{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:47:03Z","timestamp":1766983623087,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600253","81827808","81870178"],"award-info":[{"award-number":["81600253","81827808","81870178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s10495-020-01606-4","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T15:03:48Z","timestamp":1588950228000},"page":"400-411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The function of RNase L and its degradation mechanism in cardiac acute ischemic injury"],"prefix":"10.1007","volume":"25","author":[{"given":"Qiang","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yundai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"1606_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijcard.2017.06.120","volume":"248","author":"M Fedchenko","year":"2017","unstructured":"Fedchenko M, Mandalenakis Z, Rosengren A, Lappas G, Eriksson P, Skoglund K, Dellborg M (2017) Ischemic heart disease in children and young adults with congenital heart disease in Sweden. Int J Cardiol 248:143\u2013148. https:\/\/doi.org\/10.1016\/j.ijcard.2017.06.120","journal-title":"Int J Cardiol"},{"issue":"7","key":"1606_CR2","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.cjca.2016.12.013","volume":"33","author":"GD Lopaschuk","year":"2017","unstructured":"Lopaschuk GD (2017) Metabolic modulators in heart disease: past, present, and future. Can J Cardiol 33(7):838\u2013849. https:\/\/doi.org\/10.1016\/j.cjca.2016.12.013","journal-title":"Can J Cardiol"},{"issue":"6","key":"1606_CR3","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2217\/fca.12.58","volume":"8","author":"KA Webster","year":"2012","unstructured":"Webster KA (2012) Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species. Future Cardiol 8(6):863\u2013884. https:\/\/doi.org\/10.2217\/fca.12.58","journal-title":"Future Cardiol"},{"key":"1606_CR4","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ejphar.2018.06.029","volume":"833","author":"A Jovanovic","year":"2018","unstructured":"Jovanovic A (2018) Cardioprotective signalling: past, present and future. Eur J Pharmacol 833:314\u2013319. https:\/\/doi.org\/10.1016\/j.ejphar.2018.06.029","journal-title":"Eur J Pharmacol"},{"issue":"12 Suppl","key":"1606_CR5","doi-asserted-by":"publisher","first-page":"S423","DOI":"10.1097\/01.CCM.0000191716.38566.E0","volume":"33","author":"PT Schumacker","year":"2005","unstructured":"Schumacker PT (2005) Hypoxia-inducible factor-1 (HIF-1). Crit Care Med 33(12 Suppl):S423\u2013425","journal-title":"Crit Care Med"},{"issue":"11","key":"1606_CR6","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1073\/pnas.1815071116","volume":"116","author":"S Banerjee","year":"2019","unstructured":"Banerjee S, Gusho E, Gaughan C, Dong B, Gu X, Holvey-Bates E, Talukdar M, Li Y, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH (2019) OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug. Proc Natl Acad Sci USA 116(11):5071\u20135076. https:\/\/doi.org\/10.1073\/pnas.1815071116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5\u20136","key":"1606_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cytogfr.2007.06.012","volume":"18","author":"RH Silverman","year":"2007","unstructured":"Silverman RH (2007) A scientific journey through the 2\u20135A\/RNase L system. Cytokine Growth Factor Rev 18(5\u20136):381\u2013388. https:\/\/doi.org\/10.1016\/j.cytogfr.2007.06.012","journal-title":"Cytokine Growth Factor Rev"},{"issue":"8","key":"1606_CR8","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1093\/nar\/gku118","volume":"42","author":"DA Cooper","year":"2014","unstructured":"Cooper DA, Jha BK, Silverman RH, Hesselberth JR, Barton DJ (2014) Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. Nucleic Acids Res 42(8):5202\u20135216. https:\/\/doi.org\/10.1093\/nar\/gku118","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"1606_CR9","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1073\/pnas.1519657113","volume":"113","author":"Y Li","year":"2016","unstructured":"Li Y, Banerjee S, Wang Y, Goldstein SA, Dong B, Gaughan C, Silverman RH, Weiss SR (2016) Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses. Proc Natl Acad Sci USA 113(8):2241\u20132246. https:\/\/doi.org\/10.1073\/pnas.1519657113","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1606_CR10","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1074\/jbc.M305893200","volume":"279","author":"G Li","year":"2004","unstructured":"Li G, Xiang Y, Sabapathy K, Silverman RH (2004) An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase. J Biol Chem 279(2):1123\u20131131. https:\/\/doi.org\/10.1074\/jbc.M305893200","journal-title":"J Biol Chem"},{"issue":"52","key":"1606_CR11","doi-asserted-by":"publisher","first-page":"43651","DOI":"10.1074\/jbc.M112.399964","volume":"287","author":"MA Siddiqui","year":"2012","unstructured":"Siddiqui MA, Malathi K (2012) RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways. J Biol Chem 287(52):43651\u201343664. https:\/\/doi.org\/10.1074\/jbc.M112.399964","journal-title":"J Biol Chem"},{"issue":"21","key":"1606_CR12","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1038\/sj.onc.1210111","volume":"26","author":"JB Andersen","year":"2007","unstructured":"Andersen JB, Li XL, Judge CS, Zhou A, Jha BK, Shelby S, Zhou L, Silverman RH, Hassel BA (2007) Role of 2\u20135A-dependent RNase-L in senescence and longevity. Oncogene 26(21):3081\u20133088. https:\/\/doi.org\/10.1038\/sj.onc.1210111","journal-title":"Oncogene"},{"issue":"7","key":"1606_CR13","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1021\/bi027147i","volume":"42","author":"RH Silverman","year":"2003","unstructured":"Silverman RH (2003) Implications for RNase L in prostate cancer biology. Biochemistry 42(7):1805\u20131812. https:\/\/doi.org\/10.1021\/bi027147i","journal-title":"Biochemistry"},{"issue":"24","key":"1606_CR14","doi-asserted-by":"publisher","first-page":"9144","DOI":"10.1158\/0008-5472.CAN-04-2226","volume":"64","author":"K Malathi","year":"2004","unstructured":"Malathi K, Paranjape JM, Ganapathi R, Silverman RH (2004) HPC1\/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 64(24):9144\u20139151. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-2226","journal-title":"Cancer Res"},{"issue":"5","key":"1606_CR15","doi-asserted-by":"publisher","first-page":"6903","DOI":"10.3892\/mmr.2015.4333","volume":"12","author":"JW Li","year":"2015","unstructured":"Li JW, He SY, Feng ZZ, Zhao L, Jia WK, Liu P, Zhu Y, Jian Z, Xiao YB (2015) MicroRNA-146b inhibition augments hypoxia-induced cardiomyocyte apoptosis. Mol Med Rep 12(5):6903\u20136910. https:\/\/doi.org\/10.3892\/mmr.2015.4333","journal-title":"Mol Med Rep"},{"issue":"21","key":"1606_CR16","doi-asserted-by":"publisher","first-page":"6355","DOI":"10.1093\/emboj\/16.21.6355","volume":"16","author":"A Zhou","year":"1997","unstructured":"Zhou A, Paranjape J, Brown TL, Nie H, Naik S, Dong B, Chang A, Trapp B, Fairchild R, Colmenares C, Silverman RH (1997) Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J 16(21):6355\u20136363. https:\/\/doi.org\/10.1093\/emboj\/16.21.6355","journal-title":"EMBO J"},{"issue":"3","key":"1606_CR17","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.ajpath.2011.11.012","volume":"180","author":"U Tomaru","year":"2012","unstructured":"Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M (2012) Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. Am J Pathol 180(3):963\u2013972. https:\/\/doi.org\/10.1016\/j.ajpath.2011.11.012","journal-title":"Am J Pathol"},{"key":"1606_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.neulet.2014.12.045","volume":"588","author":"L Wang","year":"2015","unstructured":"Wang L, Wang W, Zhang L, Dai P, Wang K, Hui H, Rao W, Peng C, Yang J, Yan Z, Fei Z (2015) Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production. Neurosci Lett 588:147\u2013153. https:\/\/doi.org\/10.1016\/j.neulet.2014.12.045","journal-title":"Neurosci Lett"},{"key":"1606_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.mce.2016.02.008","volume":"426","author":"W Wang","year":"2016","unstructured":"Wang W, Wang WH, Azadzoi KM, Dai P, Wang Q, Sun JB, Zhang WT, Shu Y, Yang JH, Yan Z (2016) Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells. Mol Cell Endocrinol 426:91\u2013100. https:\/\/doi.org\/10.1016\/j.mce.2016.02.008","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"1606_CR20","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.cell.2012.03.036","volume":"149","author":"V Tarallo","year":"2012","unstructured":"Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Nunez G, Baffi JZ, Kleinman ME, Ambati J (2012) DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 149(4):847\u2013859. https:\/\/doi.org\/10.1016\/j.cell.2012.03.036","journal-title":"Cell"},{"issue":"21","key":"1606_CR21","doi-asserted-by":"publisher","first-page":"4464","DOI":"10.1111\/j.1742-4658.2010.07833.x","volume":"277","author":"A Sato","year":"2010","unstructured":"Sato A, Naito T, Hiramoto A, Goda K, Omi T, Kitade Y, Sasaki T, Matsuda A, Fukushima M, Wataya Y, Kim HS (2010) Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line. FEBS J 277(21):4464\u20134473. https:\/\/doi.org\/10.1111\/j.1742-4658.2010.07833.x","journal-title":"FEBS J"},{"issue":"5","key":"1606_CR22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s10495-006-5541-0","volume":"11","author":"E Domingo-Gil","year":"2006","unstructured":"Domingo-Gil E, Esteban M (2006) Role of mitochondria in apoptosis induced by the 2\u20135A system and mechanisms involved. Apoptosis 11(5):725\u2013738. https:\/\/doi.org\/10.1007\/s10495-006-5541-0","journal-title":"Apoptosis"},{"key":"1606_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010074","author":"HJ Ezelle","year":"2016","unstructured":"Ezelle HJ, Malathi K, Hassel BA (2016) The roles of RNase-L in antimicrobial immunity and the cytoskeleton-associated innate response. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms17010074","journal-title":"Int J Mol Sci"},{"issue":"11","key":"1606_CR24","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","volume":"120","author":"JM Bravo-San Pedro","year":"2017","unstructured":"Bravo-San Pedro JM, Kroemer G, Galluzzi L (2017) Autophagy and mitophagy in cardiovascular disease. Circ Res 120(11):1812\u20131824. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311082","journal-title":"Circ Res"},{"issue":"2","key":"1606_CR25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/cvr\/cvu146","volume":"103","author":"M Luedde","year":"2014","unstructured":"Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lullmann-Rauch R, Adam D, Flogel U, Heikenwalder M, Luedde T, Frey N (2014) RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. Cardiovasc Res 103(2):206\u2013216. https:\/\/doi.org\/10.1093\/cvr\/cvu146","journal-title":"Cardiovasc Res"},{"key":"1606_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","volume":"72","author":"RS Whelan","year":"2010","unstructured":"Whelan RS, Kaplinskiy V, Kitsis RN (2010) Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol 72:19\u201344. https:\/\/doi.org\/10.1146\/annurev.physiol.010908.163111","journal-title":"Annu Rev Physiol"},{"issue":"2","key":"1606_CR27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1096\/fj.01-0629com","volume":"16","author":"C Gill","year":"2002","unstructured":"Gill C, Mestril R, Samali A (2002) Losing heart: the role of apoptosis in heart disease: a novel therapeutic target? FASEB J 16(2):135\u2013146. https:\/\/doi.org\/10.1096\/fj.01-0629com","journal-title":"FASEB J"},{"issue":"4","key":"1606_CR28","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/stem.2777","volume":"36","author":"Q Ma","year":"2018","unstructured":"Ma Q, Yang J, Huang X, Guo W, Li S, Zhou H, Li J, Cao F, Chen Y (2018) Poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) nanoparticles loaded with melatonin protect adipose-derived stem cells transplanted in infarcted heart tissue. Stem Cells 36(4):540\u2013550. https:\/\/doi.org\/10.1002\/stem.2777","journal-title":"Stem Cells"},{"key":"1606_CR29","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008024","author":"X Wang","year":"2018","unstructured":"Wang X, Guo Z, Ding Z, Mehta JL (2018) Inflammation, autophagy, and apoptosis after myocardial infarction. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.117.008024","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"1606_CR30","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1084\/jem.186.6.967","volume":"186","author":"JC Castelli","year":"1997","unstructured":"Castelli JC, Hassel BA, Wood KA, Li XL, Amemiya K, Dalakas MC, Torrence PF, Youle RJ (1997) A study of the interferon antiviral mechanism: apoptosis activation by the 2\u20135A system. J Exp Med 186(6):967\u2013972","journal-title":"J Exp Med"},{"issue":"2","key":"1606_CR31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11626-010-9368-1","volume":"47","author":"SJ Watkins","year":"2011","unstructured":"Watkins SJ, Borthwick GM, Arthur HM (2011) The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro. Vitro Cell Dev Biol Anim 47(2):125\u2013131. https:\/\/doi.org\/10.1007\/s11626-010-9368-1","journal-title":"Vitro Cell Dev Biol Anim"},{"issue":"3","key":"1606_CR32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.vascn.2007.06.001","volume":"56","author":"BN Zordoky","year":"2007","unstructured":"Zordoky BN, El-Kadi AO (2007) H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart. J Pharmacol Toxicol Methods 56(3):317\u2013322. https:\/\/doi.org\/10.1016\/j.vascn.2007.06.001","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"20","key":"1606_CR33","doi-asserted-by":"publisher","first-page":"11311","DOI":"10.1128\/JVI.00270-12","volume":"86","author":"A Chakrabarti","year":"2012","unstructured":"Chakrabarti A, Ghosh PK, Banerjee S, Gaughan C, Silverman RH (2012) RNase L triggers autophagy in response to viral infections. J Virol 86(20):11311\u201311321. https:\/\/doi.org\/10.1128\/JVI.00270-12","journal-title":"J Virol"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-020-01606-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-020-01606-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-020-01606-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T01:45:21Z","timestamp":1620438321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-020-01606-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,8]]},"references-count":33,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1606"],"URL":"https:\/\/doi.org\/10.1007\/s10495-020-01606-4","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"type":"print","value":"1360-8185"},{"type":"electronic","value":"1573-675X"}],"subject":[],"published":{"date-parts":[[2020,5,8]]},"assertion":[{"value":"8 May 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the procedures were in accordance with the Guide for the Care and Use of Laboratory Animals Published by the US National Institutes of Health (NIH Publication, 8th Edition, 2011) and were approved by the Ethics Committee of the Chinese People\u2019s Liberation Army General Hospital, Beijing, China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}