{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:32:26Z","timestamp":1790947946037,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T00:00:00Z","timestamp":1446249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272042"],"award-info":[{"award-number":["81272042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472135"],"award-info":[{"award-number":["81472135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["S2012010008875"],"award-info":[{"award-number":["S2012010008875"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["S2012040006830"],"award-info":[{"award-number":["S2012040006830"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s10495-015-1191-4","type":"journal-article","created":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T12:55:45Z","timestamp":1446296145000},"page":"36-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Advanced oxidation protein products induce chondrocyte apoptosis via receptor for advanced glycation end products-mediated, redox-dependent intrinsic apoptosis pathway"],"prefix":"10.1007","volume":"21","author":[{"given":"Qian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Ming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Rui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Huan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Ting","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Song","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,31]]},"reference":[{"key":"1191_CR1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","volume":"7","author":"IB McInnes","year":"2007","unstructured":"McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429\u2013442","journal-title":"Nat Rev Immunol"},{"key":"1191_CR2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1063-4584(03)00156-0","volume":"11","author":"AJ Schuerwegh","year":"2003","unstructured":"Schuerwegh AJ, Dombrecht EJ, Stevens WJ, Van Offel JF, Bridts CH, De Clerck LS (2003) Influence of pro-inflammatory (IL-1 alpha, IL-6, TNF-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function. Osteoarthritis Cartilage 11:681\u2013687","journal-title":"Osteoarthritis Cartilage"},{"key":"1191_CR3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/08916930701356721","volume":"40","author":"K Polzer","year":"2007","unstructured":"Polzer K, Schett G, Zwerina J (2007) The lonely death: chondrocyte apoptosis in TNF-induced arthritis. Autoimmunity 40:333\u2013336","journal-title":"Autoimmunity"},{"key":"1191_CR4","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1097\/00003086-200110001-00011","volume":"391","author":"M Lotz","year":"2001","unstructured":"Lotz M (2001) Cytokines in cartilage injury and repair. Clin Orthop Relat Res 391:S108\u2013S115","journal-title":"Clin Orthop Relat Res"},{"key":"1191_CR5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/ard.2010.132720","volume":"70","author":"CJ Wruck","year":"2011","unstructured":"Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, Hassenpflug J, Freitag-Wolf S, Varoga D, Lippross S, Pufe T (2011) Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis 70:844\u2013850","journal-title":"Ann Rheum Dis"},{"key":"1191_CR6","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1186\/ar2102","volume":"8","author":"J Fay","year":"2006","unstructured":"Fay J, Varoga D, Wruck CJ, Kurz B, Goldring MB, Pufe T (2006) Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants. Arthritis Res Ther 8:R189","journal-title":"Arthritis Res Ther"},{"key":"1191_CR7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/ar1447","volume":"6","author":"CA Hitchon","year":"2004","unstructured":"Hitchon CA, El-Gabalawy HS (2004) Oxidation in rheumatoid arthritis. Arthritis Res Ther 6:265\u2013278","journal-title":"Arthritis Res Ther"},{"key":"1191_CR8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/art.10085","volume":"46","author":"M Bandt De","year":"2002","unstructured":"De Bandt M, Grossin M, Driss F, Pincemail J, Babin-Chevaye C, Pasquier C (2002) Vitamin E uncouples joint destruction and clinical inflammation in a transgenic mouse model of rheumatoid arthritis. Arthritis Rheum 46:522\u2013532","journal-title":"Arthritis Rheum"},{"key":"1191_CR9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(94)92211-X","volume":"344","author":"B Halliwell","year":"1994","unstructured":"Halliwell B (1994) Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 344:721\u2013724","journal-title":"Lancet"},{"key":"1191_CR10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0891-5849(97)00271-2","volume":"24","author":"T Reinheckel","year":"1998","unstructured":"Reinheckel T, Nedelev B, Prause J, Augustin W, Schulz HU, Lippert H, Halangk W (1998) Occurrence of oxidatively modified proteins: an early event in experimental acute pancreatitis. Free Radic Biol Med 24:393\u2013400","journal-title":"Free Radic Biol Med"},{"key":"1191_CR11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0773.1998.tb01445.x","volume":"83","author":"SM DeAtley","year":"1998","unstructured":"DeAtley SM, Aksenov MY, Aksenova MV, Carney JM, Butterfield DA (1998) Adriamycin induces protein oxidation in erythrocyte membranes. Pharmacol Toxicol 83:62\u201368","journal-title":"Pharmacol Toxicol"},{"key":"1191_CR12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ki.1996.186","volume":"49","author":"V Witko-Sarsat","year":"1996","unstructured":"Witko-Sarsat V, Friedlander M, Capeillere-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49:1304\u20131313","journal-title":"Kidney Int"},{"key":"1191_CR13","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1093\/rheumatology\/kes193","volume":"51","author":"LK Stamp","year":"2012","unstructured":"Stamp LK, Khalilova I, Tarr JM, Senthilmohan R, Turner R, Haigh RC, Winyard PG, Kettle AJ (2012) Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology (Oxford) 51:1796\u20131803","journal-title":"Rheumatology (Oxford)"},{"key":"1191_CR14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/cbf.1257","volume":"24","author":"G Baskol","year":"2006","unstructured":"Baskol G, Demir H, Baskol M, Kilic E, Ates F, Karakukcu C, Ustdal M (2006) Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis. Cell Biochem Funct 24:307\u2013311","journal-title":"Cell Biochem Funct"},{"key":"1191_CR15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/ars.2012.4603","volume":"18","author":"W Cao","year":"2013","unstructured":"Cao W, Xu J, Zhou ZM, Wang GB, Hou FF, Nie J (2013) Advanced oxidation protein products activate intrarenal renin-angiotensin system via a CD36-mediated, redox-dependent pathway. Antioxid Redox Signal 18:19\u201335","journal-title":"Antioxid Redox Signal"},{"key":"1191_CR16","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/ki.2009.322","volume":"76","author":"LL Zhou","year":"2009","unstructured":"Zhou LL, Hou FF, Wang GB, Yang F, Xie D, Wang YP, Tian JW (2009) Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms. Kidney Int 76:1148\u20131160","journal-title":"Kidney Int"},{"key":"1191_CR17","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1089\/ars.2007.1999","volume":"10","author":"ZJ Guo","year":"2008","unstructured":"Guo ZJ, Niu HX, Hou FF, Zhang L, Fu N, Nagai R, Lu X, Chen BH, Shan YX, Tian JW, Nagaraj RH, Xie D, Zhang X (2008) Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway. Antioxid Redox Signal 10:1699\u20131712","journal-title":"Antioxid Redox Signal"},{"key":"1191_CR18","doi-asserted-by":"crossref","first-page":"e1006","DOI":"10.1038\/cddis.2013.542","volume":"5","author":"F Xie","year":"2014","unstructured":"Xie F, Sun S, Xu A, Zheng S, Xue M, Wu P, Zeng JH, Bai L (2014) Advanced oxidation protein products induce intestine epithelial cell death through a redox-dependent, c-jun N-terminal kinase and poly (ADP-ribose) polymerase-1-mediated pathway. Cell Death Dis 5:e1006","journal-title":"Cell Death Dis"},{"key":"1191_CR19","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1159\/000354500","volume":"32","author":"S Zheng","year":"2013","unstructured":"Zheng S, Zhong ZM, Qin S, Chen GX, Wu Q, Zeng JH, Ye WB, Li W, Yuan K, Yao L, Chen JT (2013) Advanced oxidation protein products induce inflammatory response in fibroblast-like synoviocytes through NADPH oxidase -dependent activation of NF-kappaB. Cell Physiol Biochem 32:972\u2013985","journal-title":"Cell Physiol Biochem"},{"key":"1191_CR20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000227818","volume":"24","author":"ZM Zhong","year":"2009","unstructured":"Zhong ZM, Bai L, Chen JT (2009) Advanced oxidation protein products inhibit proliferation and differentiation of rat osteoblast-like cells via NF-kappaB pathway. Cell Physiol Biochem 24:105\u2013114","journal-title":"Cell Physiol Biochem"},{"key":"1191_CR21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ki.2012.184","volume":"82","author":"LL Zhou","year":"2012","unstructured":"Zhou LL, Cao W, Xie C, Tian J, Zhou Z, Zhou Q, Zhu P, Li A, Liu Y, Miyata T, Hou FF, Nie J (2012) The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Kidney Int 82:759\u2013770","journal-title":"Kidney Int"},{"key":"1191_CR22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2119\/molmed.2012.00309","volume":"19","author":"T Takahashi","year":"2013","unstructured":"Takahashi T, Katsuta S, Tamura Y, Nagase N, Suzuki K, Nomura M, Tomatsu S, Miyamoto K, Kobayashi S (2013) Bone-targeting endogenous secretory receptor for advanced glycation end products rescues rheumatoid arthritis. Mol Med 19:183\u2013194","journal-title":"Mol Med"},{"key":"1191_CR23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2013.02.012","volume":"60","author":"AJ Valente","year":"2013","unstructured":"Valente AJ, Yoshida T, Clark RA, Delafontaine P, Siebenlist U, Chandrasekar B (2013) Advanced oxidation protein products induce cardiomyocyte death via Nox2\/Rac1\/superoxide-dependent TRAF3IP2\/JNK signaling. Free Radic Biol Med 60:125\u2013135","journal-title":"Free Radic Biol Med"},{"key":"1191_CR24","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.12659\/MSM.894347","volume":"21","author":"Q Wu","year":"2015","unstructured":"Wu Q, Zhong ZM, Pan Y, Zeng JH, Zheng S, Zhu SY, Chen JT (2015) Advanced oxidation protein products as a novel marker of oxidative stress in postmenopausal osteoporosis. Med Sci Monit 21:2428\u20132432","journal-title":"Med Sci Monit"},{"key":"1191_CR25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/art.33449","volume":"64","author":"A Opolka","year":"2012","unstructured":"Opolka A, Straub RH, Pasoldt A, Grifka J, Grassel S (2012) Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis. Arthritis Rheum 64:729\u2013739","journal-title":"Arthritis Rheum"},{"key":"1191_CR26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13075-015-0720-4","volume":"17","author":"X Yang","year":"2015","unstructured":"Yang X, Teguh D, Wu JP, He B, Kirk TB, Qin S, Li S, Chen H, Xue W, Ng B, Chim SM, Tickner J, Xu J (2015) Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments. Arthritis Res Ther 17:210","journal-title":"Arthritis Res Ther"},{"key":"1191_CR27","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.7150\/ijms.5645","volume":"10","author":"ZM Zhong","year":"2013","unstructured":"Zhong ZM, Li T, Xu ZX, Meng TT, Zeng JH, Zheng S, Ye WB, Wu Q, Chen JT (2013) Effect of melatonin on the proliferation and differentiation of chondrocytes from rat vertebral body growth plate in vitro. Int J Med Sci 10:1392\u20131398","journal-title":"Int J Med Sci"},{"key":"1191_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2003.09.015","volume":"12","author":"K Kuhn","year":"2004","unstructured":"Kuhn K, D\u2019Lima DD, Hashimoto S, Lotz M (2004) Cell death in cartilage. Osteoarthritis Cartilage 12:1\u201316","journal-title":"Osteoarthritis Cartilage"},{"key":"1191_CR29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356\u2013361","journal-title":"Nature"},{"key":"1191_CR30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/os.12179","volume":"7","author":"H Yu","year":"2015","unstructured":"Yu H, Ye WB, Zhong ZM, Ding RT, Chen JT (2015) Effect of advanced oxidation protein products on articular cartilage and synovium in a rabbit osteoarthritis model. Orthop Surg 7:161\u2013167","journal-title":"Orthop Surg"},{"key":"1191_CR31","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1172\/JCI69485","volume":"123","author":"N Adan","year":"2013","unstructured":"Adan N, Guzman-Morales J, Ledesma-Colunga MG, Perales-Canales SI, Quintanar-Stephano A, Lopez-Barrera F, Mendez I, Moreno-Carranza B, Triebel J, Binart N, Martinez DLEG, Thebault S, Clapp C (2013) Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis. J Clin Invest 123:3902\u20133913","journal-title":"J Clin Invest"},{"key":"1191_CR32","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.joca.2014.04.025","volume":"22","author":"Y Uehara","year":"2014","unstructured":"Uehara Y, Hirose J, Yamabe S, Okamoto N, Okada T, Oyadomari S, Mizuta H (2014) Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C\/EBP homologous protein. Osteoarthritis Cartilage 22:1007\u20131017","journal-title":"Osteoarthritis Cartilage"},{"key":"1191_CR33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11010-014-2187-z","volume":"397","author":"KN Reed","year":"2014","unstructured":"Reed KN, Wilson G, Pearsall A, Grishko VI (2014) The role of mitochondrial reactive oxygen species in cartilage matrix destruction. Mol Cell Biochem 397:195\u2013201","journal-title":"Mol Cell Biochem"},{"key":"1191_CR34","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s00018-002-8520-9","volume":"59","author":"PV Vignais","year":"2002","unstructured":"Vignais PV (2002) The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell Mol Life Sci 59:1428\u20131459","journal-title":"Cell Mol Life Sci"},{"key":"1191_CR35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00005-012-0176-z","volume":"60","author":"P Kleniewska","year":"2012","unstructured":"Kleniewska P, Piechota A, Skibska B, Goraca A (2012) The NADPH oxidase family and its inhibitors. Arch Immunol Ther Exp (Warsz) 60:277\u2013294","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"1191_CR36","doi-asserted-by":"crossref","first-page":"462361","DOI":"10.1155\/2013\/462361","volume":"2013","author":"S Joshi","year":"2013","unstructured":"Joshi S, Peck AB, Khan SR (2013) NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys. Oxid Med Cell Longev 2013:462361","journal-title":"Oxid Med Cell Longev"},{"key":"1191_CR37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.semarthrit.2012.07.002","volume":"42","author":"LS Tam","year":"2013","unstructured":"Tam LS, Shang Q, Li EK, Wong S, Li RJ, Lee KL, Leung YY, Ying KY, Yim CW, Kun EW, Leung MH, Li M, Li TK, Zhu TY, Chui RK, Tseung L, Yu SL, Kuan WP, Yu CM (2013) Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis\u2013a prospective study. Semin Arthritis Rheum 42:333\u2013345","journal-title":"Semin Arthritis Rheum"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-015-1191-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-015-1191-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-015-1191-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T01:59:27Z","timestamp":1589594367000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-015-1191-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,31]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["1191"],"URL":"https:\/\/doi.org\/10.1007\/s10495-015-1191-4","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,31]]}}}