{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:13:33Z","timestamp":1788599613044,"version":"build-2803163510"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antonie van Leeuwenhoek"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10482-026-02414-7","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:35:21Z","timestamp":1788291321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome mining reveals an architecturally expanded pyoluteorin-associated biosynthetic gene cluster and a divergent flavin-dependent halogenase-like sequence in deep-sea Pseudomonas Aeruginosa from the Gulf of Guinea"],"prefix":"10.1007","volume":"119","author":[{"given":"Sunday Babatunde","family":"Akinde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Sunday","family":"Fajoyegbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwaseyi Paul","family":"Olaniyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omokaro","family":"Obire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adedolapo Aishat","family":"Salami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola Ayodele","family":"Adesoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waidi Folorunso","family":"Sule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah Kolawole","family":"Oladipo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olabisi Olaniyi","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2414_CR1","doi-asserted-by":"crossref","unstructured":"Akinde SB, Iwuozor CC (2012) Alkane degradative potentials of bacteria isolated from the deep Atlantic Ocean of the Gulf of Guinea.\u00a0J Bioremediation Biodegradation\u00a03(01)","DOI":"10.4172\/2155-6199.1000135"},{"issue":"6","key":"2414_CR2","first-page":"470","volume":"2","author":"SB Akinde","year":"2011","unstructured":"Akinde SB, Obire O (2011) In-situ physico-chemical properties of the deep Atlantic Ocean water column and their implications on heterotrophic bacterial distribution in the Gulf of Guinea. Adv Appl Sci Res 2(6):470\u2013482","journal-title":"Adv Appl Sci Res"},{"issue":"4","key":"2414_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/md18040199","volume":"18","author":"L Albarano","year":"2020","unstructured":"Albarano L, Esposito R, Ruocco N, Costantini M (2020) Genome mining as new challenge in natural products discovery. Mar Drugs 18(4):199","journal-title":"Mar Drugs"},{"issue":"7","key":"2414_CR4","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1080\/09583157.2020.1750562","volume":"30","author":"HM Al-Ghafri","year":"2020","unstructured":"Al-Ghafri HM, Velazhahan R, Shahid MS, Al-Sadi AM (2020) Antagonistic activity of Pseudomonas aeruginosa from compost against Pythium aphanidermatum and Fusarium solani. Biocontrol Sci Technol 30(7):642\u2013658","journal-title":"Biocontrol Sci Technol"},{"key":"2414_CR5","unstructured":"Altuner EM (2025) Inoculum Standardisation: Ensuring Reliable Antimicrobial Study Outcomes.\u00a0Altuner. me 5(29):1\u20135"},{"issue":"1","key":"2414_CR6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA (2000) Gene ontology: tool for the unification of biology. Nat Genet 25(1):25\u201329","journal-title":"Nat Genet"},{"issue":"1","key":"2414_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2164-9-75","volume":"9","author":"RK Aziz","year":"2008","unstructured":"Aziz RK, Bartels D, Best AA, DeJongh M, Disz T, Edwards RA, Formsma K, Gerdes S, Glass EM, Kubal M, Meyer F (2008) The RAST server: rapid annotations using subsystems technology. BMC Genomics 9(1):75","journal-title":"BMC Genomics"},{"issue":"5","key":"2414_CR8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","volume":"19","author":"A Bankevich","year":"2012","unstructured":"Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, Lesin VM, Nikolenko SI, Pham S, Prjibelski AD, Pyshkin AV (2012) SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol 19(5):455\u2013477","journal-title":"J Comput Biol"},{"issue":"24","key":"2414_CR9","doi-asserted-by":"publisher","first-page":"15352","DOI":"10.1021\/acscatal.2c05231","volume":"12","author":"RD Barker","year":"2022","unstructured":"Barker RD, Yu Y, De Maria L, Johannissen LO, Scrutton NS (2022) Mechanism of action of flavin-dependent halogenases. ACS Catal 12(24):15352\u201315360","journal-title":"ACS Catal"},{"key":"2414_CR10","first-page":"69","volume-title":"Techniques to measure food safety and quality: microbial, chemical, and sensory","author":"S Basak","year":"2021","unstructured":"Basak S, Shetty PH (2021) Conventional microbial counting and identification techniques. Techniques to measure food safety and quality: microbial, chemical, and sensory. Springer International Publishing, Cham, pp 69\u201389"},{"key":"2414_CR11","doi-asserted-by":"crossref","unstructured":"Blin K, Shaw S, Augustijn HE, Reitz ZL, Biermann F, Alanjary M, Fetter A, Terlouw BR, Metcalf WW, Helfrich EJ, Van Wezel GP (2023) antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation.\u00a0Nucleic Acids Research\u00a051(W1):W46\u2013W50","DOI":"10.1093\/nar\/gkad344"},{"issue":"8","key":"2414_CR12","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.chembiol.2023.06.011","volume":"30","author":"N B\u00f6hringer","year":"2023","unstructured":"B\u00f6hringer N, Kramer JC, de la Mora E, Padva L, Wuisan ZG, Liu Y, Kurz M, Marner M, Nguyen H, Amara P, Yokoyama K (2023) Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase. Cell Chem Biol 30(8):943\u2013952","journal-title":"Cell Chem Biol"},{"issue":"15","key":"2414_CR13","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B (2014) Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30(15):2114\u20132120","journal-title":"Bioinformatics"},{"issue":"6","key":"2414_CR15","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1136\/jcp.18.6.752","volume":"18","author":"VI Brown","year":"1965","unstructured":"Brown VI, Lowbury EJL (1965) Use of an improved cetrimide agar medium and other culture methods for Pseudomonas aeruginosa. J Clin Pathol 18(6):752\u2013756","journal-title":"J Clin Pathol"},{"issue":"2","key":"2414_CR16","first-page":"82","volume":"11","author":"L \u00c7ava\u015f","year":"2025","unstructured":"\u00c7ava\u015f L, Bilgin Y, K\u0131rk\u0131z \u0130 (2025) A comprehensive genome mining analysis of biosynthetic gene clusters in Pseudomonas sp. SXM-1. Turk J Marit Mar Sci 11(2):82\u201394","journal-title":"Turk J Marit Mar Sci"},{"key":"2414_CR17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fmicb.2016.00118","volume":"7","author":"JJ Davis","year":"2016","unstructured":"Davis JJ, Gerdes S, Olsen GJ, Olson R, Pusch GD, Shukla M, Vonstein V, Wattam AR, Yoo H (2016) PATtyFams: protein families for the microbial genomes in the PATRIC database. Front Microbiol 7:118","journal-title":"Front Microbiol"},{"issue":"4","key":"2414_CR18","doi-asserted-by":"publisher","first-page":"e70004","DOI":"10.1002\/jobm.70004","volume":"65","author":"T de Sousa","year":"2025","unstructured":"de Sousa T, Silva C, Igrejas G, H\u00e9braud M, Poeta P (2025) The interactive dynamics of Pseudomonas aeruginosa in global ecology. J Basic Microbiol 65(4):e70004","journal-title":"J Basic Microbiol"},{"issue":"7","key":"2414_CR19","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/jphp.13262","volume":"72","author":"T Ding","year":"2020","unstructured":"Ding T, Yang LJ, Zhang WD, Shen YH (2020) Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol 72(7):969\u2013978","journal-title":"J Pharm Pharmacol"},{"issue":"5","key":"2414_CR21","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"RC Edgar","year":"2004","unstructured":"Edgar RC (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32(5):1792\u20131797","journal-title":"Nucleic Acids Res"},{"key":"2414_CR22","doi-asserted-by":"publisher","first-page":"1010782","DOI":"10.3389\/ffunb.2022.1010782","volume":"3","author":"P Escribano","year":"2022","unstructured":"Escribano P, Guinea J (2022) Fluconazole-resistant Candida parapsilosis: a new emerging threat in the fungi arena. Front Fungal Biol 3:1010782","journal-title":"Front Fungal Biol"},{"issue":"4","key":"2414_CR24","doi-asserted-by":"publisher","first-page":"e00029-23","DOI":"10.1128\/mmbr.00029-23","volume":"88","author":"T Gabald\u00f3n","year":"2024","unstructured":"Gabald\u00f3n T (2024) Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens. Microbiol Mol Biol Rev 88(4):e00029-23","journal-title":"Microbiol Mol Biol Rev"},{"issue":"6","key":"2414_CR25","doi-asserted-by":"publisher","first-page":"fuab033","DOI":"10.1093\/femsre\/fuab033","volume":"45","author":"R Gallegos-Monterrosa","year":"2021","unstructured":"Gallegos-Monterrosa R, Coulthurst SJ (2021) The ecological impact of a bacterial weapon: microbial interactions and the Type VI secretion system. FEMS Microbiol Rev 45(6):fuab033","journal-title":"FEMS Microbiol Rev"},{"key":"2414_CR26","doi-asserted-by":"publisher","first-page":"1231765","DOI":"10.3389\/fctls.2023.1231765","volume":"3","author":"J Gebauer","year":"2023","unstructured":"Gebauer J, Pietruszka J, Classen T (2023) Expression and characterisation of PrnC\u2014a flavin-dependent halogenase from the pyrrolnitrin biosynthetic pathway of Pseudomonas protegens Pf-5. Front Catal 3:1231765","journal-title":"Front Catal"},{"issue":"20","key":"2414_CR27","doi-asserted-by":"publisher","first-page":"26341","DOI":"10.1007\/s13399-023-04855-w","volume":"14","author":"T Gillani","year":"2024","unstructured":"Gillani T, Ullah N, Sarwar A, Farooq MH, Aziz T, Alharbi M, Alsahammari A, Alasmari AF (2024) Optimisation of pyoverdine pigment biosynthesis conditions from a locally isolated strain of Pseudomonas aeruginosa. Biomass Convers Biorefinery 14(20):26341\u201326353","journal-title":"Biomass Convers Biorefinery"},{"key":"2414_CR28","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/s41557-019-0349-z","volume":"11","author":"DS Gkotsi","year":"2019","unstructured":"Gkotsi DS, Ludewig H, Sharma SV, Connolly JA, Dhaliwal J, Wang Y, Unsworth WP, Taylor RJK, McLachlan MMW, Shanahan S, Naismith JH (2019a) A marine viral halogenase that iodinates diverse substrates. Nat Chem 11:1091\u20131097","journal-title":"Nat Chem"},{"issue":"12","key":"2414_CR29","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/s41557-019-0349-z","volume":"11","author":"DS Gkotsi","year":"2019","unstructured":"Gkotsi DS, Ludewig H, Sharma SV, Connolly JA, Dhaliwal J, Wang Y, Unsworth WP, Taylor RJ, McLachlan MM, Shanahan S, Naismith JH (2019b) A marine viral halogenase that iodinates diverse substrates. Nat Chem 11(12):1091\u20131097","journal-title":"Nat Chem"},{"issue":"11","key":"2414_CR30","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1039\/b817075b","volume":"26","author":"H Gross","year":"2009","unstructured":"Gross H, Loper JE (2009) Genomics of secondary metabolite production by Pseudomonas spp. Nat Prod Rep 26(11):1408\u20131446","journal-title":"Nat Prod Rep"},{"issue":"1","key":"2414_CR32","doi-asserted-by":"publisher","first-page":"17310","DOI":"10.1038\/s41598-022-22256-3","volume":"12","author":"T Hebra","year":"2022","unstructured":"Hebra T, Pollet N, Touboul D, Eparvier V (2022) Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi. Sci Rep 12(1):17310","journal-title":"Sci Rep"},{"key":"2414_CR33","doi-asserted-by":"publisher","first-page":"xtad005","DOI":"10.1093\/femsmc\/xtad005","volume":"4","author":"PJ Hesketh-Best","year":"2023","unstructured":"Hesketh-Best PJ, January GG, Koch MJ, Warburton PJ, Howell KL, Upton M (2023) Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential. FEMS Microbes 4:xtad005","journal-title":"FEMS Microbes"},{"issue":"7","key":"2414_CR34","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/cbic.200600375","volume":"8","author":"A Hornung","year":"2007","unstructured":"Hornung A, Bertazzo M, Dziarnowski A, Schneider K, Welzel K, Wohlert SE, Holzenk\u00e4mpfer M, Nicholson GJ, Bechthold A, S\u00fcssmuth RD, Vente A (2007) A genomic screening approach to the structure-guided identification of drug candidates from natural sources. ChemBioChem 8(7):757\u2013766","journal-title":"ChemBioChem"},{"issue":"1","key":"2414_CR36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.gene.2006.02.009","volume":"376","author":"X Huang","year":"2006","unstructured":"Huang X, Yan A, Zhang X, Xu Y (2006) Identification and characterisation of a putative ABC transporter PltHIJKN required for pyoluteorin production in Pseudomonas sp. M18. Gene 376(1):68\u201378","journal-title":"Gene"},{"key":"2414_CR37","doi-asserted-by":"crossref","unstructured":"Huang X, Zhu D, Ge Y, Hu H, Zhang X, Xu Y (2004) Identification and characterisation of pltZ, a gene involved in the repression of pyoluteorin biosynthesis in Pseudomonas sp. M18.\u00a0FEMS Microbiology Letters\u00a0232(2):197\u2013202","DOI":"10.1016\/S0378-1097(04)00074-6"},{"issue":"D1","key":"2414_CR38","doi-asserted-by":"publisher","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","volume":"44","author":"M Kanehisa","year":"2016","unstructured":"Kanehisa M, Sato Y, Kawashima M, Furumichi M, Tanabe M (2016) KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res 44(D1):D457\u2013D462","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"2414_CR39","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1016\/j.sjbs.2020.10.007","volume":"27","author":"N Karmegham","year":"2020","unstructured":"Karmegham N, Vellasamy S, Natesan B, Sharma MP, Al Farraj DA, Elshikh MS (2020) Characterisation of antifungal metabolite phenazine from rice rhizosphere fluorescent pseudomonads (FPs) and their effect on sheath blight of rice. Saudi J Biol Sci 27(12):3313\u20133326","journal-title":"Saudi J Biol Sci"},{"issue":"4","key":"2414_CR40","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1128\/MMBR.00027-10","volume":"74","author":"VL Kung","year":"2010","unstructured":"Kung VL, Ozer EA, Hauser AR (2010) The accessory genome of Pseudomonas aeruginosa. Microbiol Mol Biol Rev 74(4):621\u2013641","journal-title":"Microbiol Mol Biol Rev"},{"issue":"4","key":"2414_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/jof6040189","volume":"6","author":"L Kunyeit","year":"2020","unstructured":"Kunyeit L, Ka AA, Rao RP (2020) Application of probiotic yeasts on Candida species associated infection. J Fungi 6(4):189","journal-title":"J Fungi"},{"issue":"1","key":"2414_CR42","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s12879-025-10722-y","volume":"25","author":"JE Lee","year":"2025","unstructured":"Lee JE, Kang DH, Ju H, Oh DK, Lee SY, Park MH, Lim CM, Lee SI (2025) Epidemiology and risk factors of fungal pathogens in sepsis: a prospective nationwide multicenter cohort study. BMC Infect Dis 25(1):331","journal-title":"BMC Infect Dis"},{"key":"2414_CR43","doi-asserted-by":"crossref","unstructured":"Lefort V, Desper R, Gascuel O (2015) FastME 2.0: a comprehensive, accurate, and fast distance-based phylogeny inference program.\u00a0Molecular Biology and Evolution\u00a032(10):2798\u20132800","DOI":"10.1093\/molbev\/msv150"},{"issue":"W1","key":"2414_CR44","doi-asserted-by":"publisher","first-page":"W293","DOI":"10.1093\/nar\/gkab301","volume":"49","author":"I Letunic","year":"2021","unstructured":"Letunic I, Bork P (2021) Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Nucleic Acids Res 49(W1):W293\u2013W296","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"2414_CR45","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1021\/acs.accounts.4c00172","volume":"57","author":"JC Lewis","year":"2024","unstructured":"Lewis JC (2024) Identifying and engineering flavin-dependent halogenases for selective biocatalysis. Acc Chem Res 57(15):2067\u20132079","journal-title":"Acc Chem Res"},{"issue":"1","key":"2414_CR47","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1038\/s41467-019-11658-z","volume":"10","author":"V Libis","year":"2019","unstructured":"Libis V, Antonovsky N, Zhang M, Shang Z, Montiel D, Maniko J, Ternei MA, Calle PY, Lemetre C, Owen JG, Brady SF (2019) Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences. Nat Commun 10(1):3848","journal-title":"Nat Commun"},{"issue":"1","key":"2414_CR48","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1471-2105-14-60","volume":"14","author":"JP Meier-Kolthoff","year":"2013","unstructured":"Meier-Kolthoff JP, Auch AF, Klenk HP, G\u00f6ker M (2013) Genome sequence-based species delimitation with confidence intervals and improved distance functions. BMC Bioinformatics 14(1):60","journal-title":"BMC Bioinformatics"},{"key":"2414_CR49","doi-asserted-by":"publisher","first-page":"i142","DOI":"10.1093\/bioinformatics\/bty266","volume":"34","author":"A Mikheenko","year":"2018","unstructured":"Mikheenko A, Prjibelski A, Saveliev V, Antipov D, Gurevich A (2018) Versatile genome assembly evaluation with QUAST-LG. Bioinformatics 34:i142\u2013i150","journal-title":"Bioinformatics"},{"issue":"1","key":"2414_CR50","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/s41467-019-09215-9","volume":"10","author":"S Mori","year":"2019","unstructured":"Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV (2019) Unusual substrate and halide versatility of phenolic halogenase PltM. Nat Commun 10(1):1255","journal-title":"Nat Commun"},{"issue":"W1","key":"2414_CR51","doi-asserted-by":"publisher","first-page":"W546","DOI":"10.1093\/nar\/gkaa374","volume":"48","author":"MD Mungan","year":"2020","unstructured":"Mungan MD, Alanjary M, Blin K, Weber T, Medema MH, Ziemert N (2020) ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining. Nucleic Acids Res 48(W1):W546\u2013W552","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"2414_CR52","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1128\/JB.181.7.2166-2174.1999","volume":"181","author":"B Nowak-Thompson","year":"1999","unstructured":"Nowak-Thompson B, Chaney N, Wing JS, Gould SJ, Loper JE (1999) Characterisation of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol 181(7):2166\u20132174","journal-title":"J Bacteriol"},{"issue":"D1","key":"2414_CR54","doi-asserted-by":"publisher","first-page":"D206","DOI":"10.1093\/nar\/gkt1226","volume":"42","author":"R Overbeek","year":"2014","unstructured":"Overbeek R, Olson R, Pusch GD, Olsen GJ, Davis JJ, Disz T, Edwards RA, Gerdes S, Parrello B, Shukla M, Vonstein V (2014) The SEED and the rapid annotation of microbial genomes using subsystems technology (RAST). Nucleic Acids Res 42(D1):D206\u2013D214","journal-title":"Nucleic Acids Res"},{"key":"2414_CR55","doi-asserted-by":"publisher","first-page":"112563","DOI":"10.1016\/j.jenvman.2021.112563","volume":"289","author":"GO Oyetibo","year":"2021","unstructured":"Oyetibo GO, Ige OO, Obinani PK, Amund OO (2021) Ecological risk potentials of petroleum hydrocarbons and heavy metals shape the bacterial communities of marine hydrosphere at Atlantic Ocean, Atlas Cove, Nigeria. J Environ Manage 289:112563","journal-title":"J Environ Manage"},{"issue":"3","key":"2414_CR101","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jsb.2015.09.013","volume":"192","author":"AH Pang","year":"2015","unstructured":"Pang AH, Garneau-Tsodikova S, Tsodikov OV (2015) Crystal structure of halogenase PltA from the pyoluteorinbiosynthetic pathway. J Struct Biol 192(3):349\u2013357","journal-title":"J Struct Biol"},{"issue":"7","key":"2414_CR57","doi-asserted-by":"publisher","first-page":"e0288504","DOI":"10.1371\/journal.pone.0288504","volume":"18","author":"LE Romero-Gonz\u00e1lez","year":"2023","unstructured":"Romero-Gonz\u00e1lez LE, Rojas-Vargas J, Muriel-Mill\u00e1n LF, Bustos-Mart\u00ednez J, Bustamante VH, Pardo-L\u00f3pez L (2023) Genomic and phenotypic characterisation of Pseudomonas sp. GOM7, a novel marine bacterial species with antimicrobial activity against multidrug-resistant Staphylococcus aureus. PLoS ONE 18(7):e0288504","journal-title":"PLoS ONE"},{"issue":"2","key":"2414_CR58","first-page":"000758","volume":"8","author":"Z Saati-Santamar\u00eda","year":"2022","unstructured":"Saati-Santamar\u00eda Z, Selem-Mojica N, Peral-Aranega E, Rivas R, Garc\u00eda-Fraile P (2022) Unveiling the genomic potential of Pseudomonas type strains for discovering new natural products. Microb Genom 8(2):000758","journal-title":"Microb Genom"},{"issue":"4","key":"2414_CR59","doi-asserted-by":"publisher","first-page":"98839","DOI":"10.5501\/wjv.v13.i4.98839","volume":"13","author":"NK Saeed","year":"2024","unstructured":"Saeed NK, Almusawi S, Al-Beltagi M (2024) Candidemia chronicles: retrospective analysis of candidemia epidemiology, species distribution, and antifungal susceptibility patterns in Bahrain. World J Virol 13(4):98839","journal-title":"World J Virol"},{"key":"2414_CR60","doi-asserted-by":"crossref","unstructured":"Schomburg I, Chang A, Ebeling C, Gremse M, Heldt C, Huhn G, Schomburg D (2004) BRENDA, the enzyme database: updates and major new developments.\u00a0Nucleic Acids Research\u00a032(suppl_1):D431\u2013D433","DOI":"10.1093\/nar\/gkh081"},{"key":"2414_CR63","first-page":"3340","volume":"23","author":"N Sivri","year":"2014","unstructured":"Sivri N, Jones M, Allen MJ (2014) Pseudomonas aeruginosa isolated from the marine environments in the Istanbul coastal area (Turkey). Fresenius Environ Bull 23:3340\u20133344","journal-title":"Fresenius Environ Bull"},{"issue":"6799","key":"2414_CR64","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/35023079","volume":"406","author":"CK Stover","year":"2000","unstructured":"Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FSL, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL (2000) Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 406(6799):959\u2013964","journal-title":"Nature"},{"issue":"17","key":"2414_CR65","doi-asserted-by":"publisher","first-page":"4749","DOI":"10.1021\/ja01550a093","volume":"80","author":"R Takeda","year":"1958","unstructured":"Takeda R (1958) Structure of a new antibiotic, pyoluteorin. J Am Chem Soc 80(17):4749\u20134750","journal-title":"J Am Chem Soc"},{"issue":"14","key":"2414_CR66","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1093\/nar\/gkw569","volume":"44","author":"T Tatusova","year":"2016","unstructured":"Tatusova T, DiCuccio M, Badretdin A, Chetvernin V, Nawrocki EP, Zaslavsky L, Lomsadze A, Pruitt KD, Borodovsky M, Ostell J (2016) NCBI prokaryotic genome annotation pipeline. Nucleic Acids Res 44(14):6614\u20136624","journal-title":"Nucleic Acids Res"},{"key":"2414_CR67","doi-asserted-by":"crossref","unstructured":"Tenebro CP, Trono DJV, Balida LAP, Bayog LKA, Bruna JR, Sabido EM, Caspe DPC, de Los Santos ELC, Saludes JP, Dalisay DS (2023) Synergy between genome mining, metabolomics, and bioinformatics uncovers antibacterial chlorinated carbazole alkaloids and their biosynthetic gene cluster from Streptomyces tubbatahanensis sp. nov., a novel actinomycete isolated from Sulu Sea, Philippines.\u00a0Microbiology Spectrum\u00a011(2):e03661\u201322","DOI":"10.1128\/spectrum.03661-22"},{"key":"2414_CR68","doi-asserted-by":"crossref","unstructured":"Terlouw BR, Blin K, Navarro-Munoz JC, Avalon NE, Chevrette MG, Egbert S, Lee S, Meijer D, Recchia MJ, Reitz ZL, Van Santen JA (2023) MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters.\u00a0Nucleic Acids Research\u00a051(D1):D603\u2013D610","DOI":"10.1093\/nar\/gkac1049"},{"issue":"3","key":"2414_CR69","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1007\/s13204-021-01944-y","volume":"13","author":"A Thacharodi","year":"2023","unstructured":"Thacharodi A, Priyadharshini R, Karthikeyan G, Jeganathan C, Reghu AP, Pugazhendhi A (2023) Extraction, purification and characterisation of phenazine from Pseudomonas aeruginosa isolate of wastewater sources: a panacea towards clinical pathogens. Appl Nanosci 13(3):2365\u20132378","journal-title":"Appl Nanosci"},{"issue":"2","key":"2414_CR70","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S1074-5521(02)00100-X","volume":"9","author":"MG Thomas","year":"2002","unstructured":"Thomas MG, Burkart MD, Walsh CT (2002) Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem Biol 9(2):171\u2013184","journal-title":"Chem Biol"},{"issue":"10","key":"2414_CR71","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41579-020-0379-y","volume":"18","author":"DA van Bergeijk","year":"2020","unstructured":"van Bergeijk DA, Terlouw BR, Medema MH, van Wezel GP (2020) Ecology and genomics of Actinobacteria: new concepts for natural product discovery. Nat Rev Microbiol 18(10):546\u2013558","journal-title":"Nat Rev Microbiol"},{"issue":"13","key":"2414_CR74","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.7150\/ijms.18896","volume":"14","author":"LQ Xu","year":"2017","unstructured":"Xu LQ, Zeng JW, Jiang CH, Wang H, Li YZ, Wen WH, Li JH, Wang F, Ting WJ, Sun ZY, Huang CY (2017) Isolation and determination of four potential antimicrobial components from Pseudomonas aeruginosa extracts. Int J Med Sci 14(13):1368","journal-title":"Int J Med Sci"},{"key":"2414_CR100","doi-asserted-by":"crossref","unstructured":"Yan A, Huang X, Liu H, Dong D, Zhang D, Zhang X, Xu Y (2007) An rhl-like quorum-sensing system negatively regulates pyoluteorinproduction in Pseudomonas sp. M18. Microbiology 153(1):16\u201328","DOI":"10.1099\/mic.0.29211-0"},{"issue":"3","key":"2414_CR75","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3390\/md12031281","volume":"12","author":"M Yuan","year":"2014","unstructured":"Yuan M, Yu Y, Li HR, Dong N, Zhang XH (2014) Phylogenetic diversity and biological activity of actinobacteria isolated from the Chukchi Shelf marine sediments in the Arctic Ocean. Mar Drugs 12(3):1281\u20131297","journal-title":"Mar Drugs"}],"container-title":["Antonie van Leeuwenhoek"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-026-02414-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10482-026-02414-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10482-026-02414-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:03:06Z","timestamp":1788598986000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10482-026-02414-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2414"],"URL":"https:\/\/doi.org\/10.1007\/s10482-026-02414-7","relation":{},"ISSN":["0003-6072","1572-9699"],"issn-type":[{"value":"0003-6072","type":"print"},{"value":"1572-9699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"27 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests or personal relationships that could influence the work reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This study did not involve human participants, animal experimentation, or clinical interventions beyond routine microbiological screening.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"211"}}