{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:21:43Z","timestamp":1774462903834,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan","award":["26462000"],"award-info":[{"award-number":["26462000"]}]},{"name":"Grant-in-Aid for Research on seeds for Publicly Essential Drugs and Medical Devices from the Ministry of Health, Labor and Welfare of Japan","award":["H23-seisakutansaku-009"],"award-info":[{"award-number":["H23-seisakutansaku-009"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s10495-015-1171-8","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T15:19:17Z","timestamp":1442330357000},"page":"1587-1598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma"],"prefix":"10.1007","volume":"20","author":[{"given":"Suguru","family":"Yamauchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoko","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Morinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Shingyoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Tada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Hiroshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Tagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"1171_CR1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1186\/1471-2407-14-471","volume":"14","author":"GK Gresham","year":"2014","unstructured":"Gresham GK, Wells GA, Gill S, Cameron C, Jonker DJ (2014) Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis. BMC Cancer 14:471","journal-title":"BMC Cancer"},{"key":"1171_CR2","doi-asserted-by":"crossref","first-page":"13343","DOI":"10.3748\/wjg.v20.i37.13343","volume":"20","author":"SX Liu","year":"2014","unstructured":"Liu SX, Xia ZS, Zhong YQ (2014) Gene therapy in pancreatic cancer. World J Gastroenterol 20:13343\u201313368","journal-title":"World J Gastroenterol"},{"key":"1171_CR3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1349-7006.2006.00206.x","volume":"97","author":"H Shimada","year":"2006","unstructured":"Shimada H, Matsubara H, Shiratori T, Shimizu T, Miyazaki S, Okazumi S et al (2006) Phase I\/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma. Cancer Sci 97:554\u2013561","journal-title":"Cancer Sci"},{"key":"1171_CR4","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3171\/jns.2000.92.6.1002","volume":"92","author":"K Asaoka","year":"2000","unstructured":"Asaoka K, Tada M, Sawamura Y, Ikeda J, Abe H (2000) Dependence of efficient adenoviral gene delivery in malignant glioma cells on the expression levels of the Coxsackievirus and adenovirus receptor. J Neurosurg 92:1002\u20131008","journal-title":"J Neurosurg"},{"key":"1171_CR5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/sj.cgt.7700830","volume":"12","author":"H Kasuya","year":"2005","unstructured":"Kasuya H, Takeda S, Nomoto S, Nakao A (2005) The potential of oncolytic virus therapy for pancreatic cancer. Cancer Gene Ther 12:725\u2013736","journal-title":"Cancer Gene Ther"},{"key":"1171_CR6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/1566523213666131125095046","volume":"13","author":"WS Wold","year":"2013","unstructured":"Wold WS, Toth K (2013) Adenovirus vectors for gene therapy, vaccination and cancer gene therapy. Curr Gene Ther 13:421\u2013433","journal-title":"Curr Gene Ther"},{"key":"1171_CR7","first-page":"89","volume":"27","author":"K Kawamura","year":"2007","unstructured":"Kawamura K, Yu L, Tomizawa M, Shimozato O, Ma G, Li Q et al (2007) Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene in human tumors and enhance the sensitivity to a prodrug. Anticancer Res 27:89\u201393","journal-title":"Anticancer Res"},{"key":"1171_CR8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1112>3.0.CO;2-X","volume":"91","author":"M Miyauchi","year":"2001","unstructured":"Miyauchi M, Yoshida Y, Tada Y, Narita M, Maeda T, Bahar R et al (2001) Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Int J Cancer 91:723\u2013727","journal-title":"Int J Cancer"},{"key":"1171_CR9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/mthe.2001.0275","volume":"3","author":"M Yamamoto","year":"2001","unstructured":"Yamamoto M, Alemany R, Adachi Y, Grizzle WE, Curiel DT (2001) Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers. Mol Ther 3:385\u2013394","journal-title":"Mol Ther"},{"key":"1171_CR10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.virusres.2009.02.010","volume":"143","author":"A Sharma","year":"2009","unstructured":"Sharma A, Li X, Bangari DS, Mittal SK (2009) Adenovirus receptors and their implications in gene delivery. Virus Res 143:184\u2013194","journal-title":"Virus Res"},{"key":"1171_CR11","first-page":"8680","volume":"63","author":"RC Pong","year":"2003","unstructured":"Pong RC, Lai YJ, Chen H, Okegawa T, Frenkel E, Sagalowsky A et al (2003) Epigenetic regulation of coxsackie and adenovirus receptor (CAR) gene promoter in urogenital cancer cells. Cancer Res 63:8680\u20138686","journal-title":"Cancer Res"},{"key":"1171_CR12","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1158\/0008-5472.CAN-04-0884","volume":"64","author":"BD Anderson","year":"2004","unstructured":"Anderson BD, Nakamura T, Russell SJ, Peng KW (2004) High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virus. Cancer Res 64:4919\u20134926","journal-title":"Cancer Res"},{"key":"1171_CR13","first-page":"831","volume":"14","author":"L Yu","year":"2005","unstructured":"Yu L, Takenobu H, Shimozato O, Kawamura K, Nimura Y, Seki N et al (2005) Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells. Oncol Rep 14:831\u2013835","journal-title":"Oncol Rep"},{"key":"1171_CR14","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.ejca.2011.12.020","volume":"48","author":"Y Yamasaki","year":"2012","unstructured":"Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S et al (2012) A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression. Eur J Cancer 48:2282\u20132291","journal-title":"Eur J Cancer"},{"key":"1171_CR15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1158\/1535-7163.MCT-12-0869","volume":"12","author":"J Hasei","year":"2013","unstructured":"Hasei J, Sasaki T, Tazawa H, Osaki S, Yamakawa Y, Kunisada T et al (2013) Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells. Mol Cancer Ther 12:314\u2013325","journal-title":"Mol Cancer Ther"},{"key":"1171_CR16","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","volume":"11","author":"G Kroemer","year":"2005","unstructured":"Kroemer G, Martin SJ (2005) Caspase-independent cell death. Nat Med 11:725\u2013730","journal-title":"Nat Med"},{"key":"1171_CR17","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1038\/onc.2008.311","volume":"27","author":"SW Tait","year":"2008","unstructured":"Tait SW, Green DR (2008) Caspase-independent cell death: leaving the set without the final cut. Oncogene 27:6452\u20136461","journal-title":"Oncogene"},{"key":"1171_CR18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4161\/cc.7.8.5720","volume":"7","author":"K Kitagawa","year":"2008","unstructured":"Kitagawa K, Niikura Y (2008) Caspase-independent mitotic death (CIMD). Cell Cycle 7:1001\u20131005","journal-title":"Cell Cycle"},{"key":"1171_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/cdd.2011.91","volume":"19","author":"L Cabon","year":"2012","unstructured":"Cabon L, Gal\u00e1n-Malo P, Bouharrour A, Delavall\u00e9e L, Brunelle-Navas MN, Lorenzo HK et al (2012) BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ 19:245\u2013256","journal-title":"Cell Death Differ"},{"key":"1171_CR20","doi-asserted-by":"crossref","first-page":"920161","DOI":"10.4061\/2010\/920161","volume":"2010","author":"M Podhorecka","year":"2010","unstructured":"Podhorecka M, Skladanowski A, Bozko P (2010) H2AX phosphorylation: its role in DNA damage response and cancer therapy. J Nucleic Acids 2010:920161","journal-title":"J Nucleic Acids"},{"key":"1171_CR21","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/v6020856","volume":"6","author":"D He","year":"2014","unstructured":"He D, Sun L, Li C, Hu N, Sheng Y, Chen Z et al (2014) Anti-tumor effects of an oncolytic adenovirus expressing hemagglutinin-neuraminidase of Newcastle disease virus in vitro and in vivo. Viruses 6:856\u2013874","journal-title":"Viruses"},{"key":"1171_CR22","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/mt.2013.179","volume":"21","author":"CK Kim","year":"2013","unstructured":"Kim CK, Ahmed AU, Auffinger B, Ulasov IV, Tobias AL, Moon KS et al (2013) N-acetylcysteine amide augments the therapeutic effect of neural stem cell-based antiglioma oncolytic virotherapy. Mol Ther 21:2063\u20132073","journal-title":"Mol Ther"},{"key":"1171_CR23","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.4161\/cc.5.19.3263","volume":"5","author":"G Cherubini","year":"2006","unstructured":"Cherubini G, Petouchoff T, Grossi M, Piersanti S, Cundari E, Saggio I (2006) E1B55K-deleted adenovirus (ONYX-015) overrides G1\/S and G2\/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells. Cell Cycle 5:2244\u20132252","journal-title":"Cell Cycle"},{"key":"1171_CR24","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1158\/0008-5472.CAN-08-1054","volume":"68","author":"M Parre\u00f1o","year":"2008","unstructured":"Parre\u00f1o M, Casanova I, C\u00e9spedes MV, Vaqu\u00e9 JP, Pav\u00f3n MA, Leon J et al (2008) Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance. Cancer Res 68:6313\u20136323","journal-title":"Cancer Res"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-015-1171-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-015-1171-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-015-1171-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T18:41:39Z","timestamp":1559155299000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-015-1171-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["1171"],"URL":"https:\/\/doi.org\/10.1007\/s10495-015-1171-8","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,15]]}}}