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All animal use in this study followed the guidelines of the Peking University Animal Care and Use Committee. Ethics approval was obtained from the Biomedical Ethics Committee of Peking University (No.LA2022421).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}