{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:58:28Z","timestamp":1787731108494,"version":"build-2784847793"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82302419"],"award-info":[{"award-number":["82302419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170587"],"award-info":[{"award-number":["82170587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82100679"],"award-info":[{"award-number":["82100679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s10495-024-02034-4","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:06:43Z","timestamp":1730506003000},"page":"149-166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis"],"prefix":"10.1007","volume":"30","author":[{"given":"Boyuan","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"2034_CR1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s40265-022-01766-4","volume":"82","author":"P Szatmary","year":"2022","unstructured":"Szatmary P, Grammatikopoulos T, Cai W et al (2022) Acute Pancreatitis: diagnosis and treatment. Drugs 82:1251\u20131276","journal-title":"Drugs"},{"key":"2034_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12944-024-02057-5","volume":"23","author":"W Zhou","year":"2024","unstructured":"Zhou W, Liu Q, Wang Z, Yao L, Chen J, Yang X (2024) Analysis of the clinical profile and treatment efficiency of hyperlipidemic acute pancreatitis. Lipids Health Dis 23:70","journal-title":"Lipids Health Dis"},{"key":"2034_CR3","doi-asserted-by":"crossref","unstructured":"Jeong YK, Kim H (2017) A Mini-review on the Effect of Docosahexaenoic Acid (DHA) on Cerulein-Induced and Hypertriglyceridemic Acute Pancreatitis. Int J Mol Sci 18","DOI":"10.3390\/ijms18112239"},{"key":"2034_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.jcmgh.2016.05.007","volume":"2","author":"M Sendler","year":"2016","unstructured":"Sendler M, Mayerle J, Lerch MM (2016) Necrosis, apoptosis, Necroptosis, pyroptosis: it matters how Acinar cells die during pancreatitis. Cell Mol Gastroenterol Hepatol 2:407\u2013408","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2034_CR5","doi-asserted-by":"publisher","first-page":"8298","DOI":"10.7150\/thno.46934","volume":"10","author":"J-H Tan","year":"2020","unstructured":"Tan J-H, Cao R-C, Zhou L et al (2020) ATF6 aggravates acinar cell apoptosis and injury by regulating p53\/AIFM2 transcription in severe Acute Pancreatitis. Theranostics 10:8298\u20138314","journal-title":"Theranostics"},{"key":"2034_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41419-021-03923-1","volume":"12","author":"J He","year":"2021","unstructured":"He J, Ma M, Li D et al (2021) Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS\/ER stress\/Cathepsin B axis. Cell Death Dis 12:626","journal-title":"Cell Death Dis"},{"key":"2034_CR7","doi-asserted-by":"publisher","first-page":"6621","DOI":"10.1093\/nar\/gkl989","volume":"34","author":"P Zhang","year":"2006","unstructured":"Zhang P, Du J, Sun B et al (2006) Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res 34:6621\u20136628","journal-title":"Nucleic Acids Res"},{"key":"2034_CR8","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s42255-020-0203-z","volume":"2","author":"Y Wei","year":"2020","unstructured":"Wei Y, Tian C, Zhao Y et al (2020) MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism. Nat Metab 2:447\u2013460","journal-title":"Nat Metab"},{"key":"2034_CR9","doi-asserted-by":"crossref","unstructured":"Jiang N, Li Y-B, Jin J-Y et al (2024) Structural and functional insights into the epigenetic regulator MRG15. Acta Pharmacol Sin","DOI":"10.1038\/s41401-023-01211-6"},{"key":"2034_CR10","doi-asserted-by":"publisher","first-page":"100253","DOI":"10.1016\/j.mcpro.2022.100253","volume":"21","author":"M Devoucoux","year":"2022","unstructured":"Devoucoux M, Roques C, Lachance C et al (2022) MRG proteins Are Shared by multiple protein complexes with distinct functions. Mol Cell Proteom 21:100253","journal-title":"Mol Cell Proteom"},{"key":"2034_CR11","doi-asserted-by":"crossref","unstructured":"Tian C, Gu X, Jiang C, Ding Q (2024) Emerging roles of MRG15 in liver metabolic diseases. Trends Mol Med","DOI":"10.1016\/j.molmed.2024.03.002"},{"key":"2034_CR12","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.jhep.2022.07.017","volume":"77","author":"C Tian","year":"2022","unstructured":"Tian C, Min X, Zhao Y et al (2022) MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM. J Hepatol 77:1491\u20131503","journal-title":"J Hepatol"},{"key":"2034_CR13","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/00000658-199201000-00007","volume":"215","author":"J Schmidt","year":"1992","unstructured":"Schmidt J, Rattner DW, Lewandrowski K et al (1992) A better model of acute pancreatitis for evaluating therapy. Ann Surg 215:44\u201356","journal-title":"Ann Surg"},{"key":"2034_CR14","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41419-022-05310-w","volume":"13","author":"W Chen","year":"2022","unstructured":"Chen W, Wang Y, Xia W, Zhang J, Zhao Y (2022) Neddylation-mediated degradation of hnRNPA2B1 contributes to hypertriglyceridemia pancreatitis. Cell Death Dis 13:863","journal-title":"Cell Death Dis"},{"key":"2034_CR15","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1007\/s10753-020-01228-7","volume":"43","author":"Q Mei","year":"2020","unstructured":"Mei Q, Zeng Y, Huang C et al (2020) Rapamycin alleviates hypertriglyceridemia-related Acute Pancreatitis via restoring autophagy flux and inhibiting endoplasmic reticulum stress. Inflammation 43:1510\u20131523","journal-title":"Inflammation"},{"key":"2034_CR16","doi-asserted-by":"publisher","first-page":"112898","DOI":"10.1016\/j.intimp.2024.112898","volume":"140","author":"B Gu","year":"2024","unstructured":"Gu B, Jiang Y, Huang Z et al (2024) MRG15 aggravates sepsis-related liver injury by promoting PCSK9 synthesis and secretion. Int Immunopharmacol 140:112898","journal-title":"Int Immunopharmacol"},{"key":"2034_CR17","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/s41401-023-01211-6","volume":"45","author":"N Jiang","year":"2024","unstructured":"Jiang N, Li Y-B, Jin J-Y et al (2024) Structural and functional insights into the epigenetic regulator MRG15. Acta Pharmacol Sin 45:879\u2013889","journal-title":"Acta Pharmacol Sin"},{"key":"2034_CR18","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1196\/annals.1395.031","volume":"1100","author":"AN Pena","year":"2007","unstructured":"Pena AN, Pereira-Smith OM (2007) The role of the MORF\/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. Ann N Y Acad Sci 1100:299\u2013305","journal-title":"Ann N Y Acad Sci"},{"key":"2034_CR19","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1007\/s00018-011-0666-x","volume":"68","author":"Y-J Cho","year":"2011","unstructured":"Cho Y-J, Liang P (2011) S-phase-coupled apoptosis in tumor suppression. Cell Mol Life Sci 68:1883\u20131896","journal-title":"Cell Mol Life Sci"},{"key":"2034_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/1476-4598-12-114","volume":"12","author":"X Song","year":"2013","unstructured":"Song X, Wang J, Zheng T et al (2013) LBH589 inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin\/STAT3\/Akt pathway. Mol Cancer 12:114","journal-title":"Mol Cancer"},{"key":"2034_CR21","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s41419-022-05460-x","volume":"13","author":"Y Bi","year":"2022","unstructured":"Bi Y, Xu H, Wang X et al (2022) FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM. Cell Death Dis 13:1020","journal-title":"Cell Death Dis"},{"key":"2034_CR22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41418-021-00868-y","volume":"29","author":"C-Y Choi","year":"2022","unstructured":"Choi C-Y, Vo MT, Nicholas J, Choi YB (2022) Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis. Cell Death Differ 29:451\u2013464","journal-title":"Cell Death Differ"},{"key":"2034_CR23","doi-asserted-by":"publisher","first-page":"432","DOI":"10.4161\/auto.23026","volume":"9","author":"Y Lei","year":"2013","unstructured":"Lei Y, Wen H, Ting JPY (2013) The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy. Autophagy 9:432\u2013433","journal-title":"Autophagy"},{"key":"2034_CR24","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"DB Zorov","year":"2014","unstructured":"Zorov DB, Juhaszova M, Sollott SJ (2014) Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 94:909\u2013950","journal-title":"Physiol Rev"},{"key":"2034_CR25","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1080\/15548627.2022.2112830","volume":"19","author":"Y Tang","year":"2023","unstructured":"Tang Y, Wang L, Qin J, Lu Y, Shen H-M, Chen H-B (2023) Targeting mitophagy to promote apoptosis is a potential therapeutic strategy for cancer. Autophagy 19:1031\u20131033","journal-title":"Autophagy"},{"key":"2034_CR26","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1080\/15548627.2020.1848971","volume":"17","author":"Q Lin","year":"2021","unstructured":"Lin Q, Li S, Jiang N et al (2021) Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy 17:2975\u20132990","journal-title":"Autophagy"},{"key":"2034_CR27","doi-asserted-by":"crossref","unstructured":"Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351","DOI":"10.1042\/0264-6021:3510095"},{"key":"2034_CR28","first-page":"409","volume":"41","author":"X Yu","year":"2018","unstructured":"Yu X, Cui L, Hou F et al (2018) Angiotensin-converting enzyme 2-angiotensin (1\u20137)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase\/nuclear factor-\u03baB pathway. Int J Mol Med 41:409\u2013420","journal-title":"Int J Mol Med"},{"key":"2034_CR29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.molmed.2024.03.002","volume":"30","author":"C Tian","year":"2024","unstructured":"Tian C, Gu X, Jiang C, Ding Q (2024) Emerging roles of MRG15 in liver metabolic diseases. Trends Mol Med 30:527\u2013529","journal-title":"Trends Mol Med"},{"key":"2034_CR30","doi-asserted-by":"publisher","first-page":"E5408","DOI":"10.1073\/pnas.1611995113","volume":"113","author":"N Iwamori","year":"2016","unstructured":"Iwamori N, Tominaga K, Sato T et al (2016) MRG15 is required for pre-mRNA splicing and spermatogenesis. Proc Natl Acad Sci U S A 113:E5408\u2013E5415","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2034_CR31","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1016\/j.yexcr.2011.02.001","volume":"317","author":"AN Pe\u00f1a","year":"2011","unstructured":"Pe\u00f1a AN, Tominaga K, Pereira-Smith OM (2011) MRG15 activates the cdc2 promoter via histone acetylation in human cells. Exp Cell Res 317:1534\u20131540","journal-title":"Exp Cell Res"},{"key":"2034_CR32","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nrm2239","volume":"8","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741\u2013752","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2034_CR33","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.ijbiomac.2022.02.005","volume":"204","author":"K Prerna","year":"2022","unstructured":"Prerna K, Dubey VK (2022) Beclin1-mediated interplay between autophagy and apoptosis: New understanding. Int J Biol Macromol 204:258\u2013273","journal-title":"Int J Biol Macromol"},{"key":"2034_CR34","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1080\/15548627.2019.1591672","volume":"15","author":"BL Baechler","year":"2019","unstructured":"Baechler BL, Bloemberg D, Quadrilatero J (2019) Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation. Autophagy 15:1606\u20131619","journal-title":"Autophagy"},{"key":"2034_CR35","first-page":"825","volume":"116","author":"KG Parhofer","year":"2019","unstructured":"Parhofer KG, Laufs U (2019) The diagnosis and treatment of Hypertriglyceridemia. Dtsch Arztebl Int 116:825\u2013832","journal-title":"Dtsch Arztebl Int"},{"key":"2034_CR36","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMc2306575","volume":"390","author":"VJ Alexander","year":"2024","unstructured":"Alexander VJ, Karwatowska-Prokopczuk E, Prohaska TA et al (2024) Volanesorsen to prevent Acute Pancreatitis in Hypertriglyceridemia. N Engl J Med 390:476\u2013477","journal-title":"N Engl J Med"},{"key":"2034_CR37","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/clinchem\/hvad094","volume":"69","author":"SEJ Hansen","year":"2023","unstructured":"Hansen SEJ, Varbo A, Nordestgaard BG, Langsted A (2023) Hypertriglyceridemia-Associated Pancreatitis: New concepts and potential mechanisms. Clin Chem 69:1132\u20131144","journal-title":"Clin Chem"},{"key":"2034_CR38","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","volume":"59","author":"C Brenner","year":"2013","unstructured":"Brenner C, Galluzzi L, Kepp O, Kroemer G (2013) Decoding cell death signals in liver inflammation. J Hepatol 59:583\u2013594","journal-title":"J Hepatol"},{"key":"2034_CR39","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","volume":"16","author":"PJ Lee","year":"2019","unstructured":"Lee PJ, Papachristou GI (2019) New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol 16:479\u2013496","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2034_CR40","doi-asserted-by":"publisher","first-page":"e13916","DOI":"10.1111\/apha.13916","volume":"237","author":"L Kiss","year":"2023","unstructured":"Kiss L, F\u0171r G, Pisipati S et al (2023) Mechanisms linking hypertriglyceridemia to acute pancreatitis. Acta Physiol (Oxf) 237:e13916","journal-title":"Acta Physiol (Oxf)"},{"key":"2034_CR41","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","volume":"103","author":"JS Harrington","year":"2023","unstructured":"Harrington JS, Ryter SW, Plataki M, Price DR, Choi AMK (2023) Mitochondria in health, disease, and aging. Physiol Rev 103:2349\u20132422","journal-title":"Physiol Rev"},{"key":"2034_CR42","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.1038\/onc.2008.308","volume":"27","author":"P Pinton","year":"2008","unstructured":"Pinton P, Giorgi C, Siviero R, Zecchini E, Rizzuto R (2008) Calcium and apoptosis: ER-mitochondria Ca2\u2009+\u2009transfer in the control of apoptosis. Oncogene 27:6407\u20136418","journal-title":"Oncogene"},{"key":"2034_CR43","doi-asserted-by":"crossref","unstructured":"Lin J, Chen K, Chen W et al (2020) Paradoxical Mitophagy Regulation by PINK1 and TUFm. Mol Cell 80","DOI":"10.1016\/j.molcel.2020.10.007"},{"key":"2034_CR44","doi-asserted-by":"publisher","first-page":"1424385","DOI":"10.3389\/fimmu.2024.1424385","volume":"15","author":"N Liu","year":"2024","unstructured":"Liu N, Pang B, Kang L, Li D, Jiang X, Zhou C-M (2024) TUFM in health and disease: exploring its multifaceted roles. Front Immunol 15:1424385","journal-title":"Front Immunol"},{"key":"2034_CR45","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12967-016-0912-y","volume":"14","author":"AM Archer","year":"2016","unstructured":"Archer AM, Saber R, Rose S et al (2016) ApoE deficiency exacerbates the development and sustainment of a semi-chronic K\/BxN serum transfer-induced arthritis model. J Transl Med 14:170","journal-title":"J Transl Med"},{"key":"2034_CR46","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1038\/s41467-018-04194-9","volume":"9","author":"JMJ Romac","year":"2018","unstructured":"Romac JMJ, Shahid RA, Swain SM, Vigna SR, Liddle RA (2018) Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. Nat Commun 9:1715","journal-title":"Nat Commun"},{"key":"2034_CR47","doi-asserted-by":"crossref","unstructured":"Gout J, Pommier RM, Vincent DF et al (2013) Isolation and culture of mouse primary pancreatic acinar cells. J Vis Exp","DOI":"10.3791\/50514"},{"key":"2034_CR48","doi-asserted-by":"publisher","first-page":"108892","DOI":"10.1016\/j.intimp.2022.108892","volume":"108","author":"T Li","year":"2022","unstructured":"Li T, Bai J, Du Y et al (2022) Thiamine pretreatment improves endotoxemia-related liver injury and cholestatic complications by regulating galactose metabolism and inhibiting macrophage activation. Int Immunopharmacol 108:108892","journal-title":"Int Immunopharmacol"},{"key":"2034_CR49","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12967-023-04786-0","volume":"22","author":"R Dong","year":"2024","unstructured":"Dong R, Zhang Q, Peng H (2024) Gastroesophageal reflux disease and the risk of respiratory diseases: a mendelian randomization study. J Transl Med 22:60","journal-title":"J Transl Med"},{"key":"2034_CR50","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen C-Y, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet 50:693\u2013698","journal-title":"Nat Genet"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-024-02034-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-024-02034-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-024-02034-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T20:48:14Z","timestamp":1738788494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-024-02034-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":50,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["2034"],"URL":"https:\/\/doi.org\/10.1007\/s10495-024-02034-4","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,2]]},"assertion":[{"value":"20 October 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}