{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:01:38Z","timestamp":1790434898508,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["GRNT4180006"],"award-info":[{"award-number":["GRNT4180006"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000096","name":"National Center on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["G12MD007597"],"award-info":[{"award-number":["G12MD007597"]}],"id":[{"id":"10.13039\/100000096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s10495-017-1438-3","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T08:09:21Z","timestamp":1513152561000},"page":"79-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["SDF-1 induces TNF-mediated apoptosis in cardiac myocytes"],"prefix":"10.1007","volume":"23","author":[{"given":"Andrew A.","family":"Jarrah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Schwarskopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"LaRocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Dhume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahouria","family":"Hadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Hajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison D.","family":"Schecter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-4587","authenticated-orcid":false,"given":"Sima T.","family":"Tarzami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"1438_CR1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1126\/science.283.5403.845","volume":"283","author":"A Peled","year":"1999","unstructured":"Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L et al (1999) Dependence of human stem cell engraftment and repopulation of NOD\/SCID mice on CXCR4. Science 283:845\u2013848","journal-title":"Science"},{"key":"1438_CR2","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/nm1075","volume":"10","author":"DJ Ceradini","year":"2004","unstructured":"Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10:858\u2013864","journal-title":"Nat Med"},{"key":"1438_CR3","doi-asserted-by":"publisher","first-page":"I186","DOI":"10.1161\/CIRCULATIONAHA.105.001610","volume":"114","author":"S Mieno","year":"2006","unstructured":"Mieno S, Ramlawi B, Boodhwani M, Clements RT, Minamimura K, Maki T, Xu SH, Bianchi C, Li J, Sellke FW (2006) Role of stromal-derived factor-1alpha in the induction of circulating CD34 + CXCR4 + progenitor cells after cardiac surgery. Circulation 114:I186\u2013I192","journal-title":"Circulation"},{"key":"1438_CR4","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.2353\/ajpath.2010.090451","volume":"176","author":"J Chen","year":"2010","unstructured":"Chen J, Chemaly E, Liang L, Kho C, Lee A, Park J, Altman P, Schecter AD, Hajjar RJ, Tarzami ST (2010) Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury. Am J Pathol 176:1705\u20131715","journal-title":"Am J Pathol"},{"key":"1438_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1172\/JCI7954","volume":"105","author":"DY Jo","year":"2000","unstructured":"Jo DY, Rafii S, Hamada T, Moore MA (2000) Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J Clin Invest 105:101\u2013111","journal-title":"J Clin Invest"},{"key":"1438_CR6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/path.1159","volume":"197","author":"S Hughes","year":"2002","unstructured":"Hughes S (2002) Cardiac stem cells. J Pathol 197:468\u2013478","journal-title":"J Pathol"},{"key":"1438_CR7","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1161\/01.CIR.0000147780.30124.CF","volume":"110","author":"JD Abbott","year":"2004","unstructured":"Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ (2004) Stromal cell-derived factor-1\u03b1 plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110:3300\u20133305","journal-title":"Circulation"},{"key":"1438_CR8","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1089\/ten.2006.0013","volume":"13","author":"G Zhang","year":"2007","unstructured":"Zhang G, Nakamura Y, Wang X, Hu Q, Suggs LJ, Zhang J (2007) Controlled release of stromal cell-derived factor-1 alpha in situ increases c-kit + cell homing to the infarcted heart. Tissue Eng 13:2063\u20132071","journal-title":"Tissue Eng"},{"key":"1438_CR9","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.yjmcc.2007.02.001","volume":"42","author":"I Elmadbouh","year":"2007","unstructured":"Elmadbouh I, Haider H, Jiang S, Idris NM, Lu G, Ashraf M (2007) Ex vivo delivered stromal cell-derived factor-1\u03b1 promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium. J Mol Cell Cardiol 42:792\u2013803","journal-title":"J Mol Cell Cardiol"},{"key":"1438_CR10","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1161\/01.CIR.93.4.704","volume":"93","author":"G Torre-Amione","year":"1996","unstructured":"Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB, Mann DL (1996) Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 93:704\u2013711","journal-title":"Circulation"},{"key":"1438_CR11","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/346274a0","volume":"346","author":"JR Gordon","year":"1990","unstructured":"Gordon JR, Galli SJ (1990) Mast cells as a source of both preformed and immunologically inducible TNF-alpha\/cachectin. Nature 346:274\u2013276","journal-title":"Nature"},{"key":"1438_CR12","doi-asserted-by":"publisher","first-page":"R577","DOI":"10.1152\/ajpcell.1998.274.3.C577","volume":"274","author":"DR Meldrum","year":"1998","unstructured":"Meldrum DR (1998) Tumor necrosis factor in the heart. Am J Physiol 274:R577\u2013R595","journal-title":"Am J Physiol"},{"key":"1438_CR13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/phrs.1998.0463","volume":"40","author":"R Ferrari","year":"1999","unstructured":"Ferrari R (1999) The role of TNF in cardiovascular disease. Pharmacol Res 40:97\u2013105","journal-title":"Pharmacol Res"},{"key":"1438_CR14","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0735-1097(99)00600-2","volume":"35","author":"AM Feldman","year":"2000","unstructured":"Feldman AM, Combes A, Wagner D, Kadakomi T, Kubota T, Li YY, McTiernan C (2000) The role of tumor necrosis factor in the pathophysiology of heart failure. J Am Coll Cardiol 35:537\u2013544","journal-title":"J Am Coll Cardiol"},{"key":"1438_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0300-8932(02)76554-8","volume":"55","author":"EHH Garza","year":"2002","unstructured":"Garza EHH, Garza JLH, Gonzalez HR, Trevino AT, Flores MI, Amione GT (2002) Importance of tumor necrosis factor-alpha in the pathogenesis of heart failure. Rev Esp Cardiol 55:61\u201366","journal-title":"Rev Esp Cardiol"},{"key":"1438_CR16","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1161\/01.CIR.97.14.1375","volume":"97","author":"D Bryant","year":"1998","unstructured":"Bryant D, Becker L, Richardson J, Shelton J, Franco F, Peshock R, Thompson M, Giroir B (1998) Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 97:1375\u20131381","journal-title":"Circulation"},{"key":"1438_CR17","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1006\/cyto.1995.0037","volume":"7","author":"Y Seino","year":"1995","unstructured":"Seino Y, Ikeda U, Sekiguchi H, Morita M, Konishi K, Kasahara T, Shimada K (1995) Expression of leukocyte chemotactic cytokines in myocardial tissue. Cytokine 7:301\u2013304","journal-title":"Cytokine"},{"key":"1438_CR18","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/01.RES.81.5.664","volume":"81","author":"T Shioi","year":"1997","unstructured":"Shioi T, Matsumori A, Kihara Y, Inoko M, Ono K, Iwanaga Y, Yamada T, Iwasaki A, Matsushima K, Sasayama S (1997) Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. Circ Res 81:664\u2013671","journal-title":"Circ Res"},{"key":"1438_CR19","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1161\/01.CIR.102.11.1315","volume":"102","author":"TM Behr","year":"2000","unstructured":"Behr TM, Wang X, Aiyar N, Coatney RW, Li X, Koster P, Angermann CE, Ohlstein E, Feuerstein GZ, Winaver J (2000) Monocyte chemoattractant protein-1 is upregulated in rats with volume-overload congestive heart failure. Circulation 102:1315\u20131322","journal-title":"Circulation"},{"key":"1438_CR20","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1161\/01.CIR.0000141560.18364.63","volume":"110","author":"NG Frangogiannis","year":"2004","unstructured":"Frangogiannis NG, Entman ML (2004) Targeting the chemokines in myocardial inflammation. Circulation 110:1341\u20131342","journal-title":"Circulation"},{"key":"1438_CR21","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.ejheart.2005.06.005","volume":"7","author":"FP Limbourg","year":"2005","unstructured":"Limbourg FP, Ringes-Lichtenberg S, Schaefer A, Jacoby C, Mehraein Y, Jager MD, Limbourg A, Fuchs M, Klein G, Ballmaier M et al (2005) Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment. Eur J Heart Fail 7:722\u2013729","journal-title":"Eur J Heart Fail"},{"key":"1438_CR22","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","volume":"114","author":"AP Beltrami","year":"2003","unstructured":"Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K et al (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114:763\u2013776","journal-title":"Cell"},{"key":"1438_CR23","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/86498","volume":"7","author":"AA Kocher","year":"2001","unstructured":"Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S (2001) Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7:430\u2013436","journal-title":"Nat Med"},{"key":"1438_CR24","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1161\/01.CIR.0000095788.78169.AF","volume":"108","author":"MB Britten","year":"2003","unstructured":"Britten MB, Abolmaali ND, Assmus B, Lehmann R, Honold J, Schmitt J, Vogl TJ, Martin H, Schachinger V, Dimmeler S et al (2003) Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation 108:2212\u20132218","journal-title":"Circulation"},{"key":"1438_CR25","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1146\/annurev.pathol.2.010506.092038","volume":"2","author":"MA Laflamme","year":"2007","unstructured":"Laflamme MA, Zbinden S, Epstein SE, Murry CE (2007) Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms. Annu Rev Pathol 2:307\u2013339","journal-title":"Annu Rev Pathol"},{"key":"1438_CR26","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0140-6736(04)15689-4","volume":"363","author":"HJ Kang","year":"2004","unstructured":"Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, Kim YJ, Soo Lee D, Sohn DW, Han KS et al (2004) Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 363:751\u2013756","journal-title":"Lancet"},{"key":"1438_CR27","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/ni813","volume":"3","author":"I Petit","year":"2002","unstructured":"Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, Ponomaryov T, Taichman RS, Arenzana-Seisdedos F, Fujii N et al (2002) G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 3:687\u2013694","journal-title":"Nat Immunol"},{"key":"1438_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/MOH.0b013e3282f29012","volume":"15","author":"HE Broxmeyer","year":"2008","unstructured":"Broxmeyer HE (2008) Chemokines in hematopoiesis. Curr Opin Hematol 15:49\u201358","journal-title":"Curr Opin Hematol"},{"key":"1438_CR29","doi-asserted-by":"publisher","first-page":"9448","DOI":"10.1073\/pnas.95.16.9448","volume":"95","author":"Q Ma","year":"1998","unstructured":"Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA (1998) Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95:9448\u20139453","journal-title":"Proc Natl Acad Sci USA"},{"key":"1438_CR30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/31269","volume":"393","author":"YR Zou","year":"1998","unstructured":"Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595\u2013599","journal-title":"Nature"},{"key":"1438_CR31","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1749-6632.2001.tb03572.x","volume":"938","author":"MA Moore","year":"2001","unstructured":"Moore MA, Hattori K, Heissig B, Shieh JH, Dias S, Crystal RG, Rafii S (2001) Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1. Ann N Y Acad Sci 938:36\u201345 (discussion 45\u201337)","journal-title":"Ann N Y Acad Sci"},{"key":"1438_CR32","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1161\/01.CIR.0000128213.96779.61","volume":"109","author":"K Hiasa","year":"2004","unstructured":"Hiasa K, Ishibashi M, Ohtani K, Inoue S, Zhao Q, Kitamoto S, Sata M, Ichiki T, Takeshita A, Egashira K (2004) Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor\/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization. Circulation 109:2454\u20132461","journal-title":"Circulation"},{"key":"1438_CR33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1089\/aid.2004.20.1063","volume":"20","author":"MZ Khan","year":"2004","unstructured":"Khan MZ, Brandimarti R, Patel JP, Huynh N, Wang J, Huang Z, Fatatis A, Meucci O (2004) Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Res Hum Retroviruses 20:1063\u20131071","journal-title":"AIDS Res Hum Retroviruses"},{"key":"1438_CR34","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1161\/CIRCULATIONAHA.106.672451","volume":"116","author":"X Hu","year":"2007","unstructured":"Hu X, Dai S, Wu WJ, Tan W, Zhu X, Mu J, Guo Y, Bolli R, Rokosh G (2007) Stromal cell derived factor-1 alpha confers protection against myocardial ischemia\/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation 116:654\u2013663","journal-title":"Circulation"},{"issue":"Suppl 1","key":"1438_CR35","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/S0167-5273(04)90007-1","volume":"95","author":"MS Penn","year":"2004","unstructured":"Penn MS, Zhang M, Deglurkar I, Topol EJ (2004) Role of stem cell homing in myocardial regeneration. Int J Cardiol 95(Suppl 1):S23\u2013S25","journal-title":"Int J Cardiol"},{"key":"1438_CR36","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1097\/00002030-200004140-00017","volume":"14","author":"ML Colamussi","year":"2000","unstructured":"Colamussi ML, Secchiero P, Zella D, Curreli S, Mirandola P, Capitani S, Zauli G (2000) Stromal derived factor-1 alpha induces apoptosis in activated primary CD4+ T cells. Aids 14:748\u2013750","journal-title":"Aids"},{"key":"1438_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2008.10.015","volume":"298","author":"A Ilhan","year":"2009","unstructured":"Ilhan A, Nabokikh A, Maj M, Vidakovic M, Nielsen JH, Prikoszovich T, Niederle B, Base W, Luger A, Wagner L (2009) CXCL12\/SDF-1 over-expression in human insulinomas and its biological relevance. Mol Cell Endocrinol 298:1\u201310","journal-title":"Mol Cell Endocrinol"},{"key":"1438_CR38","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1172\/JCI12629","volume":"108","author":"Y Han","year":"2001","unstructured":"Han Y, He T, Huang DR, Pardo CA, Ransohoff RM (2001) TNF-alpha mediates SDF-1 alpha-induced NF-kappa B activation and cytotoxic effects in primary astrocytes. J Clin Invest 108:425\u2013435","journal-title":"J Clin Invest"},{"key":"1438_CR39","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/FJC.0b013e3181f713fe","volume":"56","author":"TJ LaRocca","year":"2010","unstructured":"LaRocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ et al (2010) \u03b22-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. J Cardiovasc Pharmacol 56:548\u2013559","journal-title":"J Cardiovasc Pharmacol"},{"key":"1438_CR40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/pros.21231","volume":"71","author":"C Zhang","year":"2011","unstructured":"Zhang C, Soori M, Miles FL, Sikes RA, Carson DD, Chung LW, Farach-Carson MC (2011) Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells. Prostate 71:157\u2013167","journal-title":"Prostate"},{"key":"1438_CR41","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1021\/cb400800q","volume":"9","author":"ER Sharlow","year":"2014","unstructured":"Sharlow ER, Leimgruber S, Murray S, Lira A, Sciotti RJ, Hickman M, Hudson T, Leed S, Caridha D, Barrios AM et al (2014) Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity. ACS Chem Biol 9:663\u2013672","journal-title":"ACS Chem Biol"},{"key":"1438_CR42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","volume":"464","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104\u2013107","journal-title":"Nature"},{"key":"1438_CR43","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.bbrc.2005.07.168","volume":"335","author":"ST Tarzami","year":"2005","unstructured":"Tarzami ST, Calderon TM, Deguzman A, Lopez L, Kitsis RN, Berman JW (2005) MCP-1\/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a G(alphai)-independent pathway. Biochem Biophys Res Commun 335:1008\u20131016","journal-title":"Biochem Biophys Res Commun"},{"key":"1438_CR44","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/75022","volume":"6","author":"MC Poznansky","year":"2000","unstructured":"Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Scadden DT (2000) Active movement of T cells away from a chemokine. Nat Med 6:543\u2013548","journal-title":"Nat Med"},{"key":"1438_CR45","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S0008-6363(00)00142-5","volume":"47","author":"JK Damas","year":"2000","unstructured":"Damas JK, Eiken HG, Oie E, Bjerkeli V, Yndestad A, Ueland T, Tonnessen T, Geiran OR, Aass H, Simonsen S et al (2000) Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure. Cardiovasc Res 47:778\u2013787","journal-title":"Cardiovasc Res"},{"key":"1438_CR46","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0008-6363(99)00262-X","volume":"45","author":"JK Damas","year":"2000","unstructured":"Damas JK, Gullestad L, Ueland T, Solum NO, Simonsen S, Froland SS, Aukrust P (2000) CXC-chemokines, a new group of cytokines in congestive heart failure\u2014possible role of platelets and monocytes. Cardiovasc Res 45:428\u2013436","journal-title":"Cardiovasc Res"},{"key":"1438_CR47","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s004010100432","volume":"103","author":"JP Rossiter","year":"2002","unstructured":"Rossiter JP, Anderson LL, Yang F, Cole GM (2002) Caspase-3 activation and caspase-like proteolytic activity in human perinatal hypoxic-ischemic brain injury. Acta Neuropathol 103:66\u201373","journal-title":"Acta Neuropathol"},{"key":"1438_CR48","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1073\/pnas.95.9.4997","volume":"95","author":"JM Jurgensmeier","year":"1998","unstructured":"Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95:4997\u20135002","journal-title":"Proc Natl Acad Sci USA"},{"key":"1438_CR49","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1074\/jbc.274.4.2225","volume":"274","author":"DM Finucane","year":"1999","unstructured":"Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR (1999) Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 274:2225\u20132233","journal-title":"J Biol Chem"},{"key":"1438_CR50","doi-asserted-by":"publisher","first-page":"e0134694","DOI":"10.1371\/journal.pone.0134694","volume":"10","author":"P Chen","year":"2015","unstructured":"Chen P, Hu YF, Wang L, Xiao WF, Bao XY, Pan C, Yi HS, Chen XY, Pan MH, Lu C (2015) Mitochondrial apoptotic pathway is activated by H2O2-mediated oxidative stress in BmN-SWU1 cells from Bombyx mori ovary. PLoS ONE 10:e0134694","journal-title":"PLoS ONE"},{"key":"1438_CR51","doi-asserted-by":"publisher","first-page":"34528","DOI":"10.1074\/jbc.M002844200","volume":"275","author":"S Saito","year":"2000","unstructured":"Saito S, Hiroi Y, Zou Y, Aikawa R, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I (2000) Beta-adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J Biol Chem 275:34528\u201334533","journal-title":"J Biol Chem"},{"key":"1438_CR52","doi-asserted-by":"publisher","first-page":"5777","DOI":"10.1038\/ncomms6777","volume":"5","author":"SY Shin","year":"2014","unstructured":"Shin SY, Kim T, Lee HS, Kang JH, Lee JY, Cho KH, Kim DH (2014) The switching role of beta-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes. Nat Commun 5:5777","journal-title":"Nat Commun"},{"key":"1438_CR53","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s00395-002-0364-9","volume":"97","author":"C Steenbergen","year":"2002","unstructured":"Steenbergen C (2002) The role of p38 mitogen-activated protein kinase in myocardial ischemia\/reperfusion injury; relationship to ischemic preconditioning. Basic Res Cardiol 97:276\u2013285","journal-title":"Basic Res Cardiol"},{"key":"1438_CR54","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1161\/CIRCRESAHA.109.213199","volume":"106","author":"JM Streicher","year":"2010","unstructured":"Streicher JM, Ren S, Herschman H, Wang Y (2010) MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. Circ Res 106:1434\u20131443","journal-title":"Circ Res"},{"key":"1438_CR55","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.yjmcc.2010.10.021","volume":"51","author":"MS Marber","year":"2011","unstructured":"Marber MS, Rose B, Wang Y (2011) The p38 mitogen-activated protein kinase pathway\u2014a potential target for intervention in infarction, hypertrophy, and heart failure. J Mol Cell Cardiol 51:485\u2013490","journal-title":"J Mol Cell Cardiol"},{"key":"1438_CR56","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1126\/science.288.5467.870","volume":"288","author":"C Tournier","year":"2000","unstructured":"Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288:870\u2013874","journal-title":"Science"},{"key":"1438_CR57","first-page":"137","volume":"12","author":"M Kunz","year":"2001","unstructured":"Kunz M, Ibrahim S, Koczan D, Thiesen HJ, Kohler HJ, Acker T, Plate KH, Ludwig S, Rapp UR, Brocker EB et al (2001) Activation of c-Jun NH2-terminal kinase\/stress-activated protein kinase (JNK\/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma. Cell Growth Differ 12:137\u2013145","journal-title":"Cell Growth Differ"},{"key":"1438_CR58","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.yjmcc.2006.08.008","volume":"41","author":"RT Pyo","year":"2006","unstructured":"Pyo RT, Sui J, Dhume A, Palomeque J, Blaxall BC, Diaz G, Tunstead J, Logothetis DE, Hajjar RJ, Schecter AD (2006) CXCR4 modulates contractility in adult cardiac myocytes. J Mol Cell Cardiol 41:834\u2013844","journal-title":"J Mol Cell Cardiol"},{"key":"1438_CR59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0014-5793(98)00830-8","volume":"432","author":"P Proost","year":"1998","unstructured":"Proost P, Struyf S, Schols D, Durinx C, Wuyts A, Lenaerts JP, De Clercq E, De Meester I, Van Damme J (1998) Processing by CD26\/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1alpha. FEBS Lett 432:73\u201376","journal-title":"FEBS Lett"},{"key":"1438_CR60","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1161\/01.RES.86.2.131","volume":"86","author":"S Abi-Younes","year":"2000","unstructured":"Abi-Younes S, Sauty A, Mach F, Sukhova GK, Libby P, Luster AD (2000) The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. Circ Res 86:131\u2013138","journal-title":"Circ Res"},{"key":"1438_CR61","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.7314\/APJCP.2014.15.11.4519","volume":"15","author":"J Liu","year":"2014","unstructured":"Liu J, Wu N, Ma LN, Zhong JT, Liu G, Zheng LH, Lin XK (2014) p38 MAPK signaling mediates mitochondrial apoptosis in cancer cells induced by oleanolic acid. Asian Pac J Cancer Prev 15:4519\u20134525","journal-title":"Asian Pac J Cancer Prev"},{"key":"1438_CR62","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1074\/jbc.275.1.322","volume":"275","author":"S Kharbanda","year":"2000","unstructured":"Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T et al (2000) Translocation of SAPK\/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 275:322\u2013327","journal-title":"J Biol Chem"},{"key":"1438_CR63","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.yjmcc.2012.05.016","volume":"53","author":"TJ Larocca","year":"2012","unstructured":"Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST (2012) CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol 53:223\u2013232","journal-title":"J Mol Cell Cardiol"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-017-1438-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-017-1438-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-017-1438-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T14:59:55Z","timestamp":1589727595000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-017-1438-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,13]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["1438"],"URL":"https:\/\/doi.org\/10.1007\/s10495-017-1438-3","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,13]]},"assertion":[{"value":"13 December 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}