{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:33:02Z","timestamp":1793323982800,"version":"4.5.0"},"reference-count":152,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10495-025-02087-z","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:39:45Z","timestamp":1741631985000},"page":"1182-1201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Role of oxeiptosis in disease mechanisms and therapeutic opportunities"],"prefix":"10.1007","volume":"30","author":[{"given":"K.","family":"Bhuvaneshwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Harithpriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunka Mohanram","family":"Ramkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"issue":"2","key":"2087_CR1","first-page":"245","volume":"96","author":"DL Vaux","year":"1999","unstructured":"Vaux DL, Korsmeyer SJ (1999) Cell Death Dev Cell 96(2):245\u2013254","journal-title":"Cell Death Dev Cell"},{"key":"2087_CR2","doi-asserted-by":"crossref","unstructured":"Green DR, Llambi F (2015) Cell death signaling. Cold Spring Harb Perspect Biol, 7(12)","DOI":"10.1101\/cshperspect.a006080"},{"issue":"3","key":"2087_CR3","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L et al (2018) Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ 25(3):486\u2013541","journal-title":"Cell Death Differ"},{"key":"2087_CR4","doi-asserted-by":"publisher","first-page":"115802","DOI":"10.1016\/j.biopha.2023.115802","volume":"168","author":"J Shen","year":"2023","unstructured":"Shen J et al (2023) Different types of cell death in diabetic endothelial dysfunction. Biomed Pharmacother 168:115802","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2087_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","volume":"19","author":"C Holze","year":"2017","unstructured":"Holze C et al (2017) Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol 19(2):130\u2013140","journal-title":"Nat Immunol"},{"key":"2087_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/978-1-4614-3229-6_4","volume":"747","author":"SH MacKenzie","year":"2012","unstructured":"MacKenzie SH, Clark AC (2012) Death by caspase dimerization. Adv Exp Med Biol 747:55\u201373","journal-title":"Adv Exp Med Biol"},{"issue":"23","key":"2087_CR7","doi-asserted-by":"publisher","first-page":"8057","DOI":"10.1073\/pnas.82.23.8057","volume":"82","author":"EF Plow","year":"1985","unstructured":"Plow EF et al (1985) The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Proc Natl Acad Sci U S A 82(23):8057\u20138061","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2087_CR8","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","volume":"1863","author":"M Redza-Dutordoir","year":"2016","unstructured":"Redza-Dutordoir M, Averill-Bates DA (2016) Activation of apoptosis signalling pathways by reactive oxygen species. Biochim Biophys Acta 1863(12):2977\u20132992","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"2087_CR9","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1074\/jbc.M005889200","volume":"276","author":"B Guo","year":"2001","unstructured":"Guo B, Godzik A, Reed JC (2001) Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. J Biol Chem 276(4):2780\u20132785","journal-title":"J Biol Chem"},{"issue":"5","key":"2087_CR10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nrm2153","volume":"8","author":"SJ Riedl","year":"2007","unstructured":"Riedl SJ, Salvesen GS (2007) The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 8(5):405\u2013413","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2087_CR11","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1089\/ars.2012.4905","volume":"19","author":"CC Wu","year":"2013","unstructured":"Wu CC, Bratton SB (2013) Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal 19(6):546\u2013558","journal-title":"Antioxid Redox Signal"},{"key":"2087_CR12","doi-asserted-by":"crossref","unstructured":"Jin X et al (2020) Role of pyroptosis in the pathogenesis and treatment of diseases. MedComm 2023. 4(3): p. e249","DOI":"10.1002\/mco2.249"},{"issue":"1","key":"2087_CR13","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","volume":"6","author":"P Yu","year":"2021","unstructured":"Yu P et al (2021) Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther 6(1):128","journal-title":"Signal Transduct Target Ther"},{"issue":"50","key":"2087_CR14","doi-asserted-by":"publisher","first-page":"6452","DOI":"10.1038\/onc.2008.311","volume":"27","author":"SW Tait","year":"2008","unstructured":"Tait SW, Green DR (2008) Caspase-independent cell death: leaving the set without the final cut. Oncogene 27(50):6452\u20136461","journal-title":"Oncogene"},{"issue":"2","key":"2087_CR15","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","volume":"19","author":"C Holze","year":"2018","unstructured":"Holze C et al (2018) Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol 19(2):130\u2013140","journal-title":"Nat Immunol"},{"issue":"2","key":"2087_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","volume":"14","author":"L Yu","year":"2018","unstructured":"Yu L, Chen Y, Tooze SA (2018) Autophagy pathway: cellular and molecular mechanisms. Autophagy 14(2):207\u2013215","journal-title":"Autophagy"},{"key":"2087_CR17","doi-asserted-by":"crossref","unstructured":"Das G, Shravage BV, Baehrecke EH (2012) Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol, 4(6)","DOI":"10.1101\/cshperspect.a008813"},{"issue":"5","key":"2087_CR18","first-page":"605","volume":"7","author":"E Farber","year":"1994","unstructured":"Farber E (1994) Programmed cell death: necrosis versus apoptosis. Mod Pathol 7(5):605\u2013609","journal-title":"Mod Pathol"},{"issue":"1","key":"2087_CR19","first-page":"3","volume":"146","author":"G Majno","year":"1995","unstructured":"Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146(1):3\u201315","journal-title":"Am J Pathol"},{"key":"2087_CR20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","volume":"3","author":"KL Rock","year":"2008","unstructured":"Rock KL, Kono H (2008) The inflammatory response to cell death. Annu Rev Pathol 3:99\u2013126","journal-title":"Annu Rev Pathol"},{"issue":"2","key":"2087_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nrm3737","volume":"15","author":"T Vanden Berghe","year":"2014","unstructured":"Vanden Berghe T et al (2014) Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 15(2):135\u2013147","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"2087_CR22","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1084\/jem.187.9.1477","volume":"187","author":"D Vercammen","year":"1998","unstructured":"Vercammen D et al (1998) Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 187(9):1477\u20131485","journal-title":"J Exp Med"},{"issue":"5938","key":"2087_CR23","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1126\/science.1172308","volume":"325","author":"DW Zhang","year":"2009","unstructured":"Zhang DW et al (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325(5938):332\u2013336","journal-title":"Science"},{"issue":"4","key":"2087_CR24","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.celrep.2014.04.026","volume":"7","author":"Y Dondelinger","year":"2014","unstructured":"Dondelinger Y et al (2014) MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep 7(4):971\u2013981","journal-title":"Cell Rep"},{"issue":"1","key":"2087_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","volume":"54","author":"H Wang","year":"2014","unstructured":"Wang H et al (2014) Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell 54(1):133\u2013146","journal-title":"Mol Cell"},{"issue":"2","key":"2087_CR26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.gendis.2020.11.019","volume":"9","author":"F Pu","year":"2022","unstructured":"Pu F et al (2022) Ferroptosis as a novel form of regulated cell death: implications in the pathogenesis, oncometabolism and treatment of human cancer. Genes Dis 9(2):347\u2013357","journal-title":"Genes Dis"},{"issue":"1","key":"2087_CR27","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","volume":"6","author":"HF Yan","year":"2021","unstructured":"Yan HF et al (2021) Ferroptosis: mechanisms and links with diseases. Signal Transduct Target Ther 6(1):49","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"2087_CR28","doi-asserted-by":"publisher","first-page":"e995047","DOI":"10.4161\/23723556.2014.995047","volume":"2","author":"M Conrad","year":"2015","unstructured":"Conrad M, Friedmann JP, Angeli (2015) Glutathione peroxidase 4 (Gpx4) and ferroptosis: what\u2019s so special about it? Mol Cell Oncol 2(3):e995047","journal-title":"Mol Cell Oncol"},{"issue":"8","key":"2087_CR29","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1111\/bph.12416","volume":"171","author":"AA Fatokun","year":"2014","unstructured":"Fatokun AA, Dawson VL, Dawson TM (2014) Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol 171(8):2000\u20132016","journal-title":"Br J Pharmacol"},{"key":"2087_CR30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3389\/fcell.2019.00311","volume":"7","author":"X Wang","year":"2019","unstructured":"Wang X et al (2019) Cell-in-Cell phenomenon and its relationship with tumor microenvironment and tumor progression: A review. Front Cell Dev Biol 7:311","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"2087_CR31","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/s12276-024-01227-w","volume":"56","author":"S Kim","year":"2024","unstructured":"Kim S et al (2024) Entosis: the core mechanism and crosstalk with other cell death programs. Exp Mol Med 56(4):870\u2013876","journal-title":"Exp Mol Med"},{"issue":"11\u201312","key":"2087_CR32","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1007\/s00018-016-2207-0","volume":"73","author":"S Krishna","year":"2016","unstructured":"Krishna S, Overholtzer M (2016) Mechanisms and consequences of entosis. Cell Mol Life Sci 73(11\u201312):2379\u20132386","journal-title":"Cell Mol Life Sci"},{"key":"2087_CR33","doi-asserted-by":"publisher","first-page":"p1225578","DOI":"10.1155\/2022\/1225578","volume":"2022","author":"A de Almeida","year":"2022","unstructured":"de Almeida A et al (2022) ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways. Oxid Med Cell Longev 2022:p1225578","journal-title":"Oxid Med Cell Longev"},{"key":"2087_CR34","doi-asserted-by":"crossref","unstructured":"Benhar M (2020) Oxidants, antioxidants and thiol redox switches in the control of regulated cell death pathways. Antioxid (Basel), 9(4)","DOI":"10.3390\/antiox9040309"},{"issue":"3","key":"2087_CR35","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1083\/jcb.139.3.729","volume":"139","author":"F Madeo","year":"1997","unstructured":"Madeo F, Frohlich E, Frohlich KU (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 139(3):729\u2013734","journal-title":"J Cell Biol"},{"issue":"1","key":"2087_CR36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nchembio.1416","volume":"10","author":"SJ Dixon","year":"2014","unstructured":"Dixon SJ, Stockwell BR (2014) The role of iron and reactive oxygen species in cell death. Nat Chem Biol 10(1):9\u201317","journal-title":"Nat Chem Biol"},{"key":"2087_CR37","doi-asserted-by":"publisher","first-page":"1116509","DOI":"10.3389\/fcvm.2023.1116509","volume":"10","author":"K Tian","year":"2023","unstructured":"Tian K et al (2023) The role of ROS-induced pyroptosis in CVD. Front Cardiovasc Med 10:1116509","journal-title":"Front Cardiovasc Med"},{"key":"2087_CR38","doi-asserted-by":"publisher","first-page":"p5080843","DOI":"10.1155\/2019\/5080843","volume":"2019","author":"L Su","year":"2019","unstructured":"Su L, J et al (2019) Reactive oxygen Species-Induced lipid peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med Cell Longev 2019:p5080843","journal-title":"Oxid Med Cell Longev"},{"key":"2087_CR39","doi-asserted-by":"crossref","unstructured":"Zeb A et al (2021) A novel role of KEAP1\/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol, 48","DOI":"10.1016\/j.redox.2021.102186"},{"key":"2087_CR40","doi-asserted-by":"crossref","unstructured":"Baba T et al (2021) Cleaved PGAM5 dephosphorylates nuclear serine\/arginine-rich proteins during mitophagy. Biochimica et biophysica acta (BBA) - Molecular cell research, 1868(7)","DOI":"10.1016\/j.bbamcr.2021.119045"},{"key":"2087_CR41","doi-asserted-by":"crossref","unstructured":"Zhong F et al (2024) The KEAP1\/PGAM5\/AIFM1-Mediated oxeiptosis pathway in Alzheimer\u2019s disease. Brain Res, 1845","DOI":"10.1016\/j.brainres.2024.149173"},{"key":"2087_CR42","doi-asserted-by":"crossref","unstructured":"Cheng M et al (2021) PGAM5: A crucial role in mitochondrial dynamics and programmed cell death. Eur J Cell Biol, 100(1)","DOI":"10.1016\/j.ejcb.2020.151144"},{"key":"2087_CR43","doi-asserted-by":"publisher","first-page":"p1208690","DOI":"10.1155\/2021\/1208690","volume":"2021","author":"I Venza","year":"2021","unstructured":"Venza I et al (2021) ROS as regulators of cellular processes in melanoma. Oxid Med Cell Longev 2021:p1208690","journal-title":"Oxid Med Cell Longev"},{"key":"2087_CR44","doi-asserted-by":"crossref","unstructured":"Hammad M et al (2023) Roles of oxidative stress and Nrf2 signaling in pathogenic and Non-Pathogenic cells: A possible general mechanism of resistance to therapy. Antioxid (Basel), 12(7)","DOI":"10.3390\/antiox12071371"},{"issue":"12","key":"2087_CR45","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","volume":"26","author":"Y Huang","year":"2015","unstructured":"Huang Y et al (2015) The complexity of the Nrf2 pathway: beyond the antioxidant response. J Nutr Biochem 26(12):1401\u20131413","journal-title":"J Nutr Biochem"},{"issue":"10","key":"2087_CR46","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"M Schieber","year":"2014","unstructured":"Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress. Curr Biol 24(10):R453\u2013R462","journal-title":"Curr Biol"},{"issue":"7","key":"2087_CR47","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/s41418-018-0134-3","volume":"25","author":"P Scaturro","year":"2018","unstructured":"Scaturro P, Pichlmair A (2018) Oxeiptosis-a cell death pathway to mitigate damage caused by radicals. Cell Death Differ 25(7):1191\u20131193","journal-title":"Cell Death Differ"},{"key":"2087_CR48","doi-asserted-by":"publisher","first-page":"149733","DOI":"10.1016\/j.bbrc.2024.149733","volume":"705","author":"F Fan","year":"2024","unstructured":"Fan F et al (2024) Mechanisms of chondrocyte regulated cell death in osteoarthritis: focus on ROS-triggered ferroptosis, Parthanatos, and oxeiptosis. Biochem Biophys Res Commun 705:149733","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"2087_CR49","doi-asserted-by":"publisher","first-page":"200105","DOI":"10.1098\/rsob.200105","volume":"10","author":"S Dayalan Naidu","year":"2020","unstructured":"Dayalan Naidu S, Dinkova-Kostova AT (2020) KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease. Open Biol 10(6):200105","journal-title":"Open Biol"},{"issue":"Pt B","key":"2087_CR50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2015.05.034","volume":"88","author":"P Canning","year":"2015","unstructured":"Canning P, Sorrell FJ, Bullock AN (2015) Structural basis of Keap1 interactions with Nrf2. Free Radic Biol Med 88(Pt B):101\u2013107","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"2087_CR51","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","volume":"98","author":"M Yamamoto","year":"2018","unstructured":"Yamamoto M, Kensler TW, Motohashi H (2018) The KEAP1-NRF2 system: a Thiol-Based Sensor-Effector apparatus for maintaining redox homeostasis. Physiol Rev 98(3):1169\u20131203","journal-title":"Physiol Rev"},{"key":"2087_CR52","doi-asserted-by":"publisher","first-page":"153755","DOI":"10.1016\/j.phymed.2021.153755","volume":"92","author":"R Jayasuriya","year":"2021","unstructured":"Jayasuriya R et al (2021) Targeting Nrf2\/Keap1 signaling pathway by bioactive natural agents: possible therapeutic strategy to combat liver disease. Phytomedicine 92:153755","journal-title":"Phytomedicine"},{"key":"2087_CR53","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.coi.2018.10.006","volume":"56","author":"P Scaturro","year":"2019","unstructured":"Scaturro P, Pichlmair A (2019) Oxeiptosis: a discreet way to respond to radicals. Curr Opin Immunol 56:37\u201343","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"2087_CR54","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1101\/gad.13.1.76","volume":"13","author":"K Itoh","year":"1999","unstructured":"Itoh K et al (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13(1):76\u201386","journal-title":"Genes Dev"},{"issue":"24","key":"2087_CR55","doi-asserted-by":"publisher","first-page":"21592","DOI":"10.1074\/jbc.M300931200","volume":"278","author":"M McMahon","year":"2003","unstructured":"McMahon M et al (2003) Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278(24):21592\u201321600","journal-title":"J Biol Chem"},{"key":"2087_CR56","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.phrs.2014.10.004","volume":"91","author":"E Bhakkiyalakshmi","year":"2015","unstructured":"Bhakkiyalakshmi E et al (2015) The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes. Pharmacol Res 91:104\u2013114","journal-title":"Pharmacol Res"},{"issue":"8","key":"2087_CR57","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1128\/MCB.26.8.2887-2900.2006","volume":"26","author":"KI Tong","year":"2006","unstructured":"Tong KI et al (2006) Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol 26(8):2887\u20132900","journal-title":"Mol Cell Biol"},{"issue":"6","key":"2087_CR58","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.bcp.2012.11.016","volume":"85","author":"HK Bryan","year":"2013","unstructured":"Bryan HK et al (2013) The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation. Biochem Pharmacol 85(6):705\u2013717","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"2087_CR59","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/ng1248","volume":"35","author":"N Wakabayashi","year":"2003","unstructured":"Wakabayashi N et al (2003) Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35(3):238\u2013245","journal-title":"Nat Genet"},{"issue":"18","key":"2087_CR60","doi-asserted-by":"publisher","first-page":"11908","DOI":"10.1073\/pnas.172398899","volume":"99","author":"AT Dinkova-Kostova","year":"2002","unstructured":"Dinkova-Kostova AT et al (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A 99(18):11908\u201311913","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"2087_CR61","doi-asserted-by":"publisher","first-page":"10070","DOI":"10.1073\/pnas.0502402102","volume":"102","author":"AL Eggler","year":"2005","unstructured":"Eggler AL et al (2005) Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A 102(29):10070\u201310075","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"34","key":"2087_CR62","doi-asserted-by":"publisher","first-page":"24756","DOI":"10.1074\/jbc.M601119200","volume":"281","author":"M McMahon","year":"2006","unstructured":"McMahon M et al (2006) Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a tethering mechanism: a two-site interaction model for the Nrf2-Keap1 complex. J Biol Chem 281(34):24756\u201324768","journal-title":"J Biol Chem"},{"key":"2087_CR63","doi-asserted-by":"crossref","unstructured":"Harithpriya K, Ganesan K, Ramkumar KM (2024) Pterostilbene reverses epigenetic Silencing of Nrf2 and enhances antioxidant response in endothelial cells in hyperglycemic microenvironment. Nutrients, 16(13)","DOI":"10.3390\/nu16132045"},{"key":"2087_CR64","doi-asserted-by":"publisher","first-page":"111479","DOI":"10.1016\/j.exger.2021.111479","volume":"152","author":"GV Ganesh","year":"2021","unstructured":"Ganesh GV, Ramkumar KM (2021) Dysregulation of Nrf2 redox pathway in macrophages under diabetic microenvironment. Exp Gerontol 152:111479","journal-title":"Exp Gerontol"},{"issue":"8","key":"2087_CR65","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/j.yexcr.2008.02.014","volume":"314","author":"SC Lo","year":"2008","unstructured":"Lo SC, Hannink M (2008) PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res 314(8):1789\u20131803","journal-title":"Exp Cell Res"},{"issue":"1\u20132","key":"2087_CR66","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cell.2011.11.030","volume":"148","author":"Z Wang","year":"2012","unstructured":"Wang Z et al (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148(1\u20132):228\u2013243","journal-title":"Cell"},{"issue":"19","key":"2087_CR67","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.1038\/sj.emboj.7600389","volume":"23","author":"A Chacinska","year":"2004","unstructured":"Chacinska A et al (2004) Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J 23(19):3735\u20133746","journal-title":"EMBO J"},{"key":"2087_CR68","doi-asserted-by":"publisher","first-page":"730604","DOI":"10.3389\/fnmol.2021.730604","volume":"14","author":"MZ Liang","year":"2021","unstructured":"Liang MZ, Ke TL, Chen L (2021) Mitochondrial protein PGAM5 emerges as a new regulator in neurological diseases. Front Mol Neurosci 14:730604","journal-title":"Front Mol Neurosci"},{"key":"2087_CR69","doi-asserted-by":"publisher","first-page":"102186","DOI":"10.1016\/j.redox.2021.102186","volume":"48","author":"A Zeb","year":"2021","unstructured":"Zeb A et al (2021) A novel role of KEAP1\/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48:102186","journal-title":"Redox Biol"},{"key":"2087_CR70","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ebiom.2018.03.016","volume":"30","author":"D Bano","year":"2018","unstructured":"Bano D, Prehn JHM (2018) Apoptosis-Inducing factor (AIF) in physiology and disease: the Tale of a repented natural born killer. EBioMedicine 30:29\u201337","journal-title":"EBioMedicine"},{"issue":"6718","key":"2087_CR71","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/17135","volume":"397","author":"SA Susin","year":"1999","unstructured":"Susin SA et al (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397(6718):441\u2013446","journal-title":"Nature"},{"issue":"3","key":"2087_CR72","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/iub.2390","volume":"73","author":"N Novo","year":"2021","unstructured":"Novo N, Ferreira P, Medina M (2021) The apoptosis-inducing factor family: moonlighting proteins in the crosstalk between mitochondria and nuclei. IUBMB Life 73(3):568\u2013581","journal-title":"IUBMB Life"},{"issue":"5598","key":"2087_CR73","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1126\/science.1076194","volume":"298","author":"X Wang","year":"2002","unstructured":"Wang X et al (2002) Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science 298(5598):1587\u20131592","journal-title":"Science"},{"issue":"1","key":"2087_CR74","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41420-022-00863-3","volume":"8","author":"P Kang","year":"2022","unstructured":"Kang P et al (2022) Oxeiptosis: a novel pathway of melanocytes death in response to oxidative stress in vitiligo. Cell Death Discov 8(1):70","journal-title":"Cell Death Discov"},{"issue":"1","key":"2087_CR75","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s13317-016-0083-0","volume":"7","author":"G Di Dalmazi","year":"2016","unstructured":"Di Dalmazi G et al (2016) Reactive oxygen species in organ-specific autoimmunity. Auto Immun Highlights 7(1):11","journal-title":"Auto Immun Highlights"},{"issue":"4","key":"2087_CR76","doi-asserted-by":"publisher","first-page":"397","DOI":"10.4161\/cbt.10.4.12424","volume":"10","author":"CN Marconett","year":"2010","unstructured":"Marconett CN et al (2010) BZL101, a phytochemical extract from the Scutellaria Barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biol Ther 10(4):397\u2013405","journal-title":"Cancer Biol Ther"},{"issue":"8","key":"2087_CR77","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","volume":"15","author":"X An","year":"2024","unstructured":"An X et al (2024) Oxidative cell death in cancer: mechanisms and therapeutic opportunities. Cell Death Dis 15(8):556","journal-title":"Cell Death Dis"},{"issue":"10","key":"2087_CR78","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.7150\/thno.56747","volume":"11","author":"Y Wang","year":"2021","unstructured":"Wang Y et al (2021) The double-edged roles of ROS in cancer prevention and therapy. Theranostics 11(10):4839\u20134857","journal-title":"Theranostics"},{"issue":"12","key":"2087_CR79","doi-asserted-by":"publisher","first-page":"e945","DOI":"10.1038\/cddis.2013.474","volume":"4","author":"J Wang","year":"2013","unstructured":"Wang J et al (2013) Cancer-derived Immunoglobulin G promotes tumor cell growth and proliferation through inducing production of reactive oxygen species. Cell Death Dis 4(12):e945","journal-title":"Cell Death Dis"},{"key":"2087_CR80","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.canlet.2016.03.042","volume":"387","author":"S Prasad","year":"2017","unstructured":"Prasad S, Gupta SC, Tyagi AK (2017) Reactive oxygen species (ROS) and cancer: role of antioxidative nutraceuticals. Cancer Lett 387:95\u2013105","journal-title":"Cancer Lett"},{"issue":"3","key":"2087_CR81","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/cr.2017.155","volume":"28","author":"PE Porporato","year":"2018","unstructured":"Porporato PE et al (2018) Mitochondrial metabolism and cancer. Cell Res 28(3):265\u2013280","journal-title":"Cell Res"},{"key":"2087_CR82","doi-asserted-by":"crossref","unstructured":"Garcia-Pras E et al (2021) Cell death in hepatocellular carcinoma: pathogenesis and therapeutic opportunities. Cancers (Basel), 14(1)","DOI":"10.3390\/cancers14010048"},{"issue":"10","key":"2087_CR83","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","volume":"16","author":"JD Yang","year":"2019","unstructured":"Yang JD et al (2019) A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol 16(10):589\u2013604","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"45","key":"2087_CR84","doi-asserted-by":"publisher","first-page":"e36051","DOI":"10.1097\/MD.0000000000036051","volume":"102","author":"S Lin","year":"2023","unstructured":"Lin S et al (2023) Oxeiptosis core genes and their multi-omics analysis in hepatocellular carcinoma. Med (Baltim) 102(45):e36051","journal-title":"Med (Baltim)"},{"issue":"3","key":"2087_CR85","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.bbrc.2018.02.203","volume":"498","author":"D Liu","year":"2018","unstructured":"Liu D et al (2018) Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells. Biochem Biophys Res Commun 498(3):453\u2013457","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2087_CR86","doi-asserted-by":"publisher","first-page":"286","DOI":"10.31083\/j.fbl2811286","volume":"28","author":"Y Li","year":"2023","unstructured":"Li Y et al (2023) Insights into the role of oxidative stress in hepatocellular carcinoma development. Front Biosci (Landmark Ed) 28(11):286","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"3","key":"2087_CR87","first-page":"1127","volume":"34","author":"A Mencalha","year":"2014","unstructured":"Mencalha A et al (2014) Mapping oxidative changes in breast cancer: Understanding the basic to reach the clinics. Anticancer Res 34(3):1127\u20131140","journal-title":"Anticancer Res"},{"issue":"5","key":"2087_CR88","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.3390\/cimb46050282","volume":"46","author":"LV Bel\u2019skaya","year":"2024","unstructured":"Bel\u2019skaya LV, Dyachenko EI (2024) Oxidative stress in breast cancer: A biochemical map of reactive oxygen species production. Curr Issues Mol Biol 46(5):4646\u20134687","journal-title":"Curr Issues Mol Biol"},{"key":"2087_CR89","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.critrevonc.2016.03.004","volume":"101","author":"V Somasundaram","year":"2016","unstructured":"Somasundaram V et al (2016) Nitric oxide and reactive oxygen species: clues to target oxidative damage repair defective breast cancers. Crit Rev Oncol Hematol 101:184\u2013192","journal-title":"Crit Rev Oncol Hematol"},{"issue":"4\u20135","key":"2087_CR90","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0960-0760(02)00115-2","volume":"81","author":"S Tamir","year":"2002","unstructured":"Tamir S, Izrael S, Vaya J (2002) The effect of oxidative stress on ERalpha and erbeta expression. J Steroid Biochem Mol Biol 81(4\u20135):327\u2013332","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1\u20132","key":"2087_CR91","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.mrfmmm.2004.06.041","volume":"555","author":"MK Kwak","year":"2004","unstructured":"Kwak MK, Wakabayashi N, Kensler TW (2004) Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res 555(1\u20132):133\u2013148","journal-title":"Mutat Res"},{"issue":"3","key":"2087_CR92","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/carcin\/24.3.461","volume":"24","author":"M Ramos-Gomez","year":"2003","unstructured":"Ramos-Gomez M et al (2003) Interactive effects of nrf2 genotype and Oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 24(3):461\u2013467","journal-title":"Carcinogenesis"},{"key":"2087_CR93","doi-asserted-by":"publisher","first-page":"113383","DOI":"10.1016\/j.biopha.2022.113383","volume":"153","author":"JM Macharia","year":"2022","unstructured":"Macharia JM et al (2022) Medicinal plants with anti-colorectal cancer bioactive compounds: potential game-changers in colorectal cancer management. Biomed Pharmacother 153:113383","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2087_CR94","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/ana.10614","volume":"54","author":"DL Smith","year":"2003","unstructured":"Smith DL et al (2003) Minocycline and Doxycycline are not beneficial in a model of Huntington\u2019s disease. Ann Neurol 54(2):186\u2013196","journal-title":"Ann Neurol"},{"key":"2087_CR95","doi-asserted-by":"publisher","first-page":"110170","DOI":"10.1016\/j.cbi.2022.110170","volume":"368","author":"MR Islam","year":"2022","unstructured":"Islam MR et al (2022) Colon cancer and colorectal cancer: prevention and treatment by potential natural products. Chem Biol Interact 368:110170","journal-title":"Chem Biol Interact"},{"key":"2087_CR96","doi-asserted-by":"crossref","unstructured":"Dabaghi M, Quaas R, Hilger I (2020) The treatment of heterotopic human Colon xenograft tumors in mice with 5-Fluorouracil attached to magnetic nanoparticles in combination with magnetic hyperthermia is more efficient than either therapy alone. Cancers (Basel), 12(9).","DOI":"10.3390\/cancers12092562"},{"key":"2087_CR97","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbrc.2021.11.101","volume":"587","author":"CX Wang","year":"2022","unstructured":"Wang CX et al (2022) Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation. Biochem Biophys Res Commun 587:99\u2013106","journal-title":"Biochem Biophys Res Commun"},{"key":"2087_CR98","doi-asserted-by":"publisher","first-page":"1205604","DOI":"10.3389\/fonc.2023.1205604","volume":"13","author":"YB Jin","year":"2023","unstructured":"Jin YB et al (2023) Mechanism of action of Icaritin on uterine corpus endometrial carcinoma based on network Pharmacology and experimental evaluation. Front Oncol 13:1205604","journal-title":"Front Oncol"},{"issue":"10","key":"2087_CR99","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.18632\/aging.204726","volume":"15","author":"L Niu","year":"2023","unstructured":"Niu L, Wu Z (2023) Identification and validation of oxeiptosis-associated LncRNAs and prognosis-related signature genes to predict the immune status in uterine corpus endometrial carcinoma. Aging 15(10):4236\u20134252","journal-title":"Aging"},{"key":"2087_CR100","doi-asserted-by":"crossref","unstructured":"Al-Alem LF et al (2019) Understanding and targeting apoptotic pathways in ovarian Cancer. Cancers (Basel), 11(11)","DOI":"10.3390\/cancers11111631"},{"key":"2087_CR101","doi-asserted-by":"crossref","unstructured":"Liang X, Ju J (2021) Matrine inhibits ovarian cancer cell viability and promotes apoptosis by regulating the ERK\/JNK signaling pathway via p38MAPK. Oncol Rep, 45(5)","DOI":"10.3892\/or.2021.8033"},{"key":"2087_CR102","doi-asserted-by":"crossref","unstructured":"Matuszczak M, Kiljanczyk A, Salagierski M (2023) Surg Approach Metastatic Ren Cell Carcinoma: Literature Rev Cancers (Basel), 15(6)","DOI":"10.3390\/cancers15061804"},{"key":"2087_CR103","doi-asserted-by":"crossref","unstructured":"Lei ZN et al (2020) Understanding and targeting resistance mechanisms in cancer. MedComm 2023. 4(3): p. e265","DOI":"10.1002\/mco2.265"},{"issue":"11","key":"2087_CR104","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1038\/jid.2012.181","volume":"132","author":"S Toosi","year":"2012","unstructured":"Toosi S, Orlow SJ, Manga P (2012) Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol 132(11):2601\u20132609","journal-title":"J Invest Dermatol"},{"key":"2087_CR105","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.freeradbiomed.2018.08.022","volume":"126","author":"P Kang","year":"2018","unstructured":"Kang P et al (2018) TRPM2 mediates mitochondria-dependent apoptosis of melanocytes under oxidative stress. Free Radic Biol Med 126:259\u2013268","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"2087_CR106","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1038\/jid.2014.152","volume":"134","author":"Z Jian","year":"2014","unstructured":"Jian Z et al (2014) Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress response: a possible mechanism for melanocyte degeneration in vitiligo. J Invest Dermatol 134(8):2221\u20132230","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2087_CR107","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jcp.22027","volume":"223","author":"ML Dell\u2019Anna","year":"2010","unstructured":"Dell\u2019Anna ML et al (2010) Membrane lipid defects are responsible for the generation of reactive oxygen species in peripheral blood mononuclear cells from vitiligo patients. J Cell Physiol 223(1):187\u2013193","journal-title":"J Cell Physiol"},{"issue":"3","key":"2087_CR108","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s12016-017-8634-3","volume":"55","author":"WH Boehncke","year":"2018","unstructured":"Boehncke WH, Brembilla NC (2018) Unmet needs in the field of psoriasis: pathogenesis and treatment. Clin Rev Allergy Immunol 55(3):295\u2013311","journal-title":"Clin Rev Allergy Immunol"},{"issue":"6","key":"2087_CR109","first-page":"798","volume":"17","author":"J Hu","year":"2022","unstructured":"Hu J et al (2022) A double-edged sword: ROS related therapies in the treatment of psoriasis. Asian J Pharm Sci 17(6):798\u2013816","journal-title":"Asian J Pharm Sci"},{"key":"2087_CR110","doi-asserted-by":"publisher","first-page":"101222","DOI":"10.1016\/j.molmet.2021.101222","volume":"51","author":"R Shrestha","year":"2021","unstructured":"Shrestha R, Johnson E, Byrne FL (2021) Exploring the therapeutic potential of mitochondrial uncouplers in cancer. Mol Metab 51:101222","journal-title":"Mol Metab"},{"key":"2087_CR111","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1472-6882-11-21","volume":"11","author":"O Szczurko","year":"2011","unstructured":"Szczurko O et al (2011) Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial. BMC Complement Altern Med 11:21","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"2087_CR112","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/ced.12664","volume":"41","author":"L Lu","year":"2016","unstructured":"Lu L et al (2016) Bilobalide protection of normal human melanocytes from hydrogen peroxide-induced oxidative damage via promotion of antioxidase expression and Inhibition of Endoplasmic reticulum stress. Clin Exp Dermatol 41(1):64\u201373","journal-title":"Clin Exp Dermatol"},{"issue":"8","key":"2087_CR113","doi-asserted-by":"publisher","first-page":"5193","DOI":"10.1111\/jcmm.14393","volume":"23","author":"S Zhang","year":"2019","unstructured":"Zhang S et al (2019) Ginkgo biloba extract protects human melanocytes from H(2) O(2) -induced oxidative stress by activating Nrf2. J Cell Mol Med 23(8):5193\u20135199","journal-title":"J Cell Mol Med"},{"issue":"17","key":"2087_CR114","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1016\/j.lfs.2007.01.034","volume":"80","author":"XP Liu","year":"2007","unstructured":"Liu XP et al (2007) Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway. Life Sci 80(17):1586\u20131591","journal-title":"Life Sci"},{"issue":"1","key":"2087_CR115","first-page":"1","volume":"35","author":"N Mei","year":"2017","unstructured":"Mei N et al (2017) Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 35(1):1\u201328","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"issue":"5","key":"2087_CR116","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1177\/0192623313501235","volume":"42","author":"CV Rider","year":"2014","unstructured":"Rider CV et al (2014) Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicol Pathol 42(5):830\u2013843","journal-title":"Toxicol Pathol"},{"key":"2087_CR117","doi-asserted-by":"publisher","first-page":"1113462","DOI":"10.3389\/fonc.2023.1113462","volume":"13","author":"F Cheng","year":"2023","unstructured":"Cheng F et al (2023) Adverse reactions after treatment with dasatinib in chronic myeloid leukemia: characteristics, potential mechanisms, and clinical management strategies. Front Oncol 13:1113462","journal-title":"Front Oncol"},{"issue":"6","key":"2087_CR118","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ctrv.2010.02.015","volume":"36","author":"J Araujo","year":"2010","unstructured":"Araujo J, Logothetis C (2010) Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors. Cancer Treat Rev 36(6):492\u2013500","journal-title":"Cancer Treat Rev"},{"key":"2087_CR119","doi-asserted-by":"publisher","first-page":"1264032","DOI":"10.3389\/fphar.2023.1264032","volume":"14","author":"G Strusi","year":"2023","unstructured":"Strusi G et al (2023) Phenethyl isothiocyanate and dasatinib combination synergistically reduces hepatocellular carcinoma growth via cell cycle arrest and oxeiptosis. Front Pharmacol 14:1264032","journal-title":"Front Pharmacol"},{"key":"2087_CR120","doi-asserted-by":"publisher","first-page":"896637","DOI":"10.3389\/fphar.2022.896637","volume":"13","author":"H Zhao","year":"2022","unstructured":"Zhao H et al (2022) The Angelica Dahurica: A review of traditional uses, phytochemistry and Pharmacology. Front Pharmacol 13:896637","journal-title":"Front Pharmacol"},{"key":"2087_CR121","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jff.2015.11.018","volume":"20","author":"Y Bai","year":"2016","unstructured":"Bai Y et al (2016) Coumarins from the roots of Angelica Dahurica with antioxidant and antiproliferative activities. J Funct Foods 20:453\u2013462","journal-title":"J Funct Foods"},{"issue":"3","key":"2087_CR122","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1139\/bcb-2021-0399","volume":"100","author":"J Zhang","year":"2022","unstructured":"Zhang J et al (2022) Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro. Biochem Cell Biol 100(3):213\u2013222","journal-title":"Biochem Cell Biol"},{"key":"2087_CR123","doi-asserted-by":"publisher","first-page":"p2075614","DOI":"10.1155\/2019\/2075614","volume":"2019","author":"P Aiello","year":"2019","unstructured":"Aiello P et al (2019) Medicinal plants in the prevention and treatment of Colon cancer. Oxid Med Cell Longev 2019:p2075614","journal-title":"Oxid Med Cell Longev"},{"key":"2087_CR124","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.phymed.2017.08.006","volume":"34","author":"S Galadari","year":"2017","unstructured":"Galadari S et al (2017) Molecular targets and anticancer potential of sanguinarine-a benzophenanthridine alkaloid. Phytomedicine 34:143\u2013153","journal-title":"Phytomedicine"},{"key":"2087_CR125","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-3-319-41334-1_7","volume":"928","author":"P Basu","year":"2016","unstructured":"Basu P, Kumar GS (2016) Sanguinarine and its role in chronic diseases. Adv Exp Med Biol 928:155\u2013172","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"2087_CR126","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41420-023-01376-3","volume":"9","author":"S Pallichankandy","year":"2023","unstructured":"Pallichankandy S et al (2023) Targeting oxeiptosis-mediated tumor suppression: a novel approach to treat colorectal cancers by sanguinarine. Cell Death Discov 9(1):94","journal-title":"Cell Death Discov"},{"issue":"9","key":"2087_CR127","doi-asserted-by":"publisher","first-page":"4310","DOI":"10.7150\/thno.71086","volume":"12","author":"Z Rao","year":"2022","unstructured":"Hu B et al (2022) Insights on Ferroptosis and Colorectal Cancer: Progress and Updates. Molecules 28(1):243. https:\/\/doi.org\/10.3390\/molecules28010243","journal-title":"Theranostics"},{"issue":"4","key":"2087_CR128","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1007\/s10753-023-01819-0","volume":"46","author":"Z Li","year":"2023","unstructured":"Li Z et al (2023) Itaconate: A potent macrophage Immunomodulator. Inflammation 46(4):1177\u20131191","journal-title":"Inflammation"},{"key":"2087_CR129","doi-asserted-by":"crossref","unstructured":"Li R et al (2021) Protective Role of 4-Octyl Itaconate in Murine LPS\/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis. Oxid Med Cell Longev, 2021: p. 9932099","DOI":"10.1155\/2021\/9932099"},{"issue":"7699","key":"2087_CR130","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature25986","volume":"556","author":"EL Mills","year":"2018","unstructured":"Mills EL et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556(7699):113\u2013117","journal-title":"Nature"},{"key":"2087_CR131","doi-asserted-by":"crossref","unstructured":"You M et al (2023) 4-Octyl itaconate inhibits inflammation to attenuate psoriasis as an agonist of oxeiptosis. Int Immunopharmacol, 124(Pt B): p. 110915","DOI":"10.1016\/j.intimp.2023.110915"},{"key":"2087_CR132","doi-asserted-by":"publisher","first-page":"781033","DOI":"10.3389\/fphar.2021.781033","volume":"12","author":"Y Cai","year":"2021","unstructured":"Cai Y et al (2021) Alantolactone: A natural plant extract as a potential therapeutic agent for Cancer. Front Pharmacol 12:781033","journal-title":"Front Pharmacol"},{"issue":"4","key":"2087_CR133","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3390\/ijms17040558","volume":"17","author":"Y Ding","year":"2016","unstructured":"Ding Y et al (2016) Induction of ROS overload by Alantolactone prompts oxidative DNA damage and apoptosis in colorectal Cancer cells. Int J Mol Sci 17(4):558","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2087_CR134","doi-asserted-by":"publisher","first-page":"6242","DOI":"10.1038\/s41598-017-06535-y","volume":"7","author":"A Maryam","year":"2017","unstructured":"Maryam A et al (2017) Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress. Sci Rep 7(1):6242","journal-title":"Sci Rep"},{"issue":"3","key":"2087_CR135","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s12272-017-0990-2","volume":"41","author":"L Cui","year":"2018","unstructured":"Cui L et al (2018) Apoptosis induction by Alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. Arch Pharm Res 41(3):299\u2013313","journal-title":"Arch Pharm Res"},{"issue":"9","key":"2087_CR136","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1016\/j.fct.2012.06.014","volume":"50","author":"JC Lei","year":"2012","unstructured":"Lei JC et al (2012) Alantolactone induces activation of apoptosis in human hepatoma cells. Food Chem Toxicol 50(9):3313\u20133319","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"2087_CR137","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.3892\/ol.2016.4511","volume":"11","author":"Y Jiang","year":"2016","unstructured":"Jiang Y, Xu H, Wang J (2016) Alantolactone induces apoptosis of human cervical cancer cells via reactive oxygen species generation, glutathione depletion and Inhibition of the Bcl-2\/Bax signaling pathway. Oncol Lett 11(6):4203\u20134207","journal-title":"Oncol Lett"},{"key":"2087_CR138","first-page":"101537","volume":"35","author":"M Nasirzadeh","year":"2023","unstructured":"Nasirzadeh M et al (2023) Alantolactone triggers oxeiptosis in human ovarian cancer cells via Nrf2 signaling pathway. Biochem Biophys Rep 35:101537","journal-title":"Biochem Biophys Rep"},{"key":"2087_CR139","doi-asserted-by":"crossref","unstructured":"Oikawa D, Shimizu K, Tokunaga F (2023) Pleiotropic roles of a KEAP1-Associated deubiquitinase, OTUD1. Antioxid (Basel), 12(2)","DOI":"10.3390\/antiox12020350"},{"issue":"2","key":"2087_CR140","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/S0968-0004(99)01530-3","volume":"25","author":"KS Makarova","year":"2000","unstructured":"Makarova KS, Aravind L, Koonin EV (2000) A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem Sci 25(2):50\u201352","journal-title":"Trends Biochem Sci"},{"key":"2087_CR141","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cellsig.2017.02.011","volume":"33","author":"S Piao","year":"2017","unstructured":"Piao S et al (2017) Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53. Cell Signal 33:22\u201329","journal-title":"Cell Signal"},{"issue":"8","key":"2087_CR142","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s41419-022-05145-5","volume":"13","author":"D Oikawa","year":"2022","unstructured":"Oikawa D et al (2022) OTUD1 deubiquitinase regulates NF-kappaB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways. Cell Death Dis 13(8):694","journal-title":"Cell Death Dis"},{"issue":"30","key":"2087_CR143","doi-asserted-by":"publisher","first-page":"12375","DOI":"10.1074\/jbc.R116.760884","volume":"292","author":"NW Mathy","year":"2017","unstructured":"Mathy NW, Chen XM (2017) Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses. J Biol Chem 292(30):12375\u201312382","journal-title":"J Biol Chem"},{"issue":"3","key":"2087_CR144","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.gpb.2016.12.005","volume":"15","author":"IM Dykes","year":"2017","unstructured":"Dykes IM, Emanueli C (2017) Transcriptional and Post-transcriptional gene regulation by long Non-coding RNA. Genomics Proteom Bioinf 15(3):177\u2013186","journal-title":"Genomics Proteom Bioinf"},{"issue":"1","key":"2087_CR145","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41420-021-00576-z","volume":"7","author":"Y Guo","year":"2021","unstructured":"Guo Y et al (2021) Identification of a prognostic ferroptosis-related LncRNA signature in the tumor microenvironment of lung adenocarcinoma. Cell Death Discov 7(1):190","journal-title":"Cell Death Discov"},{"issue":"3","key":"2087_CR146","doi-asserted-by":"publisher","first-page":"e1862","DOI":"10.1002\/wrna.1862","volume":"15","author":"YC Ciftci","year":"2024","unstructured":"Ciftci YC, Vatansever IE, Akgul B (2024) Unraveling the intriguing interplay: exploring the role of LncRNAs in caspase-independent cell death. Wiley Interdiscip Rev RNA 15(3):e1862","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"2087_CR147","doi-asserted-by":"crossref","unstructured":"Chen X et al (2024) Circular RNA CircFOXO3 functions as a competitive endogenous RNA for Acid-Sensing ion channel subunit 1 mediating oxeiptosis in nucleus pulposus. Biomedicines, 12(3)","DOI":"10.3390\/biomedicines12030678"},{"issue":"4","key":"2087_CR148","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495\u2013516","journal-title":"Toxicol Pathol"},{"issue":"1","key":"2087_CR149","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.trecan.2021.09.003","volume":"8","author":"J Yan","year":"2022","unstructured":"Yan J et al (2022) Necroptosis and tumor progression. Trends Cancer 8(1):21\u201327","journal-title":"Trends Cancer"},{"issue":"5","key":"2087_CR150","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","volume":"18","author":"D Bertheloot","year":"2021","unstructured":"Bertheloot D, Latz E, Franklin BS (2021) Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol Immunol 18(5):1106\u20131121","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"2087_CR151","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J et al (2020) Ferroptosis: past, present and future. Cell Death Dis 11(2):88","journal-title":"Cell Death Dis"},{"key":"2087_CR152","doi-asserted-by":"publisher","first-page":"101781","DOI":"10.1016\/j.smim.2023.101781","volume":"69","author":"SO Vasudevan","year":"2023","unstructured":"Vasudevan SO, Behl B, Rathinam VA (2023) Pyroptosis-induced inflammation and tissue damage. Semin Immunol 69:101781","journal-title":"Semin Immunol"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02087-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02087-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02087-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T06:02:20Z","timestamp":1749880940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02087-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":152,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2087"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02087-z","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"4 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}