{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:45:49Z","timestamp":1789404349025,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5-6","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2022-2-4097"],"award-info":[{"award-number":["2022-2-4097"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2024-4-40921"],"award-info":[{"award-number":["2024-4-40921"]}]},{"name":"Clinical Key Project of Peking University Third Hospital","award":["BYSY2023049"],"award-info":[{"award-number":["BYSY2023049"]}]},{"name":"Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine","award":["B2025001"],"award-info":[{"award-number":["B2025001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074193"],"award-info":[{"award-number":["82074193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cohort Construction Project of Peking University Third Hospital","award":["BYSYDL2022013"],"award-info":[{"award-number":["BYSYDL2022013"]}]},{"name":"\u201cExtensive Collection & Harmony Integration\u201d Projects of Peking University Third Hospital","award":["2404-01-01"],"award-info":[{"award-number":["2404-01-01"]}]},{"name":"Special Fund of the Beijing Clinical Key Specialty Construction Program, P. R. China","award":["BJZKBC0011"],"award-info":[{"award-number":["BJZKBC0011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s10495-025-02093-1","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T08:17:47Z","timestamp":1741162667000},"page":"1331-1350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bushen Jianpi Tiaoxue Decoction (BJTD) inhibits the LIF-mTOR signaling axis to regulate mitochondrial function and alleviate cyclophosphamide-induced diminished ovarian reserve"],"prefix":"10.1007","volume":"30","author":[{"given":"Hangqi","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"2093_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/jama.2021.4788","volume":"326","author":"SA Carson","year":"2021","unstructured":"Carson SA, Kallen AN (2021) Diagnosis and management of infertility: A review. JAMA 326:65\u201376","journal-title":"JAMA"},{"key":"2093_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.fertnstert.2015.05.017","volume":"104","author":"K Devine","year":"2015","unstructured":"Devine K, Mumford SL, Wu M, DeCherney AH, Hill MJ, Propst A (2015) Diminished ovarian reserve in the united States assisted reproductive technology population: diagnostic trends among 181,536 cycles from the society for assisted reproductive technology clinic outcomes reporting system. Fertil Steril 104:612\u2013619","journal-title":"Fertil Steril"},{"key":"2093_CR3","doi-asserted-by":"publisher","first-page":"138727","DOI":"10.1016\/j.chemosphere.2023.138727","volume":"330","author":"T Tian","year":"2023","unstructured":"Tian T, Hao Y, Wang Y, Xu X, Long X, Yan L et al (2023) Mixed and single effects of endocrine disrupting chemicals in follicular fluid on likelihood of diminished ovarian reserve: A case-control study. Chemosphere 330:138727","journal-title":"Chemosphere"},{"key":"2093_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.04.229","volume":"220","author":"W Dai","year":"2024","unstructured":"Dai W, Xu B, Ding L, Zhang Z, Yang H, He T et al (2024) Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells. Free Radic Biol Med 220:1\u201314","journal-title":"Free Radic Biol Med"},{"key":"2093_CR5","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1093\/humrep\/dey216","volume":"33","author":"RA Anderson","year":"2018","unstructured":"Anderson RA, Brewster DH, Wood R, Nowell S, Fischbacher C, Kelsey TW et al (2018) The impact of cancer on subsequent chance of pregnancy: A population-based analysis. Hum Reprod 33:1281\u20131290","journal-title":"Hum Reprod"},{"key":"2093_CR6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1093\/humupd\/dmz027","volume":"25","author":"N Spears","year":"2019","unstructured":"Spears N, Lopes F, Stefansdottir A, Rossi V, De Felici M, Anderson RA et al (2019) Ovarian damage from chemotherapy and current approaches to its protection. Hum Reprod Update 25:673\u2013693","journal-title":"Hum Reprod Update"},{"key":"2093_CR7","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1093\/humrep\/dead064","volume":"38","author":"O Kashi","year":"2023","unstructured":"Kashi O, Roness H, Spector I, Derech-Haim S, Meirow D (2023) Dual suppression of follicle activation pathways completely prevents the cyclophosphamide-induced loss of ovarian reserve. Hum Reprod 38:1086\u20131098","journal-title":"Hum Reprod"},{"key":"2093_CR8","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1093\/humrep\/dead255","volume":"39","author":"R Rosario","year":"2024","unstructured":"Rosario R, Stewart HL, Spears N, Telfer EE, Anderson RA (2024) Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while Rapamycin attenuates only PI3K signalling activation, in human ovarian cortex in vitro. Hum Reprod 39:382\u2013392","journal-title":"Hum Reprod"},{"key":"2093_CR9","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1073\/pnas.1617233114","volume":"114","author":"KN Goldman","year":"2017","unstructured":"Goldman KN, Chenette D, Arju R, Duncan FE, Keefe DL, Grifo JA et al (2017) mTORC1\/2 Inhibition preserves ovarian function and fertility during genotoxic chemotherapy. Proc Natl Acad Sci U S A 114:3186\u20133191","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2093_CR10","doi-asserted-by":"publisher","first-page":"106298","DOI":"10.1016\/j.envint.2020.106298","volume":"147","author":"M Lin","year":"2021","unstructured":"Lin M, Hua R, Ma J, Zhou Y, Li P, Xu X et al (2021) Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK\/mTOR\/ULK1 signalling pathway. Environ Int 147:106298","journal-title":"Environ Int"},{"key":"2093_CR11","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.gendis.2021.04.003","volume":"9","author":"S Viswanadhapalli","year":"2022","unstructured":"Viswanadhapalli S, Dileep KV, Zhang K, Nair HB, Vadlamudi RK (2022) Targeting LIF\/LIFR signaling in cancer. Genes Dis 9:973\u2013980","journal-title":"Genes Dis"},{"key":"2093_CR12","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1172\/JCI63428","volume":"123","author":"SC Liu","year":"2013","unstructured":"Liu SC, Tsang NM, Chiang WC, Chang KP, Hsueh C, Liang Y et al (2013) Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest 123:5269\u20135283","journal-title":"J Clin Invest"},{"key":"2093_CR13","doi-asserted-by":"publisher","first-page":"788","DOI":"10.18632\/oncotarget.1772","volume":"5","author":"X Li","year":"2014","unstructured":"Li X, Yang Q, Yu H, Wu L, Zhao Y, Zhang C et al (2014) LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget 5:788\u2013801","journal-title":"Oncotarget"},{"key":"2093_CR14","doi-asserted-by":"publisher","first-page":"12989","DOI":"10.1002\/jcp.27969","volume":"234","author":"N Shokrzadeh","year":"2019","unstructured":"Shokrzadeh N, Alivand MR, Abedelahi A, Hessam SM, Niknafs B (2019) Calcitonin administration improves endometrial receptivity via regulation of LIF, Muc-1 and MicroRNA Let-7a in mice. J Cell Physiol 234:12989\u201313000","journal-title":"J Cell Physiol"},{"key":"2093_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41420-021-00603-z","volume":"7","author":"W Tang","year":"2021","unstructured":"Tang W, Ramasamy K, Pillai S, Santhamma B, Konda S, Pitta VP et al (2021) LIF\/LIFR oncogenic signaling is a novel therapeutic target in endometrial cancer. Cell Death Discov 7:216","journal-title":"Cell Death Discov"},{"key":"2093_CR16","first-page":"a52","volume":"2020","author":"RA Anderson","year":"2020","unstructured":"Anderson RA, Amant F, Braat D, D\u2019Angelo A, Chuva DSLS, Demeestere I et al (2020) ESHRE guideline: female fertility preservation. Hum Reprod Open 2020:a52","journal-title":"Hum Reprod Open"},{"key":"2093_CR17","doi-asserted-by":"crossref","unstructured":"Li Q, Zheng T, Chen J, Li B, Zhang Q, Yang S et al (2024) Exploring melatonin\u2019s multifaceted role in female reproductive health: From follicular development to lactation and its therapeutic potential in obstetric syndromes. J Adv Res","DOI":"10.1016\/j.jare.2024.04.025"},{"key":"2093_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biopha.2018.03.056","volume":"102","author":"G Sheikhansari","year":"2018","unstructured":"Sheikhansari G, Aghebati-Maleki L, Nouri M, Jadidi-Niaragh F, Yousefi M (2018) Current approaches for the treatment of premature ovarian failure with stem cell therapy. Biomed Pharmacother 102:254\u2013262","journal-title":"Biomed Pharmacother"},{"key":"2093_CR19","doi-asserted-by":"publisher","first-page":"525145","DOI":"10.3389\/fphys.2021.525145","volume":"12","author":"Y Xu","year":"2021","unstructured":"Xu Y, Pan CS, Li Q, Zhang HL, Yan L, Anwaier G et al (2021) The ameliorating effects of Bushen Huatan granules and Kunling Wan on polycystic ovary syndrome induced by dehydroepiandrosterone in rats. Front Physiol 12:525145","journal-title":"Front Physiol"},{"key":"2093_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13048-023-01339-3","volume":"17","author":"JC Zhang","year":"2024","unstructured":"Zhang JC, Zhang HL, Xin XY, Zhu YT, Mao X, Hu HQ et al (2024) Mechanisms of Bushen Tiaoxue granules against controlled ovarian hyperstimulation-induced abnormal morphology of endometrium based on network Pharmacology. J Ovarian Res 17:25","journal-title":"J Ovarian Res"},{"key":"2093_CR21","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41467-022-28611-2","volume":"13","author":"X Qin","year":"2022","unstructured":"Qin X, Zhao Y, Zhang T, Yin C, Qiao J, Guo W et al (2022) TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice. Nat Commun 13:914","journal-title":"Nat Commun"},{"key":"2093_CR22","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/humrep\/dey045","volume":"33","author":"N Pascuali","year":"2018","unstructured":"Pascuali N, Scotti L, Di Pietro M, Oubina G, Bas D, May M et al (2018) Ceramide-1-phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure. Hum Reprod 33:844\u2013859","journal-title":"Hum Reprod"},{"key":"2093_CR23","doi-asserted-by":"publisher","first-page":"162r","DOI":"10.1126\/scitranslmed.3005402","volume":"5","author":"L Kalich-Philosoph","year":"2013","unstructured":"Kalich-Philosoph L, Roness H, Carmely A, Fishel-Bartal M, Ligumsky H, Paglin S et al (2013) Cyclophosphamide triggers follicle activation and burnout; AS101 prevents follicle loss and preserves fertility. Sci Transl Med 5:162r\u2013185r","journal-title":"Sci Transl Med"},{"key":"2093_CR24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41420-023-01705-6","volume":"9","author":"Y Chen","year":"2023","unstructured":"Chen Y, Ai L, Zhang Y, Li X, Xu S, Yang W et al (2023) The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury. Cell Death Discov 9:413","journal-title":"Cell Death Discov"},{"key":"2093_CR25","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1093\/humupd\/dmad005","volume":"29","author":"JM Stringer","year":"2023","unstructured":"Stringer JM, Alesi LR, Winship AL, Hutt KJ (2023) Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life. Hum Reprod Update 29:434\u2013456","journal-title":"Hum Reprod Update"},{"key":"2093_CR26","doi-asserted-by":"crossref","unstructured":"Tanaka Y, Amano T, Nakamura A, Yoshino F, Takebayashi A, Takahashi A et al (2024) Rapamycin prevents cyclophosphamide-induced ovarian follicular loss and potentially inhibits tumour proliferation in a breast cancer xenograft mouse model. Hum Reprod","DOI":"10.1093\/humrep\/deae085"},{"key":"2093_CR27","doi-asserted-by":"publisher","first-page":"e2303068","DOI":"10.1002\/adhm.202303068","volume":"13","author":"Y Li","year":"2024","unstructured":"Li Y, Zhang H, Cai C, Mao J, Li N, Huang D et al (2024) Microfluidic encapsulation of exosomes derived from lipopolysaccharide-treated mesenchymal stem cells in hyaluronic acid methacryloyl to restore ovarian function in mice. Adv Healthc Mater 13:e2303068","journal-title":"Adv Healthc Mater"},{"key":"2093_CR28","doi-asserted-by":"publisher","first-page":"E1688","DOI":"10.1073\/pnas.1620729114","volume":"114","author":"M Kano","year":"2017","unstructured":"Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N et al (2017) AMH\/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A 114:E1688\u2013E1697","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2093_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41698-024-00612-y","volume":"8","author":"B Ebrahimi","year":"2024","unstructured":"Ebrahimi B, Viswanadhapalli S, Pratap UP, Rahul G, Yang X, Pitta VP et al (2024) Pharmacological Inhibition of the LIF\/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis. NPJ Precis Oncol 8:118","journal-title":"NPJ Precis Oncol"},{"key":"2093_CR30","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1093\/biolre\/ioae014","volume":"110","author":"A Nahar","year":"2024","unstructured":"Nahar A, Becker J, Pasquariello R, Herrick J, Rogers H, Zhang M et al (2024) FGF2, LIF, and IGF-1 supplementation improves mouse oocyte in vitro maturation via increased glucose metabolismdagger. Biol Reprod 110:672\u2013683","journal-title":"Biol Reprod"},{"key":"2093_CR31","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1210\/er.2008-0048","volume":"30","author":"D Adhikari","year":"2009","unstructured":"Adhikari D, Liu K (2009) Molecular mechanisms underlying the activation of mammalian primordial follicles. Endocr Rev 30:438\u2013464","journal-title":"Endocr Rev"},{"key":"2093_CR32","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1093\/hmg\/ddp217","volume":"18","author":"P Reddy","year":"2009","unstructured":"Reddy P, Adhikari D, Zheng W, Liang S, Hamalainen T, Tohonen V et al (2009) PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles. Hum Mol Genet 18:2813\u20132824","journal-title":"Hum Mol Genet"},{"key":"2093_CR33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ydbio.2008.06.017","volume":"321","author":"GB John","year":"2008","unstructured":"John GB, Gallardo TD, Shirley LJ, Castrillon DH (2008) Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol 321:197\u2013204","journal-title":"Dev Biol"},{"key":"2093_CR34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12979-024-00412-9","volume":"21","author":"HH Shen","year":"2024","unstructured":"Shen HH, Zhang XY, Liu N, Zhang YY, Wu HH, Xie F et al (2024) Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis. Immun Ageing 21:10","journal-title":"Immun Ageing"},{"key":"2093_CR35","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell BR (2022) Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185:2401\u20132421","journal-title":"Cell"},{"key":"2093_CR36","doi-asserted-by":"publisher","first-page":"4463","DOI":"10.1038\/s41598-023-31712-7","volume":"13","author":"R Du","year":"2023","unstructured":"Du R, Cheng X, Ji J, Lu Y, Xie Y, Wang W et al (2023) Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin. Sci Rep 13:4463","journal-title":"Sci Rep"},{"key":"2093_CR37","doi-asserted-by":"publisher","first-page":"155681","DOI":"10.1016\/j.phymed.2024.155681","volume":"129","author":"Z Li","year":"2024","unstructured":"Li Z, Li J, Li Y, Guo L, Xu P, Du H et al (2024) The role of cistanches herba and its ingredients in improving reproductive outcomes: A comprehensive review. Phytomedicine 129:155681","journal-title":"Phytomedicine"},{"key":"2093_CR38","doi-asserted-by":"publisher","first-page":"k5382","DOI":"10.1126\/science.adk5382","volume":"384","author":"Y Liu","year":"2024","unstructured":"Liu Y, Jiang JJ, Du SY, Mu LS, Fan JJ, Hu JC et al (2024) Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction. Science 384:k5382","journal-title":"Science"},{"key":"2093_CR39","doi-asserted-by":"crossref","unstructured":"Sura MB, Cheng YX (2024) Medicinal plant resin natural products: structural diversity and biological activities. Nat Prod Rep","DOI":"10.1039\/D4NP00007B"},{"key":"2093_CR40","doi-asserted-by":"publisher","first-page":"e2311397","DOI":"10.1002\/adma.202311397","volume":"36","author":"W Zhang","year":"2024","unstructured":"Zhang W, Chan C, Zhang K, Qin H, Yu BY, Xue Z et al (2024) Discovering a new drug against acute kidney injury by using a tailored photoacoustic imaging probe. Adv Mater 36:e2311397","journal-title":"Adv Mater"},{"key":"2093_CR41","doi-asserted-by":"publisher","first-page":"117756","DOI":"10.1016\/j.jep.2024.117756","volume":"324","author":"X Liang","year":"2024","unstructured":"Liang X, Xie H, Yu L, Ouyang J, Peng Q, Chen K et al (2024) Study on the effects and mechanisms of Wenzhong Bushen formula in improving ovarian reserve decline in mice based on network Pharmacology. J Ethnopharmacol 324:117756","journal-title":"J Ethnopharmacol"},{"key":"2093_CR42","doi-asserted-by":"publisher","first-page":"116703","DOI":"10.1016\/j.jep.2023.116703","volume":"315","author":"C Su","year":"2023","unstructured":"Su C, Zhang R, Zhang X, Lv M, Liu X, Ao K et al (2023) Dingkun pill modulate ovarian function in chemotherapy-induced premature ovarian insufficiency mice by regulating PTEN\/PI3K\/AKT\/FOXO3a signaling pathway. J Ethnopharmacol 315:116703","journal-title":"J Ethnopharmacol"},{"key":"2093_CR43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12951-023-02251-0","volume":"22","author":"M Zheng","year":"2024","unstructured":"Zheng M, Liu K, Li L, Feng C, Wu G (2024) Traditional Chinese medicine inspired dual-drugs loaded inhalable nano-therapeutics alleviated idiopathic pulmonary fibrosis by targeting early inflammation and late fibrosis. J Nanobiotechnol 22:14","journal-title":"J Nanobiotechnol"},{"key":"2093_CR44","doi-asserted-by":"publisher","first-page":"153761","DOI":"10.1016\/j.phymed.2021.153761","volume":"93","author":"B Kashyap","year":"2021","unstructured":"Kashyap B, Barge SR, Bharadwaj S, Deka B, Rahman S, Ghosh A et al (2021) Evaluation of therapeutic effect of Premna herbacea in diabetic rat and isoverbascoside against insulin resistance in L6 muscle cells through bioenergetics and stimulation of JNK and AKT\/mTOR signaling cascade. Phytomedicine 93:153761","journal-title":"Phytomedicine"},{"key":"2093_CR45","doi-asserted-by":"publisher","first-page":"102637","DOI":"10.1016\/j.redox.2023.102637","volume":"61","author":"LL Song","year":"2023","unstructured":"Song LL, Qu YQ, Tang YP, Chen X, Lo HH, Qu LQ et al (2023) Hyperoside alleviates toxicity of beta-amyloid via Endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP\/PS1 double Transgenic Alzheimer\u2019s disease mice. Redox Biol 61:102637","journal-title":"Redox Biol"},{"key":"2093_CR46","doi-asserted-by":"publisher","first-page":"115527","DOI":"10.1016\/j.bios.2023.115527","volume":"237","author":"XN Wang","year":"2023","unstructured":"Wang XN, Song Y, Tang W, Li P, Li B (2023) Integration of fluorescence and MALDI imaging for microfluidic chip-based screening of potential thrombin inhibitors from natural products. Biosens Bioelectron 237:115527","journal-title":"Biosens Bioelectron"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02093-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02093-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02093-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T13:02:29Z","timestamp":1749906149000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02093-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":46,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["2093"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02093-1","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"assertion":[{"value":"8 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}