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All animal experiments were performed following a protocol approved by the Animal Protection and Use Committee of Nanjing Medical University (Approval Number: 2024-SR-753). All procedures conformed to the ethical standards of the responsible committee on human experimentation and to the Helsinki Declaration of 1964 and later versions. Informed consent or the equivalent consent was obtained from all patients included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}