{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:32:12Z","timestamp":1786980732636,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1007\/s10495-005-0887-2","type":"journal-article","created":{"date-parts":[[2005,9,8]],"date-time":"2005-09-08T19:47:31Z","timestamp":1126208851000},"page":"1131-1142","source":"Crossref","is-referenced-by-count":18,"title":["Motexafin gadolinium induces mitochondriallymediated caspase-dependent apoptosis"],"prefix":"10.1007","volume":"10","author":[{"given":"J.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sirisawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Naumovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"887_CR1","doi-asserted-by":"crossref","unstructured":"Magda D, Gerasimchuk N, Lecane P, et al. Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species. Chem Commun (Camb) 2002; 2730\u20132731.","DOI":"10.1039\/b208760j"},{"key":"887_CR2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00004424-199403000-00013","volume":"29","author":"SW Young","year":"1994","unstructured":"Young SW, Sidhu MK, Qing F, et al. Preclinical evaluation of gadolinium (III) texaphyrin complex. A new paramagnetic contrast agent for magnetic resonance imaging. Invest Radiol 1994; 29: 330\u2013338.","journal-title":"Invest Radiol"},{"key":"887_CR3","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1073\/pnas.93.13.6610","volume":"93","author":"SW Young","year":"1996","unstructured":"Young SW, Qing F, Harriman A, et al. Gadolinium(III) texaphyrin: A tumor selective radiation sensitizer that is detectable by MRI. Proc Natl Acad Sci USA 1996; 93: 6610\u20136615.","journal-title":"Proc Natl Acad Sci USA"},{"key":"887_CR4","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0360-3016(01)01810-7","volume":"51","author":"D Magda","year":"2001","unstructured":"Magda D, Lepp C, Gerasimchuk N, et al. Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species. Int J Radiat Oncol Biol Phys 2001; 51: 1025\u20131036.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"887_CR5","first-page":"3215","volume":"7","author":"RA Miller","year":"2001","unstructured":"Miller RA, Woodburn KW, Fan Q, et al. Motexafin gadolinium: A redox active drug that enhances the efficacy of bleomycin and doxorubicin. Clin Cancer Res 2001; 7: 3215\u20133221.","journal-title":"Clin Cancer Res"},{"key":"887_CR6","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0360-3016(00)01566-2","volume":"49","author":"S Xu","year":"2001","unstructured":"Xu S, Zakian K, Thaler H, et al. Effects of Motexafin gadolinium on tumor metabolism and radiation sensitivity. Int J Radiat Oncol Biol Phys 2001; 49: 1381\u20131390.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"887_CR7","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1200\/JCO.2001.19.7.2074","volume":"19","author":"P Carde","year":"2001","unstructured":"Carde P, Timmerman R, Mehta MP, et al. Multicenter phase Ib\/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases. J Clin Oncol 2001; 19: 2074\u20132083.","journal-title":"J Clin Oncol"},{"key":"887_CR8","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1200\/JCO.2002.07.500","volume":"20","author":"MP Mehta","year":"2002","unstructured":"Mehta MP, Shapiro WR, Glantz MJ, et al. Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: Centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points. J Clin Oncol 2002; 20: 3445\u20133453.","journal-title":"J Clin Oncol"},{"key":"887_CR9","first-page":"739","volume":"5","author":"DI Rosenthal","year":"1999","unstructured":"Rosenthal DI, Nurenberg P, Becerra CR, et al. A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging. Clin Cancer Res 1999; 5: 739\u2013745.","journal-title":"Clin Cancer Res"},{"key":"887_CR10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1148\/radiology.212.3.r99se10755","volume":"212","author":"J Viala","year":"1999","unstructured":"Viala J, Vanel D, Meingan P, et al. Phases IB and II multidose trial of gadolinium texaphyrin, a radiation sensitizer detectable at MR imaging: Preliminary results in brain metastases. Radiology 1999; 212: 755\u2013759.","journal-title":"Radiology"},{"key":"887_CR11","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/01.cco.0000142073.29850.98","volume":"16","author":"AM Evens","year":"2004","unstructured":"Evens AM. Motexafin gadolinium: A redox-active tumor selective agent for the treatment of cancer. Curr Opin Oncol 2004; 16: 576\u2013580.","journal-title":"Curr Opin Oncol"},{"key":"887_CR12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1586\/14737140.4.6.981","volume":"4","author":"D Khuntia","year":"2004","unstructured":"Khuntia D, Mehta M. Motexafin gadolinium: A clinical review of a novel radioenhancer for brain tumors. Expert Rev Anticancer Ther 2004; 4: 981\u2013989.","journal-title":"Expert Rev Anticancer Ther"},{"key":"887_CR13","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1182\/blood.V98.9.2603","volume":"98","author":"I Herr","year":"2001","unstructured":"Herr I, Debatin KM. Cellular stress response and apoptosis in cancer therapy. Blood 2001; 98: 2603\u20132614.","journal-title":"Blood"},{"key":"887_CR14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1023\/A:1024116916932","volume":"8","author":"TM Caserta","year":"2003","unstructured":"Caserta TM, Smith AN, Gultice AD, Reedy MA, Brown TL. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 2003; 8: 345\u2013352.","journal-title":"Apoptosis"},{"key":"887_CR15","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1093\/intimm\/6.12.1817","volume":"6","author":"M Eray","year":"1994","unstructured":"Eray M, Tuomikoski T, Wu H, et al. Cross-linking of surface IgG induces apoptosis in a bcl-2 expressing human follicular lymphoma line of mature B cell phenotype. Int Immunol 1994; 6: 1817\u20131827.","journal-title":"Int Immunol"},{"key":"887_CR16","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/1097-0142(197811)42:5<2379::AID-CNCR2820420539>3.0.CO;2-4","volume":"42","author":"AL Epstein","year":"1978","unstructured":"Epstein AL, Levy R, Kim H, et al. Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines. Cancer 1978; 42: 2379\u20132391.","journal-title":"Cancer"},{"key":"887_CR17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0014-5793(01)02593-5","volume":"500","author":"V Borutaite","year":"2001","unstructured":"Borutaite V, Brown GC. Caspases are reversibly inactivated by hydrogen peroxide. FEBS Lett 2001; 500: 114\u2013118.","journal-title":"FEBS Lett"},{"key":"887_CR18","first-page":"508","volume":"1","author":"HM Lui","year":"2003","unstructured":"Lui HM, Chen J, Wang L, Naumovski L. ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. Mol Cancer Res 2003; 1: 508\u2013518.","journal-title":"Mol Cancer Res"},{"key":"887_CR19","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770\u2013776.","journal-title":"Nature"},{"key":"887_CR20","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1496","volume":"5","author":"SJ Riedl","year":"2004","unstructured":"Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 2004; 5: 897\u2013907.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"887_CR21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.144.2.281","volume":"144","author":"EA Slee","year":"1999","unstructured":"Slee EA, Harte MT, Kluck RM, et al. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999; 144: 281\u2013292.","journal-title":"J Cell Biol"},{"key":"887_CR22","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1074\/jbc.274.8.5053","volume":"274","author":"XM Sun","year":"1999","unstructured":"Sun XM, MacFarlane M, Zhuang J, et al. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 1999; 274: 5053\u20135060.","journal-title":"J Biol Chem"},{"key":"887_CR23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1078\/0065-1281-00601","volume":"103","author":"CJ Noorden Van","year":"2001","unstructured":"Van Noorden CJ. The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition. Acta Histochem 2001; 103: 241\u2013251.","journal-title":"Acta Histochem"},{"key":"887_CR24","doi-asserted-by":"crossref","first-page":"32608","DOI":"10.1074\/jbc.273.49.32608","volume":"273","author":"M Garcia-Calvo","year":"1998","unstructured":"Garcia-Calvo M, Peterson EP, Leiting B, et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 1998; 273: 32608\u201332613.","journal-title":"J Biol Chem"},{"key":"887_CR25","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/sj.cdd.4401296","volume":"10","author":"EC Bruin de","year":"2003","unstructured":"de Bruin EC, Meersma D, de Wilde J, et al. A serine protease is involved in the initiation of DNA damage-induced apoptosis. Cell Death Differ 2003; 10: 1204\u20131212.","journal-title":"Cell Death Differ"},{"key":"887_CR26","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/sj.cdd.4400783","volume":"7","author":"SJ Korsmeyer","year":"2000","unstructured":"Korsmeyer SJ, Wei MC, Saito M, et al. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 2000; 7: 1166\u20131173.","journal-title":"Cell Death Differ"},{"key":"887_CR27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0014-5793(03)01464-9","volume":"557","author":"HK Lorenzo","year":"2004","unstructured":"Lorenzo HK, Susin SA. Mitochondrial effectors in caspase-independent cell death. FEBS Lett 2004; 557: 14\u201320.","journal-title":"FEBS Lett"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-005-0887-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-005-0887-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-005-0887-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T14:31:06Z","timestamp":1559140266000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-005-0887-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["887"],"URL":"https:\/\/doi.org\/10.1007\/s10495-005-0887-2","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}