{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:26:45Z","timestamp":1788010005223,"version":"build-2784847793"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,5,25]],"date-time":"2014-05-25T00:00:00Z","timestamp":1400976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s10495-014-0998-8","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T05:50:40Z","timestamp":1400910640000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reversal of multidrug resistance in vitro and in vivo by 5-N-formylardeemin, a new ardeemin derivative"],"prefix":"10.1007","volume":"19","author":[{"given":"Xuelian","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchuan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,25]]},"reference":[{"key":"998_CR1","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1158\/1078-0432.CCR-11-1590","volume":"18","author":"KG Chen","year":"2012","unstructured":"Chen KG, Sikic BI (2012) Molecular pathways: regulation and therapeutic implications of multidrug resistance. Clin Cancer Res 18:1863\u20131869","journal-title":"Clin Cancer Res"},{"key":"998_CR2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/sj.bjc.6604213","volume":"98","author":"C Lemos","year":"2008","unstructured":"Lemos C, Jansen G, Peters GJ (2008) Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors. Br J Cancer 98:857\u2013862","journal-title":"Br J Cancer"},{"key":"998_CR3","first-page":"827","volume":"9","author":"H Burger","year":"2003","unstructured":"Burger H, Foekens JA, Look MP et al (2003) RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin Cancer Res 9:827\u2013836","journal-title":"Clin Cancer Res"},{"key":"998_CR4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0968-0004(92)90419-A","volume":"17","author":"CF Higgins","year":"1992","unstructured":"Higgins CF, Gottesman MM (1992) Is the multidrug transporter a flippase? Trends Biochem Sci 17:18\u201321","journal-title":"Trends Biochem Sci"},{"key":"998_CR5","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1021\/jm030183a","volume":"46","author":"J Robert","year":"2003","unstructured":"Robert J, Jarry C (2003) Multidrug resistance reversal agents. J Med Chem 46:4805\u20134817","journal-title":"J Med Chem"},{"key":"998_CR6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00001813-200302000-00012","volume":"14","author":"BH Lee","year":"2003","unstructured":"Lee BH, Lee CO, Kwon MJ, Yi KY, Yoo SE, Choi SU (2003) Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity. Anticancer Drugs 14:175\u2013181","journal-title":"Anticancer Drugs"},{"key":"998_CR7","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/10428190903046722","volume":"50","author":"IV Pop","year":"2009","unstructured":"Pop IV, Pop LM, Ghetie MA, Vitetta ES (2009) Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines. Leuk Lymphoma 50:1155\u20131162","journal-title":"Leuk Lymphoma"},{"key":"998_CR8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.7164\/antibiotics.46.374","volume":"46","author":"JP Karwowski","year":"1993","unstructured":"Karwowski JP, Jackson M, Rasmussen RR et al (1993) 5-N-Acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity. J Antibiot 46:374\u2013379","journal-title":"J Antibiot"},{"key":"998_CR9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7164\/antibiotics.46.380","volume":"46","author":"JE Hochlowski","year":"1993","unstructured":"Hochlowski JE, Mullally MM, Spanton SG, Whittern DN, Hill P, McAlpine JB (1993) 5-N-Acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners. J Antibiot 46:380\u2013386","journal-title":"J Antibiot"},{"key":"998_CR10","doi-asserted-by":"crossref","first-page":"8369","DOI":"10.1073\/pnas.95.14.8369","volume":"95","author":"TC Chou","year":"1998","unstructured":"Chou TC, Depew KM, Zheng YH et al (1998) Reversal of anticancer multidrug resistance by the ardeemins. Proc Natl Acad Sci USA 95:8369\u20138374","journal-title":"Proc Natl Acad Sci USA"},{"key":"998_CR11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3835(98)00156-6","volume":"132","author":"C Mendez-Vidal","year":"1998","unstructured":"Mendez-Vidal C, Quesada AR (1998) Reversal of P-glycoprotein-mediated multidrug resistance in vitro by AV200, a new ardeemin derivative. Cancer Lett 132:45\u201350","journal-title":"Cancer Lett"},{"key":"998_CR12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1021\/jo802216z","volume":"74","author":"B He","year":"2009","unstructured":"He B, Song H, Du Y, Qin Y (2009) Total synthesis of (\u2212)-ardeemin. J Org Chem 74:298\u2013304","journal-title":"J Org Chem"},{"key":"998_CR13","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1039\/c2ob00014h","volume":"10","author":"Y Wang","year":"2012","unstructured":"Wang Y, Kong C, Du Y, Song H, Zhang D, Qin Y (2012) Silver-promoted Friedel\u2013Crafts reaction: concise total synthesis of (\u2212)-ardeemin, (\u2212)-acetylardeemin and (\u2212)-formylardeemin. Org Biomol Chem 10:2793\u20132797","journal-title":"Org Biomol Chem"},{"key":"998_CR14","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1021\/jo9023107","volume":"75","author":"S Takiguchi","year":"2010","unstructured":"Takiguchi S, Iizuka T, Kumakura YS et al (2010) Total syntheses of (-)-fructigenine A and (-)-5-N-acetylardeemin. J Org Chem 75:1126\u20131131","journal-title":"J Org Chem"},{"key":"998_CR15","doi-asserted-by":"crossref","first-page":"11953","DOI":"10.1021\/ja991558d","volume":"121","author":"KM Depew","year":"1999","unstructured":"Depew KM, Marsden SP, Zatorsk D, Zatorski A, Bornmann WG, Danishefsky SJ (1999) Total synthesis of 5-N-acetylardeemin and amauromine: practical routes to potential MDR reversal agents. J Am Chem Soc 121:11953\u201311963","journal-title":"J Am Chem Soc"},{"key":"998_CR16","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1158\/0008-5472.CAN-05-2698","volume":"66","author":"X Wang","year":"2006","unstructured":"Wang X, Ju W, Renouard J, Aden J, Belinsky SA, Lin Y (2006) 17-Allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res 66:1089\u20131095","journal-title":"Cancer Res"},{"key":"998_CR17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jnci\/81.1.55","volume":"81","author":"CK Luk","year":"1989","unstructured":"Luk CK, Tannock IF (1989) Flow cytometric analysis of doxorubicin accumulation in cells from human and rodent cell lines. J Natl Cancer Inst 81:55\u201359","journal-title":"J Natl Cancer Inst"},{"key":"998_CR18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/157018006777805558","volume":"3","author":"C Avenda\u00f1oa","year":"2006","unstructured":"Avenda\u00f1oa C, Caballeroa E, M\u00e9ndez-Vidalb C, Quesadab ARd, Men\u00e9ndez JC (2006) MDR reversal by deprenylated tetracyclic and hexacyclic analogues of N-acetylardeemin: confirmation of the ardeemin pharmacophore. Lett Drug Des Discov 3:369\u2013377","journal-title":"Lett Drug Des Discov"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-014-0998-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-014-0998-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-014-0998-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T14:41:33Z","timestamp":1559140893000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-014-0998-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,25]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["998"],"URL":"https:\/\/doi.org\/10.1007\/s10495-014-0998-8","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,25]]}}}