{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:13:53Z","timestamp":1762125233162,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/20745-6","2019\/02831-3","2014\/02843-8","2018\/2999-9"],"award-info":[{"award-number":["2015\/20745-6","2019\/02831-3","2014\/02843-8","2018\/2999-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["300625\/2012-0"],"award-info":[{"award-number":["300625\/2012-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Exp Appl Acarol"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s10493-021-00591-w","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T22:14:32Z","timestamp":1613686472000},"page":"387-398","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rhipicephalus sanguineus salivary gland extract as a source of immunomodulatory molecules"],"prefix":"10.1007","volume":"83","author":[{"given":"Melissa Carolina","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elen Fernanda","family":"Nodari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Rodrigues","family":"de Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisiery Negrini","family":"Paiatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Ucelli","family":"Simioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9418-8934","authenticated-orcid":false,"given":"Maria Izabel","family":"Camargo-Mathias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"591_CR1","volume-title":"Basic immunology: functions and disorders of the immune system","author":"AK Abbas","year":"2015","unstructured":"Abbas AK, Lichtman AH, Pillai S (2015) Basic immunology: functions and disorders of the immune system, 5th edn. Elsevier, Philadelphia, PA","edition":"5"},{"key":"591_CR4","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1354\/VP.39-1-74","volume":"39","author":"VK Affolter","year":"2002","unstructured":"Affolter VK, Moore PF (2002) Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. Vet Pathol 39:74\u201383. https:\/\/doi.org\/10.1354\/VP.39-1-74","journal-title":"Vet Pathol"},{"key":"591_CR5","first-page":"61","volume":"4","author":"GH Bechara","year":"1995","unstructured":"Bechara GH, Szab\u00f3 MPJ, Ferreira BR, Garcia M (1995) Rhipicephalus sanguineus tick in Brazil: feeding and reproductive aspects under laboratorial conditions. Braz J Vet Parasitol 4:61\u201366","journal-title":"Braz J Vet Parasitol"},{"key":"591_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0020-7519(78)90004-8","volume":"8","author":"KC Binnington","year":"1978","unstructured":"Binnington KC (1978) Sequential changes in salivary gland structure during attachment and feeding of the cattle tick Boophilus microplus. Int J Parasitol 8:97\u2013115","journal-title":"Int J Parasitol"},{"key":"591_CR7","first-page":"87","volume":"36","author":"LMF Borges","year":"2007","unstructured":"Borges LMF, Soares SF, Fonseca IN et al (2007) Resist\u00eancia carrapaticida em larvas de Rhipicephalus sanguineus (Acari: Ixodidae) de Goi\u00e2nia-GO, Brasil. Rev Patol Trop 36:87\u201395","journal-title":"Rev Patol Trop"},{"issue":"Suppl","key":"591_CR8","doi-asserted-by":"publisher","first-page":"S161","DOI":"10.1017\/S0031182004004834","volume":"129","author":"M Brossard","year":"2004","unstructured":"Brossard M, Wikel SK (2004) Tick immunobiology. Parasitology 129(Suppl):S161\u2013S176","journal-title":"Parasitology"},{"key":"591_CR9","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/sj.cdd.4401261","volume":"10","author":"B Br\u00fcne","year":"2003","unstructured":"Br\u00fcne B (2003) Nitric oxide: NO apoptosis or turning it ON? Cell Death Differ 10:864\u2013869. https:\/\/doi.org\/10.1038\/sj.cdd.4401261","journal-title":"Cell Death Differ"},{"key":"591_CR10","doi-asserted-by":"crossref","DOI":"10.7476\/9788595462861","volume-title":"Inside ticks: morphophysiology, toxicology and therapeutic perspectives","author":"MI Camargo-Mathias","year":"2018","unstructured":"Camargo-Mathias MI (2018) Inside ticks: morphophysiology, toxicology and therapeutic perspectives. Editora Unesp, S\u00e3o Paulo"},{"key":"591_CR11","first-page":"167","volume-title":"Advances in zoology research","author":"MI Camargo-Mathias","year":"2013","unstructured":"Camargo-Mathias MI, Furquim KCS (2013) The histology as a tool for the understanding of the morphophysiolgy of the brown dog tick (Rhipicephalus sanguineus). In: Jenkins OP (ed) Advances in zoology research. Nova Science Publishers, New York, pp 167\u2013191"},{"key":"591_CR12","first-page":"231","volume":"8","author":"MI Camargo-Mathias","year":"2011","unstructured":"Camargo-Mathias MI, Furquim KCS, Nunes PH (2011) Immunomodulatory effects of tick saliva. Invertebr Surviv J 8:231\u2013240","journal-title":"Invertebr Surviv J"},{"key":"591_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.vetpar.2007.12.030","volume":"152","author":"F Dantas-Torres","year":"2008","unstructured":"Dantas-Torres F (2008) The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): from taxonomy to control. Vet Parasitol 152:173\u2013185. https:\/\/doi.org\/10.1016\/j.vetpar.2007.12.030","journal-title":"Vet Parasitol"},{"key":"591_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-3305-3-1","volume":"3","author":"F Dantas-Torres","year":"2010","unstructured":"Dantas-Torres F (2010) Biology and ecology of the brown dog tick, Rhipicephalus sanguineus. Parasit Vectors 3:1\u201311","journal-title":"Parasit Vectors"},{"key":"591_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4172\/2376-0419.1000121","volume":"1","author":"MR de Abreu","year":"2014","unstructured":"de Abreu MR, Rocha FA, Furquim KCS et al (2014) Salivary glands of female ticks Rhipicephalus sanguineus like a potential source of molecules with inhibitory action: In vivo study with Walker 256 tumor cells. J Pharm Care Health Syst 1:121. https:\/\/doi.org\/10.4172\/2376-0419.1000121","journal-title":"J Pharm Care Health Syst"},{"key":"591_CR3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.vetimm.2018.11.017","volume":"207","author":"MR de Abreu","year":"2019","unstructured":"de Abreu MR, Pereira MC, Simioni PU et al (2019) Immunomodulatory and morphophysiological effects of Rhipicephalus sanguineus s.l. (Acari: Ixodidae) salivary gland extracts. Vet Immunol Immunopathol 207:36\u201345. https:\/\/doi.org\/10.1016\/j.vetimm.2018.11.017","journal-title":"Vet Immunol Immunopathol"},{"key":"591_CR15","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0165-2427(98)00135-4","volume":"64","author":"BR Ferreira","year":"1998","unstructured":"Ferreira BR, Silva JS (1998) Saliva of Rhipicephalus sanguineus tick impairs T cell proliferation and IFN-gamma-induced macrophage microbicidal activity. Vet Immunol Immunopathol 64:279\u2013293","journal-title":"Vet Immunol Immunopathol"},{"key":"591_CR16","doi-asserted-by":"publisher","first-page":"946","DOI":"10.2307\/3282875","volume":"75","author":"BH Fivaz","year":"1989","unstructured":"Fivaz BH (1989) Immune suppression induced by the brown ear tick Rhipicephalus appendiculatus Neumann, 1901. J Parasitol 75:946\u2013952","journal-title":"J Parasitol"},{"key":"591_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00436-010-2238-7","volume":"109","author":"KCS Furquim","year":"2011","unstructured":"Furquim KCS, Mathias MIC, Hebling LMGF et al (2011) Ticks\u2019 response to feeding on host immunized with glandular extracts of Rhipicephalus sanguineus females fed for 2, 4, and 6 days. I. Inactivity or early degeneration of salivary glands? Parasitol Res 109:147\u2013162. https:\/\/doi.org\/10.1007\/s00436-010-2238-7","journal-title":"Parasitol Res"},{"key":"591_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/9780470376928.ch2","volume-title":"Tumors in domestic animals","author":"MH Goldschmidt","year":"2008","unstructured":"Goldschmidt MH, Hendrick MJ (2008) Tumors of the skin and soft tissues. In: Meuten DJ (ed) Tumors in domestic animals. Iowa State Press, Ames, IA, pp 45\u2013117"},{"key":"591_CR19","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/cber.187901201117","volume":"12","author":"JP Griess","year":"1879","unstructured":"Griess JP (1879) Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt \u201cUeber einige Azoverbindungen.\u201d Berichte der Dtsch Chem Gesellschaft 12:426\u2013428","journal-title":"Berichte der Dtsch Chem Gesellschaft"},{"key":"591_CR20","volume-title":"Skin diseases of the dog and cat: clinical and histopathologic diagnosis","author":"TL Gross","year":"2006","unstructured":"Gross TL, Ihrke P, Walder EJ, Affolter VK (2006) Skin diseases of the dog and cat: clinical and histopathologic diagnosis, 2nd edn. Blackwell Publishing, Ames, IA","edition":"2"},{"key":"591_CR21","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00436-012-3169-2","volume":"112","author":"LMGF Hebling","year":"2013","unstructured":"Hebling LMGF, Furquim KCS, Bechara GH, Camargo-Mathias MI (2013) Inoculation of salivary gland extracts obtained from female of Rhipicephalus sanguineus (Latreille, 1806) (Acari, Ixodidae) with 2, 4, and 6 days of feeding in rabbit: I\u2014histopathology of the feeding lesion. Parasitol Res 112:577\u2013584. https:\/\/doi.org\/10.1007\/s00436-012-3169-2","journal-title":"Parasitol Res"},{"key":"591_CR22","volume-title":"T\u00e9cnicas b\u00e1sicas de citologia e histologia","author":"LCU Junqueira","year":"1983","unstructured":"Junqueira LCU, Junqueira LMMS (1983) T\u00e9cnicas b\u00e1sicas de citologia e histologia. Livraria Editora Santos, S\u00e3o Paulo"},{"key":"591_CR23","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12906-015-0896-9","volume":"15","author":"OR Justo","year":"2015","unstructured":"Justo OR, Simioni PU, Gabriel DL et al (2015) Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type. BMC Complement Altern Med 15:390. https:\/\/doi.org\/10.1186\/s12906-015-0896-9","journal-title":"BMC Complement Altern Med"},{"key":"591_CR24","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1055\/s-0028-1088347","volume":"75","author":"E Koh","year":"2009","unstructured":"Koh E, Kim H, Kim S et al (2009) Modulation of macrophage functions by compounds isolated from Zingiber officinale. Planta Med 75:148\u2013151. https:\/\/doi.org\/10.1055\/s-0028-1088347","journal-title":"Planta Med"},{"key":"591_CR25","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1046\/j.1365-3024.1999.00233.x","volume":"21","author":"J Kopecky","year":"1999","unstructured":"Kopecky J, Kuthejlova M, Pechova J (1999) Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-gama by the upregulation of interleukin-10. Parasite Immunol 21:351\u2013356","journal-title":"Parasite Immunol"},{"key":"591_CR26","first-page":"113","volume":"82","author":"M Kubes","year":"1994","unstructured":"Kubes M, Fuchsberger N, Labuda M et al (1994) Salivary gland extracts of partially fed Dermacentor reticulatus ticks decrease natural killer cell activity in vitro. Immunology 82:113\u2013116","journal-title":"Immunology"},{"key":"591_CR27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1128\/IAI.69.1.575-578.2001","volume":"69","author":"M Kuthejlov\u00e1","year":"2001","unstructured":"Kuthejlov\u00e1 M, Kopeck\u00fd J, Step\u00e1nov\u00e1 G, Macela A (2001) Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages. Infect Immun 69:575\u2013578. https:\/\/doi.org\/10.1128\/IAI.69.1.575-578.2001","journal-title":"Infect Immun"},{"key":"591_CR28","first-page":"123","volume":"13","author":"MB Labruna","year":"2004","unstructured":"Labruna MB (2004) Biologia-ecologia de Rhipicephalus sanguineus (Acari: Ixodidae). Rev Bras Parasitol Vet 13:123\u2013124","journal-title":"Rev Bras Parasitol Vet"},{"key":"591_CR29","first-page":"2531","volume":"51","author":"L Li","year":"1991","unstructured":"Li L, Kilbourn RG, Adams J, Fidler IJ (1991) Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res 51:2531\u20132535","journal-title":"Cancer Res"},{"key":"591_CR30","doi-asserted-by":"publisher","first-page":"10960","DOI":"10.1074\/jbc.M110.205047","volume":"286","author":"CJF Oliveira","year":"2011","unstructured":"Oliveira CJF, S\u00e1-Nunes A, Francischetti IMB et al (2011) Deconstructing tick saliva: non-protein molecules with potent immunomodulatory properties. J Biol Chem 286:10960\u201310969. https:\/\/doi.org\/10.1074\/jbc.M110.205047","journal-title":"J Biol Chem"},{"key":"591_CR31","volume-title":"Citologia cl\u00ednica de c\u00e3es e gatos: atlas colorido e guia de interpreta\u00e7\u00e3o","author":"RE Raskin","year":"2011","unstructured":"Raskin RE, Meyer DJ (2011) Citologia cl\u00ednica de c\u00e3es e gatos: atlas colorido e guia de interpreta\u00e7\u00e3o, 2nd edn. Elsevier, Rio de Janeiro","edition":"2"},{"key":"591_CR32","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/0014-4894(90)90121-R","volume":"70","author":"JMC Ribeiro","year":"1990","unstructured":"Ribeiro JMC, Weiss JJ, Telford SR (1990) Saliva of the tick Ixodes dammini inhibits neutrophil function. Exp Parasitol 70:382\u2013388","journal-title":"Exp Parasitol"},{"key":"591_CR33","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/S0022-1910(99)00210-3","volume":"46","author":"JR Sauer","year":"2000","unstructured":"Sauer JR, Essenberg RC, Bowman AS (2000) Salivary glands in ixodid ticks: control and mechanism of secretion. J Insect Physiol 46:1069\u20131078. https:\/\/doi.org\/10.1016\/S0022-1910(99)00210-3","journal-title":"J Insect Physiol"},{"key":"591_CR34","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/0003-2697(77)90428-6","volume":"79","author":"JJ Sedmak","year":"1977","unstructured":"Sedmak JJ, Grossberg SE (1977) A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. Anal Biochem 79:544\u2013552","journal-title":"Anal Biochem"},{"key":"591_CR35","volume-title":"Biology of ticks","author":"DE Sonenshine","year":"2014","unstructured":"Sonenshine DE, Roe RM (2014) Biology of ticks, vol 1. Oxford University Press, New York, NY"},{"key":"591_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxicon.2005.09.010","volume":"47","author":"NA Steen","year":"2006","unstructured":"Steen NA, Barker SC, Alewood PF (2006) Proteins in the saliva of the Ixodida (ticks): pharmacological features and biological significance. Toxicon 47:1\u201320. https:\/\/doi.org\/10.1016\/j.toxicon.2005.09.010","journal-title":"Toxicon"},{"key":"591_CR37","first-page":"1352","volume":"54","author":"LL Thomsen","year":"1994","unstructured":"Thomsen LL, Lawton FG, Knowles RG et al (1994) Nitric oxide synthase activity in human gynecological cancer. Cancer Res 54:1352\u20131354","journal-title":"Cancer Res"},{"key":"591_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4236\/jbise.2012.55032","volume":"5","author":"CEP Toledo","year":"2012","unstructured":"Toledo CEP, Souza MA, Fraga MR et al (2012) Cellular viability and Nitric Oxide (NO) production by J774 macrophages in the presence of orthodontic archwires. J Biomed Sci Eng 5:255\u2013262. https:\/\/doi.org\/10.4236\/jbise.2012.55032","journal-title":"J Biomed Sci Eng"},{"key":"591_CR39","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1084\/JEM.180.3.1077","volume":"180","author":"S Urioste","year":"1994","unstructured":"Urioste S, Hall LR, Telford SR, Titus RG (1994) Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism. J Exp Med 180:1077\u20131085. https:\/\/doi.org\/10.1084\/JEM.180.3.1077","journal-title":"J Exp Med"},{"key":"591_CR40","first-page":"167","volume-title":"Complementary and alternative approaches to biomedicine","author":"H Wako","year":"2004","unstructured":"Wako H, Deng H (2004) Chinese medicine and immunity. In: Yamaguchi N, Cooper E (eds) Complementary and alternative approaches to biomedicine. Springer, New York, pp 167\u2013169"},{"key":"591_CR41","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/00034983.1985.11811906","volume":"79","author":"SK Wikel","year":"1985","unstructured":"Wikel SK (1985) Effects of tick infestation on the plaque-forming cell response to a thymic dependent antigen. Ann Trop Med Parasitol 79:195\u2013198","journal-title":"Ann Trop Med Parasitol"}],"container-title":["Experimental and Applied Acarology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10493-021-00591-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10493-021-00591-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10493-021-00591-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T03:07:09Z","timestamp":1671332829000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10493-021-00591-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["591"],"URL":"https:\/\/doi.org\/10.1007\/s10493-021-00591-w","relation":{},"ISSN":["0168-8162","1572-9702"],"issn-type":[{"type":"print","value":"0168-8162"},{"type":"electronic","value":"1572-9702"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"assertion":[{"value":"4 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declared that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}