"Alonso R, Pisa D, Aguado B, Carrasco L (2017) Identification of fungal species in brain tissue from Alzheimer\u2019s disease by next-generation sequencing. J Alzheimers Dis 58:55\u201367. https:\/\/doi.org\/10.3233\/JAD-170058","journal-title":"J Alzheimers Dis"},{"key":"2412_CR6","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.nbd.2018.05.022","volume":"117","author":"R Alonso","year":"2018","unstructured":"Alonso R, Fern\u00e1ndez-Fern\u00e1ndez AM, Pisa D, Carrasco L (2018) Multiple sclerosis and mixed microbial infections. Direct identification of fungi and bacteria in nervous tissue. Neurobiol Dis 117:42\u201361. https:\/\/doi.org\/10.1016\/j.nbd.2018.05.022","journal-title":"Neurobiol Dis"},{"key":"2412_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1570-7458.2010.00997.x","volume":"136","author":"C Anagnostou","year":"2010","unstructured":"Anagnostou C, Dorsch M, Rohlfs M (2010) Influence of dietary yeasts on Drosophila melanogaster life-history traits. Entomol Exp Appl 136:1\u201311. https:\/\/doi.org\/10.1111\/j.1570-7458.2010.00997.x","journal-title":"Entomol Exp Appl"},{"key":"2412_CR8","doi-asserted-by":"publisher","first-page":"e1011063","DOI":"10.1371\/journal.pgen.1011063","volume":"19","author":"ML Atilano","year":"2023","unstructured":"Atilano ML, Hull A, Romila C-A et al (2023) Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease. PLoS Genet 19:e1011063. https:\/\/doi.org\/10.1371\/journal.pgen.1011063","journal-title":"PLoS Genet"},{"key":"2412_CR9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41586-019-1608-2","volume":"574","author":"B Aykut","year":"2019","unstructured":"Aykut B, Pushalkar S, Chen R et al (2019) The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature 574:264\u2013267. https:\/\/doi.org\/10.1038\/s41586-019-1608-2","journal-title":"Nature"},{"key":"2412_CR10","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1039\/c9bm00539k","volume":"7","author":"A Bajgar","year":"2019","unstructured":"Bajgar A, Salo\u0148 I, Krej\u010dov\u00e1 G et al (2019) Yeast glucan particles enable intracellular protein delivery in Drosophila without compromising the immune system. Biomater Sci 7:4708\u20134719. https:\/\/doi.org\/10.1039\/c9bm00539k","journal-title":"Biomater Sci"},{"key":"2412_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114087","author":"AJ Barron","year":"2024","unstructured":"Barron AJ, Agrawal S, Lesperance DNA et al (2024) Microbiome-derived acidity protects against microbial invasion in Drosophila. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2024.114087","journal-title":"Cell Rep"},{"key":"2412_CR12","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1111\/j.1365-2435.2012.02006.x","volume":"26","author":"PG Becher","year":"2012","unstructured":"Becher PG, Flick G, Rozp\u0119dowska E et al (2012) Yeast, not fruit volatiles mediate Drosophila melanogaster attraction, oviposition and development. Funct Ecol 26:822\u2013828. https:\/\/doi.org\/10.1111\/j.1365-2435.2012.02006.x","journal-title":"Funct Ecol"},{"key":"2412_CR13","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s10340-017-0932-2","volume":"91","author":"N Bellutti","year":"2018","unstructured":"Bellutti N, Gallmetzer A, Innerebner G et al (2018) Dietary yeast affects preference and performance in Drosophila suzukii. J Pest Sci 91:651\u2013660. https:\/\/doi.org\/10.1007\/s10340-017-0932-2","journal-title":"J Pest Sci"},{"key":"2412_CR14","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3390\/jof8101046","volume":"8","author":"P Belvoncikova","year":"2022","unstructured":"Belvoncikova P, Splichalova P, Videnska P, Gardlik R (2022) The human mycobiome: colonization, composition and the role in health and disease. J Fungi 8:1046. https:\/\/doi.org\/10.3390\/jof8101046","journal-title":"J Fungi"},{"key":"2412_CR15","doi-asserted-by":"publisher","first-page":"6106","DOI":"10.1038\/s41467-020-19826-2","volume":"11","author":"B Benmimoun","year":"2020","unstructured":"Benmimoun B, Papastefanaki F, P\u00e9richon B et al (2020) An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing. Nat Commun 11:6106. https:\/\/doi.org\/10.1038\/s41467-020-19826-2","journal-title":"Nat Commun"},{"key":"2412_CR16","doi-asserted-by":"publisher","first-page":"13807","DOI":"10.1038\/s41598-023-41027-2","volume":"13","author":"B Bozkurt","year":"2023","unstructured":"Bozkurt B, Terlemez G, Sezgin E (2023) Basidiomycota species in Drosophila gut are associated with host fat metabolism. Sci Rep 13:13807. https:\/\/doi.org\/10.1038\/s41598-023-41027-2","journal-title":"Sci Rep"},{"key":"2412_CR17","doi-asserted-by":"publisher","first-page":"e0009923","DOI":"10.1128\/aem.00099-23","volume":"89","author":"JJ Brown","year":"2023","unstructured":"Brown JJ, Jandov\u00e1 A, Jeffs CT et al (2023) Microbiome structure of a wild Drosophila community along tropical elevational gradients and comparison to laboratory lines. Appl Environ Microbiol 89:e0009923. https:\/\/doi.org\/10.1128\/aem.00099-23","journal-title":"Appl Environ Microbiol"},{"key":"2412_CR18","doi-asserted-by":"publisher","first-page":"870","DOI":"10.3390\/insects15110870","volume":"15","author":"S Casas-Tint\u00f3","year":"2024","unstructured":"Casas-Tint\u00f3 S (2024) Drosophila as a model for human disease: insights into rare and ultra-rare diseases. InSects 15:870. https:\/\/doi.org\/10.3390\/insects15110870","journal-title":"InSects"},{"key":"2412_CR19","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1086\/500950","volume":"193","author":"G Chamilos","year":"2006","unstructured":"Chamilos G, Lionakis MS, Lewis RE et al (2006) Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species. J Infect Dis 193:1014\u20131022. https:\/\/doi.org\/10.1086\/500950","journal-title":"J Infect Dis"},{"key":"2412_CR20","doi-asserted-by":"publisher","first-page":"7327","DOI":"10.1128\/AEM.01741-12","volume":"78","author":"JA Chandler","year":"2012","unstructured":"Chandler JA, Eisen JA, Kopp A (2012) Yeast communities of diverse Drosophila species: comparison of two symbiont groups in the same hosts. Appl Environ Microbiol 78:7327\u20137336. https:\/\/doi.org\/10.1128\/AEM.01741-12","journal-title":"Appl Environ Microbiol"},{"key":"2412_CR21","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3390\/biomedicines10030596","volume":"10","author":"M-H Chiang","year":"2022","unstructured":"Chiang M-H, Ho S-M, Wu H-Y et al (2022) Drosophila model for studying gut microbiota in behaviors and neurodegenerative diseases. Biomedicines 10:596. https:\/\/doi.org\/10.3390\/biomedicines10030596","journal-title":"Biomedicines"},{"key":"2412_CR22","doi-asserted-by":"publisher","first-page":"106071","DOI":"10.1016\/j.nbd.2023.106071","volume":"180","author":"EG Contreras","year":"2023","unstructured":"Contreras EG, Kl\u00e4mbt C (2023) The Drosophila blood-brain barrier emerges as a model for understanding human brain diseases. Neurobiol Dis 180:106071. https:\/\/doi.org\/10.1016\/j.nbd.2023.106071","journal-title":"Neurobiol Dis"},{"key":"2412_CR23","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1080\/21505594.2021.1980989","volume":"12","author":"K Csonka","year":"2021","unstructured":"Csonka K, Tasi Z, Vedelek V et al (2021) Deciphering of Candida parapsilosis induced immune response in Drosophila melanogaster. Virulence 12:2571\u20132582. https:\/\/doi.org\/10.1080\/21505594.2021.1980989","journal-title":"Virulence"},{"key":"2412_CR24","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/myc.13630","volume":"66","author":"B da Costa","year":"2023","unstructured":"da Costa B, Pippi B, Merkel S et al (2023) Drosophila melanogaster as a model of systemic dermatophytosis. Mycoses 66:906\u2013910. https:\/\/doi.org\/10.1111\/myc.13630","journal-title":"Mycoses"},{"key":"2412_CR25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41684-018-0065-0","volume":"47","author":"AE Douglas","year":"2018","unstructured":"Douglas AE (2018) The Drosophila model for microbiome research. Lab Anim 47:157\u2013164. https:\/\/doi.org\/10.1038\/s41684-018-0065-0","journal-title":"Lab Anim"},{"key":"2412_CR26","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.3390\/ijms25042105","volume":"25","author":"G Elovsson","year":"2024","unstructured":"Elovsson G, Klingstedt T, Brown M et al (2024) A novel Drosophila model of Alzheimer\u2019s disease to study A\u03b2 proteotoxicity in the digestive tract. Int J Mol Sci 25:2105. https:\/\/doi.org\/10.3390\/ijms25042105","journal-title":"Int J Mol Sci"},{"key":"2412_CR27","doi-asserted-by":"publisher","first-page":"e0314832","DOI":"10.1371\/journal.pone.0314832","volume":"20","author":"G Elovsson","year":"2025","unstructured":"Elovsson G, Klingstedt T, Nilsson KPR, Brorsson A-C (2025) Diversity of A\u03b2 aggregates produced in a gut-based Drosophila model of Alzheimer\u2019s disease. PLoS ONE 20:e0314832. https:\/\/doi.org\/10.1371\/journal.pone.0314832","journal-title":"PLoS ONE"},{"key":"2412_CR28","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.3390\/ijms26157485","volume":"26","author":"MG Giansanti","year":"2025","unstructured":"Giansanti MG, Frappaolo A, Piergentili R (2025) Drosophila melanogaster: how and why it became a model organism. Int J Mol Sci 26:7485. https:\/\/doi.org\/10.3390\/ijms26157485","journal-title":"Int J Mol Sci"},{"key":"2412_CR29","doi-asserted-by":"publisher","first-page":"13070","DOI":"10.1038\/s41598-018-31561-9","volume":"8","author":"C Grangeteau","year":"2018","unstructured":"Grangeteau C, Yahou F, Everaerts C et al (2018) Yeast quality in juvenile diet affects Drosophila melanogaster adult life traits. Sci Rep 8:13070. https:\/\/doi.org\/10.1038\/s41598-018-31561-9","journal-title":"Sci Rep"},{"key":"2412_CR30","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.3390\/cells10081850","volume":"10","author":"Q Guo","year":"2021","unstructured":"Guo Q, Wang B, Wang X et al (2021) Activation of Nrf2 in astrocytes suppressed PD-like phenotypes via antioxidant and autophagy pathways in rat and Drosophila models. Cells 10:1850. https:\/\/doi.org\/10.3390\/cells10081850","journal-title":"Cells"},{"key":"2412_CR31","doi-asserted-by":"publisher","first-page":"e1009846","DOI":"10.1371\/journal.ppat.1009846","volume":"17","author":"MA Hanson","year":"2021","unstructured":"Hanson MA, Cohen LB, Marra A et al (2021) The Drosophila baramicin polypeptide gene protects against fungal infection. PLoS Pathog 17:e1009846. https:\/\/doi.org\/10.1371\/journal.ppat.1009846","journal-title":"PLoS Pathog"},{"key":"2412_CR32","doi-asserted-by":"publisher","first-page":"110626","DOI":"10.1016\/j.cbpa.2019.110626","volume":"241","author":"Y Henry","year":"2020","unstructured":"Henry Y, Overgaard J, Colinet H (2020) Dietary nutrient balance shapes phenotypic traits of Drosophila melanogaster in interaction with gut microbiota. Comp Biochem Physiol A Mol Integr Physiol 241:110626. https:\/\/doi.org\/10.1016\/j.cbpa.2019.110626","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"2412_CR33","doi-asserted-by":"publisher","first-page":"2316533","DOI":"10.1080\/19490976.2024.2316533","volume":"16","author":"S-M Ho","year":"2024","unstructured":"Ho S-M, Tsai W-H, Lai C-H et al (2024) Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons. Gut Microbes 16:2316533. https:\/\/doi.org\/10.1080\/19490976.2024.2316533","journal-title":"Gut Microbes"},{"key":"2412_CR34","doi-asserted-by":"publisher","first-page":"3833","DOI":"10.1038\/srep03833","volume":"4","author":"AA Inamdar","year":"2014","unstructured":"Inamdar AA, Bennett JW (2014) A common fungal volatile organic compound induces a nitric oxide mediated inflammatory response in Drosophila melanogaster. Sci Rep 4:3833. https:\/\/doi.org\/10.1038\/srep03833","journal-title":"Sci Rep"},{"key":"2412_CR35","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.molcel.2018.01.029","volume":"69","author":"N Issa","year":"2018","unstructured":"Issa N, Guillaumot N, Lauret E et al (2018) The circulating protease Persephone is an immune sensor for microbial proteolytic activities upstream of the Drosophila Toll pathway. Mol Cell 69:539-550.e6. https:\/\/doi.org\/10.1016\/j.molcel.2018.01.029","journal-title":"Mol Cell"},{"key":"2412_CR36","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3390\/microorganisms10030553","volume":"10","author":"D Ji","year":"2022","unstructured":"Ji D, Sun H, Yang W et al (2022) Transfer of human microbiome to Drosophila gut model. Microorganisms 10:553. https:\/\/doi.org\/10.3390\/microorganisms10030553","journal-title":"Microorganisms"},{"key":"2412_CR37","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1038\/s41467-021-23041-y","volume":"12","author":"Y Jia","year":"2021","unstructured":"Jia Y, Jin S, Hu K et al (2021) Gut microbiome modulates Drosophila aggression through octopamine signaling. Nat Commun 12:2698. https:\/\/doi.org\/10.1038\/s41467-021-23041-y","journal-title":"Nat Commun"},{"key":"2412_CR38","doi-asserted-by":"publisher","first-page":"jeb247932","DOI":"10.1242\/jeb.247932","volume":"227","author":"Y Jim\u00e9nez-Padilla","year":"2024","unstructured":"Jim\u00e9nez-Padilla Y, Adewusi B, Lachance M-A, Sinclair BJ (2024) Live yeasts accelerate Drosophila melanogaster larval development. J Exp Biol 227:jeb247932. https:\/\/doi.org\/10.1242\/jeb.247932","journal-title":"J Exp Biol"},{"key":"2412_CR39","doi-asserted-by":"publisher","unstructured":"Kim H (2025) Behavioral correlates of anxiety and depression in a Drosophila melanogaster model of Alzheimer\u2019s disease. J High Sch Sci. 9. https:\/\/doi.org\/10.64336\/001c.151317","DOI":"10.64336\/001c.151317"},{"key":"2412_CR40","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3233\/JAD-215031","volume":"84","author":"F Kitani-Morii","year":"2021","unstructured":"Kitani-Morii F, Friedland RP, Yoshida H, Mizuno T (2021) Drosophila as a model for microbiota studies of neurodegeneration. J Alzheimers Dis 84:479\u2013490. https:\/\/doi.org\/10.3233\/JAD-215031","journal-title":"J Alzheimers Dis"},{"key":"2412_CR41","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/oik.07180","volume":"129","author":"S Koerte","year":"2020","unstructured":"Koerte S, Keesey IW, Easson MLAE et al (2020) Variable dependency on associated yeast communities influences host range in Drosophila species. Oikos 129:964\u2013982. https:\/\/doi.org\/10.1111\/oik.07180","journal-title":"Oikos"},{"key":"2412_CR42","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.2217\/fmb-2018-0185","volume":"13","author":"Y Kong","year":"2018","unstructured":"Kong Y, Jiang B, Luo X (2018) Gut microbiota influences Alzheimer\u2019s disease pathogenesis by regulating acetate in Drosophila model. Future Microbiol 13:1117\u20131128. https:\/\/doi.org\/10.2217\/fmb-2018-0185","journal-title":"Future Microbiol"},{"key":"2412_CR43","first-page":"136","volume":"13","author":"SS Kumar","year":"2023","unstructured":"Kumar SS, Priscilla S, Srivastava P et al (2023) Influence of probiotics, synbiotics, and heat-killed Lactobacillus fermentum on ageing using Drosophila model\u2014a preliminary study. J Appl Pharm Sci 13:136\u2013140","journal-title":"J Appl Pharm Sci"},{"key":"2412_CR44","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/ecco-jcc\/jjv209","volume":"10","author":"G Liguori","year":"2016","unstructured":"Liguori G, Lamas B, Richard ML et al (2016) Fungal dysbiosis in mucosa-associated microbiota of Crohn\u2019s disease patients. J Crohns Colitis 10:296\u2013305. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv209","journal-title":"J Crohns Colitis"},{"key":"2412_CR45","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1159\/000489831","volume":"10","author":"SA Lindsay","year":"2018","unstructured":"Lindsay SA, Lin SJH, Wasserman SA (2018) Short-form bomanins mediate humoral immunity in Drosophila. J Innate Immun 10:306\u2013314. https:\/\/doi.org\/10.1159\/000489831","journal-title":"J Innate Immun"},{"key":"2412_CR46","doi-asserted-by":"publisher","first-page":"488","DOI":"10.4161\/viru.1.6.13311","volume":"1","author":"MS Lionakis","year":"2010","unstructured":"Lionakis MS, Kontoyiannis DP (2010) The growing promise of Toll-deficient Drosophila melanogaster as a model for studying Aspergillus pathogenesis and treatment. Virulence 1:488\u2013499. https:\/\/doi.org\/10.4161\/viru.1.6.13311","journal-title":"Virulence"},{"key":"2412_CR47","doi-asserted-by":"publisher","first-page":"e00176","DOI":"10.1128\/spectrum.00176-23","volume":"11","author":"X Liu","year":"2023","unstructured":"Liu X, Yang M, Liu R et al (2023) The impact of Parkinson\u2019s disease-associated gut microbiota on the transcriptome in Drosophila. Microbiol Spectr 11:e00176-e223. https:\/\/doi.org\/10.1128\/spectrum.00176-23","journal-title":"Microbiol Spectr"},{"key":"2412_CR48","doi-asserted-by":"publisher","first-page":"e1008398","DOI":"10.1371\/journal.ppat.1008398","volume":"16","author":"WB Ludington","year":"2020","unstructured":"Ludington WB, Ja WW (2020) Drosophila as a model for the gut microbiome. PLoS Pathog 16:e1008398. https:\/\/doi.org\/10.1371\/journal.ppat.1008398","journal-title":"PLoS Pathog"},{"key":"2412_CR49","doi-asserted-by":"publisher","first-page":"111232","DOI":"10.1016\/j.ecoenv.2020.111232","volume":"206","author":"GE Macedo","year":"2020","unstructured":"Macedo GE, De Brum Vieira P, Rodrigues NR et al (2020) Fungal compound 1-octen-3-ol induces mitochondrial morphological alterations and respiration dysfunctions in Drosophila melanogaster. Ecotoxicol Environ Saf 206:111232. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111232","journal-title":"Ecotoxicol Environ Saf"},{"key":"2412_CR50","doi-asserted-by":"publisher","first-page":"ycae134","DOI":"10.1093\/ismeco\/ycae134","volume":"4","author":"MJ Medeiros","year":"2024","unstructured":"Medeiros MJ, Seo L, Macias A et al (2024) Bacterial and fungal components of the microbiome have distinct roles in Hawaiian Drosophila reproduction. ISME Commun 4:ycae134. https:\/\/doi.org\/10.1093\/ismeco\/ycae134","journal-title":"ISME Commun"},{"key":"2412_CR51","doi-asserted-by":"publisher","first-page":"1696606","DOI":"10.3389\/fevo.2025.1696606","volume":"13","author":"MJ Medeiros","year":"2025","unstructured":"Medeiros MJ, Burger AD, Price DK, Yew JY (2025) Microbiome composition of Drosophila suzukii varies across geographical regions. Front Ecol Evol 13:1696606. https:\/\/doi.org\/10.3389\/fevo.2025.1696606","journal-title":"Front Ecol Evol"},{"key":"2412_CR52","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.vetmic.2018.08.021","volume":"224","author":"S Merkel","year":"2018","unstructured":"Merkel S, Heidrich D, Danilevicz CK et al (2018) Drosophila melanogaster as a model for the study of Malassezia pachydermatis infections. Vet Microbiol 224:31\u201333. https:\/\/doi.org\/10.1016\/j.vetmic.2018.08.021","journal-title":"Vet Microbiol"},{"key":"2412_CR53","doi-asserted-by":"publisher","unstructured":"Mitra S, Kumar A, Gill A et al (2026) miR-34 regulates stress-induced depression-like state through the WDR26 ortholog melancholy in Drosophila. Res Sq. https:\/\/doi.org\/10.21203\/rs.3.rs-9339604\/v1","DOI":"10.21203\/rs.3.rs-9339604\/v1"},{"key":"2412_CR54","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/1365-2664.12688","volume":"54","author":"BA Mori","year":"2017","unstructured":"Mori BA, Whitener AB, Leinweber Y et al (2017) Enhanced yeast feeding following mating facilitates control of the invasive fruit pest Drosophila suzukii. J Appl Ecol 54:170\u2013177. https:\/\/doi.org\/10.1111\/1365-2664.12688","journal-title":"J Appl Ecol"},{"key":"2412_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1349027","author":"CD Mpamhanga","year":"2024","unstructured":"Mpamhanga CD, Kounatidis I (2024) The utility of Drosophila melanogaster as a fungal infection model. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2024.1349027","journal-title":"Front Immunol"},{"key":"2412_CR56","doi-asserted-by":"publisher","first-page":"8873","DOI":"10.1038\/s41598-019-45140-z","volume":"9","author":"J Murgier","year":"2019","unstructured":"Murgier J, Everaerts C, Farine J-P, Ferveur J-F (2019) Live yeast in juvenile diet induces species-specific effects on Drosophila adult behaviour and fitness. Sci Rep 9:8873. https:\/\/doi.org\/10.1038\/s41598-019-45140-z","journal-title":"Sci Rep"},{"key":"2412_CR57","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04270-w","author":"B Naik","year":"2024","unstructured":"Naik B, Sasikumar J, Das SP (2024) From skin and gut to the brain: the infectious journey of the human commensal fungus Malassezia and its neurological consequences. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-024-04270-w","journal-title":"Mol Neurobiol"},{"key":"2412_CR58","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.3390\/microorganisms11102369","volume":"11","author":"M Napolitano","year":"2023","unstructured":"Napolitano M, Fasulo E, Ungaro F et al (2023) Gut dysbiosis in Irritable Bowel Syndrome: a narrative review on correlation with disease subtypes and novel therapeutic implications. Microorganisms 11:2369. https:\/\/doi.org\/10.3390\/microorganisms11102369","journal-title":"Microorganisms"},{"key":"2412_CR59","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s40168-017-0373-4","volume":"5","author":"AK Nash","year":"2017","unstructured":"Nash AK, Auchtung TA, Wong MC et al (2017) The gut mycobiome of the human microbiome project healthy cohort. Microbiome 5:153. https:\/\/doi.org\/10.1186\/s40168-017-0373-4","journal-title":"Microbiome"},{"key":"2412_CR60","doi-asserted-by":"publisher","first-page":"66","DOI":"10.31083\/j.jin2102066","volume":"21","author":"N Nayak","year":"2022","unstructured":"Nayak N, Mishra M (2022) Drosophila melanogaster as a model to understand the mechanisms of infection mediated neuroinflammation in neurodegenerative diseases. J Integr Neurosci 21:66. https:\/\/doi.org\/10.31083\/j.jin2102066","journal-title":"J Integr Neurosci"},{"key":"2412_CR61","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1093\/ecco-jcc\/jjaa220","volume":"15","author":"A Nelson","year":"2021","unstructured":"Nelson A, Stewart CJ, Kennedy NA et al (2021) The impact of NOD2 genetic variants on the gut mycobiota in Crohn\u2019s disease patients in remission and in individuals without gastrointestinal inflammation. J Crohns Colitis 15:800\u2013812. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaa220","journal-title":"J Crohns Colitis"},{"key":"2412_CR62","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuint.2018.08.002","volume":"120","author":"OV Nevzglyadova","year":"2018","unstructured":"Nevzglyadova OV, Mikhailova EV, Artemov AV et al (2018) Yeast red pigment modifies cloned human \u03b1-synuclein pathogenesis in Parkinson disease models in Saccharomyces cerevisiae and Drosophila melanogaster. Neurochem Int 120:172\u2013181. https:\/\/doi.org\/10.1016\/j.neuint.2018.08.002","journal-title":"Neurochem Int"},{"key":"2412_CR63","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41522-025-00797-5","volume":"11","author":"A Ovalle","year":"2025","unstructured":"Ovalle A, L\u00f3pez E, Sierralta J et al (2025) A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson\u2019s disease. NPJ Biofilms Microbiomes 11:185. https:\/\/doi.org\/10.1038\/s41522-025-00797-5","journal-title":"NPJ Biofilms Microbiomes"},{"key":"2412_CR64","doi-asserted-by":"publisher","first-page":"23635","DOI":"10.1038\/s41598-021-02624-1","volume":"11","author":"J Parker-Character","year":"2021","unstructured":"Parker-Character J, Hager DR, Call TB et al (2021) An altered microbiome in a Parkinson\u2019s disease model Drosophila melanogaster has a negative effect on development. Sci Rep 11:23635. https:\/\/doi.org\/10.1038\/s41598-021-02624-1","journal-title":"Sci Rep"},{"key":"2412_CR65","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1371\/journal.ppat.0030026","volume":"3","author":"LN Pham","year":"2007","unstructured":"Pham LN, Dionne MS, Shirasu-Hiza M, Schneider DS (2007) A specific primed immune response in Drosophila is dependent on phagocytes. PLoS Pathog 3:e26. https:\/\/doi.org\/10.1371\/journal.ppat.0030026","journal-title":"PLoS Pathog"},{"key":"2412_CR66","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1111\/ejn.15599","volume":"55","author":"ZX Phuna","year":"2022","unstructured":"Phuna ZX, Madhavan P (2022) A closer look at the mycobiome in Alzheimer\u2019s disease: fungal species, pathogenesis and transmission. Eur J Neurosci 55:1291\u20131321. https:\/\/doi.org\/10.1111\/ejn.15599","journal-title":"Eur J Neurosci"},{"key":"2412_CR67","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.7150\/ijbs.42257","volume":"16","author":"D Pisa","year":"2020","unstructured":"Pisa D, Alonso R, Carrasco L (2020) Parkinson\u2019s disease: a comprehensive analysis of fungi and bacteria in brain tissue. Int J Biol Sci 16:1135\u20131152. https:\/\/doi.org\/10.7150\/ijbs.42257","journal-title":"Int J Biol Sci"},{"key":"2412_CR68","doi-asserted-by":"publisher","first-page":"e870","DOI":"10.1002\/cpz1.870","volume":"3","author":"MD Rand","year":"2023","unstructured":"Rand MD, Tennessen JM, Mackay TFC, Anholt RRH (2023) Perspectives on the Drosophila melanogaster model for advances in toxicological science. Curr Protoc 3:e870. https:\/\/doi.org\/10.1002\/cpz1.870","journal-title":"Curr Protoc"},{"key":"2412_CR69","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1080\/19490976.2017.1379637","volume":"9","author":"ML Richard","year":"2018","unstructured":"Richard ML, Liguori G, Lamas B et al (2018) Mucosa-associated microbiota dysbiosis in colitis associated cancer. Gut Microbes 9:131\u2013142. https:\/\/doi.org\/10.1080\/19490976.2017.1379637","journal-title":"Gut Microbes"},{"key":"2412_CR70","doi-asserted-by":"publisher","first-page":"a019810","DOI":"10.1101\/cshperspect.a019810","volume":"5","author":"PC Seed","year":"2015","unstructured":"Seed PC (2015) The human mycobiome. Cold Spring Harb Perspect Med 5:a019810. https:\/\/doi.org\/10.1101\/cshperspect.a019810","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2412_CR71","doi-asserted-by":"publisher","first-page":"jkab324","DOI":"10.1093\/g3journal\/jkab324","volume":"11","author":"P Shahrestani","year":"2021","unstructured":"Shahrestani P, King E, Ramezan R et al (2021) The molecular architecture of Drosophila melanogaster defense against Beauveria bassiana explored through evolve and resequence and quantitative trait locus mapping. G3 11:jkab324. https:\/\/doi.org\/10.1093\/g3journal\/jkab324","journal-title":"G3"},{"key":"2412_CR72","doi-asserted-by":"publisher","first-page":"jeb233619","DOI":"10.1242\/jeb.233619","volume":"224","author":"V Silva","year":"2021","unstructured":"Silva V, Palacios-Mu\u00f1oz A, Okray Z et al (2021) The impact of the gut microbiome on memory and sleep in Drosophila. J Exp Biol 224:jeb233619. https:\/\/doi.org\/10.1242\/jeb.233619","journal-title":"J Exp Biol"},{"key":"2412_CR73","doi-asserted-by":"publisher","first-page":"e3003020","DOI":"10.1371\/journal.pbio.3003020","volume":"23","author":"DND Singh","year":"2025","unstructured":"Singh DND, Roberts ARE, Wang X et al (2025) Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain. PLoS Biol 23:e3003020. https:\/\/doi.org\/10.1371\/journal.pbio.3003020","journal-title":"PLoS Biol"},{"key":"2412_CR74","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s10340-020-01266-y","volume":"93","author":"U Spitaler","year":"2020","unstructured":"Spitaler U, Bianchi F, Eisenstecken D et al (2020) Yeast species affects feeding and fitness of Drosophila suzukii adults. J Pest Sci 93:1295\u20131309. https:\/\/doi.org\/10.1007\/s10340-020-01266-y","journal-title":"J Pest Sci"},{"key":"2412_CR75","doi-asserted-by":"publisher","first-page":"2208503","DOI":"10.1080\/19490976.2023.2208503","volume":"15","author":"G Tafesh-Edwards","year":"2023","unstructured":"Tafesh-Edwards G, Eleftherianos I (2023) The role of Drosophila microbiota in gut homeostasis and immunity. Gut Microbes 15:2208503. https:\/\/doi.org\/10.1080\/19490976.2023.2208503","journal-title":"Gut Microbes"},{"key":"2412_CR76","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.1007\/s12035-023-03368-x","volume":"60","author":"FHP Tan","year":"2023","unstructured":"Tan FHP, Azzam G, Najimudin N et al (2023) Behavioural effects and RNA-seq analysis of A\u03b242-mediated toxicity in a Drosophila Alzheimer\u2019s disease model. Mol Neurobiol 60:4716\u20134730. https:\/\/doi.org\/10.1007\/s12035-023-03368-x","journal-title":"Mol Neurobiol"},{"key":"2412_CR77","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cell.2017.03.033","volume":"169","author":"M Tassetto","year":"2017","unstructured":"Tassetto M, Kunitomi M, Andino R (2017) Circulating immune cells mediate a systemic RNAi-based adaptive antiviral response in Drosophila. Cell 169:314-325.e13. https:\/\/doi.org\/10.1016\/j.cell.2017.03.033","journal-title":"Cell"},{"key":"2412_CR78","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s11046-019-00413-z","volume":"185","author":"PY Tiew","year":"2020","unstructured":"Tiew PY, Mac Aogain M, Ali NABM et al (2020) The mycobiome in health and disease: emerging concepts, methodologies and challenges. Mycopathologia 185:207\u2013231. https:\/\/doi.org\/10.1007\/s11046-019-00413-z","journal-title":"Mycopathologia"},{"key":"2412_CR79","doi-asserted-by":"publisher","first-page":"100065","DOI":"10.1016\/j.soh.2024.100065","volume":"3","author":"A Tomasulo","year":"2024","unstructured":"Tomasulo A, Simionati B, Facchin S (2024) Microbiome one health model for a healthy ecosystem. Sci One Health 3:100065. https:\/\/doi.org\/10.1016\/j.soh.2024.100065","journal-title":"Sci One Health"},{"key":"2412_CR80","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.3390\/ijms20102432","volume":"20","author":"D Toor","year":"2019","unstructured":"Toor D, Wasson MK, Kumar P et al (2019) Dysbiosis disrupts gut immune homeostasis and promotes gastric diseases. Int J Mol Sci 20:2432. https:\/\/doi.org\/10.3390\/ijms20102432","journal-title":"Int J Mol Sci"},{"key":"2412_CR81","doi-asserted-by":"publisher","first-page":"649","DOI":"10.4049\/jimmunol.1002302","volume":"186","author":"S Valanne","year":"2011","unstructured":"Valanne S, Wang J-H, R\u00e4met M (2011) The Drosophila Toll signaling pathway. J Immunol 186:649\u2013656. https:\/\/doi.org\/10.4049\/jimmunol.1002302","journal-title":"J Immunol"},{"key":"2412_CR82","doi-asserted-by":"publisher","first-page":"2275493","DOI":"10.1080\/21505594.2023.2275493","volume":"14","author":"JB Wang","year":"2023","unstructured":"Wang JB, Lu H-L, Sheng H, St Leger RJ (2023) A Drosophila melanogaster model shows that fast growing Metarhizium species are the deadliest despite eliciting a strong immune response. Virulence 14:2275493. https:\/\/doi.org\/10.1080\/21505594.2023.2275493","journal-title":"Virulence"},{"key":"2412_CR83","doi-asserted-by":"publisher","first-page":"7799","DOI":"10.1038\/s41598-024-58500-1","volume":"14","author":"JB Wesseltoft","year":"2024","unstructured":"Wesseltoft JB, Danielsen CD, Andersen AM et al (2024) Feeding Drosophila gut microbiomes from young and old flies modifies the microbiome. Sci Rep 14:7799. https:\/\/doi.org\/10.1038\/s41598-024-58500-1","journal-title":"Sci Rep"},{"key":"2412_CR84","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41467-017-00040-6","volume":"8","author":"S-C Wu","year":"2017","unstructured":"Wu S-C, Cao Z-S, Chang K-M, Juang J-L (2017) Intestinal microbial dysbiosis aggravates the progression of Alzheimer\u2019s disease in Drosophila. Nat Commun 8:24. https:\/\/doi.org\/10.1038\/s41467-017-00040-6","journal-title":"Nat Commun"},{"key":"2412_CR85","doi-asserted-by":"publisher","first-page":"e56036","DOI":"10.15252\/embr.202256036","volume":"24","author":"R Xu","year":"2023","unstructured":"Xu R, Lou Y, Tidu A et al (2023) The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins. EMBO Rep 24:e56036. https:\/\/doi.org\/10.15252\/embr.202256036","journal-title":"EMBO Rep"},{"key":"2412_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1433155","author":"X Yin","year":"2024","unstructured":"Yin X, Tong Q, Wang J et al (2024) The impact of altered dietary adenine concentrations on the gut microbiota in Drosophila. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2024.1433155","journal-title":"Front Microbiol"},{"key":"2412_CR87","doi-asserted-by":"publisher","first-page":"39","DOI":"10.5734\/JGM.2023.20.2.39","volume":"20","author":"WH Yoon","year":"2023","unstructured":"Yoon WH (2023) Recent progress in using Drosophila as a platform for human genetic disease research. J Genet Med 20:39\u201345. https:\/\/doi.org\/10.5734\/JGM.2023.20.2.39","journal-title":"J Genet Med"},{"key":"2412_CR88","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3389\/fcimb.2020.00214","volume":"10","author":"S Younes","year":"2020","unstructured":"Younes S, Al-Sulaiti A, Nasser EAA et al (2020) Drosophila as a model organism in host-pathogen interaction studies. Front Cell Infect Microbiol 10:214. https:\/\/doi.org\/10.3389\/fcimb.2020.00214","journal-title":"Front Cell Infect Microbiol"},{"key":"2412_CR89","doi-asserted-by":"publisher","first-page":"905370","DOI":"10.3389\/fimmu.2022.905370","volume":"13","author":"S Yu","year":"2022","unstructured":"Yu S, Luo F, Xu Y et al (2022) Drosophila innate immunity involves multiple signaling pathways and coordinated communication between different tissues. Front Immunol 13:905370. https:\/\/doi.org\/10.3389\/fimmu.2022.905370","journal-title":"Front Immunol"},{"key":"2412_CR90","doi-asserted-by":"publisher","first-page":"e969","DOI":"10.1016\/S2666-5247(22)00203-8","volume":"3","author":"F Zhang","year":"2022","unstructured":"Zhang F, Aschenbrenner D, Yoo JY, Zuo T (2022) The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly. Lancet Microbe 3:e969\u2013e983. https:\/\/doi.org\/10.1016\/S2666-5247(22)00203-8","journal-title":"Lancet Microbe"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-026-02412-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10482-026-02412-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-026-02412-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:11:46Z","timestamp":1788595906000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10482-026-02412-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":90,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2412"],"URL":"https:\/\/doi.org\/10.1007\/s10482-026-02412-9","relation":{},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"16 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. They have no affiliations with or involvement in any organization or entity with any financial interest. The authors alone are responsible for the content and writing of the paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"202"}}