{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:04:21Z","timestamp":1781813061380,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Educational Commission of Hubei Province of China","award":["B2016078"],"award-info":[{"award-number":["B2016078"]}]},{"name":"the \u201c973\u201d Program of China","award":["2015CB553903"],"award-info":[{"award-number":["2015CB553903"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072135"],"award-info":[{"award-number":["81072135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372801"],"award-info":[{"award-number":["81372801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272426"],"award-info":[{"award-number":["81272426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81572570"],"award-info":[{"award-number":["81572570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s10495-016-1334-2","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T09:20:04Z","timestamp":1486718404000},"page":"544-557","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3\/Bcl-2 axis in ovarian cancer"],"prefix":"10.1007","volume":"22","author":[{"given":"Y.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. S.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. R.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q. L.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"1334_CR1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/onc.2010.532","volume":"30","author":"AK Mitra","year":"2011","unstructured":"Mitra AK, Sawada K, Tiwari P, Mui K, Gwin K, Lengyel E (2011) Ligand-independent activation of c-Met by fibronectin and alpha(5)beta(1)-integrin regulates ovarian cancer invasion and metastasis. Oncogene 30:1566\u20131576","journal-title":"Oncogene"},{"key":"1334_CR2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2644","volume":"9","author":"RC Bast Jr","year":"2009","unstructured":"Bast RC Jr, Hennessy B, Mills GB (2009) The biology of ovarian cancer: new opportunities for translation. Nat Rev Cancer 9:415\u2013428","journal-title":"Nat Rev Cancer"},{"key":"1334_CR3","doi-asserted-by":"crossref","first-page":"e72748","DOI":"10.1371\/journal.pone.0072748","volume":"8","author":"A De","year":"2013","unstructured":"De A, De A, Papasian C et al (2013) Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors. PLoS One 8:e72748","journal-title":"PLoS One"},{"key":"1334_CR4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.foodchem.2013.07.002","volume":"142","author":"NR Song","year":"2014","unstructured":"Song NR, Chung MY, Kang NJ et al (2014) Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting phosphatidylinositol 3-kinase. Food Chem 142:66\u201371","journal-title":"Food Chem"},{"key":"1334_CR5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/01635581.2012.725194","volume":"65","author":"A Del Follo-Martinez","year":"2013","unstructured":"Del Follo-Martinez A, Banerjee N, Li X, Safe S, Mertens-Talcott S (2013) Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutr Cancer 65:494\u2013504","journal-title":"Nutr Cancer"},{"key":"1334_CR6","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/ijc.24151","volume":"124","author":"MA Gates","year":"2009","unstructured":"Gates MA, Vitonis AF, Tworoger SS et al (2009) Flavonoid intake and ovarian cancer risk in a population-based case-control study. Int J Cancer 124:1918\u20131925","journal-title":"Int J Cancer"},{"key":"1334_CR7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","volume":"7","author":"I Kim","year":"2008","unstructured":"Kim I, Xu W, Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7:1013\u20131030.","journal-title":"Nat Rev Drug Discov"},{"key":"1334_CR8","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","volume":"1833","author":"R Sano","year":"2013","unstructured":"Sano R, Reed JC (2013) ER stress-induced cell death mechanisms. Biochim Biophys Acta 1833:3460\u20133470","journal-title":"Biochim Biophys Acta"},{"key":"1334_CR9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/febs.13206","volume":"282","author":"Z Yang","year":"2015","unstructured":"Yang Z, Liu Y, Liao J et al (2015) Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling. FEBS J 282:1111\u20131125","journal-title":"FEBS J"},{"key":"1334_CR10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/cas.12395","volume":"105","author":"L Yi","year":"2014","unstructured":"Yi L, Zongyuan Y, Cheng G, Lingyun Z, Guilian Y, Wei G (2014) Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Cancer Sci 105:520\u2013527","journal-title":"Cancer Sci"},{"key":"1334_CR11","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1193497","volume":"330","author":"JD Rabinowitz","year":"2010","unstructured":"Rabinowitz JD, White E (2010) Autophagy and metabolism. Science 330:1344\u20131348","journal-title":"Science"},{"key":"1334_CR12","doi-asserted-by":"crossref","first-page":"949","DOI":"10.4161\/auto.6788","volume":"4","author":"Y Wei","year":"2008","unstructured":"Wei Y, Sinha S, Levine B (2008) Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy 4:949\u2013951","journal-title":"Autophagy"},{"key":"1334_CR13","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/cas.12494","volume":"105","author":"Y Zhou","year":"2014","unstructured":"Zhou Y, Liang X, Chang H et al (2014) Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress. Cancer Sci 105:1279\u20131287","journal-title":"Cancer Sci"},{"key":"1334_CR14","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1080\/15548627.2015.1017185","volume":"11","author":"X Zhao","year":"2015","unstructured":"Zhao X, Fang Y, Yang Y et al (2015) Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy 11:1849\u20131863","journal-title":"Autophagy"},{"key":"1334_CR15","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4161\/auto.7.9.15863","volume":"7","author":"K Wang","year":"2011","unstructured":"Wang K, Liu R, Li J et al (2011) Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy 7:966\u2013978","journal-title":"Autophagy"},{"key":"1334_CR16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4174\/jkss.2013.85.6.249","volume":"85","author":"JH Lee","year":"2013","unstructured":"Lee JH, Lee HB, Jung GO, Oh JT, Park DE, Chae KM (2013) Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc 85:249\u2013260","journal-title":"J Korean Surg Soc"},{"key":"1334_CR17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/tox.21769","volume":"29","author":"KC Liu","year":"2014","unstructured":"Liu KC, Yen CY, Wu RS et al (2014) The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells. Environ Toxicol 29:428\u2013439","journal-title":"Environ Toxicol"},{"key":"1334_CR18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fmed.2014.00055","volume":"1","author":"L Ulianich","year":"2014","unstructured":"Ulianich L, Insabato L (2014) Endoplasmic reticulum stress in endometrial cancer. Front Med 1:55","journal-title":"Front Med"},{"key":"1334_CR19","first-page":"610140","volume":"2014","author":"DA Chistiakov","year":"2014","unstructured":"Chistiakov DA, Sobenin IA, Orekhov AN, Bobryshev YV (2014) Role of endoplasmic reticulum stress in atherosclerosis and diabetic macrovascular complications. BioMed Res Int 2014:610140","journal-title":"BioMed Res Int"},{"key":"1334_CR20","doi-asserted-by":"crossref","first-page":"e57941","DOI":"10.1371\/journal.pone.0057941","volume":"8","author":"W Duan","year":"2013","unstructured":"Duan W, Yang Y, Yi W et al (2013) New role of JAK2\/STAT3 signaling in endothelial cell oxidative stress injury and protective effect of melatonin. PLoS One 8:e57941","journal-title":"PLoS One"},{"key":"1334_CR21","doi-asserted-by":"crossref","first-page":"e51076","DOI":"10.1371\/journal.pone.0051076","volume":"7","author":"Y Shi","year":"2012","unstructured":"Shi Y, Tang B, Yu PW et al (2012) Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS One 7:e51076","journal-title":"PLoS One"},{"key":"1334_CR22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature11895","volume":"494","author":"MR Warr","year":"2013","unstructured":"Warr MR, Binnewies M, Flach J et al (2013) FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 494:323\u2013327","journal-title":"Nature"},{"key":"1334_CR23","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1172\/JCI70454","volume":"124","author":"XH Ma","year":"2014","unstructured":"Ma XH, Piao SF, Dey S et al (2014) Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. J Clin Invest 124:1406\u20131417","journal-title":"J Clin Invest"},{"key":"1334_CR24","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/nm.3322","volume":"19","author":"Y Maejima","year":"2013","unstructured":"Maejima Y, Kyoi S, Zhai P et al (2013) Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med 19:1478\u20131488","journal-title":"Nat Med"},{"key":"1334_CR25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1593\/neo.10228","volume":"12","author":"S Meister","year":"2010","unstructured":"Meister S, Frey B, Lang VR et al (2010) Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. Neoplasia 12:550\u2013561","journal-title":"Neoplasia"},{"key":"1334_CR26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.canlet.2010.07.016","volume":"332","author":"T Verfaillie","year":"2013","unstructured":"Verfaillie T, Garg AD, Agostinis P (2013) Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Lett 332:249\u2013264","journal-title":"Cancer Lett"},{"key":"1334_CR27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tips.2011.10.002","volume":"33","author":"H Kraskiewicz","year":"2012","unstructured":"Kraskiewicz H, FitzGerald U (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol Sci 33:53\u201363","journal-title":"Trends Pharmacol Sci"},{"key":"1334_CR28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.taap.2013.10.003","volume":"273","author":"J Jakubowicz-Gil","year":"2013","unstructured":"Jakubowicz-Gil J, Langner E, Badziul D, Wertel I, Rzeski W (2013) Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment. Toxicol Appl Pharmacol 273:580\u2013589","journal-title":"Toxicol Appl Pharmacol"},{"key":"1334_CR29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1254\/jphs.10217SC","volume":"115","author":"A Yamamuro","year":"2011","unstructured":"Yamamuro A, Kishino T, Ohshima Y et al (2011) Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells. J Pharmacol Sci 115:239\u2013243","journal-title":"J Pharmacol Sci"},{"key":"1334_CR30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/1756-0500-6-372","volume":"6","author":"C Thepparit","year":"2013","unstructured":"Thepparit C, Khakpoor A, Khongwichit S, et al. (2013) Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death. BMC Res Notes 6:372","journal-title":"BMC Res Notes"},{"key":"1334_CR31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.canlet.2014.08.009","volume":"354","author":"K Hui","year":"2014","unstructured":"Hui K, Yang Y, Shi K et al (2014) The p38 MAPK-regulated PKD1\/CREB\/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo. Cancer Lett 354:189\u2013199","journal-title":"Cancer Lett"},{"key":"1334_CR32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tox.2009.01.021","volume":"258","author":"Y Natsume","year":"2009","unstructured":"Natsume Y, Ito S, Satsu H, Shimizu M (2009) Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells. Toxicology 258:164\u2013175","journal-title":"Toxicology"},{"key":"1334_CR33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2014.09.046","volume":"745","author":"J Wu","year":"2014","unstructured":"Wu J, Xu X, Li Y et al (2014) Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol 745:59\u201368","journal-title":"Eur J Pharmacol"},{"key":"1334_CR34","doi-asserted-by":"crossref","first-page":"930509","DOI":"10.1155\/2010\/930509","volume":"2010","author":"T Verfaillie","year":"2010","unstructured":"Verfaillie T, Salazar M, Velasco G, Agostinis P (2010) Linking ER stress to autophagy: potential implications for cancer therapy. Int J Cell Biol 2010:930509","journal-title":"Int J Cell Biol"},{"key":"1334_CR35","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1158\/0008-5472.CAN-08-4344","volume":"69","author":"A Bommareddy","year":"2009","unstructured":"Bommareddy A, Hahm ER, Xiao D et al (2009) Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res 69:3704\u20133712","journal-title":"Cancer Res"},{"key":"1334_CR36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4161\/auto.5.2.7360","volume":"5","author":"YJ Chen","year":"2009","unstructured":"Chen YJ, Huang WP, Yang YC et al (2009) Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy 5:173\u2013183","journal-title":"Autophagy"},{"key":"1334_CR37","doi-asserted-by":"crossref","first-page":"462658","DOI":"10.1155\/2014\/462658","volume":"2014","author":"G Valente","year":"2014","unstructured":"Valente G, Morani F, Nicotra G et al (2014) Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer. BioMed Res Int 2014:462658","journal-title":"BioMed Res Int"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-016-1334-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-016-1334-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-016-1334-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T06:17:20Z","timestamp":1498371440000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-016-1334-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["1334"],"URL":"https:\/\/doi.org\/10.1007\/s10495-016-1334-2","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}