{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:29Z","timestamp":1792782929876,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"9-10","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072226"],"award-info":[{"award-number":["82072226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z201100005520049"],"award-info":[{"award-number":["Z201100005520049"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tibet Natural Science Foundation","award":["XZ2019ZR-ZY12(Z)"],"award-info":[{"award-number":["XZ2019ZR-ZY12(Z)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Endoplasmic reticulum stress (ERS) has been well documented to participate in the pathophysiological processes of apoptosis in many diseases. Inhibition of ERS ameliorates pathological organ injury. However, the upstream signaling pathways and molecular regulatory mechanisms of which are still unknown. mTOR, an evolutionarily conserved protein kinase, is a key regulator of apoptosis. Hence, in this study, a classical cecal ligation and puncture (CLP) sepsis model was constructed by using the T cell-specific knockout\n                    <jats:italic>mTOR<\/jats:italic>\n                    and\n                    <jats:italic>TSC1<\/jats:italic>\n                    (Tuberous Sclerosis Complex, the inhibitor of mTOR signaling pathway) mice to explore the underlying signaling pathway and molecular mechanism of host immune imbalance caused by apoptosis in sepsis. We found that mTOR may modulate septic T cell apoptosis by regulating Akt\u2013IRE1\u2013JNK pathway. To further clarify the possible mechanism, the specific inhibitors of PI3K-Akt and IRE1\u2013JNK were used to intervene in mice before\/after CLP, respectively. By analyzing the proteins of mTOR-ERS signaling pathway and the expression of apoptosis-related proteins and genes, we found that mTOR mediated the ER stress induced CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell apoptosis in Septic mice by negatively regulating the Akt\u2013IRE1\u2013JNK-Caspase 3 signaling cascades. These results indicate that mTOR\u2013Akt\u2013IRE1\u03b1\u2013JNK signaling pathway mediated the Endoplasmic reticulum stress induced CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell apoptosis in Septic mice.\n                  <\/jats:p>","DOI":"10.1007\/s10495-022-01740-1","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T05:03:11Z","timestamp":1656306191000},"page":"740-750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in septic mice"],"prefix":"10.1007","volume":"27","author":[{"given":"Guangxu","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"issue":"12","key":"1740_CR1","doi-asserted-by":"publisher","first-page":"e422","DOI":"10.1016\/S1473-3099(19)30567-5","volume":"19","author":"I Rubio","year":"2019","unstructured":"Rubio I, Osuchowski MF, Shankar-Hari M et al (2019) Current gaps in sepsis immunology: new opportunities for translational research. Lancet Infect Dis 19(12):e422\u2013e436","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"1740_CR2","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/SHK.0000000000000234","volume":"42","author":"AM Drewry","year":"2014","unstructured":"Drewry AM, Samra N, Skrupky LP et al (2014) Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock 42(5):383\u2013391","journal-title":"Shock"},{"issue":"2","key":"1740_CR3","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1056\/NEJMra021333","volume":"348","author":"RS Hotchkiss","year":"2003","unstructured":"Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Eng J Med 348(2):138\u2013150","journal-title":"N Eng J Med"},{"key":"1740_CR4","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nri3552","volume":"13","author":"RS Hotchkiss","year":"2013","unstructured":"Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862\u2013874","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"1740_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000135631","volume":"41","author":"T Ma","year":"2008","unstructured":"Ma T, Han L, Gao Y et al (2008) The Endoplasmic reticulum stress-mediated apoptosis signal pathway is involved in sepsis-induced abnormal lymphocyte apoptosis. Eur Surg Res 41(2):219\u2013225","journal-title":"Eur Surg Res"},{"key":"1740_CR6","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1096\/fj.06-6805com","volume":"21","author":"KC Chang","year":"2007","unstructured":"Chang KC, Unsinger J, Davis CG et al (2007) Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J 21:708\u2013719","journal-title":"FASEB J"},{"issue":"10","key":"1740_CR7","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1016\/j.bbadis.2017.02.015","volume":"1863","author":"SE Thiessen","year":"2017","unstructured":"Thiessen SE, Van den Berghe G, Vanhorebeek I (2017) Mitochondrial and endoplasmic reticulum dysfunction and related defense mechanisms in critical illness-induced multiple organ failure. Biochim Biophys Acta Mol Basis Dis 1863(10):2534\u20132545","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1740_CR8","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/srep01142","volume":"3","author":"HJ Kim","year":"2013","unstructured":"Kim HJ, Jeong JS, Kim SR et al (2013) Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-kappa B\/HIF-1 alpha signaling pathway. Sci Rep 3:1142","journal-title":"Sci Rep"},{"key":"1740_CR9","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013169","volume":"5","author":"BM Gardner","year":"2013","unstructured":"Gardner BM, Pincus D, Gotthardt K et al (2013) Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol 5:a013169","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1740_CR10","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","volume":"1833","author":"R Sano","year":"2013","unstructured":"Sano R, Reed JC (2013) ER stress-induced cell death mechanisms. Biochim Biophys Acta 1833:3460\u20133470","journal-title":"Biochim Biophys Acta"},{"key":"1740_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","volume":"40","author":"D Senft","year":"2015","unstructured":"Senft D, Ronai ZA (2015) UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci 40:141\u2013148","journal-title":"Trends Biochem Sci"},{"key":"1740_CR12","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.joca.2014.04.025","volume":"22","author":"Y Uehara","year":"2014","unstructured":"Uehara Y, Hirose J, Yamabe S et al (2014) Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C\/EBP homologous protein. Osteoarthr Cartil 22:1007\u20131017","journal-title":"Osteoarthr Cartil"},{"key":"1740_CR13","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1161\/CIRCRESAHA.110.227819","volume":"107","author":"T Minamino","year":"2010","unstructured":"Minamino T, Komuro I, Kitakaze M (2010) Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ Res 107:1071\u20131082","journal-title":"Circ Res"},{"key":"1740_CR14","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nrd2755","volume":"7","author":"I Kim","year":"2008","unstructured":"Kim I, Xu W, Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7:1013\u20131030","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"1740_CR15","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM (2017) mTOR signaling in growth, metabolism, and disease. Cell 168(6):960\u2013976","journal-title":"Cell"},{"issue":"1","key":"1740_CR16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Bio 12(1):21\u201335","journal-title":"Nat Rev Mol Cell Bio"},{"issue":"2","key":"1740_CR17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/cdd.2011.98","volume":"19","author":"H Kato","year":"2012","unstructured":"Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, Kitamura M (2012) mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell Death Differ 19(2):310\u2013320","journal-title":"Cell Death Differ"},{"key":"1740_CR18","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.molcel.2007.12.023","volume":"29","author":"U Ozcan","year":"2008","unstructured":"Ozcan U, Ozcan L, Yilmaz E et al (2008) Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell 29:541\u2013551","journal-title":"Mol Cell"},{"key":"1740_CR19","doi-asserted-by":"publisher","first-page":"16035","DOI":"10.1038\/nrdp.2016.35","volume":"2","author":"E Henske","year":"2016","unstructured":"Henske E, J\u00f3\u017awiak S, Kingswood J et al (2016) Tuberous sclerosis complex. Nat Rev Dis Prim 2:16035","journal-title":"Nat Rev Dis Prim"},{"issue":"1","key":"1740_CR20","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1080\/21505594.2019.1685151","volume":"10","author":"H Wang","year":"2019","unstructured":"Wang H, Bai G, Cui N, Han W, Long Y (2019) T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis. Virulence 10(1):892\u2013901","journal-title":"Virulence"},{"issue":"1","key":"1740_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nprot.2008.214","volume":"4","author":"D Rittirsch","year":"2009","unstructured":"Rittirsch D, Huber-Lang MS, Flierl MA et al (2009) Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 4(1):31\u201336","journal-title":"Nat Protoc"},{"key":"1740_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4798209","author":"W Han","year":"2018","unstructured":"Han W, Wang H, Su L, Long Y, Cui N, Liu D (2018) Inhibition of the mTOR pathway exerts cardioprotective effects partly through autophagy in CLP rats. Mediat Inflamm. https:\/\/doi.org\/10.1155\/2018\/4798209","journal-title":"Mediat Inflamm"},{"key":"1740_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106049","volume":"78","author":"H Chen","year":"2020","unstructured":"Chen H, Han H, Li Y et al (2020) Hydrogen alleviated organ injury and dysfunction in sepsis: the role of cross-talk between autophagy and endoplasmic reticulum stress: experimental research. Int Immunopharmacol 78:106049","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"1740_CR24","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1093\/infdis\/jit036","volume":"207","author":"M Gao","year":"2013","unstructured":"Gao M, Ha T, Zhang X et al (2013) The Toll-like receptor 9 ligand, CpG Oligodeoxynucleotide, attenuates cardiac dysfunction in polymicrobial sepsis, involving activation of both Phosphoinositide 3 Kinase\/Akt and extracellular-signal-related kinase signaling. J Infect Dis 207(9):1471\u20131479","journal-title":"J Infect Dis"},{"key":"1740_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/591572","volume":"2015","author":"G Pizzino","year":"2015","unstructured":"Pizzino G, Bitto A, Pallio G et al (2015) Blockade of the JNK signalling as a rational therapeutic approach to modulate the early and late steps of the inflammatory cascade in polymicrobial sepsis. Mediat Inflamm 2015:1\u20137","journal-title":"Mediat Inflamm"},{"issue":"3","key":"1740_CR26","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/mutage\/ges080","volume":"28","author":"A Gupta","year":"2013","unstructured":"Gupta A, Hunt CR, Pandita RK et al (2013) T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice. Mutagenesis 28(3):263\u2013270","journal-title":"Mutagenesis"},{"issue":"27","key":"1740_CR27","doi-asserted-by":"publisher","first-page":"23058","DOI":"10.18632\/oncotarget.5492","volume":"6","author":"RV Sionov","year":"2015","unstructured":"Sionov RV, Vlahopoulos SA, Granot Z (2015) Regulation of bim in health and disease. Oncotarget 6(27):23058\u201323134","journal-title":"Oncotarget"},{"issue":"8","key":"1740_CR28","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315(8):801","journal-title":"JAMA"},{"issue":"7","key":"1740_CR29","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1097\/00003246-199907000-00002","volume":"27","author":"RS Hotchkiss","year":"2009","unstructured":"Hotchkiss RS, Swanson PE, Freeman BD et al (2009) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27(7):1230\u20131251","journal-title":"Crit Care Med"},{"key":"1740_CR30","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.phrs.2016.07.019","volume":"111","author":"NK Patil","year":"2016","unstructured":"Patil NK, Bohannon JK, Sherwood ER (2016) Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression. Pharmacol Res 111:688\u2013702","journal-title":"Pharmacol Res"},{"key":"1740_CR31","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/sj.cdd.4401817","volume":"13","author":"M Boyce","year":"2006","unstructured":"Boyce M, Yuan J (2006) Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 13:363\u2013373","journal-title":"Cell Death Differ"},{"key":"1740_CR32","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/sj.embor.7400779","volume":"7","author":"E Szegezdi","year":"2006","unstructured":"Szegezdi E, Logue SE, Gorman AM, Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7:880\u2013885","journal-title":"EMBO Rep"},{"issue":"1","key":"1740_CR33","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.fob.2014.07.006","volume":"4","author":"O Kapuy","year":"2014","unstructured":"Kapuy O, Vinod PK, B\u00e1nhegyi G (2014) mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress\u2014an experimental and modeling study. FEBS Open Bio 4(1):704\u2013713","journal-title":"FEBS Open Bio"},{"issue":"1","key":"1740_CR34","doi-asserted-by":"publisher","first-page":"16497","DOI":"10.1038\/s41598-017-16662-1","volume":"7","author":"M Sanchez-Alvarez","year":"2017","unstructured":"Sanchez-Alvarez M, Del Pozo MA, Bakal C (2017) AKT-mTOR signaling modulates the dynamics of IRE1 RNAse activity by regulating ER-mitochondria contacts. Sci Rep-UK 7(1):16497","journal-title":"Sci Rep-UK"},{"key":"1740_CR35","doi-asserted-by":"publisher","first-page":"695041","DOI":"10.3389\/fcell.2021.695041","volume":"9","author":"Z Li","year":"2021","unstructured":"Li Z, Huang Z, Zhang H et al (2021) IRE1-mTOR-PERK axis coordinates autophagy and ER stress-apoptosis induced by P2X7-mediated Ca2+ influx in osteoarthritis. Front Cell Dev Biol 9:695041","journal-title":"Front Cell Dev Biol"},{"issue":"6108","key":"1740_CR36","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.1226191","volume":"338","author":"JP Upton","year":"2012","unstructured":"Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L et al (2012) IRE1 cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science 338(6108):818\u2013822","journal-title":"Science"},{"issue":"3","key":"1740_CR37","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","volume":"138","author":"D Han","year":"2009","unstructured":"Han D, Lerner AG, Vande Walle L, Upton J, Xu W, Hagen A et al (2009) IRE1\u03b1 kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138(3):562\u2013575","journal-title":"Cell"},{"key":"1740_CR38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mce.2015.02.016","volume":"406","author":"B Zhang","year":"2015","unstructured":"Zhang B, Liu Y, Zhang JS et al (2015) Cortistatin protects myocardium from endoplasmic reticulum stress induced apoptosis during sepsis. Mol Cell Endocrinol 406:40\u201348","journal-title":"Mol Cell Endocrinol"},{"key":"1740_CR39","doi-asserted-by":"publisher","first-page":"3936","DOI":"10.1074\/jbc.M114.594028","volume":"290","author":"S Ghosh","year":"2015","unstructured":"Ghosh S, Adhikary A, Chakraborty S et al (2015) Cross-talk between endoplasmic reticulum (ER) stress and the MEK\/ERK pathway potentiates apoptosis in human triple negative breast carcinoma cells: role of a dihydropyrimidone, nifetepimine. J Biol Chem 290:3936\u20133949","journal-title":"J Biol Chem"},{"issue":"1","key":"1740_CR40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/SHK.0000000000000367","volume":"44","author":"J Zhang","year":"2015","unstructured":"Zhang J, Xie X, Pan H et al (2015) Role of endoplasmic reticulum stress in brain damage after cardiopulmonary resuscitation in rats. Shock 44(1):65\u201371","journal-title":"Shock"},{"key":"1740_CR41","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1111\/ajt.12711","volume":"14","author":"J Rao","year":"2014","unstructured":"Rao J, Yue S, Fu Y et al (2014) ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am J Transplant 14:1552\u20131561","journal-title":"Am J Transplant"},{"issue":"1","key":"1740_CR42","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/SHK.0000000000000373","volume":"44","author":"F Xiu","year":"2015","unstructured":"Xiu F, Catapano M, Diao L et al (2015) Prolonged ER stressed-hepatocytes drives an alternative macrophage polarization. Shock 44(1):44\u201351","journal-title":"Shock"},{"issue":"8","key":"1740_CR43","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1158\/2326-6066.CIR-17-0081","volume":"5","author":"JE Thaxton","year":"2017","unstructured":"Thaxton JE, Wallace C, Riesenberg B et al (2017) Modulation of endoplasmic reticulum stress controls CD4(+) T-cell activation and antitumor function. Cancer Immunol Res 5(8):666\u2013675","journal-title":"Cancer Immunol Res"},{"issue":"2","key":"1740_CR44","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1189\/jlb.6A0214-097R","volume":"97","author":"WS Lee","year":"2015","unstructured":"Lee WS, Sung MS, Lee EG et al (2015) A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78\/BiP in T lymphocyte systemic lupus erythematosus. J Leukoc Biol 97(2):425\u2013433","journal-title":"J Leukoc Biol"},{"issue":"5","key":"1740_CR45","first-page":"964","volume":"13","author":"L Lei","year":"2020","unstructured":"Lei L, Xin P, Lichun G et al (2020) Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway. Int J Clin Exp Pathol 13(5):964\u2013971","journal-title":"Int J Clin Exp Pathol"},{"key":"1740_CR46","doi-asserted-by":"publisher","first-page":"653601","DOI":"10.3389\/fphys.2021.653601","volume":"12","author":"Y Chen","year":"2021","unstructured":"Chen Y, Teng X, Hu Z et al (2021) hydrogen sulfide attenuated sepsis-induced myocardial dysfunction through TLR4 pathway and endoplasmic reticulum stress. Front Physiol 12:653601","journal-title":"Front Physiol"},{"key":"1740_CR47","first-page":"1","volume":"2018","author":"X Chen","year":"2018","unstructured":"Chen X, Wang Y, Xie X et al (2018) Heme oxygenase-1 reduces sepsis-induced endoplasmic reticulum stress and acute lung injury. Mediat Inflamm 2018:1\u201310","journal-title":"Mediat Inflamm"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-022-01740-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-022-01740-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-022-01740-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T03:03:20Z","timestamp":1663470200000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-022-01740-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":47,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["1740"],"URL":"https:\/\/doi.org\/10.1007\/s10495-022-01740-1","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,27]]},"assertion":[{"value":"25 May 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal study was reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) of Peking Union Medical College Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}