{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:44:44Z","timestamp":1789764284972,"version":"4.0.1"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R03 NS084386"],"award-info":[{"award-number":["R03 NS084386"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R03 NS092024"],"award-info":[{"award-number":["R03 NS092024"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2018509S"],"award-info":[{"award-number":["A2018509S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s10495-019-01520-4","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T13:57:41Z","timestamp":1549461461000},"page":"341-358","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects"],"prefix":"10.1007","volume":"24","author":[{"given":"Timothy","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Thant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Joseph A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupkatha","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhasirie","family":"Thuamsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-9397","authenticated-orcid":false,"given":"Shermali","family":"Gunawardena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"issue":"5","key":"1520_CR1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/md14050102","volume":"14","author":"IIJA White","year":"2016","unstructured":"White IIJA, Banerjee R, Gunawardena S (2016) Axonal transport and neurodegenerative disease: how marine drugs can be used a therapeutics. Mar Drugs 14(5):102","journal-title":"Mar Drugs"},{"key":"1520_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1750-1326-7-29","volume":"7","author":"C Fang","year":"2012","unstructured":"Fang C, Bourdette D, Banker G (2012) Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases. Mol Neurodegener 7:29. \n                    https:\/\/doi.org\/10.1186\/1750-1326-7-29","journal-title":"Mol Neurodegener"},{"issue":"9","key":"1520_CR3","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1523\/JNEUROSCI.1503-13.2014","volume":"34","author":"A Almenar-Queralt","year":"2014","unstructured":"Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS (2014) UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci 34(9):3320\u20133339. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.1503-13.2014","journal-title":"J Neurosci"},{"issue":"4","key":"1520_CR4","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/jnc.14230","volume":"144","author":"GJ Iacobucci","year":"2018","unstructured":"Iacobucci GJ, Gunawardena S (2018) Ethanol stimulates the in vivo axonal movement of neuropeptide dense-core vesicles in Drosophila motor neurons. J Neurochem 144(4):466\u2013482.","journal-title":"J Neurochem"},{"key":"1520_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","volume":"40","author":"S Gunawardena","year":"2003","unstructured":"Gunawardena S, Her L, Laymon RA, Brusch RG, Niesman IR, Sintasath L, Bonini NM, Goldstein LSB (2003) Disruption of axonal transport by loss of huntingtin or expression of poly Q protein in Drosophila. Neuron 40:25\u201340","journal-title":"Neuron"},{"key":"1520_CR6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1126\/science.275.5300.661","volume":"275","author":"H Dudek","year":"1997","unstructured":"Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME (1997) Regulation of neuronal survival by the serine-threonine protein kinase AKT. Science 275, 661\u2013665","journal-title":"Science"},{"key":"1520_CR7","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","volume":"129","author":"BD Manning","year":"2007","unstructured":"Manning BD, Cantley LC (2007) AKT\/PKB signaling: navigating downstream. Cell 129:1261\u20131274","journal-title":"Cell"},{"key":"1520_CR8","doi-asserted-by":"publisher","first-page":"a026609","DOI":"10.1101\/cshperspect.a026609","volume":"7","author":"BA Hemmings","year":"2015","unstructured":"Hemmings BA, Restuccia DF (2015) The PI3K-PKB\/Akt pathway. Cold Spring Harb Perspect Biol 7:a026609 \n                    https:\/\/doi.org\/10.1101\/cshperspect.a026609","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"8","key":"1520_CR9","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1523\/JNEUROSCI.18-08-02933.1998","volume":"18","author":"RJ Crowder","year":"1998","unstructured":"Crowder RJ, Freeman RS (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18(8):2933\u20132943","journal-title":"J Neurosci"},{"issue":"44","key":"1520_CR10","doi-asserted-by":"publisher","first-page":"34266","DOI":"10.1074\/jbc.M006160200","volume":"3","author":"RJ Crowder","year":"2000","unstructured":"Crowder RJ, Freeman RS (2000) Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal. J Biol Chem 3(44):34266\u201334271","journal-title":"J Biol Chem"},{"issue":"2","key":"1520_CR11","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.neuropharm.2009.10.009","volume":"58","author":"Y Xia","year":"2010","unstructured":"Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM (2010) Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K\/Akt pathways. Neuropharmacology 58(2):330\u2013336","journal-title":"Neuropharmacology"},{"issue":"Pt 7","key":"1520_CR12","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1242\/jcs.138057","volume":"127","author":"U Maurer","year":"2014","unstructured":"Maurer U, Preiss F, Brauns-Schubert P, Schlicher L, Charvet C (2014) GSK-3\u2014at the crossroads of cell death and survival. J Cell Sci 127(Pt 7):1369\u20131378","journal-title":"J Cell Sci"},{"issue":"6","key":"1520_CR13","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/j.1939-1676.2011.00818.x","volume":"25","author":"EJ Dickey","year":"2011","unstructured":"Dickey EJ, Long SN, Hunt RW (2011) Hypoxic ischemic encephalopathy\u2013what can we learn from humans? J Vet Intern Med 25(6):1231\u20131240. \n                    https:\/\/doi.org\/10.1111\/j.1939-1676.2011.00818.x","journal-title":"J Vet Intern Med"},{"issue":"4","key":"1520_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s12017-008-8052-z","volume":"10","author":"AY Sun","year":"2008","unstructured":"Sun AY, Wang Q, Simonyi A, Sun GY (2008) Botanical phenolics and brain health. Neuromol Med 10(4):259\u2013274. \n                    https:\/\/doi.org\/10.1007\/s12017-008-8052-z","journal-title":"Neuromol Med"},{"issue":"16","key":"1520_CR15","doi-asserted-by":"publisher","first-page":"6643","DOI":"10.1158\/0008-5472","volume":"68","author":"S Kotliarova","year":"2008","unstructured":"Kotliarova S, Pastorino S, Kovell LC, Kotliarov Y, Song H, Zhang W, Bailey R, Maric D, Zenklusen JC, Lee J, Fine HA (2008) Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res 68(16):6643\u20136651. \n                    https:\/\/doi.org\/10.1158\/0008-5472","journal-title":"Cancer Res"},{"key":"1520_CR16","doi-asserted-by":"publisher","first-page":"35660","DOI":"10.1038\/srep35660","volume":"6","author":"L Romorini","year":"2006","unstructured":"Romorini L, Garate X, Neiman G, Luzzani C, Furmento VA, Guberman AS, Sevlever GE, Scassa ME, Miriuka SG (2006) AKT\/GSK3\u03b2 signaling pathway is critically involved in human pluripotent stem cell survival. Sci Rep 6:35660. \n                    https:\/\/doi.org\/10.1038\/srep35660","journal-title":"Sci Rep"},{"issue":"4","key":"1520_CR17","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0301-0082(01)00011-9","volume":"65","author":"CA Grimes","year":"2001","unstructured":"Grimes CA, Jope RS (2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65(4):391\u2013426","journal-title":"Prog Neurobiol"},{"issue":"12","key":"1520_CR18","doi-asserted-by":"publisher","first-page":"7951","DOI":"10.1073\/pnas.122062299","volume":"99","author":"P Watcharasit","year":"2002","unstructured":"Watcharasit P, Bijur GN, Zmijewski JW, Song L, Zmijewska A, Chen X, Johnson GV, Jope RS (2002) Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proc Natl Acad Sci USA 99(12):7951\u20137955","journal-title":"Proc Natl Acad Sci USA"},{"key":"1520_CR19","doi-asserted-by":"crossref","unstructured":"Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE, Thotala D (2012) GSK-3\u03b2: a bifunctional role in cell death pathways Int J Cell Biol 930710","DOI":"10.1155\/2012\/930710"},{"issue":"25","key":"1520_CR20","doi-asserted-by":"publisher","first-page":"7182","DOI":"10.1093\/hmg\/ddv415","volume":"24","author":"IIJA White","year":"2015","unstructured":"White IIJA, Anderson E, Zimmerman K, Zheng K, Rouhani R, Gunawardena S (2015) Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo. Hum Mol Genet 24(25):7182\u20137195","journal-title":"Hum Mol Genet"},{"issue":"24","key":"1520_CR21","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1093\/hmg\/ddn281","volume":"17","author":"D Zala","year":"2008","unstructured":"Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F (2008) Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum Mol Genet 17(24):3837\u20133846","journal-title":"Hum Mol Genet"},{"issue":"50","key":"1520_CR22","doi-asserted-by":"publisher","first-page":"13662","DOI":"10.1523\/JNEUROSCI.4144-08.2008","volume":"28","author":"LS Her","year":"2008","unstructured":"Her LS, Goldstein LS (2008) Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J Neurosci 28(50):13662\u201313672","journal-title":"J Neurosci"},{"key":"1520_CR23","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0896-6273(01)00496-2","volume":"32","author":"S Gunawardena","year":"2001","unstructured":"Gunawardena S, Goldstein LSB (2001) Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32:389\u2013401","journal-title":"Neuron"},{"issue":"11","key":"1520_CR24","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1091\/mbc.10.11.3717","volume":"10","author":"M Martin","year":"1999","unstructured":"Martin M, Iyadurai SJ, Gassman A, Gindhart JG Jr, Hays TS, Saxton WM (1999) Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Mol Biol Cell 10(11):3717\u20133728","journal-title":"Mol Biol Cell"},{"issue":"2","key":"1520_CR25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1083\/jcb.131.2.411","volume":"131","author":"M McGrail","year":"1995","unstructured":"McGrail M, Gepner J, Silvanovich A, Ludmann S, Serr M, Hays TS (1995) Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. J Cell Biol 131(2):411\u2013425","journal-title":"J Cell Biol"},{"issue":"3\u20135","key":"1520_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0736-5748(02)00047-3","volume":"20","author":"EE Rodgers","year":"2002","unstructured":"Rodgers EE, Theibert AB (2002) Functions of PI 3-kinase in development of the nervous system. Int J Dev Neurosci Jun\u2013Aug 20(3\u20135):187\u2013197","journal-title":"Int J Dev Neurosci JunAug"},{"issue":"12","key":"1520_CR27","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","volume":"26","author":"D Heras-Sandoval","year":"2014","unstructured":"Heras-Sandoval D, P\u00e9rez-Rojas JM, Hern\u00e1ndez-Dami\u00e1n J, Pedraza-Chaverri J (2014) The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal 26(12):2694\u20132701. \n                    https:\/\/doi.org\/10.1016\/j.cellsig.2014.08.019","journal-title":"Cell Signal"},{"key":"1520_CR28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0736-5748(02)00047-3","volume":"20","author":"EE Rodgers","year":"2002","unstructured":"Rodgers EE, Theibert AB (2002) Functions of PI 3-kinase in development of the nervous system. Int J Dev Neurosci 20:187\u2013197","journal-title":"Int J Dev Neurosci"},{"issue":"23","key":"1520_CR29","doi-asserted-by":"publisher","first-page":"6584","DOI":"10.1002\/j.1460-2075.1996.tb01049.x","volume":"15","author":"SJ Leevers","year":"1996","unstructured":"Leevers SJ, Weinkove D, MacDougall LK, Hafen E, Waterfield MD (1996) The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J 15(23):6584\u20136594","journal-title":"EMBO J"},{"issue":"35","key":"1520_CR30","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1038\/sj.onc.1203739","volume":"19","author":"SE Scanga","year":"2000","unstructured":"Scanga SE, Ruel L, Binari RC, Snow B, Stambolic V, Bouchard D, Peters M, Calvieri B, Mak TW, Woodgett JR, Manoukian AS (2000) The conserved PI3\u2032K\/PTEN\/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19(35):3971\u20133977","journal-title":"Oncogene"},{"issue":"4","key":"1520_CR31","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nrn1886","volume":"7","author":"MP Mattson","year":"2006","unstructured":"Mattson MP, Magnus T (2006) Ageing and neuronal vulnerability. Nat Rev Neurosci 7(4):278\u2013294","journal-title":"Nat Rev Neurosci"},{"issue":"12","key":"1520_CR32","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/ncb2373","volume":"13","author":"S Wakatsuki","year":"2011","unstructured":"Wakatsuki S, Saitoh F, Araki T (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Bio 13(12):1415\u20131423","journal-title":"Nat Cell Bio"},{"issue":"1","key":"1520_CR33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/hmg\/ddu430","volume":"24","author":"M Cassar","year":"2015","unstructured":"Cassar M, Issa AR, Riemensperger T, Petitgas C, Rival T, Coulom H, Ich\u00e9-Torres M, Han KA, Birman S (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum Mol Genet 24(1):197\u2013212","journal-title":"Hum Mol Genet"},{"issue":"1","key":"1520_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/arch.21094","volume":"83","author":"R Hosamani","year":"2013","unstructured":"Hosamani R, Muralidhara (2013) Acute exposure of Drosophila melanogaster to paraquat causes oxidative stress and mitochondrial dysfunction. Arch Insect Biochem Physiol 83(1):25\u201340","journal-title":"Arch Insect Biochem Physiol"},{"key":"1520_CR35","isbn-type":"print","volume-title":"Herbicides\u2014properties, synthesis and control of weeds","author":"R Lascano","year":"2012","unstructured":"Lascano R, Mu\u00f1oz N, Robert G, Rodriguez M, Melchiorre M, Trippi V, Quero G (2012) Paraquat: an oxidative stress inducer. In: Hasaneen MNAEG (ed.) Herbicides\u2014properties, synthesis and control of weeds. Intech, Rijeka. ISBN 978-953-307-803-8","ISBN":"https:\/\/id.crossref.org\/isbn\/9789533078038"},{"issue":"6","key":"1520_CR36","doi-asserted-by":"publisher","first-page":"e98886","DOI":"10.1371\/journal.pone.0098886","volume":"9","author":"AK Shukla","year":"2014","unstructured":"Shukla AK, Pragya P, Chaouhan HS, Tiwari AK, Patel DK, Abdin MZ et al (2014) Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of parkinson\u2019s disease. PLoS ONE 9(6):e98886","journal-title":"PLoS ONE"},{"key":"1520_CR37","doi-asserted-by":"publisher","first-page":"32626","DOI":"10.1074\/jbc.M404596200","volume":"279","author":"J Peng","year":"2004","unstructured":"Peng J, Mao XO, Stevenson FF, Hsu M, Andersen JK (2004) The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem 279:32626\u201332632","journal-title":"J Biol Chem"},{"issue":"1","key":"1520_CR38","doi-asserted-by":"publisher","first-page":"e30745","DOI":"10.1371\/journal.pone.0030745","volume":"7","author":"J Wills","year":"2012","unstructured":"Wills J, Credle J, Oaks AW, Duka V, Lee J-H, Jones J et al (2012) Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through Inhibition of proteasomal and autophagic pathways. PLoS ONE 7(1):e30745. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0030745","journal-title":"PLoS ONE"},{"issue":"2","key":"1520_CR39","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ab.2011.08.023","volume":"419","author":"TZ Rzezniczak","year":"2011","unstructured":"Rzezniczak TZ, Douglas LA, Watterson JH, Merritt TJ (2011) Paraquat administration in Drosophila for use in metabolic studies of oxidative stress. Anal Biochem 419(2):345\u2013347","journal-title":"Anal Biochem"},{"issue":"5","key":"1520_CR40","doi-asserted-by":"publisher","first-page":"e0178105","DOI":"10.1371\/journal.pone.0178105","volume":"12","author":"PC Liao","year":"2017","unstructured":"Liao PC, Tandarich LC, Hollenbeck PJ (2017) ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila. PLoS ONE 12(5):e0178105","journal-title":"PLoS ONE"},{"issue":"32","key":"1520_CR41","doi-asserted-by":"publisher","first-page":"19929","DOI":"10.1074\/jbc.273.32.19929","volume":"273","author":"M Pap","year":"1998","unstructured":"Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase\/Akt cell survival pathway. J Biol Chem 273(32):19929\u201319932","journal-title":"J Biol Chem"},{"key":"1520_CR42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/bj3030021","volume":"303","author":"DA Cross","year":"1994","unstructured":"Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P (1994) The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 303:21\u201326","journal-title":"Biochem J"},{"issue":"15","key":"1520_CR43","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1158\/0008-5472.CAN-09-0820","volume":"69","author":"M Maurer","year":"2009","unstructured":"Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R (2009) 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res 69(15):6299\u20136306. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-0820","journal-title":"Cancer Res"},{"key":"1520_CR44","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/378785a0","volume":"378","author":"DA Cross","year":"1995","unstructured":"Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785\u2013789. \n                    https:\/\/doi.org\/10.1038\/378785a0","journal-title":"Nature"},{"issue":"10","key":"1520_CR45","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/bies.1134","volume":"23","author":"MJ van Hemert","year":"2001","unstructured":"van Hemert MJ, Steensma HY, van Heusden GP (2001) 14-3-3 proteins: key regulators of cell division, signalling and apoptosis. Bioessays 23(10):936\u2013946","journal-title":"Bioessays"},{"key":"1520_CR46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.semcancer.2006.03.003","volume":"16","author":"GW Porter","year":"2006","unstructured":"Porter GW, Khuri FR, Fu H (2006) Dynamic 14-3-3\/client protein interactions integrate survival and apoptotic pathways. Semin Cancer Biol 16:193\u2013202","journal-title":"Semin Cancer Biol"},{"issue":"22","key":"1520_CR47","doi-asserted-by":"publisher","first-page":"10142","DOI":"10.1073\/pnas.92.22.10142","volume":"92","author":"N Bonnefoy-B\u00e9rard","year":"1995","unstructured":"Bonnefoy-B\u00e9rard N, Liu YC, von Willebrand M, Sung A, Elly C, Mustelin T, Yoshida H, Ishizaka K, Altman A (1995) Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Proc Natl Acad Sci U S A 92(22):10142\u201310146","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1520_CR48","doi-asserted-by":"publisher","first-page":"11663","DOI":"10.1074\/jbc.272.17.11663","volume":"272","author":"A Craparo","year":"1997","unstructured":"Craparo A, Freund R, Gustafson TA (1997) 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J Biol Chem 272:11663\u201311669","journal-title":"J Biol Chem"},{"key":"1520_CR49","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.1128\/MCB.01837-07","volume":"28","author":"A Lonic","year":"2008","unstructured":"Lonic A, Barry EF, Quach C, Kobe B, Saunders N, Guthridge MA (2008) Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Mol Cell Biol 28:3372\u20133385","journal-title":"Mol Cell Biol"},{"key":"1520_CR50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1182\/blood.V96.2.577","volume":"96","author":"AD Munday","year":"2000","unstructured":"Munday AD, Berndt MC, Mitchell CA (2000) Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta. Blood 96:577\u2013584","journal-title":"Blood"},{"key":"1520_CR51","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.febslet.2004.05.068","volume":"569","author":"MP Oksvold","year":"2004","unstructured":"Oksvold MP, Huitfeldt HS, Langdon WY (2004) Identification of 14-3-3zeta as an EGF receptor interacting protein. FEBS Lett 569:207\u2013210","journal-title":"FEBS Lett"},{"key":"1520_CR52","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1750-1326-4-14","volume":"16","author":"K Bhaskar","year":"2009","unstructured":"Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT (2009) The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener 16:4:14","journal-title":"Mol Neurodegener"},{"issue":"27","key":"1520_CR53","doi-asserted-by":"publisher","first-page":"19773","DOI":"10.1074\/jbc.M113.457622","volume":"288","author":"RM Uranga","year":"2013","unstructured":"Uranga RM, Katz S, Salvador GA (2013) Enhanced phosphatidylinositol 3-kinase (PI3K)\/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem 288(27):19773\u201319784","journal-title":"J Biol Chem"},{"key":"1520_CR54","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1007\/s10495-010-0547-z","volume":"15","author":"L Wang","year":"2010","unstructured":"Wang L, Yang HJ, Xia YY et al (2010) Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT\/GSK-3beta\/JNK signaling. Apoptosis 15:1470\u20131479","journal-title":"Apoptosis"},{"key":"1520_CR55","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/j.neurobiolaging.2014.01.021","volume":"35","author":"W Kim","year":"2014","unstructured":"Kim W, Lee Y, McKenna ND et al (2014) miR-126 contributes to parkinson\u2019s disease by dysregulating the insulin-like growth factor\/phosphoinositide 3-kinase signaling. Neurobiol Aging 35:1712\u20131721","journal-title":"Neurobiol Aging"},{"issue":"5","key":"1520_CR56","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1091\/mbc.E08-07-0777","volume":"20","author":"HK Lee","year":"2009","unstructured":"Lee HK, Kumar P, Fu Q, Rosen KM, Querfurth HW (2009) The insulin\/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol Biol Cell 20(5):1533\u20131544. \n                    https:\/\/doi.org\/10.1091\/mbc.E08-07-0777","journal-title":"Mol Biol Cell"},{"key":"1520_CR57","doi-asserted-by":"crossref","unstructured":"Frevert EU, Bj\u00f8rbaek C, Venable CL, Keller SR, Kahn BB (1998) Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes.J Biol Chem. 273(39):25480\u201325487","DOI":"10.1074\/jbc.273.39.25480"},{"issue":"10","key":"1520_CR58","doi-asserted-by":"publisher","first-page":"e267","DOI":"10.1038\/oncsis.2016.65","volume":"5","author":"MR Sheen","year":"2016","unstructured":"Sheen MR, Marotti JD, Allegrezza MJ, Rutkowski M, Conejo-Garcia JR, Fiering S (2016) Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis 5(10):e267. \n                    https:\/\/doi.org\/10.1038\/oncsis.2016.65","journal-title":"Oncogenesis"},{"issue":"36","key":"1520_CR59","doi-asserted-by":"publisher","first-page":"14354","DOI":"10.1073\/pnas.0703175104","volume":"104","author":"C Costa","year":"2007","unstructured":"Costa C, Barberis L, Ambrogio C, Manazza AD, Patrucco E, Azzolino O, Neilsen PO, Ciraolo E, Altruda F, Prestwich GD, Chiarle R, Wymann M, Ridley A, Hirsch E (2007) Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma. Proc Natl Acad Sci USA 104(36):14354\u201314359","journal-title":"Proc Natl Acad Sci USA"},{"key":"1520_CR60","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1038\/ncomms3690","volume":"4","author":"EM Saijilafu. Hur","year":"2013","unstructured":"Saijilafu. Hur EM, Liu CM, Jiao Z, Xu WL, Zhou FQ (2013) PI3K\u2013GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1. Nat Commun 4:2690. \n                    https:\/\/doi.org\/10.1038\/ncomms3690","journal-title":"Nat Commun"},{"key":"1520_CR61","doi-asserted-by":"publisher","first-page":"10417","DOI":"10.1073\/pnas.152161099","volume":"99","author":"JF Morley","year":"2002","unstructured":"Morley JF, Brignull HR, Weyers JJ, Morimoto RI (2002) The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci USA 99:10417\u201310422","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1520_CR62","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3892\/ijmm.2016.2833","volume":"39","author":"N Nakano","year":"2017","unstructured":"Nakano N, Matsuda S, Ichimura M, Minami A, Ogino M, Murai T, Kitagishi Y (2017) PI3K\/AKT signaling mediated by G proteincoupled receptors is involved in neurodegenerative parkinson\u2019s disease. Int J Mol Med 39(2):253\u2013260. \n                    https:\/\/doi.org\/10.3892\/ijmm.2016.2833","journal-title":"Int J Mol Med"},{"issue":"2","key":"1520_CR63","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/(SICI)1098-2280(1999)33:2<144::AID-EM6>3.0.CO;2-V","volume":"33","author":"GN Bijur","year":"1999","unstructured":"Bijur GN, Briggs B, Hitchcock CL, Williams MV (1999) Ascorbic acid-dehydroascorbate induces cell cycle arrest at G2\/M DNA damage checkpoint during oxidative stress. Environ Mol Mutagen 33(2):144\u2013152","journal-title":"Environ Mol Mutagen"},{"key":"1520_CR64","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1046\/j.1471--4159.2001.t01--1--00251.x","volume":"77","author":"DA Cross","year":"2010","unstructured":"Cross DA, Culbert AA, Chalmers KA, Facci L, Skaper SD, Reith AD (2010) Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J Neurochem 77:94\u2013102. \n                    https:\/\/doi.org\/10.1046\/j.1471--4159.2001.t01--1--00251.x","journal-title":"J Neurochem"},{"issue":"5","key":"1520_CR65","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1083\/jcb.200410136","volume":"168","author":"V Cavalli","year":"2005","unstructured":"Cavalli V, Kujala P, Klumperman J, Goldstein LS (2005) Sunday driver links axonal transport to damage signaling. J Cell Biol 168(5):775\u2013787","journal-title":"J Cell Biol"},{"issue":"2","key":"1520_CR66","doi-asserted-by":"publisher","first-page":"e1003303","DOI":"10.1371\/journal.pgen.1003303","volume":"9","author":"CM Drerup","year":"2013","unstructured":"Drerup CM, Nechiporuk AV (2013) JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet 2013;9(2):e1003303. \n                    https:\/\/doi.org\/10.1371\/journal.pgen.1003303","journal-title":"PLoS Genet"},{"issue":"31","key":"1520_CR67","doi-asserted-by":"publisher","first-page":"12764","DOI":"10.1523\/JNEUROSCI.5160-12.2013","volume":"33","author":"S Klinedinst","year":"2013","unstructured":"Klinedinst S, Wang X, Xiong X, Haenfler JM, Collins CA (2013) Independent pathways downstream of the Wnd\/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling. J Neurosci 33(31):12764\u201312778. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.5160-12.2013\n                    \n                  . (2013)","journal-title":"J Neurosci"},{"key":"1520_CR68","first-page":"2151","volume":"44","author":"ML Kuznicki","year":"2010","unstructured":"Kuznicki ML, Gunawardena S (2010) In vivo visualization of synaptic vesicles within Drosophila larval segmental axons. J Vis Exp 44:2151","journal-title":"J Vis Exp"},{"issue":"19","key":"1520_CR69","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1093\/hmg\/ddt237","volume":"22","author":"S Gunawardena","year":"2013","unstructured":"Gunawardena S, Yang G, Goldstein LSB (2013) Presenilin controls kinesin-1 and dynein activity during axonal transport. Hum Mol Genet 22(19):3828\u20133843","journal-title":"Hum Mol Genet"},{"key":"1520_CR70","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1091\/mbc.e11-11-0938","volume":"23","author":"GF Reis","year":"2012","unstructured":"Reis GF, Yang G, Szpankowski L, Weaver C, Shah SB, Robinson JT, Hays TS, Danuser G, Goldstein LS (2012) Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila. Mol Biol Cell 23:1700\u20131714","journal-title":"Mol Biol Cell"},{"key":"1520_CR71","first-page":"2128","volume":"43","author":"S Fye","year":"2010","unstructured":"Fye S, Dolma K, Kang MJ, Gunawardena S (2010) Visualization of larval segmental nerves in 3rd instar Drosophila larval preparations. J Vis Exp 43:2128","journal-title":"J Vis Exp"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-019-01520-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-019-01520-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-019-01520-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T15:00:24Z","timestamp":1589727624000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-019-01520-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":71,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["1520"],"URL":"https:\/\/doi.org\/10.1007\/s10495-019-01520-4","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]},"assertion":[{"value":"6 February 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest or competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}