{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:29:12Z","timestamp":1773293352037,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,9,24]],"date-time":"2011-09-24T00:00:00Z","timestamp":1316822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1007\/s10495-011-0656-3","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T10:57:30Z","timestamp":1316775450000},"page":"37-47","source":"Crossref","is-referenced-by-count":44,"title":["\u03b2-Amyloid protein (A\u03b2) and human amylin regulation of apoptotic genes occurs through the amylin receptor"],"prefix":"10.1007","volume":"17","author":[{"given":"Jack H.","family":"Jhamandas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"MacTavish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,9,24]]},"reference":[{"key":"656_CR1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1358\/dot.2006.42.7.973588","volume":"42","author":"MK Sun","year":"2006","unstructured":"Sun MK, Alkon DL (2006) Links between Alzheimer\u2019s disease and diabetes. Drugs Today (Barcelona) 42:481\u2013489","journal-title":"Drugs Today (Barcelona)"},{"key":"656_CR2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/156720507780362137","volume":"4","author":"S Craft","year":"2007","unstructured":"Craft S (2007) Insulin resistance and Alzheimer\u2019s disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 4:147\u2013152","journal-title":"Curr Alzheimer Res"},{"key":"656_CR3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.brainresrev.2007.09.001","volume":"56","author":"L Lin","year":"2007","unstructured":"Lin L, Holscher C (2007) Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 56:384\u2013402","journal-title":"Brain Res Rev"},{"key":"656_CR4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00018-009-9070-1","volume":"66","author":"J G\u00f6tz","year":"2009","unstructured":"G\u00f6tz J, Ittner LM, Lim YA (2009) Common features between diabetes mellitus and Alzheimer\u2019s disease. Cell Mol Life Sci 66:1321\u20131325","journal-title":"Cell Mol Life Sci"},{"key":"656_CR5","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1073\/pnas.0230450100","volume":"100","author":"W Farris","year":"2003","unstructured":"Farris W, Mansourian S, Chang YL, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 100:4162\u20134167","journal-title":"Proc Natl Acad Sci USA"},{"key":"656_CR6","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0166-2236(03)00163-2","volume":"26","author":"L Gasparini","year":"2003","unstructured":"Gasparini L, Xu H (2003) Potential roles of insulin and IGF-1 in Alzheimer\u2019s disease. Trends Neurosci 26:404\u2013406","journal-title":"Trends Neurosci"},{"key":"656_CR7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s007020050069","volume":"105","author":"G Munch","year":"1998","unstructured":"Munch G, Schinzel R, Loske C, Wong A, Durany N, Li JJ, Vlassara H, Smith MA, Perry G, Riederer P (1998) Alzheimer\u2019s disease\u2014synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm 105:439\u2013461","journal-title":"J Neural Transm"},{"key":"656_CR8","first-page":"129","volume":"23","author":"S Yamagishi","year":"2003","unstructured":"Yamagishi S, Takeuchi M, Inagaki Y, Nakamura K, Imaizumi T (2003) Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res 23:129\u2013134","journal-title":"Int J Clin Pharmacol Res"},{"key":"656_CR9","doi-asserted-by":"crossref","first-page":"21614","DOI":"10.1016\/S0021-9258(17)31849-5","volume":"269","author":"MD Ledesma","year":"1994","unstructured":"Ledesma MD, Bonay P, Colaco C, Avila J (1994) Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem 269:21614\u201321619","journal-title":"J Biol Chem"},{"key":"656_CR10","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","volume":"84","author":"GJ Cooper","year":"1987","unstructured":"Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628\u20138632","journal-title":"Proc Natl Acad Sci USA"},{"key":"656_CR11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/368756a0","volume":"368","author":"A Lorenzo","year":"1994","unstructured":"Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756\u2013760","journal-title":"Nature"},{"key":"656_CR12","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.febslet.2008.05.006","volume":"582","author":"YA Lim","year":"2008","unstructured":"Lim YA, Ittner LM, Lim YL, G\u00f6tz J (2008) Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Lett 582:2188\u20132194","journal-title":"FEBS Lett"},{"key":"656_CR13","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1074\/jbc.R800018200","volume":"284","author":"BA Yankner","year":"2009","unstructured":"Yankner BA, Lu T (2009) Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 284:4755\u20134759","journal-title":"J Biol Chem"},{"key":"656_CR14","doi-asserted-by":"crossref","first-page":"10573","DOI":"10.1073\/pnas.90.22.10573","volume":"90","author":"N Arispe","year":"1993","unstructured":"Arispe N, Pollard HB, Rojas E (1993) Giant multilevel cation channels formed by Alzheimer disease amyloid \u03b2-protein [A\u03b2P-(1\u201340)] in bilayer membrane. Proc Natl Acad Sci USA 90:10573\u201310577","journal-title":"Proc Natl Acad Sci USA"},{"key":"656_CR15","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.2174\/138161210793176545","volume":"16","author":"M Kawahara","year":"2010","unstructured":"Kawahara M (2010) Neurotoxicity of \u03b2-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis. Curr Pharm Des 16:2779\u20132789","journal-title":"Curr Pharm Des"},{"key":"656_CR16","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1152\/jn.2001.86.3.1312","volume":"86","author":"JH Jhamandas","year":"2001","unstructured":"Jhamandas JH, Cho C, Jassar B, Harris K, MacTavish D, Easaw J (2001) Cellular mechanisms for amyloid-\u03b2 protein activation of rat cholinergic basal forebrain neurons. J Neurophysiol 86:1312\u20131320","journal-title":"J Neurophysiol"},{"key":"656_CR17","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1152\/jn.00616.2003","volume":"90","author":"JH Jhamandas","year":"2003","unstructured":"Jhamandas JH, Harris KH, Cho C, Fu W, MacTavish D (2003) Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. J Neurophysiol 90:3130\u20133136","journal-title":"J Neurophysiol"},{"key":"656_CR18","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1523\/JNEUROSCI.1051-04.2004","volume":"24","author":"JH Jhamandas","year":"2004","unstructured":"Jhamandas JH, MacTavish D (2004) Antagonist of the amylin receptor blocks \u03b2-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci 24:5579\u20135584","journal-title":"J Neurosci"},{"key":"656_CR19","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/pmic.200900651","volume":"10","author":"YA Lim","year":"2010","unstructured":"Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Gotz J (2010) A\u03b2 and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10:1621\u20131633","journal-title":"Proteomics"},{"key":"656_CR20","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/35037739","volume":"407","author":"J Yuan","year":"2000","unstructured":"Yuan J, Yankner BA (2000) Apoptosis in the nervous system. Nature 407:802\u2013809","journal-title":"Nature"},{"key":"656_CR21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nature05293","volume":"443","author":"DE Bredesen","year":"2006","unstructured":"Bredesen DE, Rao RV, Mehlen P (2006) Cell death in the nervous system. Nature 443:796\u2013802","journal-title":"Nature"},{"key":"656_CR22","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1074\/jbc.M210207200","volume":"278","author":"WB Stine Jr","year":"2003","unstructured":"Stine WB Jr, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 278:11612\u201311622","journal-title":"J Biol Chem"},{"key":"656_CR23","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nbd.2004.12.013","volume":"18","author":"JA White","year":"2005","unstructured":"White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ (2005) Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiol Dis 18:459\u2013465","journal-title":"Neurobiol Dis"},{"key":"656_CR24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ajpath.2010.11.022","volume":"178","author":"JH Jhamandas","year":"2011","unstructured":"Jhamandas JH, Li Z, Westaway D, Yang J, Jassar S, MacTavish D (2011) Actions of \u03b2-amyloid (A\u03b2) on human neurons are expressed through the amylin receptor. Am J Pathol 178:140\u2013149","journal-title":"Am J Pathol"},{"key":"656_CR25","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.4049\/jimmunol.179.8.5493","volume":"179","author":"A Afkhami-Goli","year":"2007","unstructured":"Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C (2007) Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer\u2019s disease. J Immunol 179:5493\u20135503","journal-title":"J Immunol"},{"key":"656_CR26","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1523\/JNEUROSCI.12-02-00376.1992","volume":"12","author":"MP Mattson","year":"1992","unstructured":"Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992) \u03b2-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12:376\u2013389","journal-title":"J Neurosci"},{"key":"656_CR27","doi-asserted-by":"crossref","first-page":"20936","DOI":"10.1073\/pnas.0905654106","volume":"106","author":"SD Ryan","year":"2009","unstructured":"Ryan SD, Whitehead SN, Swayne LA, Moffat TC, Hou W, Ethier M, Bourgeois AJ, Rashidian J, Blanchard AP, Fraser PE, Park DS, Figeys D, Bennett SA (2009) Amyloid-{beta}42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci USA 106:20936\u201320941","journal-title":"Proc Natl Acad Sci USA"},{"key":"656_CR28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1042\/BST0320865","volume":"32","author":"DL Hay","year":"2004","unstructured":"Hay DL, Christopoulos G, Christopoulos A, Sexton PM (2004) Amylin receptors: molecular composition and pharmacology. Biochem Soc Trans 32:865\u2013867","journal-title":"Biochem Soc Trans"},{"key":"656_CR29","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1210\/en.2007-1735","volume":"149","author":"M Morfis","year":"2008","unstructured":"Morfis M, Tilakaratne N, Furness SG, Christopoulos G, Werry TD, Christopoulos A, Sexton PM (2008) Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology 149:5423\u20135431","journal-title":"Endocrinology"},{"key":"656_CR30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.cdd.4401143","volume":"10","author":"G Cantarella","year":"2003","unstructured":"Cantarella G, Uberti D, Carsana T, Lombardo G, Bernardini R, Memo M (2003) Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity. Cell Death Differ 10:134\u2013141","journal-title":"Cell Death Differ"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-011-0656-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-011-0656-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-011-0656-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T08:32:20Z","timestamp":1638779540000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-011-0656-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,24]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["656"],"URL":"https:\/\/doi.org\/10.1007\/s10495-011-0656-3","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,24]]}}}