{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:04:02Z","timestamp":1772132642401,"version":"3.50.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2012,8,26]],"date-time":"2012-08-26T00:00:00Z","timestamp":1345939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1007\/s10495-012-0752-z","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T23:59:04Z","timestamp":1345852744000},"page":"1210-1222","source":"Crossref","is-referenced-by-count":25,"title":["Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis"],"prefix":"10.1007","volume":"17","author":[{"given":"Claudia","family":"Giampietri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Petrungaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Padula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"D\u2019Alessio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elettra Sara","family":"Marini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Facchiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Filippini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Ziparo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,26]]},"reference":[{"key":"752_CR1","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/sj.bjc.6601814","volume":"90","author":"V Michalaki","year":"2004","unstructured":"Michalaki V, Syrigos K, Charles P, Waxman J (2004) Serum levels of IL-6 and TNF-alpha correlate with clinicopathological features and patient survival in patients with prostate cancer. Br J Cancer 90:2312\u20132316","journal-title":"Br J Cancer"},{"key":"752_CR2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10495-009-0416-9","volume":"15","author":"S Srinivasan","year":"2010","unstructured":"Srinivasan S, Kumar R, Koduru S, Chandramouli A, Damodaran C (2010) Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer. Apoptosis 15:153\u2013161","journal-title":"Apoptosis"},{"key":"752_CR3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.cdd.4400594","volume":"6","author":"PG Ekert","year":"1999","unstructured":"Ekert PG, Silke J, Vaux DL (1999) Caspase inhibitors. Cell Death Differ 6:1081\u20131086","journal-title":"Cell Death Differ"},{"key":"752_CR4","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.4161\/cbt.7.8.6712","volume":"7","author":"KL Nastiuk","year":"2008","unstructured":"Nastiuk KL, Krolewski JJ (2008) FLIP-ping out: death receptor signaling in the prostate. Cancer Biol Ther 7:1171\u20131179","journal-title":"Cancer Biol Ther"},{"key":"752_CR5","doi-asserted-by":"crossref","first-page":"18542","DOI":"10.1074\/jbc.272.30.18542","volume":"272","author":"SM Srinivasula","year":"1997","unstructured":"Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES (1997) FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas\/TNFR1-induced apoptosis. J Biol Chem 272:18542\u201318545","journal-title":"J Biol Chem"},{"key":"752_CR6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/156800908783497087","volume":"8","author":"AR Safa","year":"2008","unstructured":"Safa AR, Day TW, Wu CH (2008) Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. Curr Cancer Drug Targets 8:37\u201346","journal-title":"Curr Cancer Drug Targets"},{"key":"752_CR7","doi-asserted-by":"crossref","first-page":"22320","DOI":"10.1074\/jbc.M202458200","volume":"277","author":"Y Kim","year":"2002","unstructured":"Kim Y, Suh N, Sporn M, Reed JC (2002) An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem 277:22320\u201322329","journal-title":"J Biol Chem"},{"key":"752_CR8","doi-asserted-by":"crossref","first-page":"27345","DOI":"10.1074\/jbc.M504019200","volume":"280","author":"M Poukkula","year":"2005","unstructured":"Poukkula M, Kaunisto A, Hietakangas V, Denessiouk K, Katajamaki T, Johnson MS, Sistonen L, Eriksson JE (2005) Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail. J Biol Chem 280:27345\u201327355","journal-title":"J Biol Chem"},{"key":"752_CR9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/ni.1754","volume":"10","author":"M Kundu","year":"2009","unstructured":"Kundu M, Pathak SK, Kumawat K, Basu S, Chatterjee G, Pathak S, Noguchi T, Takeda K, Ichijo H, Thien CB, Langdon WY, Basu J (2009) A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis. Nat Immunol 10:918\u2013926","journal-title":"Nat Immunol"},{"key":"752_CR10","doi-asserted-by":"crossref","first-page":"9425","DOI":"10.1158\/0008-5472.CAN-07-1310","volume":"67","author":"X Zhang","year":"2007","unstructured":"Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, DeWolf WC, Khosravi-Far R, Olumi AF (2007) c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells. Cancer Res 67:9425\u20139434","journal-title":"Cancer Res"},{"key":"752_CR11","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1038\/onc.2008.80","volume":"27","author":"AN Cornforth","year":"2008","unstructured":"Cornforth AN, Davis JS, Khanifar E, Nastiuk KL, Krolewski JJ (2008) FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells. Oncogene 27:4422\u20134433","journal-title":"Oncogene"},{"key":"752_CR12","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1074\/jbc.M304736200","volume":"279","author":"C Skurk","year":"2004","unstructured":"Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K (2004) The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem 279:1513\u20131525","journal-title":"J Biol Chem"},{"key":"752_CR13","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1002\/pros.20844","volume":"68","author":"KA Raclaw","year":"2008","unstructured":"Raclaw KA, Heemers HV, Kidd EM, Dehm SM, Tindall DJ (2008) Induction of FLIP expression by androgens protects prostate cancer cells from TRAIL-mediated apoptosis. Prostate 68:1696\u20131706","journal-title":"Prostate"},{"key":"752_CR14","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1073\/pnas.80.8.2179","volume":"80","author":"GE Mortimore","year":"1983","unstructured":"Mortimore GE, Hutson NJ, Surmacz CA (1983) Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding. Proc Natl Acad Sci USA 80:2179\u20132183","journal-title":"Proc Natl Acad Sci USA"},{"key":"752_CR15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","volume":"40","author":"G Kroemer","year":"2010","unstructured":"Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40:280\u2013293","journal-title":"Mol Cell"},{"key":"752_CR16","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069\u20131075","journal-title":"Nature"},{"key":"752_CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","volume":"10","author":"K Degenhardt","year":"2006","unstructured":"Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10:51\u201364","journal-title":"Cancer Cell"},{"key":"752_CR18","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrc2254","volume":"7","author":"R Mathew","year":"2007","unstructured":"Mathew R, Karantza-Wadsworth V, White E (2007) Role of autophagy in cancer. Nat Rev Cancer 7:961\u2013967","journal-title":"Nat Rev Cancer"},{"key":"752_CR19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4161\/auto.5209","volume":"4","author":"M Li","year":"2008","unstructured":"Li M, Jiang X, Liu D, Na Y, Gao GF, Xi Z (2008) Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy 4:54\u201360","journal-title":"Autophagy"},{"key":"752_CR20","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cellsig.2011.04.008","volume":"23","author":"RR Chhipa","year":"2011","unstructured":"Chhipa RR, Wu Y, Ip C (2011) AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. Cell Signal 23:1466\u20131472","journal-title":"Cell Signal"},{"key":"752_CR21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.500","volume":"7","author":"A Fleming","year":"2011","unstructured":"Fleming A, Noda T, Yoshimori T, Rubinsztein DC (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol 7:9\u201317","journal-title":"Nat Chem Biol"},{"key":"752_CR22","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.4161\/auto.7.9.16163","volume":"7","author":"SK Bhutia","year":"2011","unstructured":"Bhutia SK, Das SK, Azab B, Dash R, Su ZZ, Lee SG, Dent P, Curiel DT, Sarkar D, Fisher PB (2011) Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7\/interleukin-24 (mda-7\/IL-24). Autophagy 7:1076\u20131077","journal-title":"Autophagy"},{"key":"752_CR23","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/pros.21131","volume":"70","author":"A Parikh","year":"2010","unstructured":"Parikh A, Childress C, Deitrick K, Lin Q, Rukstalis D, Yang W (2010) Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells. Prostate 70:971\u2013981","journal-title":"Prostate"},{"key":"752_CR24","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/carcin\/bgq115","volume":"31","author":"Y Suh","year":"2010","unstructured":"Suh Y, Afaq F, Khan N, Johnson JJ, Khusro FH, Mukhtar H (2010) Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis 31:1424\u20131433","journal-title":"Carcinogenesis"},{"key":"752_CR25","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/HJH.0b013e3282f6a179","volume":"26","author":"C Giampietri","year":"2008","unstructured":"Giampietri C, Petrungaro S, Musumeci M, Coluccia P, Antonangeli F, De Cesaris P, Filippini A, Marano G, Ziparo E (2008) c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload. J Hypertens 26:1008\u20131016","journal-title":"J Hypertens"},{"key":"752_CR26","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1038\/cddis.2010.17","volume":"1","author":"C Giampietri","year":"2010","unstructured":"Giampietri C, Petrungaro S, Coluccia P, Antonangeli F, Giannakakis K, Faraggiana T, Filippini A, Cossu G, Ziparo E (2010) c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging. Cell Death Dis 1:e38","journal-title":"Cell Death Dis"},{"key":"752_CR27","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s10495-006-0086-9","volume":"11","author":"M Ricote","year":"2006","unstructured":"Ricote M, Garcia-Tunon I, Fraile B, Fernandez C, Aller P, Paniagua R, Royuela M (2006) P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells. Apoptosis 11:1969\u20131975","journal-title":"Apoptosis"},{"key":"752_CR28","doi-asserted-by":"crossref","first-page":"22886","DOI":"10.1074\/jbc.M110.199950","volume":"286","author":"A Colleran","year":"2011","unstructured":"Colleran A, Ryan A, O\u2019Gorman A, Mureau C, Liptrot C, Dockery P, Fearnhead H, Egan LJ (2011) Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity. J Biol Chem 286:22886\u201322893","journal-title":"J Biol Chem"},{"key":"752_CR29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cyto.2011.08.022","volume":"56","author":"J Harris","year":"2011","unstructured":"Harris J (2011) Autophagy and cytokines. Cytokine 56:140\u2013144","journal-title":"Cytokine"},{"key":"752_CR30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0161-5890(02)00207-9","volume":"39","author":"AK Garg","year":"2002","unstructured":"Garg AK, Aggarwal BB (2002) Reactive oxygen intermediates in TNF signaling. Mol Immunol 39:509\u2013517","journal-title":"Mol Immunol"},{"key":"752_CR31","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.4049\/jimmunol.180.5.3072","volume":"180","author":"L Wang","year":"2008","unstructured":"Wang L, Azad N, Kongkaneramit L, Chen F, Lu Y, Jiang BH, Rojanasakul Y (2008) The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation. J Immunol 180:3072\u20133080","journal-title":"J Immunol"},{"key":"752_CR32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2006.01.021","volume":"124","author":"L Chang","year":"2006","unstructured":"Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124:601\u2013613","journal-title":"Cell"},{"key":"752_CR33","doi-asserted-by":"crossref","first-page":"26517","DOI":"10.1074\/jbc.M300852200","volume":"278","author":"A Bhattacharyya","year":"2003","unstructured":"Bhattacharyya A, Pathak S, Basak C, Law S, Kundu M, Basu J (2003) Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1\/p38 mitogen-activated protein kinase signaling and caspase 8 activation. J Biol Chem 278:26517\u201326525","journal-title":"J Biol Chem"},{"key":"752_CR34","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/s10495-011-0605-1","volume":"16","author":"JH Kim","year":"2011","unstructured":"Kim JH, Jeong SJ, Kwon TR, Yun SM, Jung JH, Kim M, Lee HJ, Lee MH, Ko SG, Chen CY, Kim SH (2011) Cryptotanshinone enhances TNF-alpha-induced apoptosis in chronic myeloid leukemia KBM-5 cells. Apoptosis 16:696\u2013707","journal-title":"Apoptosis"},{"key":"752_CR35","doi-asserted-by":"crossref","first-page":"e27441","DOI":"10.1371\/journal.pone.0027441","volume":"6","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, Teruya K, Eto H, Shirahata S (2011) Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways. PLoS ONE 6:e27441","journal-title":"PLoS ONE"},{"key":"752_CR36","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2174\/138945011796150299","volume":"12","author":"JY Yang","year":"2011","unstructured":"Yang JY, Hung MC (2011) Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets 12:1284\u20131290","journal-title":"Curr Drug Targets"},{"key":"752_CR37","doi-asserted-by":"crossref","first-page":"e15288","DOI":"10.1371\/journal.pone.0015288","volume":"5","author":"Q Chen","year":"2010","unstructured":"Chen Q, Ganapathy S, Singh KP, Shankar S, Srivastava RK (2010) Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS ONE 5:e15288","journal-title":"PLoS ONE"},{"key":"752_CR38","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1182\/blood-2009-05-222976","volume":"115","author":"Y Sakoe","year":"2010","unstructured":"Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N (2010) FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia. Blood 115:3787\u20133795","journal-title":"Blood"},{"key":"752_CR39","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/sj.cdd.4402039","volume":"14","author":"MJ Abedin","year":"2007","unstructured":"Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A (2007) Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 14:500\u2013510","journal-title":"Cell Death Differ"},{"key":"752_CR40","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1128\/MCB.25.3.1025-1040.2005","volume":"25","author":"P Boya","year":"2005","unstructured":"Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G (2005) Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25:1025\u20131040","journal-title":"Mol Cell Biol"},{"key":"752_CR41","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1158\/0008-5472.CAN-06-1597","volume":"66","author":"MM Hippert","year":"2006","unstructured":"Hippert MM, O\u2019Toole PS, Thorburn A (2006) Autophagy in cancer: good, bad, or both? Cancer Res 66:9349\u20139351","journal-title":"Cancer Res"},{"key":"752_CR42","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/sj.cdd.4401359","volume":"11","author":"T Kanzawa","year":"2004","unstructured":"Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S (2004) Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 11:448\u2013457","journal-title":"Cell Death Differ"},{"key":"752_CR43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cell.2004.11.046","volume":"120","author":"JJ Lum","year":"2005","unstructured":"Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120:237\u2013248","journal-title":"Cell"},{"key":"752_CR44","doi-asserted-by":"crossref","first-page":"904","DOI":"10.4161\/auto.7.8.15704","volume":"7","author":"R Kang","year":"2011","unstructured":"Kang R, Livesey KM, Zeh HJ III, Lotze MT, Tang D (2011) HMGB1 as an autophagy sensor in oxidative stress. Autophagy 7:904\u2013906","journal-title":"Autophagy"},{"key":"752_CR45","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc2628","volume":"9","author":"F Balkwill","year":"2009","unstructured":"Balkwill F (2009) Tumour necrosis factor and cancer. Nat Rev Cancer 9:361\u2013371","journal-title":"Nat Rev Cancer"},{"key":"752_CR46","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/pros.22487","volume":"72","author":"A Saleem","year":"2012","unstructured":"Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, Dipaola RS (2012) Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate 72:1374\u20131381","journal-title":"Prostate"},{"key":"752_CR47","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1074\/jbc.M710169200","volume":"283","author":"J Han","year":"2008","unstructured":"Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, Rabinowich H (2008) Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 283:19665\u201319677","journal-title":"J Biol Chem"},{"key":"752_CR48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/sj.cdd.4401137","volume":"10","author":"C Giampietri","year":"2003","unstructured":"Giampietri C, Petrungaro S, Coluccia P, D\u2019Alessio A, Starace D, Riccioli A, Padula F, Srinivasula SM, Alnemri E, Palombi F, Filippini A, Ziparo E, De Cesaris P (2003) FLIP is expressed in mouse testis and protects germ cells from apoptosis. Cell Death Differ 10:175\u2013184","journal-title":"Cell Death Differ"},{"key":"752_CR49","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1096\/fj.04-2022fje","volume":"19","author":"C Giampietri","year":"2005","unstructured":"Giampietri C, Petrungaro S, Klinger FG, Coluccia P, Paone A, Vivarelli E, Filippini A, De Cesaris P, De Felici M, Ziparo E (2005) c-Flip expression and function in fetal mouse gonocytes. Faseb J 19:124","journal-title":"Faseb J"},{"key":"752_CR50","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1016\/j.febslet.2006.10.010","volume":"580","author":"C Giampietri","year":"2006","unstructured":"Giampietri C, Petrungaro S, Coluccia P, Antonangeli F, Paone A, Padula F, De Cesaris P, Ziparo E, Filippini A (2006) c-Flip(L) is expressed in undifferentiated mouse male germ cells. FEBS Lett 580:6109\u20136114","journal-title":"FEBS Lett"},{"key":"752_CR51","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.bbamcr.2007.06.003","volume":"1773","author":"D Amran","year":"2007","unstructured":"Amran D, Sanchez Y, Fernandez C, Ramos AM, de Blas E, Breard J, Calle C, Aller P (2007) Arsenic trioxide sensitizes promonocytic leukemia cells to TNFalpha-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways. Biochim Biophys Acta 1773:1653\u20131663","journal-title":"Biochim Biophys Acta"},{"key":"752_CR52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2353\/ajpath.2009.080853","volume":"175","author":"K Bajbouj","year":"2009","unstructured":"Bajbouj K, Poehlmann A, Kuester D, Drewes T, Haase K, Hartig R, Teller A, Kliche S, Walluscheck D, Ivanovska J, Chakilam S, Ulitzsch A, Bommhardt U, Leverkus M, Roessner A, Schneider-Stock R (2009) Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells. Am J Pathol 175:557\u2013570","journal-title":"Am J Pathol"},{"key":"752_CR53","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ccr.2006.12.013","volume":"11","author":"I Dolado","year":"2007","unstructured":"Dolado I, Swat A, Ajenjo N, De Vita G, Cuadrado A, Nebreda AR (2007) p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11:191\u2013205","journal-title":"Cancer Cell"},{"key":"752_CR54","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1158\/0008-5472.CAN-09-1287","volume":"69","author":"A Panner","year":"2009","unstructured":"Panner A, Crane CA, Weng C, Feletti A, Parsa AT, Pieper RO (2009) A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer Res 69:7911\u20137916","journal-title":"Cancer Res"},{"key":"752_CR55","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1128\/JVI.77.4.2651-2662.2003","volume":"77","author":"D Perez","year":"2003","unstructured":"Perez D, White E (2003) E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S. J Virol 77:2651\u20132662","journal-title":"J Virol"},{"key":"752_CR56","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/onc.2009.343","volume":"29","author":"K Zhu","year":"2010","unstructured":"Zhu K, Dunner K Jr, McConkey DJ (2010) Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene 29:451\u2013462","journal-title":"Oncogene"},{"key":"752_CR57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1097-0045(19990501)39:2<87::AID-PROS2>3.0.CO;2-Z","volume":"39","author":"SM Sintich","year":"1999","unstructured":"Sintich SM, Steinberg J, Kozlowski JM, Lee C, Pruden S, Sayeed S, Sensibar JA (1999) Cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin). Prostate 39:87\u201393","journal-title":"Prostate"},{"key":"752_CR58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/geno.1997.5122","volume":"47","author":"MJ Anderson","year":"1998","unstructured":"Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (1998) Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 47:187\u2013199","journal-title":"Genomics"},{"key":"752_CR59","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"A Brunet","year":"1999","unstructured":"Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857\u2013868","journal-title":"Cell"},{"key":"752_CR60","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1038\/onc.2008.318","volume":"27","author":"Y Wang","year":"2008","unstructured":"Wang Y, Mikhailova M, Bose S, Pan CX, deVere White RW, Ghosh PM (2008) Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. Oncogene 27:7106\u20137117","journal-title":"Oncogene"},{"key":"752_CR61","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3858\/emm.2010.42.10.070","volume":"42","author":"EJ Lim","year":"2010","unstructured":"Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH (2010) Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Exp Mol Med 42:712\u2013720","journal-title":"Exp Mol Med"},{"key":"752_CR62","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1074\/jbc.273.10.5939","volume":"273","author":"MF Lin","year":"1998","unstructured":"Lin MF, Meng TC, Rao PS, Chang C, Schonthal AH, Lin FF (1998) Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines. J Biol Chem 273:5939\u20135947","journal-title":"J Biol Chem"},{"key":"752_CR63","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1158\/1541-7786.MCR-04-0163","volume":"3","author":"RL Lynch","year":"2005","unstructured":"Lynch RL, Konicek BW, McNulty AM, Hanna KR, Lewis JE, Neubauer BL, Graff JR (2005) The progression of LNCaP human prostate cancer cells to androgen independence involves decreased FOXO3a expression and reduced p27KIP1 promoter transactivation. Mol Cancer Res 3:163\u2013169","journal-title":"Mol Cancer Res"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-012-0752-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-012-0752-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-012-0752-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T23:51:06Z","timestamp":1562111466000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-012-0752-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,26]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["752"],"URL":"https:\/\/doi.org\/10.1007\/s10495-012-0752-z","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,26]]}}}