{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:20:34Z","timestamp":1776090034412,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9-10","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82002777"],"award-info":[{"award-number":["82002777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University","award":["YG2019QNA26"],"award-info":[{"award-number":["YG2019QNA26"]}]},{"name":"Shanghai Sailing Program","award":["22YF1424500"],"award-info":[{"award-number":["22YF1424500"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s10495-023-01866-w","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T05:01:32Z","timestamp":1687842092000},"page":"1484-1495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Neutrophil extracellular traps mediate TLR9\/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression"],"prefix":"10.1007","volume":"28","author":[{"given":"Linli","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"issue":"20","key":"1866_CR1","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1056\/NEJMra1001389","volume":"363","author":"WD Foulkes","year":"2010","unstructured":"Foulkes WD, Smith IE, Reis-Filho JS (2010) Triple-negative breast cancer. N Engl J Med 363(20):1938\u20131948","journal-title":"N Engl J Med"},{"key":"1866_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ctrv.2017.10.014","volume":"62","author":"C Wang","year":"2018","unstructured":"Wang C et al (2018) Triple negative breast cancer in Asia: an insider\u2019s view. Cancer Treat Rev 62:29\u201338","journal-title":"Cancer Treat Rev"},{"issue":"6409","key":"1866_CR3","doi-asserted-by":"publisher","first-page":"eaa04227","DOI":"10.1126\/science.aao4227","volume":"361","author":"J Albrengues","year":"2018","unstructured":"Albrengues J et al (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361(6409):eaa04227","journal-title":"Science"},{"issue":"4","key":"1866_CR4","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1245\/s10434-015-4934-0","volume":"23","author":"Y Asano","year":"2016","unstructured":"Asano Y et al (2016) Predictive value of neutrophil\/lymphocyte ratio for efficacy of preoperative chemotherapy in triple-negative breast cancer. Ann Surg Oncol 23(4):1104\u20131110","journal-title":"Ann Surg Oncol"},{"issue":"5663","key":"1866_CR5","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V et al (2004) Neutrophil extracellular traps kill bacteria. Science 303(5663):1532\u20131535","journal-title":"Science"},{"issue":"361","key":"1866_CR6","doi-asserted-by":"publisher","first-page":"361ra38","DOI":"10.1126\/scitranslmed.aag1711","volume":"8","author":"J Park","year":"2016","unstructured":"Park J et al (2016) Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med 8(361):361ra38","journal-title":"Sci Transl Med"},{"key":"1866_CR7","doi-asserted-by":"publisher","first-page":"4891","DOI":"10.2147\/CMAR.S180695","volume":"10","author":"K Ren","year":"2018","unstructured":"Ren K et al (2018) Prognostic role of derived neutrophil-to-lymphocyte ratio in surgical triple-negative breast cancer. Cancer Manag Res 10:4891\u20134898","journal-title":"Cancer Manag Res"},{"issue":"4","key":"1866_CR8","first-page":"309","volume":"57","author":"G Teucher","year":"1987","unstructured":"Teucher G, Schindler AE (1987) Postoperative fever and prognosis in breast cancer. Arch Geschwulstforsch 57(4):309\u2013317","journal-title":"Arch Geschwulstforsch"},{"issue":"6245","key":"1866_CR9","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1126\/science.aaa8064","volume":"349","author":"A Warnatsch","year":"2015","unstructured":"Warnatsch A et al (2015) Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science 349(6245):316\u2013320","journal-title":"Science"},{"issue":"6","key":"1866_CR10","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1158\/0008-5472.CAN-15-1591","volume":"76","author":"S Tohme","year":"2016","unstructured":"Tohme S et al (2016) Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress. Cancer Res 76(6):1367\u20131380","journal-title":"Cancer Res"},{"issue":"1","key":"1866_CR11","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/s41467-022-28492-5","volume":"13","author":"X Xia","year":"2022","unstructured":"Xia X et al (2022) Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications. Nat Commun 13(1):1017","journal-title":"Nat Commun"},{"issue":"21","key":"1866_CR12","doi-asserted-by":"publisher","first-page":"5626","DOI":"10.1158\/0008-5472.CAN-19-0800","volume":"79","author":"HO Yazdani","year":"2019","unstructured":"Yazdani HO et al (2019) Neutrophil extracellular traps drive mitochondrial homeostasis in tumors to augment growth. Cancer Res 79(21):5626\u20135639","journal-title":"Cancer Res"},{"issue":"4","key":"1866_CR13","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1053\/j.gastro.2018.07.010","volume":"155","author":"XM Yang","year":"2018","unstructured":"Yang XM et al (2018) Overexpression of Rac GTPase activating protein 1 contributes to proliferation of cancer cells by reducing hippo signaling to promote cytokinesis. Gastroenterology 155(4):1233-1249.e22","journal-title":"Gastroenterology"},{"issue":"4","key":"1866_CR14","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/cr.2017.27","volume":"27","author":"J Cooper","year":"2017","unstructured":"Cooper J, Giancotti FG (2017) Cancer: a new role for non-canonical Hippo signaling. Cell Res 27(4):459\u2013460","journal-title":"Cell Res"},{"issue":"3","key":"1866_CR15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.15252\/embr.201642455","volume":"18","author":"E Heidary Arash","year":"2017","unstructured":"Heidary Arash E et al (2017) MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. EMBO Rep 18(3):420\u2013436","journal-title":"EMBO Rep"},{"issue":"19","key":"1866_CR16","doi-asserted-by":"publisher","first-page":"17685","DOI":"10.18632\/oncotarget.3779","volume":"6","author":"C Wang","year":"2015","unstructured":"Wang C et al (2015) The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1. Oncotarget 6(19):17685\u201317697","journal-title":"Oncotarget"},{"issue":"6","key":"1866_CR17","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3390\/cancers12061542","volume":"12","author":"K Martins-Cardoso","year":"2020","unstructured":"Martins-Cardoso K et al (2020) Neutrophil extracellular traps (NETs) promote pro-metastatic phenotype in human breast cancer cells through epithelial-mesenchymal transition. Cancers (Basel) 12(6):1542","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1866_CR18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"V Papayannopoulos","year":"2018","unstructured":"Papayannopoulos V (2018) Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol 18(2):134\u2013147","journal-title":"Nat Rev Immunol"},{"key":"1866_CR19","doi-asserted-by":"publisher","first-page":"613039","DOI":"10.3389\/fimmu.2020.613039","volume":"11","author":"A Zahid","year":"2020","unstructured":"Zahid A et al (2020) Molecular and structural basis of DNA sensors in antiviral innate immunity. Front Immunol 11:613039","journal-title":"Front Immunol"},{"issue":"1","key":"1866_CR20","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12964-020-00544-7","volume":"18","author":"M Mota","year":"2020","unstructured":"Mota M, Shevde LA (2020) Merlin regulates signaling events at the nexus of development and cancer. Cell Commun Signal 18(1):63","journal-title":"Cell Commun Signal"},{"issue":"2","key":"1866_CR21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/mco2.22","volume":"1","author":"JL Qi","year":"2020","unstructured":"Qi JL et al (2020) Pulmonary Staphylococcus aureus infection regulates breast cancer cell metastasis via neutrophil extracellular traps (NETs) formation. MedComm 1(2):188\u2013201","journal-title":"MedComm"},{"issue":"20","key":"1866_CR22","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","volume":"133","author":"FVS Castanheira","year":"2019","unstructured":"Castanheira FVS, Kubes P (2019) Neutrophils and NETs in modulating acute and chronic inflammation. Blood 133(20):2178\u20132185","journal-title":"Blood"},{"issue":"4 Suppl 98","key":"1866_CR23","first-page":"6","volume":"34","author":"J Hahn","year":"2016","unstructured":"Hahn J et al (2016) Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation. Clin Exp Rheumatol 34(4 Suppl 98):6\u20138","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"1866_CR24","doi-asserted-by":"publisher","first-page":"112707","DOI":"10.1016\/j.yexcr.2021.112707","volume":"405","author":"B Zhu","year":"2021","unstructured":"Zhu B et al (2021) NF-kappaB and neutrophil extracellular traps cooperate to promote breast cancer progression and metastasis. Exp Cell Res 405(2):112707","journal-title":"Exp Cell Res"},{"issue":"7814","key":"1866_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41586-020-2394-6","volume":"583","author":"L Yang","year":"2020","unstructured":"Yang L et al (2020) DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature 583(7814):133\u2013138","journal-title":"Nature"},{"issue":"32","key":"1866_CR26","doi-asserted-by":"publisher","first-page":"13076","DOI":"10.1073\/pnas.1200419109","volume":"109","author":"M Demers","year":"2012","unstructured":"Demers M et al (2012) Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci USA 109(32):13076\u201313081","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"1866_CR27","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"6","key":"1866_CR28","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1158\/1078-0432.CCR-18-1226","volume":"25","author":"M Nie","year":"2019","unstructured":"Nie M et al (2019) Neutrophil extracellular traps induced by IL8 promote diffuse large B-cell lymphoma progression via the TLR9 signaling. Clin Cancer Res 25(6):1867\u20131879","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1866_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13045-020-01016-8","volume":"14","author":"Y Ding","year":"2021","unstructured":"Ding Y et al (2021) Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. J Hematol Oncol 14(1):19","journal-title":"J Hematol Oncol"},{"key":"1866_CR30","doi-asserted-by":"publisher","first-page":"597434","DOI":"10.3389\/fonc.2020.597434","volume":"10","author":"X Song","year":"2020","unstructured":"Song X et al (2020) Role of GPX4-mediated ferroptosis in the sensitivity of triple negative breast cancer cells to gefitinib. Front Oncol 10:597434","journal-title":"Front Oncol"},{"issue":"10","key":"1866_CR31","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1111\/cas.14181","volume":"110","author":"M Yu","year":"2019","unstructured":"Yu M et al (2019) Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells. Cancer Sci 110(10):3173\u20133182","journal-title":"Cancer Sci"},{"issue":"7","key":"1866_CR32","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.7150\/thno.52028","volume":"11","author":"Z Zhang","year":"2021","unstructured":"Zhang Z et al (2021) Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer. Theranostics 11(7):3167\u20133182","journal-title":"Theranostics"},{"issue":"4","key":"1866_CR33","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/1878-0261.12896","volume":"15","author":"M Mota","year":"2021","unstructured":"Mota M et al (2021) Merlin deficiency alters the redox management program in breast cancer. Mol Oncol 15(4):942\u2013956","journal-title":"Mol Oncol"},{"issue":"1","key":"1866_CR34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neo.2015.11.010","volume":"18","author":"C Couderc","year":"2016","unstructured":"Couderc C et al (2016) AMOTL1 promotes breast cancer progression and is antagonized by merlin. Neoplasia 18(1):10\u201324","journal-title":"Neoplasia"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-023-01866-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-023-01866-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-023-01866-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T15:33:25Z","timestamp":1692027205000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-023-01866-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":34,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1866"],"URL":"https:\/\/doi.org\/10.1007\/s10495-023-01866-w","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"14 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests with the contents of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The studies involving human participants were reviewed and approved by The Affiliated Huaian Hospital of Xuzhou Medical University. The patients\/participants provided their written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}