{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:45:22Z","timestamp":1781941522340,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,5,24]],"date-time":"2015-05-24T00:00:00Z","timestamp":1432425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s10495-015-1139-8","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T05:11:00Z","timestamp":1432530660000},"page":"1048-1055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microglia activation and interaction with neuronal cells in a biochemical model of mevalonate kinase deficiency"],"prefix":"10.1007","volume":"20","author":[{"given":"Paola Maura","family":"Tricarico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Piscianz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Monasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Kleiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Marcuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,24]]},"reference":[{"key":"1139_CR1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1056\/NEJM198606193142504","volume":"314","author":"G Hoffmann","year":"1986","unstructured":"Hoffmann G, Gibson KM, Brandt IK, Bader PI, Wappner RS, Sweetman L (1986) Mevalonic aciduria\u2013an inborn error of cholesterol and nonsterol isoprene biosynthesis. N Engl J Med 314:1610\u20131614","journal-title":"N Engl J Med"},{"key":"1139_CR2","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1056\/NEJMoa070715","volume":"356","author":"B Neven","year":"2007","unstructured":"Neven B, Valayannopoulos V, Quartier P, Blanche S, Prieur AM, Debr\u00e9 M, Rolland MO, Rabier D, Cuisset L, Cavazzana-Calvo M, de Lonlay P, Fischer A (2007) Allogeneic bone marrow transplantation in mevalonic aciduria. N Engl J Med 356:2700\u20132703","journal-title":"N Engl J Med"},{"key":"1139_CR3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1750-1172-1-13","volume":"1","author":"D Haas","year":"2006","unstructured":"Haas D, Hoffmann GF (2006) Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. Orphanet J Rare Dis 1:13","journal-title":"Orphanet J Rare Dis"},{"key":"1139_CR4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.plipres.2011.06.002","volume":"50","author":"FW Pfrieger","year":"2011","unstructured":"Pfrieger FW, Ungerer N (2011) Cholesterol metabolism in neurons and astrocytes. Prog Lipid Res 50:357\u2013371","journal-title":"Prog Lipid Res"},{"key":"1139_CR5","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s10545-007-0776-7","volume":"30","author":"EJ Hager","year":"2007","unstructured":"Hager EJ, Tse HM, Piganelli JD, Gupta M, Baetscher M, Tse TE, Pappu AS, Steiner RD, Hoffmann GF, Gibson KM (2007) Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. J Inherit Metab Dis 30:888\u2013895","journal-title":"J Inherit Metab Dis"},{"key":"1139_CR6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijdevneu.2012.06.002","volume":"30","author":"A Marcuzzi","year":"2012","unstructured":"Marcuzzi A, Zanin V, Piscianz E, Tricarico PM, Vuch J, Girardelli M, Monasta L, Bianco AM, Crovella S (2012) Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line. Int J Dev Neurosci Off J Int Soc Dev Neurosci 30:451\u2013456","journal-title":"Int J Dev Neurosci Off J Int Soc Dev Neurosci"},{"key":"1139_CR7","doi-asserted-by":"crossref","first-page":"e585","DOI":"10.1038\/cddis.2013.112","volume":"4","author":"A Marcuzzi","year":"2013","unstructured":"Marcuzzi A, Tricarico PM, Piscianz E, Kleiner G, Vecchi Brumatti L, Crovella S (2013) Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line. Cell Death Dis 4:e585","journal-title":"Cell Death Dis"},{"key":"1139_CR8","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1074\/jbc.M113.536920","volume":"289","author":"R Burgh van der","year":"2014","unstructured":"van der Burgh R, Nijhuis L, Pervolaraki K, Compeer EB, Jongeneel LH, van Gijn M, Coffer PJ, Murphy MP, Mastroberardino PG, Frenkel J, Boes M (2014) Defects in mitochondrial clearance predispose human monocytes to interleukin-1\u03b2 hypersecretion. J Biol Chem 289:5000\u20135012","journal-title":"J Biol Chem"},{"key":"1139_CR9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.mehy.2007.08.030","volume":"70","author":"P Celec","year":"2008","unstructured":"Celec P, Behuliak M (2008) The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria. Med Hypotheses 70:938\u2013940","journal-title":"Med Hypotheses"},{"key":"1139_CR10","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1542\/peds.2010-2192","volume":"129","author":"A Ruiz Gomez","year":"2012","unstructured":"Ruiz Gomez A, Couce ML, Garcia-Villoria J, Torres A, Ba\u00f1a Souto A, Yag\u00fce J, Vilaseca MA, Ribes A, Ar\u00f3stegui JI (2012) Clinical, genetic, and therapeutic diversity in 2 patients with severe mevalonate kinase deficiency. Pediatrics 129:e535\u2013e539","journal-title":"Pediatrics"},{"key":"1139_CR11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s10495-011-0621-1","volume":"16","author":"A Marcuzzi","year":"2011","unstructured":"Marcuzzi A, Piscianz E, Girardelli M, Crovella S, Pontillo A (2011) Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes. Apoptosis 16:882\u2013888","journal-title":"Apoptosis"},{"key":"1139_CR12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","volume":"11","author":"K Saijo","year":"2011","unstructured":"Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11:775\u2013787","journal-title":"Nat Rev Immunol"},{"key":"1139_CR13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S1740925X12000063","volume":"7","author":"H Wake","year":"2011","unstructured":"Wake H, Moorhouse AJ, Nabekura J (2011) Functions of microglia in the central nervous system-beyond the immune response. Neuron Glia Biol 7:47\u201353","journal-title":"Neuron Glia Biol"},{"key":"1139_CR14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2012.12.023","volume":"77","author":"H Kettenmann","year":"2013","unstructured":"Kettenmann H, Kirchhoff F, Verkhratsky A (2013) Microglia: new roles for the synaptic stripper. Neuron 77:10\u201318","journal-title":"Neuron"},{"key":"1139_CR15","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1038\/ncomms5486","volume":"5","author":"Z Chen","year":"2014","unstructured":"Chen Z, Jalabi W, Hu W, Park HJ, Gale JT, Kidd GJ, Bernatowicz R, Gossman ZC, Chen JT, Dutta R, Trapp BD (2014) Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat Commun 5:4486","journal-title":"Nat Commun"},{"key":"1139_CR16","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1177\/1352458514533230","volume":"20","author":"J Correale","year":"2014","unstructured":"Correale J (2014) The role of microglial activation in disease progression. Mult Scler 20:1288\u20131295","journal-title":"Mult Scler"},{"key":"1139_CR17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","volume":"91","author":"H Kettenmann","year":"2011","unstructured":"Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91:461\u2013553","journal-title":"Physiol Rev"},{"key":"1139_CR18","first-page":"437483","volume":"2014","author":"Y Li","year":"2014","unstructured":"Li Y, Tan MS, Jiang T, Tan L (2014) Microglia in Alzheimer\u2019s disease. Biomed Res Int 2014:437483","journal-title":"Biomed Res Int"},{"key":"1139_CR19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/1756-3305-7-372","volume":"7","author":"YH Zhang","year":"2014","unstructured":"Zhang YH, Chen H, Chen Y, Wang L, Cai YH, Li M, Wen HQ, Du J, An R, Luo QL, Wang XL, Lun ZR, Xu YH, Shen JL (2014) Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis. Parasit Vectors 7:372","journal-title":"Parasit Vectors"},{"key":"1139_CR20","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/nn1805","volume":"9","author":"SE Haynes","year":"2006","unstructured":"Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9:1512\u20131519","journal-title":"Nat Neurosci"},{"key":"1139_CR21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1684\/ecn.2009.0163","volume":"20","author":"S Normand","year":"2009","unstructured":"Normand S, Massonnet B, Delwail A, Favot L, Cuisset L, Grateau G, Morel F, Silvain C, Lecron JC (2009) Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation. Eur Cytokine Netw 20:101\u2013107","journal-title":"Eur Cytokine Netw"},{"key":"1139_CR22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s12265-013-9506-8","volume":"6","author":"V Zanin","year":"2013","unstructured":"Zanin V, Marcuzzi A, Kleiner G, Piscianz E, Monasta L, Zacchigna S, Crovella S, Zauli G (2013) Lovastatin dose-dependently potentiates the pro-inflammatory activity of lipopolysaccharide both in vitro and in vivo. J Cardiovasc Transl Res 6:981\u2013988","journal-title":"J Cardiovasc Transl Res"},{"key":"1139_CR23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1159\/000363041","volume":"34","author":"J Zhu","year":"2014","unstructured":"Zhu J, Qu C, Lu X, Zhang S (2014) Activation of microglia by histamine and substance p. Cell Physiol Biochem 34:768\u2013780","journal-title":"Cell Physiol Biochem"},{"key":"1139_CR24","doi-asserted-by":"crossref","first-page":"17151","DOI":"10.1073\/pnas.0806682105","volume":"105","author":"K Riazi","year":"2008","unstructured":"Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ (2008) Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation. Proc Natl Acad Sci USA 105:17151\u201317156","journal-title":"Proc Natl Acad Sci USA"},{"key":"1139_CR25","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1182\/blood.V85.12.3586.bloodjournal85123586","volume":"85","author":"JP Drenth","year":"1995","unstructured":"Drenth JP, van Deuren M, van der Ven-Jongekrijg J, Schalkwijk CG, van der Meer JW (1995) Cytokine activation during attacks of the hyperimmunoglobulinemia D and periodic fever syndrome. Blood 85:3586\u20133593","journal-title":"Blood"},{"key":"1139_CR26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10545-006-0408-7","volume":"29","author":"M Cailliez","year":"2006","unstructured":"Cailliez M, Garaix F, Rousset-Rouvi\u00e8re C, Bruno D, Kone-Paut I, Sarles J, Chabrol B, Tsimaratos M (2006) Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis. J Inherit Metab Dis 29:763","journal-title":"J Inherit Metab Dis"},{"key":"1139_CR27","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1136\/ard.2011.149922","volume":"70","author":"EJ Bodar","year":"2011","unstructured":"Bodar EJ, Kuijk LM, Drenth JPH, van der Meer JWM, Simon A, Frenkel J (2011) On-demand anakinra treatment is effective in mevalonate kinase deficiency. Ann Rheum Dis 70:2155\u20132158","journal-title":"Ann Rheum Dis"},{"key":"1139_CR28","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/rheumatology\/kes097","volume":"51","author":"C Galeotti","year":"2012","unstructured":"Galeotti C, Meinzer U, Quartier P, Rossi-Semerano L, Bader-Meunier B, Pillet P, Kon\u00e9-Paut I (2012) Efficacy of interleukin-1-targeting drugs in mevalonate kinase deficiency. Rheumatol Oxf Engl 51:1855\u20131859","journal-title":"Rheumatol Oxf Engl"},{"key":"1139_CR29","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/nm.2965","volume":"18","author":"J Vom Berg","year":"2012","unstructured":"Vom Berg J, Prokop S, Miller KR, Obst J, K\u00e4lin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O, Winter Y, Becher B, Heppner FL (2012) Inhibition of IL-12\/IL-23 signaling reduces Alzheimer\u2019s disease-like pathology and cognitive decline. Nat Med 18:1812\u20131819","journal-title":"Nat Med"},{"key":"1139_CR30","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1056\/NEJMcibr1214546","volume":"368","author":"WST Griffin","year":"2013","unstructured":"Griffin WST (2013) Neuroinflammatory cytokine signaling and Alzheimer\u2019s disease. N Engl J Med 368:770\u2013771","journal-title":"N Engl J Med"},{"key":"1139_CR31","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00018-009-0255-4","volume":"67","author":"SH Liu","year":"2010","unstructured":"Liu SH, Yang CN, Pan HC, Sung YJ, Liao KK, Chen WB, Lin WZ, Sheu ML (2010) IL-13 downregulates PPAR-gamma\/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cell Mol Life Sci CMLS 67:1465\u20131476","journal-title":"Cell Mol Life Sci CMLS"},{"key":"1139_CR32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2013.02.017","volume":"242","author":"CH Chen","year":"2013","unstructured":"Chen CH, Huang SY, Chen NF, Feng CW, Hung HC, Sung CS, Jean YH, Wen ZH, Chen WF (2013) Intrathecal granulocyte colony-stimulating factor modulate glial cell line-derived neurotrophic factor and vascular endothelial growth factor A expression in glial cells after experimental spinal cord ischemia. Neuroscience 242:39\u201352","journal-title":"Neuroscience"},{"key":"1139_CR33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","volume":"76","author":"ML Block","year":"2005","unstructured":"Block ML, Hong JS (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77\u201398","journal-title":"Prog Neurobiol"},{"key":"1139_CR34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12950-015-0048-5","volume":"12","author":"F Celsi","year":"2015","unstructured":"Celsi F, Piscianz E, Romano M, Crovella S (2015) Knockdown of MVK does not lead to changes in NALP3 expression or activation. J Inflamm (Lond) 12:7","journal-title":"J Inflamm (Lond)"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-015-1139-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-015-1139-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-015-1139-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T15:04:16Z","timestamp":1599059056000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-015-1139-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,24]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["1139"],"URL":"https:\/\/doi.org\/10.1007\/s10495-015-1139-8","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,24]]}}}