{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:43:21Z","timestamp":1767858201367,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08-CA151450"],"award-info":[{"award-number":["K08-CA151450"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Comer Children's Hospital Development Board, University of Chicago Medicine"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10495-020-01593-6","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T20:57:12Z","timestamp":1580245032000},"page":"247-260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization"],"prefix":"10.1007","volume":"25","author":[{"given":"Lindsey M.","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Roach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel G.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-4695","authenticated-orcid":false,"given":"James L.","family":"LaBelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"issue":"4","key":"1593_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JF Kerr","year":"1972","unstructured":"Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26(4):239\u2013257","journal-title":"Br J Cancer"},{"issue":"5381","key":"1593_CR2","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","volume":"281","author":"A Ashkenazi","year":"1998","unstructured":"Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281(5381):1305\u20131308","journal-title":"Science"},{"issue":"1","key":"1593_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar PE, Lessene G, Strasser A, Adams JM (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 15(1):49\u201363. https:\/\/doi.org\/10.1038\/nrm3722","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1593_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","volume":"116","author":"NN Danial","year":"2004","unstructured":"Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116(2):205\u2013219","journal-title":"Cell"},{"key":"1593_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fped.2016.00135","volume":"4","author":"LM Ludwig","year":"2016","unstructured":"Ludwig LM, Nassin ML, Hadji A, LaBelle JL (2016) Killing two cells with one stone: pharmacologic BCL-2 family targeting for cancer cell death and immune modulation. Front Pediatr 4:135. https:\/\/doi.org\/10.3389\/fped.2016.00135","journal-title":"Front Pediatr"},{"issue":"4","key":"1593_CR6","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.bbamcr.2010.11.024","volume":"1813","author":"A Shamas-Din","year":"2011","unstructured":"Shamas-Din A, Brahmbhatt H, Leber B, Andrews DW (2011) BH3-only proteins: orchestrators of apoptosis. Biochim Biophys Acta 1813(4):508\u2013520. https:\/\/doi.org\/10.1016\/j.bbamcr.2010.11.024","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"1593_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2004.12.030","volume":"17","author":"L Chen","year":"2005","unstructured":"Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17(3):393\u2013403. https:\/\/doi.org\/10.1016\/j.molcel.2004.12.030","journal-title":"Mol Cell"},{"issue":"10","key":"1593_CR8","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/ncb3236","volume":"17","author":"HC Chen","year":"2015","unstructured":"Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH (2015) An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nat Cell Biol 17(10):1270\u20131281. https:\/\/doi.org\/10.1038\/ncb3236","journal-title":"Nat Cell Biol"},{"issue":"4","key":"1593_CR9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.molcel.2005.02.003","volume":"17","author":"T Kuwana","year":"2005","unstructured":"Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD (2005) BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17(4):525\u2013535. https:\/\/doi.org\/10.1016\/j.molcel.2005.02.003","journal-title":"Mol Cell"},{"issue":"6009","key":"1593_CR10","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1126\/science.1190217","volume":"330","author":"D Ren","year":"2010","unstructured":"Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH (2010) BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 330(6009):1390\u20131393. https:\/\/doi.org\/10.1126\/science.1190217","journal-title":"Science"},{"issue":"5445","key":"1593_CR11","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","volume":"286","author":"P Bouillet","year":"1999","unstructured":"Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286(5445):1735\u20131738","journal-title":"Science"},{"issue":"6874","key":"1593_CR12","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/415922a","volume":"415","author":"P Bouillet","year":"2002","unstructured":"Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H, Pellegrini M, Cory S, Adams JM, Strasser A (2002) BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415(6874):922\u2013926. https:\/\/doi.org\/10.1038\/415922a","journal-title":"Nature"},{"issue":"7","key":"1593_CR13","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1084\/jem.20030411","volume":"198","author":"A Enders","year":"2003","unstructured":"Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A (2003) Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med 198(7):1119\u20131126. https:\/\/doi.org\/10.1084\/jem.20030411","journal-title":"J Exp Med"},{"issue":"6","key":"1593_CR14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.ceb.2010.08.003","volume":"22","author":"JB Hernandez","year":"2010","unstructured":"Hernandez JB, Newton RH, Walsh CM (2010) Life and death in the thymus\u2013cell death signaling during T cell development. Curr Opin Cell Biol 22(6):865\u2013871. https:\/\/doi.org\/10.1016\/j.ceb.2010.08.003","journal-title":"Curr Opin Cell Biol"},{"key":"1593_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/nyas.12045","volume":"1285","author":"TT Renault","year":"2013","unstructured":"Renault TT, Chipuk JE (2013) Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci 1285:59\u201379. https:\/\/doi.org\/10.1111\/nyas.12045","journal-title":"Ann N Y Acad Sci"},{"issue":"27","key":"1593_CR16","doi-asserted-by":"publisher","first-page":"23058","DOI":"10.18632\/oncotarget.5492","volume":"6","author":"RV Sionov","year":"2015","unstructured":"Sionov RV, Vlahopoulos SA, Granot Z (2015) Regulation of Bim in health and disease. Oncotarget 6(27):23058\u201323134. https:\/\/doi.org\/10.18632\/oncotarget.5492","journal-title":"Oncotarget"},{"issue":"3","key":"1593_CR17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nri1568","volume":"5","author":"A Strasser","year":"2005","unstructured":"Strasser A (2005) The role of BH3-only proteins in the immune system. Nat Rev Immunol 5(3):189\u2013200. https:\/\/doi.org\/10.1038\/nri1568","journal-title":"Nat Rev Immunol"},{"key":"1593_CR18","doi-asserted-by":"publisher","first-page":"e1446","DOI":"10.1038\/cddis.2014.409","volume":"5","author":"MJ Herold","year":"2014","unstructured":"Herold MJ, Stuchbery R, Merino D, Willson T, Strasser A, Hildeman D, Bouillet P (2014) Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice. Cell Death Dis 5:e1446. https:\/\/doi.org\/10.1038\/cddis.2014.409","journal-title":"Cell Death Dis"},{"issue":"5","key":"1593_CR19","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.coi.2007.05.005","volume":"19","author":"D Hildeman","year":"2007","unstructured":"Hildeman D, Jorgensen T, Kappler J, Marrack P (2007) Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol 19(5):516\u2013521. https:\/\/doi.org\/10.1016\/j.coi.2007.05.005","journal-title":"Curr Opin Immunol"},{"issue":"8","key":"1593_CR20","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.ejcb.2017.09.002","volume":"96","author":"S Shukla","year":"2017","unstructured":"Shukla S, Saxena S, Singh BK, Kakkar P (2017) BH3-only protein BIM: an emerging target in chemotherapy. Eur J Cell Biol 96(8):728\u2013738. https:\/\/doi.org\/10.1016\/j.ejcb.2017.09.002","journal-title":"Eur J Cell Biol"},{"issue":"5","key":"1593_CR21","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/cdd.2017.30","volume":"24","author":"EM Carrington","year":"2017","unstructured":"Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM (2017) Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo. Cell Death Differ 24(5):878\u2013888. https:\/\/doi.org\/10.1038\/cdd.2017.30","journal-title":"Cell Death Differ"},{"issue":"24","key":"1593_CR22","doi-asserted-by":"publisher","first-page":"5237","DOI":"10.1182\/blood-2010-04-279687","volume":"116","author":"S Biswas","year":"2010","unstructured":"Biswas S, Shi Q, Matise L, Cleveland S, Dave U, Zinkel S (2010) A role for proapoptotic Bax and Bak in T-cell differentiation and transformation. Blood 116(24):5237\u20135246. https:\/\/doi.org\/10.1182\/blood-2010-04-279687","journal-title":"Blood"},{"issue":"6","key":"1593_CR23","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1182\/blood-2013-04-499079","volume":"123","author":"SG Katz","year":"2014","unstructured":"Katz SG, Labelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD (2014) Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood 123(6):884\u2013893. https:\/\/doi.org\/10.1182\/blood-2013-04-499079","journal-title":"Blood"},{"issue":"32","key":"1593_CR24","doi-asserted-by":"publisher","first-page":"11272","DOI":"10.1073\/pnas.0504783102","volume":"102","author":"O Takeuchi","year":"2005","unstructured":"Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci USA 102(32):11272\u201311277. https:\/\/doi.org\/10.1073\/pnas.0504783102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6967","key":"1593_CR25","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nature02067","volume":"426","author":"JT Opferman","year":"2003","unstructured":"Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ (2003) Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426(6967):671\u2013676. https:\/\/doi.org\/10.1038\/nature02067","journal-title":"Nature"},{"issue":"6","key":"1593_CR26","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1182\/blood.V99.6.2146","volume":"99","author":"JL LaBelle","year":"2002","unstructured":"LaBelle JL, Hanke CA, Blazar BR, Truitt RL (2002) Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. Blood 99(6):2146\u20132153","journal-title":"Blood"},{"key":"1593_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0076-6879(08)01623-6","volume":"446","author":"K Pitter","year":"2008","unstructured":"Pitter K, Bernal F, Labelle J, Walensky LD (2008) Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains. Methods Enzymol 446:387\u2013408. https:\/\/doi.org\/10.1016\/S0076-6879(08)01623-6","journal-title":"Methods Enzymol"},{"issue":"9","key":"1593_CR28","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3324\/haematol.2014.104166","volume":"99","author":"K Murase","year":"2014","unstructured":"Murase K, Kim HT, Bascug OR, Kawano Y, Ryan J, Matsuoka K, Davids MS, Koreth J, Ho VT, Cutler C, Armand P, Alyea EP, Blazar BR, Antin JH, Soiffer RJ, Letai A, Ritz J (2014) Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation. Haematologica 99(9):1499\u20131508. https:\/\/doi.org\/10.3324\/haematol.2014.104166","journal-title":"Haematologica"},{"issue":"2","key":"1593_CR29","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ymeth.2013.04.006","volume":"61","author":"J Ryan","year":"2013","unstructured":"Ryan J, Letai A (2013) BH3 profiling in whole cells by fluorimeter or FACS. Methods 61(2):156\u2013164. https:\/\/doi.org\/10.1016\/j.ymeth.2013.04.006","journal-title":"Methods"},{"issue":"8","key":"1593_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.imbio.2007.05.003","volume":"212","author":"J Hutcheson","year":"2007","unstructured":"Hutcheson J, Perlman H (2007) Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes. Immunobiology 212(8):629\u2013636. https:\/\/doi.org\/10.1016\/j.imbio.2007.05.003","journal-title":"Immunobiology"},{"issue":"5","key":"1593_CR31","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1046\/j.1365-3083.2003.01206.x","volume":"57","author":"L Li","year":"2003","unstructured":"Li L, Hsu HC, Grizzle WE, Stockard CR, Ho KJ, Lott P, Yang PA, Zhang HG, Mountz JD (2003) Cellular mechanism of thymic involution. Scand J Immunol 57(5):410\u2013422","journal-title":"Scand J Immunol"},{"issue":"13","key":"1593_CR32","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1084\/jem.20061552","volume":"203","author":"M Erlacher","year":"2006","unstructured":"Erlacher M, Labi V, Manzl C, Bock G, Tzankov A, Hacker G, Michalak E, Strasser A, Villunger A (2006) Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med 203(13):2939\u20132951. https:\/\/doi.org\/10.1084\/jem.20061552","journal-title":"J Exp Med"},{"issue":"1","key":"1593_CR33","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4049\/jimmunol.1001505","volume":"186","author":"CA Chougnet","year":"2011","unstructured":"Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA (2011) A major role for Bim in regulatory T cell homeostasis. J Immunol 186(1):156\u2013163. https:\/\/doi.org\/10.4049\/jimmunol.1001505","journal-title":"J Immunol"},{"key":"1593_CR34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3389\/fimmu.2017.00283","volume":"8","author":"I Harpaz","year":"2017","unstructured":"Harpaz I, Bhattacharya U, Elyahu Y, Strominger I, Monsonego A (2017) Old mice accumulate activated effector CD4 T cells refractory to regulatory T cell-induced immunosuppression. Front Immunol 8:283. https:\/\/doi.org\/10.3389\/fimmu.2017.00283","journal-title":"Front Immunol"},{"issue":"1","key":"1593_CR35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jaut.2011.12.008","volume":"38","author":"D Tischner","year":"2012","unstructured":"Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, Thuille N, Villunger A, Jan Wiegers G (2012) Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice. J Autoimmun 38(1):59\u201369. https:\/\/doi.org\/10.1016\/j.jaut.2011.12.008","journal-title":"J Autoimmun"},{"issue":"11","key":"1593_CR36","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1084\/jem.20070601","volume":"204","author":"TM McCaughtry","year":"2007","unstructured":"McCaughtry TM, Wilken MS, Hogquist KA (2007) Thymic emigration revisited. J Exp Med 204(11):2513\u20132520. https:\/\/doi.org\/10.1084\/jem.20070601","journal-title":"J Exp Med"},{"key":"1593_CR37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fimmu.2014.00013","volume":"5","author":"AJ Yates","year":"2014","unstructured":"Yates AJ (2014) Theories and quantification of thymic selection. Front Immunol 5:13. https:\/\/doi.org\/10.3389\/fimmu.2014.00013","journal-title":"Front Immunol"},{"issue":"Pt 5","key":"1593_CR38","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1242\/jcs.090514","volume":"125","author":"L Happo","year":"2012","unstructured":"Happo L, Strasser A, Cory S (2012) BH3-only proteins in apoptosis at a glance. J Cell Sci 125(Pt 5):1081\u20131087. https:\/\/doi.org\/10.1242\/jcs.090514","journal-title":"J Cell Sci"},{"issue":"5","key":"1593_CR39","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ccr.2006.03.027","volume":"9","author":"M Certo","year":"2006","unstructured":"Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9(5):351\u2013365. https:\/\/doi.org\/10.1016\/j.ccr.2006.03.027","journal-title":"Cancer Cell"},{"issue":"2","key":"1593_CR40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ccr.2007.07.001","volume":"12","author":"J Deng","year":"2007","unstructured":"Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A (2007) BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 12(2):171\u2013185. https:\/\/doi.org\/10.1016\/j.ccr.2007.07.001","journal-title":"Cancer Cell"},{"issue":"10","key":"1593_CR41","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/icb.2017.72","volume":"95","author":"EM Carrington","year":"2017","unstructured":"Carrington EM, Tarlinton DM, Gray DH, Huntington ND, Zhan Y, Lew AM (2017) The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules. Immunol Cell Biol 95(10):870\u2013877. https:\/\/doi.org\/10.1038\/icb.2017.72","journal-title":"Immunol Cell Biol"},{"issue":"3","key":"1593_CR42","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.200905153","volume":"186","author":"D Merino","year":"2009","unstructured":"Merino D, Giam M, Hughes PD, Siggs OM, Heger K, O\u2019Reilly LA, Adams JM, Strasser A, Lee EF, Fairlie WD, Bouillet P (2009) The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol 186(3):355\u2013362. https:\/\/doi.org\/10.1083\/jcb.200905153","journal-title":"J Cell Biol"},{"issue":"7","key":"1593_CR43","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1084\/jem.20070618","volume":"204","author":"S Wojciechowski","year":"2007","unstructured":"Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA (2007) Bim\/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med 204(7):1665\u20131675. https:\/\/doi.org\/10.1084\/jem.20070618","journal-title":"J Exp Med"},{"issue":"3","key":"1593_CR44","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.4049\/jimmunol.181.3.1835","volume":"181","author":"CS Lages","year":"2008","unstructured":"Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C (2008) Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol 181(3):1835\u20131848","journal-title":"J Immunol"},{"issue":"279","key":"1593_CR45","doi-asserted-by":"publisher","first-page":"279ra240","DOI":"10.1126\/scitranslmed.aaa4642","volume":"7","author":"JD Leverson","year":"2015","unstructured":"Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, Belmont LD, Nimmer P, Xiao Y, Ma XM, Lowes KN, Kovar P, Chen J, Jin S, Smith M, Xue J, Zhang H, Oleksijew A, Magoc TJ, Vaidya KS, Albert DH, Tarrant JM, La N, Wang L, Tao ZF, Wendt MD, Sampath D, Rosenberg SH, Tse C, Huang DC, Fairbrother WJ, Elmore SW, Souers AJ (2015) Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. Sci Transl Med 7(279):279ra240. https:\/\/doi.org\/10.1126\/scitranslmed.aaa4642","journal-title":"Sci Transl Med"},{"issue":"38","key":"1593_CR46","doi-asserted-by":"publisher","first-page":"26481","DOI":"10.1074\/jbc.M114.569632","volume":"289","author":"TT Renault","year":"2014","unstructured":"Renault TT, Elkholi R, Bharti A, Chipuk JE (2014) B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro-and anti-apoptotic BCL-2 family proteins. J Biol Chem 289(38):26481\u201326491. https:\/\/doi.org\/10.1074\/jbc.M114.569632","journal-title":"J Biol Chem"},{"key":"1593_CR47","doi-asserted-by":"publisher","first-page":"10538","DOI":"10.1038\/ncomms10538","volume":"7","author":"J Lopez","year":"2016","unstructured":"Lopez J, Bessou M, Riley JS, Giampazolias E, Todt F, Rochegue T, Oberst A, Green DR, Edlich F, Ichim G, Tait SW (2016) Mito-priming as a method to engineer Bcl-2 addiction. Nat Commun 7:10538. https:\/\/doi.org\/10.1038\/ncomms10538","journal-title":"Nat Commun"},{"issue":"3","key":"1593_CR48","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1535-6108(02)00127-7","volume":"2","author":"A Letai","year":"2002","unstructured":"Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2(3):183\u2013192","journal-title":"Cancer Cell"},{"issue":"22","key":"1593_CR49","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.4161\/cc.26696","volume":"12","author":"M Delgado","year":"2013","unstructured":"Delgado M, Tesfaigzi Y (2013) BH3-only proteins, Bmf and Bim, in autophagy. Cell Cycle 12(22):3453\u20133454. https:\/\/doi.org\/10.4161\/cc.26696","journal-title":"Cell Cycle"},{"issue":"3","key":"1593_CR50","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1084\/jem.20071658","volume":"205","author":"V Labi","year":"2008","unstructured":"Labi V, Erlacher M, Kiessling S, Manzl C, Frenzel A, O\u2019Reilly L, Strasser A, Villunger A (2008) Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med 205(3):641\u2013655. https:\/\/doi.org\/10.1084\/jem.20071658","journal-title":"J Exp Med"},{"issue":"17","key":"1593_CR51","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1182\/blood-2013-11-537217","volume":"123","author":"V Labi","year":"2014","unstructured":"Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A (2014) Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf. Blood 123(17):2652\u20132662. https:\/\/doi.org\/10.1182\/blood-2013-11-537217","journal-title":"Blood"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-020-01593-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10495-020-01593-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-020-01593-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:10:28Z","timestamp":1611706228000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10495-020-01593-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":51,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1593"],"URL":"https:\/\/doi.org\/10.1007\/s10495-020-01593-6","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]},"assertion":[{"value":"28 January 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}