{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:09:27Z","timestamp":1791151767084,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T00:00:00Z","timestamp":1258761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s10495-009-0424-9","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T15:47:25Z","timestamp":1258732045000},"page":"219-229","source":"Crossref","is-referenced-by-count":30,"title":["Aspirin induces apoptosis in human leukemia cells independently of NF-\u03baB and MAPKs through alteration of the Mcl-1\/Noxa balance"],"prefix":"10.1007","volume":"15","author":[{"given":"Daniel","family":"Iglesias-Serret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Piqu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Barrag\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Cosialls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio F.","family":"Santidri\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Gonz\u00e1lez-Giron\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloren\u00e7","family":"Coll-Mulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"de Frias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,11,21]]},"reference":[{"key":"424_CR1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00018-008-7511-x","volume":"65","author":"NR Jana","year":"2008","unstructured":"Jana NR (2008) NSAIDs and apoptosis. Cell Mol Life Sci 65:1295\u20131301","journal-title":"Cell Mol Life Sci"},{"key":"424_CR2","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1182\/blood.V92.4.1406","volume":"92","author":"B Bellosillo","year":"1998","unstructured":"Bellosillo B, Pique M, Barragan M, Castano E, Villamor N, Colomer D, Montserrat E, Pons G, Gil J (1998) Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood 92:1406\u20131414","journal-title":"Blood"},{"key":"424_CR3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-5793(00)01922-0","volume":"480","author":"M Pique","year":"2000","unstructured":"Pique M, Barragan M, Dalmau M, Bellosillo B, Pons G, Gil J (2000) Aspirin induces apoptosis through mitochondrial cytochrome c release. FEBS Lett 480:193\u2013196","journal-title":"FEBS Lett"},{"key":"424_CR4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0003-9861(03)00345-X","volume":"417","author":"D Iglesias-Serret","year":"2003","unstructured":"Iglesias-Serret D, Pique M, Gil J, Pons G, Lopez JM (2003) Transcriptional and translational control of Mcl-1 during apoptosis. Arch Biochem Biophys 417:141\u2013152","journal-title":"Arch Biochem Biophys"},{"key":"424_CR5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.critrevonc.2006.07.001","volume":"61","author":"DJ Groot de","year":"2007","unstructured":"de Groot DJ, de Vries EG, Groen HJ, de Jong S (2007) Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to clinic. Crit Rev Oncol Hematol 61:52\u201369","journal-title":"Crit Rev Oncol Hematol"},{"key":"424_CR6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.med.57.121304.131253","volume":"58","author":"YI Cha","year":"2007","unstructured":"Cha YI, DuBois RN (2007) NSAIDs and cancer prevention: targets downstream of COX-2. Annu Rev Med 58:239\u2013252","journal-title":"Annu Rev Med"},{"key":"424_CR7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1084\/jem.190.4.451","volume":"190","author":"X Zhang","year":"1999","unstructured":"Zhang X, Morham SG, Langenbach R, Young DA (1999) Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. J Exp Med 190:451\u2013459","journal-title":"J Exp Med"},{"key":"424_CR8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0092-8674(00)81664-5","volume":"99","author":"TC He","year":"1999","unstructured":"He TC, Chan TA, Vogelstein B, Kinzler KW (1999) PPAR delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99:335\u2013345","journal-title":"Cell"},{"key":"424_CR9","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1073\/pnas.051630998","volume":"98","author":"BH Park","year":"2001","unstructured":"Park BH, Vogelstein B, Kinzler KW (2001) Genetic disruption of PPAR delta decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci USA 98:2598\u20132603","journal-title":"Proc Natl Acad Sci USA"},{"key":"424_CR10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/B:MCBI.0000049138.67699.7b","volume":"266","author":"JM Lopez","year":"2004","unstructured":"Lopez JM, Fernandez MA, Pique M, Gil J (2004) Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem 266:57\u201363","journal-title":"Mol Cell Biochem"},{"key":"424_CR11","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","volume":"15","author":"I Tegeder","year":"2001","unstructured":"Tegeder I, Pfeilschifter J, Geisslinger G (2001) Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J 15:2057\u20132072","journal-title":"FASEB J"},{"key":"424_CR12","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.8052854","volume":"265","author":"E Kopp","year":"1994","unstructured":"Kopp E, Ghosh S (1994) Inhibition of NF-Kappa B by sodium salicylate and aspirin. Science 265:956\u2013959","journal-title":"Science"},{"key":"424_CR13","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri1703","volume":"5","author":"M Karin","year":"2005","unstructured":"Karin M, Greten FR (2005) NF-KappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5:749\u2013759","journal-title":"Nat Rev Immunol"},{"key":"424_CR14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/23948","volume":"396","author":"MJ Yin","year":"1998","unstructured":"Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(Kappa)B kinase-beta. Nature 396:77\u201380","journal-title":"Nature"},{"key":"424_CR15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1124\/jpet.106.107367","volume":"319","author":"S Zhuang","year":"2006","unstructured":"Zhuang S, Schnellmann RG (2006) A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther 319:991\u2013997","journal-title":"J Pharmacol Exp Ther"},{"key":"424_CR16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.neo.7900120","volume":"2","author":"KC Zimmermann","year":"2000","unstructured":"Zimmermann KC, Waterhouse NJ, Goldstein JC, Schuler M, Green DR (2000) Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia 2:505\u2013513","journal-title":"Neoplasia"},{"key":"424_CR17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","volume":"9","author":"RJ Youle","year":"2008","unstructured":"Youle RJ, Strasser A (2008) The BCL-2 Protein Family: Opposing Activities That Mediate Cell Death. Nat.Rev.Mol.Cell Biol. 9:47\u201359","journal-title":"Nat.Rev.Mol.Cell Biol."},{"key":"424_CR18","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S1097-2765(00)00136-2","volume":"6","author":"T Lindsten","year":"2000","unstructured":"Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB (2000) The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues. Mol Cell 6:1389\u20131399","journal-title":"Mol Cell"},{"key":"424_CR19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.leu.2404483","volume":"21","author":"D Iglesias-Serret","year":"2007","unstructured":"Iglesias-Serret D, de Frias M, Santidrian AF, Coll-Mulet L, Cosialls AM, Barragan M, Domingo A, Gil J, Pons G (2007) Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells. Leukemia 21:281\u2013287","journal-title":"Leukemia"},{"key":"424_CR20","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1073\/pnas.96.13.7563","volume":"96","author":"TD Warner","year":"1999","unstructured":"Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96:7563\u20137568","journal-title":"Proc Natl Acad Sci USA"},{"key":"424_CR21","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1182\/blood.V91.8.2991.2991_2991_2997","volume":"91","author":"JP Meijerink","year":"1998","unstructured":"Meijerink JP, Mensink EJ, Wang K, Sedlak TW, Sloetjes AW, de Witte T, Waksman G, Korsmeyer SJ (1998) Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91:2991\u20132997","journal-title":"Blood"},{"key":"424_CR22","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.cell.2005.06.009","volume":"121","author":"Q Zhong","year":"2005","unstructured":"Zhong Q, Gao W, Du F, Wang X (2005) Mule\/ARF-BP1, a BH3-Only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121:1085\u20131095","journal-title":"Cell"},{"key":"424_CR23","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1073\/pnas.94.7.2869","volume":"94","author":"P Schwenger","year":"1997","unstructured":"Schwenger P, Bellosta P, Vietor I, Basilico C, Skolnik EY, Vilcek J (1997) Sodium salicylate induces apoptosis via P38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced C-Jun N-terminal kinase\/stress-activated protein kinase activation. Proc Natl Acad Sci USA 94:2869\u20132873","journal-title":"Proc Natl Acad Sci USA"},{"key":"424_CR24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.176.2.957","volume":"176","author":"M Derouet","year":"2006","unstructured":"Derouet M, Thomas L, Moulding DA, Akgul C, Cross A, Moots RJ, Edwards SW (2006) Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1. J Immunol 176:957\u2013965","journal-title":"J Immunol"},{"key":"424_CR25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.290.5493.989","volume":"290","author":"L Zhang","year":"2000","unstructured":"Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B (2000) Role of BAX in the apoptotic response to anticancer agents. Science 290:989\u2013992","journal-title":"Science"},{"key":"424_CR26","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bbrc.2007.03.034","volume":"356","author":"T Ishihara","year":"2007","unstructured":"Ishihara T, Hoshino T, Namba T, Tanaka K, Mizushima T (2007) Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis. Biochem Biophys Res Commun 356:711\u2013717","journal-title":"Biochem Biophys Res Commun"},{"key":"424_CR27","doi-asserted-by":"crossref","first-page":"22551","DOI":"10.1074\/jbc.M702673200","volume":"282","author":"RM Fritsch","year":"2007","unstructured":"Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM (2007) Translational repression of MCL-1 couples stress-induced EIF2 alpha phosphorylation to mitochondrial apoptosis initiation. J Biol Chem 282:22551\u201322562","journal-title":"J Biol Chem"},{"key":"424_CR28","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1101\/gad.1156903","volume":"17","author":"A Cuconati","year":"2003","unstructured":"Cuconati A, Mukherjee C, Perez D, White E (2003) DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev 17:2922\u20132932","journal-title":"Genes Dev"},{"key":"424_CR29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1101\/gad.1093903","volume":"17","author":"D Nijhawan","year":"2003","unstructured":"Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Wang X (2003) Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17:1475\u20131486","journal-title":"Genes Dev"},{"key":"424_CR30","doi-asserted-by":"crossref","first-page":"35217","DOI":"10.1074\/jbc.M506551200","volume":"280","author":"M Rahmani","year":"2005","unstructured":"Rahmani M, Davis EM, Bauer C, Dent P, Grant S (2005) Apoptosis induced by the kinase inhibitor BAY 43\u20139006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. J Biol Chem 280:35217\u201335227","journal-title":"J Biol Chem"},{"key":"424_CR31","doi-asserted-by":"crossref","first-page":"29228","DOI":"10.1074\/jbc.M602629200","volume":"281","author":"P Dikshit","year":"2006","unstructured":"Dikshit P, Chatterjee M, Goswami A, Mishra A, Jana NR (2006) Aspirin induces apoptosis through the inhibition of proteasome function. J Biol Chem 281:29228\u201329235","journal-title":"J Biol Chem"},{"key":"424_CR32","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/sj.onc.1210744","volume":"27","author":"DA Fennell","year":"2008","unstructured":"Fennell DA, Chacko A, Mutti L (2008) BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 27:1189\u20131197","journal-title":"Oncogene"},{"key":"424_CR33","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.immuni.2006.03.018","volume":"24","author":"NL Alves","year":"2006","unstructured":"Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E (2006) The noxa\/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. Immunity 24:703\u2013716","journal-title":"Immunity"},{"key":"424_CR34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1593\/neo.07589","volume":"9","author":"Y Mei","year":"2007","unstructured":"Mei Y, Xie C, Xie W, Tian X, Li M, Wu M (2007) Noxa\/Mcl-1 balance regulates susceptibility of cells to camptothecin-induced apoptosis. Neoplasia. 9:871\u2013881","journal-title":"Neoplasia."},{"key":"424_CR35","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/sj.cdd.4402211","volume":"14","author":"DY Hallaert","year":"2007","unstructured":"Hallaert DY, Spijker R, Jak M, Derks IA, Alves NL, Wensveen FM, de Boer JP, de Jong D, Green SR, van Oers MH, Eldering E (2007) Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1\/Noxa axis and gradual exhaustion of Bcl-2 protection. Cell Death Differ 14:1958\u20131967","journal-title":"Cell Death Differ"},{"key":"424_CR36","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1182\/blood-2004-10-3984","volume":"105","author":"A Nencioni","year":"2005","unstructured":"Nencioni A, Hua F, Dillon CP, Yokoo R, Scheiermann C, Cardone MH, Barbieri E, Rocco I, Garuti A, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A (2005) Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis. Blood 105:3255\u20133262","journal-title":"Blood"},{"key":"424_CR37","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1158\/1078-0432.CCR-06-2294","volume":"13","author":"SR Hussain","year":"2007","unstructured":"Hussain SR, Cheney CM, Johnson AJ, Lin TS, Grever MR, Caligiuri MA, Lucas DM, Byrd JC (2007) Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity. Clin Cancer Res 13:2144\u20132150","journal-title":"Clin Cancer Res"},{"key":"424_CR38","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1182\/blood-2007-05-089037","volume":"111","author":"PG Longo","year":"2008","unstructured":"Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG (2008) The Akt\/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 111:846\u2013855","journal-title":"Blood"},{"key":"424_CR39","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature02067","volume":"426","author":"JT Opferman","year":"2003","unstructured":"Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ (2003) Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426:671\u2013676","journal-title":"Nature"},{"key":"424_CR40","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1182\/blood-2006-05-021683","volume":"109","author":"LA Smit","year":"2007","unstructured":"Smit LA, Hallaert DY, Spijker R, de Goeij B, Jaspers A, Kater AP, van Oers MH, van Noesel CJ, Eldering E (2007) Differential Noxa\/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. Blood 109:1660\u20131668","journal-title":"Blood"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-009-0424-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-009-0424-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-009-0424-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T20:14:42Z","timestamp":1590264882000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-009-0424-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,21]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["424"],"URL":"https:\/\/doi.org\/10.1007\/s10495-009-0424-9","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,21]]}}}