{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:21:32Z","timestamp":1791177692597,"version":"4.1.0"},"reference-count":181,"publisher":"Springer Science and Business Media LLC","issue":"9-10","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10495-025-02134-9","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:48:11Z","timestamp":1752140891000},"page":"1931-1960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploiting autophagy and related pathways: pioneering new horizons in cataract therapy"],"prefix":"10.1007","volume":"30","author":[{"given":"Mehrdad","family":"Hashemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pezhman","family":"Shafiei Asheghabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Moassesfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Malek Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Rafedoust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh","family":"Razeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeganeh","family":"Esfahaniolasl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Mirzayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Keikhavani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Tajbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Alimohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Taheriazam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najma","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiavash","family":"Hushmandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliheh","family":"Entezari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"issue":"7182","key":"2134_CR1","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451(7182):1069\u20131075. https:\/\/doi.org\/10.1038\/nature06639","journal-title":"Nature"},{"issue":"1","key":"2134_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/cr.2013.169","volume":"24","author":"Y Ohsumi","year":"2014","unstructured":"Ohsumi Y (2014) Historical landmarks of autophagy research. Cell Res 24(1):9\u201323. https:\/\/doi.org\/10.1038\/cr.2013.169","journal-title":"Cell Res"},{"issue":"1","key":"2134_CR3","doi-asserted-by":"publisher","first-page":"2178996","DOI":"10.1080\/27694127.2023.2178996","volume":"2","author":"PB Liton","year":"2023","unstructured":"Liton PB, Boesze-Battaglia K, Boulton ME, Boya P, Ferguson TA, Ganley IG et al (2023) Autophagy in the eye: from physiology to pathophysiology. Autophagy Rep 2(1):2178996","journal-title":"Autophagy Rep"},{"issue":"3","key":"2134_CR4","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/life11030189","volume":"11","author":"JA Fernandez-Albarral","year":"2021","unstructured":"Fernandez-Albarral JA, de Julian-Lopez E, Soler-Dominguez C, de Hoz R, Lopez-Cuenca I, Salobrar-Garcia E et al (2021) The role of autophagy in eye diseases. Life (Basel) 11(3):189. https:\/\/doi.org\/10.3390\/life11030189","journal-title":"Life (Basel)"},{"key":"2134_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.exer.2013.08.017","volume":"116","author":"MJ Costello","year":"2013","unstructured":"Costello MJ, Brennan LA, Basu S, Chauss D, Mohamed A, Gilliland KO et al (2013) Autophagy and mitophagy participate in ocular lens organelle degradation. Exp Eye Res 116:141\u2013150. https:\/\/doi.org\/10.1016\/j.exer.2013.08.017","journal-title":"Exp Eye Res"},{"issue":"1","key":"2134_CR6","doi-asserted-by":"publisher","first-page":"4856431","DOI":"10.1155\/2016\/4856431","volume":"2016","author":"J Zhou","year":"2016","unstructured":"Zhou J, Yao K, Zhang Y, Chen G, Lai K, Yin H, Yu Y (2016) Thioredoxin binding Protein-2 regulates autophagy of human Lens epithelial cells under oxidative stress via Inhibition of Akt phosphorylation. Oxid Med Cell Longev 2016(1):4856431. https:\/\/doi.org\/10.1155\/2016\/4856431","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"2134_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s10020-022-00540-2","volume":"28","author":"J Ma","year":"2022","unstructured":"Ma J, Ye W, Yang Y, Wu T, Wang Y, Li J et al (2022) The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD\/ULK1 is involved in the formation of diabetic cataracts. Mol Med 28(1):116","journal-title":"Mol Med"},{"issue":"11","key":"2134_CR8","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.7150\/ijbs.16245","volume":"12","author":"P Chai","year":"2016","unstructured":"Chai P, Ni H, Zhang H, Fan X (2016) The evolving functions of autophagy in ocular health: A Double-edged sword. Int J Biol Sci 12(11):1332\u20131340. https:\/\/doi.org\/10.7150\/ijbs.16245","journal-title":"Int J Biol Sci"},{"issue":"19","key":"2134_CR9","doi-asserted-by":"publisher","first-page":"e108863","DOI":"10.15252\/embj.2021108863","volume":"40","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P et al (2021) Autophagy in major human diseases. EMBO J 40(19):e108863. https:\/\/doi.org\/10.15252\/embj.2021108863","journal-title":"EMBO J"},{"issue":"1","key":"2134_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev-cellbio-100818-125300","volume":"35","author":"H Morishita","year":"2019","unstructured":"Morishita H, Mizushima N (2019) Diverse cellular roles of autophagy. Annu Rev Cell Dev Biol 35(1):453\u2013475. https:\/\/doi.org\/10.1146\/annurev-cellbio-100818-125300","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2134_CR11","doi-asserted-by":"publisher","first-page":"155811DOI","DOI":"10.1016\/j.metabol.2024.155811","volume":"154","author":"Z Dashti","year":"2024","unstructured":"Dashti Z, Yousefi Z, Kiani P, Taghizadeh M, Maleki MH, Borji M et al (2024) Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth. Metabolism 154:155811DOI. https:\/\/doi.org\/10.1016\/j.metabol.2024.155811","journal-title":"Metabolism"},{"key":"2134_CR12","doi-asserted-by":"publisher","first-page":"101468","DOI":"10.1016\/j.arr.2021.101468","volume":"72","author":"S Kaushik","year":"2021","unstructured":"Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM (2021) Autophagy and the hallmarks of aging. Ageing Res Rev 72:101468. https:\/\/doi.org\/10.1016\/j.arr.2021.101468","journal-title":"Ageing Res Rev"},{"issue":"5","key":"2134_CR13","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/s41556-021-00669-y","volume":"23","author":"C Chang","year":"2021","unstructured":"Chang C, Jensen LE, Hurley JH (2021) Autophagosome biogenesis comes out of the black box. Nat Cell Biol 23(5):450\u2013456. https:\/\/doi.org\/10.1038\/s41556-021-00669-y","journal-title":"Nat Cell Biol"},{"issue":"6","key":"2134_CR14","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1007\/s11010-025-05207-0","volume":"480","author":"P Kiani","year":"2025","unstructured":"Kiani P, Khodadadi ES, Nikdasti A, Yarahmadi S, Gheibi M, Yousefi Z et al (2025) Autophagy and the peroxisome proliferator-activated receptor signaling pathway: a molecular Ballet in lipid metabolism and homeostasis. Mol Cell Biochem 480(6):3477\u20133499. https:\/\/doi.org\/10.1007\/s11010-025-05207-0","journal-title":"Mol Cell Biochem"},{"key":"2134_CR15","doi-asserted-by":"publisher","first-page":"1015500","DOI":"10.3389\/fphys.2022.1015500","volume":"13","author":"S Wang","year":"2022","unstructured":"Wang S, Li H, Yuan M, Fan H, Cai Z (2022) Role of AMPK in autophagy. Front Physiol 13:1015500. https:\/\/doi.org\/10.3389\/fphys.2022.1015500","journal-title":"Front Physiol"},{"issue":"3","key":"2134_CR16","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1042\/EBC20240007","volume":"68","author":"WJ Smiles","year":"2024","unstructured":"Smiles WJ, Ovens AJ, Kemp BE, Galic S, Petersen J, Oakhill JS (2024) New developments in AMPK and mTORC1 cross-talk. Essays Biochem 68(3):321\u2013336. https:\/\/doi.org\/10.1042\/EBC20240007","journal-title":"Essays Biochem"},{"issue":"12","key":"2134_CR17","doi-asserted-by":"publisher","first-page":"e0313302","DOI":"10.1371\/journal.pone.0313302","volume":"19","author":"O Kapuy","year":"2024","unstructured":"Kapuy O, Holczer M, Csabai L, Korcsmaros T (2024) Oscillatory autophagy induction is enabled by an updated AMPK-ULK1 regulatory wiring. PLoS ONE 19(12):e0313302. https:\/\/doi.org\/10.1371\/journal.pone.0313302","journal-title":"PLoS ONE"},{"issue":"1","key":"2134_CR18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jmb.2019.05.010","volume":"432","author":"V Kirkin","year":"2020","unstructured":"Kirkin V (2020) History of the selective autophagy research: How did it begin and where does it stand today? J Mol Biol 432(1):3\u201327","journal-title":"J Mol Biol"},{"issue":"1","key":"2134_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1146\/annurev-cellbio-120219-035530","volume":"37","author":"T Lamark","year":"2021","unstructured":"Lamark T, Johansen T (2021) Mechanisms of selective autophagy. Annu Rev Cell Dev Biol 37(1):143\u2013169. https:\/\/doi.org\/10.1146\/annurev-cellbio-120219-035530","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"2134_CR20","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jmb.2019.06.032","volume":"432","author":"L Montava-Garriga","year":"2020","unstructured":"Montava-Garriga L, Ganley IG (2020) Outstanding questions in mitophagy: what we do and do not know. J Mol Biol 432(1):206\u2013230","journal-title":"J Mol Biol"},{"issue":"1","key":"2134_CR21","doi-asserted-by":"publisher","first-page":"5763658","DOI":"10.1155\/2019\/5763658","volume":"2019","author":"X Yang","year":"2019","unstructured":"Yang X, Pan X, Zhao X, Luo J, Xu M, Bai D et al (2019) Autophagy and age-related eye diseases. Biomed Res Int 2019(1):5763658. https:\/\/doi.org\/10.1155\/2019\/5763658","journal-title":"Biomed Res Int"},{"issue":"1","key":"2134_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.nutr.27.061406.093749","volume":"27","author":"N Mizushima","year":"2007","unstructured":"Mizushima N, Klionsky DJ (2007) Protein turnover via autophagy: implications for metabolism. Annu Rev Nutr 27(1):19\u201340. https:\/\/doi.org\/10.1146\/annurev.nutr.27.061406.093749","journal-title":"Annu Rev Nutr"},{"issue":"33","key":"2134_CR23","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","volume":"282","author":"S Pankiv","year":"2007","unstructured":"Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H et al (2007) p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282(33):24131\u201324145. https:\/\/doi.org\/10.1074\/jbc.M702824200","journal-title":"J Biol Chem"},{"issue":"7095","key":"2134_CR24","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nature04724","volume":"441","author":"T Hara","year":"2006","unstructured":"Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R et al (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441(7095):885\u2013889. https:\/\/doi.org\/10.1038\/nature04724","journal-title":"Nature"},{"issue":"7095","key":"2134_CR25","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nature04723","volume":"441","author":"M Komatsu","year":"2006","unstructured":"Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I et al (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441(7095):880\u2013884. https:\/\/doi.org\/10.1038\/nature04723","journal-title":"Nature"},{"issue":"8","key":"2134_CR26","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1101\/gad.2016211","volume":"25","author":"A Takamura","year":"2011","unstructured":"Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S et al (2011) Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25(8):795\u2013800. https:\/\/doi.org\/10.1101\/gad.2016211","journal-title":"Genes Dev"},{"issue":"7020","key":"2134_CR27","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/nature03029","volume":"432","author":"A Kuma","year":"2004","unstructured":"Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al (2004) The role of autophagy during the early neonatal starvation period. Nature 432(7020):1032\u20131036. https:\/\/doi.org\/10.1038\/nature03029","journal-title":"Nature"},{"issue":"1\u20133","key":"2134_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.vetimm.2008.10.293","volume":"128","author":"J Harris","year":"2009","unstructured":"Harris J, Master SS, De Haro SA, Delgado M, Roberts EA, Hope JC et al (2009) Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages. Vet Immunol Immunopathol 128(1\u20133):37\u201343. https:\/\/doi.org\/10.1016\/j.vetimm.2008.10.293","journal-title":"Vet Immunol Immunopathol"},{"issue":"11","key":"2134_CR29","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.4161\/auto.36184","volume":"10","author":"SK Mitter","year":"2014","unstructured":"Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D et al (2014) Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy;10(11):1989\u20132005","journal-title":"Autophagy"},{"issue":"10","key":"2134_CR30","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.exger.2013.04.002","volume":"48","author":"M Kawashima","year":"2013","unstructured":"Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T et al (2013) Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol 48(10):1096\u20131100. https:\/\/doi.org\/10.1016\/j.exger.2013.04.002","journal-title":"Exp Gerontol"},{"issue":"12","key":"2134_CR31","doi-asserted-by":"publisher","first-page":"4349","DOI":"10.1046\/j.1460-9568.1999.00868.x","volume":"11","author":"SK Rehen","year":"1999","unstructured":"Rehen SK, Neves DD, Fragel-Madeira L, Britto LR, Linden R (1999) Selective sensitivity of early postmitotic retinal cells to apoptosis induced by Inhibition of protein synthesis. Eur J Neurosci 11(12):4349\u20134356. https:\/\/doi.org\/10.1046\/j.1460-9568.1999.00868.x","journal-title":"Eur J Neurosci"},{"issue":"7","key":"2134_CR32","doi-asserted-by":"publisher","first-page":"973","DOI":"10.4161\/auto.24546","volume":"9","author":"K Kaarniranta","year":"2013","unstructured":"Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A et al (2013) Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9(7):973\u2013984. https:\/\/doi.org\/10.4161\/auto.24546","journal-title":"Autophagy"},{"key":"2134_CR33","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.exer.2014.04.010","volume":"124","author":"LS Frost","year":"2014","unstructured":"Frost LS, Mitchell CH, Boesze-Battaglia K (2014) Autophagy in the eye: implications for ocular cell health. Exp Eye Res 124:56\u201366. https:\/\/doi.org\/10.1016\/j.exer.2014.04.010","journal-title":"Exp Eye Res"},{"issue":"7","key":"2134_CR34","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1080\/15548627.2019.1580509","volume":"15","author":"TG McWilliams","year":"2019","unstructured":"McWilliams TG, Prescott AR, Villarejo-Zori B, Ball G, Boya P, Ganley IG (2019) A comparative map of macroautophagy and mitophagy in the vertebrate eye. Autophagy 15(7):1296\u20131308. https:\/\/doi.org\/10.1080\/15548627.2019.1580509","journal-title":"Autophagy"},{"issue":"1\u20132","key":"2134_CR35","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/0006-8993(86)90550-0","volume":"369","author":"C Reme","year":"1986","unstructured":"Reme C, Wirz-Justice A, Rhyner A, Hofmann S (1986) Circadian rhythm in the light response of rat retinal disk-shedding and autophagy. Brain Res 369(1\u20132):356\u2013360. https:\/\/doi.org\/10.1016\/0006-8993(86)90550-0","journal-title":"Brain Res"},{"issue":"5","key":"2134_CR36","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1167\/iovs.13-13336","volume":"55","author":"J Yao","year":"2014","unstructured":"Yao J, Jia L, Shelby SJ, Ganios AM, Feathers K, Thompson DA, Zacks DN (2014) Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium. Invest Ophthalmol Vis Sci 55(5):3237\u20133246. https:\/\/doi.org\/10.1167\/iovs.13-13336","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"2134_CR37","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/cne.902830310","volume":"283","author":"JP Hornung","year":"1989","unstructured":"Hornung JP, Koppel H, Clarke PG (1989) Endocytosis and autophagy in dying neurons: an ultrastructural study in chick embryos. J Comp Neurol 283(3):425\u2013437. https:\/\/doi.org\/10.1002\/cne.902830310","journal-title":"J Comp Neurol"},{"issue":"6","key":"2134_CR38","doi-asserted-by":"publisher","first-page":"610","DOI":"10.4161\/auto.4867","volume":"3","author":"V Karantza","year":"2007","unstructured":"Karantza V, White E (2007) Role of autophagy in breast cancer. Autophagy 3(6):610\u2013613","journal-title":"Autophagy"},{"issue":"1","key":"2134_CR39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","volume":"10","author":"K Degenhardt","year":"2006","unstructured":"Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G et al (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10(1):51\u201364. https:\/\/doi.org\/10.1016\/j.ccr.2006.06.001","journal-title":"Cancer Cell"},{"issue":"2","key":"2134_CR40","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/ncb1537","volume":"9","author":"J Liang","year":"2007","unstructured":"Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M et al (2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9(2):218\u2013224. https:\/\/doi.org\/10.1038\/ncb1537","journal-title":"Nat Cell Biol"},{"issue":"9","key":"2134_CR41","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nrm2239","volume":"8","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8(9):741\u2013752","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2134_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","volume":"17","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S et al (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy 17(1):1\u2013382. https:\/\/doi.org\/10.1080\/15548627.2020.1797280","journal-title":"Autophagy"},{"issue":"16","key":"2134_CR43","doi-asserted-by":"publisher","first-page":"11436","DOI":"10.1074\/jbc.M112.437103","volume":"288","author":"H Morishita","year":"2013","unstructured":"Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML et al (2013) Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem 288(16):11436\u201311447. https:\/\/doi.org\/10.1074\/jbc.M112.437103","journal-title":"J Biol Chem"},{"issue":"3","key":"2134_CR44","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","volume":"15","author":"N Mizushima","year":"2004","unstructured":"Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15(3):1101\u20131111. https:\/\/doi.org\/10.1091\/mbc.e03-09-0704","journal-title":"Mol Biol Cell"},{"issue":"3","key":"2134_CR45","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1083\/jcb.201603039","volume":"214","author":"TG McWilliams","year":"2016","unstructured":"McWilliams TG, Prescott AR, Allen GF, Tamjar J, Munson MJ, Thomson C et al (2016) mito-QC illuminates mitophagy and mitochondrial architecture in vivo. J Cell Biol 214(3):333\u2013345. https:\/\/doi.org\/10.1083\/jcb.201603039","journal-title":"J Cell Biol"},{"issue":"2","key":"2134_CR46","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.cmet.2017.12.008","volume":"27","author":"TG McWilliams","year":"2018","unstructured":"McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E et al (2018) Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand. Cell Metab 27(2):439\u2013449. e5.DOIhttps:\/\/doi.org\/10.1016\/j.cmet.2017.12.008","journal-title":"Cell Metab"},{"key":"2134_CR47","doi-asserted-by":"publisher","first-page":"101038","DOI":"10.1016\/j.mam.2021.101038","volume":"82","author":"B Villarejo-Zori","year":"2021","unstructured":"Villarejo-Zori B, Jim\u00e9nez-Loygorri JI, Zapata-Mu\u00f1oz J, Bell K, Boya P (2021) New insights into the role of autophagy in retinal and eye diseases. Mol Aspects Med 82:101038","journal-title":"Mol Aspects Med"},{"issue":"1","key":"2134_CR48","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41420-020-0257-4","volume":"6","author":"K Bell","year":"2020","unstructured":"Bell K, Rosignol I, Sierra-Filardi E, Rodriguez-Muela N, Schmelter C, Cecconi F et al (2020) Age related retinal ganglion cell susceptibility in context of autophagy deficiency. Cell Death Discov 6(1):21. https:\/\/doi.org\/10.1038\/s41420-020-0257-4","journal-title":"Cell Death Discov"},{"issue":"1","key":"2134_CR49","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/jcm10010078","volume":"10","author":"A Nettesheim","year":"2020","unstructured":"Nettesheim A, Shim MS, Dixon A, Raychaudhuri U, Gong H, Liton PB (2020) Cathepsin B localizes in the caveolae and participates in the proteolytic cascade in trabecular meshwork cells. Potential new drug target for the treatment of Glaucoma. J Clin Med 10(1):78. https:\/\/doi.org\/10.3390\/jcm10010078","journal-title":"J Clin Med"},{"issue":"1","key":"2134_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41433-019-0632-7","volume":"34","author":"H Choquet","year":"2020","unstructured":"Choquet H, Wiggs JL, Khawaja AP (2020) Clinical implications of recent advances in primary open-angle glaucoma genetics. Eye (Lond) 34(1):29\u201339. https:\/\/doi.org\/10.1038\/s41433-019-0632-7","journal-title":"Eye (Lond)"},{"key":"2134_CR51","doi-asserted-by":"publisher","first-page":"107702DOI","DOI":"10.1016\/j.exer.2019.107702","volume":"186","author":"NC Sears","year":"2019","unstructured":"Sears NC, Boese EA, Miller MA, Fingert JH (2019) Mendelian genes in primary open angle glaucoma. Exp Eye Res 186:107702DOI. https:\/\/doi.org\/10.1016\/j.exer.2019.107702","journal-title":"Exp Eye Res"},{"key":"2134_CR52","doi-asserted-by":"publisher","first-page":"1287DOI","DOI":"10.3389\/fimmu.2018.01287","volume":"9","author":"G Swarup","year":"2018","unstructured":"Swarup G, Sayyad Z (2018) Altered functions and interactions of glaucoma-associated mutants of optineurin. Front Immunol 9:1287DOI. https:\/\/doi.org\/10.3389\/fimmu.2018.01287","journal-title":"Front Immunol"},{"issue":"11","key":"2134_CR53","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1093\/hmg\/ddy107","volume":"27","author":"J Zhang","year":"2018","unstructured":"Zhang J, Ji Y, Lu Y, Fu R, Xu M, Liu X, Guan MX (2018) Leber\u2019s hereditary optic neuropathy (LHON)-associated ND5 12338T\u2009>\u2009C mutation altered the assembly and function of complex I, apoptosis and mitophagy. Hum Mol Genet 27(11):1999\u20132011. https:\/\/doi.org\/10.1093\/hmg\/ddy107","journal-title":"Hum Mol Genet"},{"issue":"3","key":"2134_CR54","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/hmg\/ddy354","volume":"28","author":"LK Sharma","year":"2019","unstructured":"Sharma LK, Tiwari M, Rai NK, Bai Y (2019) Mitophagy activation repairs leber\u2019s hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survival. Hum Mol Genet 28(3):422\u2013433. https:\/\/doi.org\/10.1093\/hmg\/ddy354","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2134_CR55","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1038\/s41467-020-17821-1","volume":"11","author":"M Zaninello","year":"2020","unstructured":"Zaninello M, Palikaras K, Naon D, Iwata K, Herkenne S, Quintana-Cabrera R et al (2020) Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy. Nat Commun 11(1):4029. https:\/\/doi.org\/10.1038\/s41467-020-17821-1","journal-title":"Nat Commun"},{"issue":"6","key":"2134_CR56","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.survophthal.2019.06.001","volume":"64","author":"A Abel","year":"2019","unstructured":"Abel A, McClelland C, Lee MS (2019) Critical review: typical and atypical optic neuritis. Surv Ophthalmol 64(6):770\u2013779. https:\/\/doi.org\/10.1016\/j.survophthal.2019.06.001","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"2134_CR57","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1016\/S2214-109X(13)70113-X","volume":"1","author":"RR Bourne","year":"2013","unstructured":"Bourne RR, Stevens GA, White RA, Smith JL, Flaxman SR, Price H et al (2013) Causes of vision loss worldwide, 1990\u20132010: a systematic analysis. Lancet Glob Health 1(6):e339\u2013e349. https:\/\/doi.org\/10.1016\/S2214-109X(13)70113-X","journal-title":"Lancet Glob Health"},{"key":"2134_CR58","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.exer.2018.08.017","volume":"178","author":"E Bejarano","year":"2019","unstructured":"Bejarano E, Taylor A (2019) Too sweet: problems of protein glycation in the eye. Exp Eye Res 178:255\u2013262. https:\/\/doi.org\/10.1016\/j.exer.2018.08.017","journal-title":"Exp Eye Res"},{"issue":"7823","key":"2134_CR59","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41586-020-2589-x","volume":"585","author":"L Alarcon-Martinez","year":"2020","unstructured":"Alarcon-Martinez L, Villafranca-Baughman D, Quintero H, Kacerovsky JB, Dotigny F, Murai KK et al (2020) Interpericyte tunnelling nanotubes regulate neurovascular coupling. Nature 585(7823):91\u201395. https:\/\/doi.org\/10.1038\/s41586-020-2589-x","journal-title":"Nature"},{"key":"2134_CR60","doi-asserted-by":"publisher","first-page":"100919DOI","DOI":"10.1016\/j.preteyeres.2020.100919","volume":"83","author":"D Tonade","year":"2021","unstructured":"Tonade D, Kern TS (2021) Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Prog Retin Eye Res 83:100919DOI. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100919","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"2134_CR61","doi-asserted-by":"publisher","first-page":"bio038521","DOI":"10.1242\/bio.038521","volume":"8","author":"TS Devi","year":"2019","unstructured":"Devi TS, Yumnamcha T, Yao F, Somayajulu M, Kowluru RA, Singh LP (2019) TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells. Biol Open 8(4):bio038521. https:\/\/doi.org\/10.1242\/bio.038521","journal-title":"Biol Open"},{"issue":"23","key":"2134_CR62","doi-asserted-by":"publisher","first-page":"e129760","DOI":"10.1172\/jci.insight.129760","volume":"4","author":"JR Hombrebueno","year":"2019","unstructured":"Hombrebueno JR, Cairns L, Dutton LR, Lyons TJ, Brazil DP, Moynagh P et al (2019) Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy. JCI Insight 4(23):e129760.","journal-title":"JCI Insight"},{"issue":"4","key":"2134_CR63","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.3390\/ijms22042096","volume":"22","author":"L Olivares-Gonzalez","year":"2021","unstructured":"Olivares-Gonzalez L, Velasco S, Campillo I, Rodrigo R (2021) Retinal inflammation, cell death and inherited retinal dystrophies. Int J Mol Sci 22(4):2096. https:\/\/doi.org\/10.3390\/ijms22042096","journal-title":"Int J Mol Sci"},{"issue":"13","key":"2134_CR64","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/j.febslet.2013.05.020","volume":"587","author":"D Athanasiou","year":"2013","unstructured":"Athanasiou D, Aguila M, Bevilacqua D, Novoselov SS, Parfitt DA, Cheetham ME (2013) The cell stress machinery and retinal degeneration. FEBS Lett 587(13):2008\u20132017. https:\/\/doi.org\/10.1016\/j.febslet.2013.05.020","journal-title":"FEBS Lett"},{"issue":"1","key":"2134_CR65","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nn.2234","volume":"12","author":"C Punzo","year":"2009","unstructured":"Punzo C, Kornacker K, Cepko CL (2009) Stimulation of the insulin\/mtor pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12(1):44\u201352. https:\/\/doi.org\/10.1038\/nn.2234","journal-title":"Nat Neurosci"},{"issue":"8","key":"2134_CR66","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1080\/15548627.2020.1796015","volume":"17","author":"M Pan","year":"2021","unstructured":"Pan M, Yin Y, Wang X, Wang Q, Zhang L, Hu H, Wang C (2021) Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. Autophagy 17(8):1873\u20131888. https:\/\/doi.org\/10.1080\/15548627.2020.1796015","journal-title":"Autophagy"},{"issue":"7","key":"2134_CR67","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1080\/15548627.2018.1463121","volume":"14","author":"J Yao","year":"2018","unstructured":"Yao J, Qiu Y, Frontera E, Jia L, Khan NW, Klionsky DJ et al (2018) Inhibiting autophagy reduces retinal degeneration caused by protein misfolding. Autophagy 14(7):1226\u20131238. https:\/\/doi.org\/10.1080\/15548627.2018.1463121","journal-title":"Autophagy"},{"issue":"4","key":"2134_CR68","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/s41418-020-00653-3","volume":"28","author":"M Samardzija","year":"2021","unstructured":"Samardzija M, Corna A, Gomez-Sintes R, Jarboui MA, Armento A, Roger JE et al (2021) HDAC Inhibition ameliorates cone survival in retinitis pigmentosa mice. Cell Death Differ 28(4):1317\u20131332. https:\/\/doi.org\/10.1038\/s41418-020-00653-3","journal-title":"Cell Death Differ"},{"key":"2134_CR69","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3389\/fcell.2020.00689","volume":"8","author":"H Sundaramurthi","year":"2020","unstructured":"Sundaramurthi H, Roche SL, Grice GL, Moran A, Dillion ET, Campiani G et al (2020) Selective histone deacetylase 6 inhibitors restore cone photoreceptor vision or outer segment morphology in zebrafish and mouse models of retinal blindness. Front Cell Dev Biol 8:689. https:\/\/doi.org\/10.3389\/fcell.2020.00689","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"2134_CR70","doi-asserted-by":"publisher","first-page":"e102468","DOI":"10.15252\/embj.2019102468","volume":"39","author":"F Naso","year":"2020","unstructured":"Naso F, Intartaglia D, Falanga D, Soldati C, Polishchuk E, Giamundo G et al (2020) Light-responsive MicroRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance. EMBO J 39(8):e102468. https:\/\/doi.org\/10.15252\/embj.2019102468","journal-title":"EMBO J"},{"issue":"11","key":"2134_CR71","doi-asserted-by":"publisher","first-page":"7506","DOI":"10.1074\/jbc.M112.439935","volume":"288","author":"Y Chen","year":"2013","unstructured":"Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A (2013) Autophagy protects the retina from light-induced degeneration. J Biol Chem 288(11):7506\u20137518. https:\/\/doi.org\/10.1074\/jbc.M112.439935","journal-title":"J Biol Chem"},{"key":"2134_CR72","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.exer.2015.08.021","volume":"144","author":"Y Chen","year":"2016","unstructured":"Chen Y, Perusek L, Maeda A (2016) Autophagy in light-induced retinal damage. Exp Eye Res 144:64\u201372. https:\/\/doi.org\/10.1016\/j.exer.2015.08.021","journal-title":"Exp Eye Res"},{"issue":"16","key":"2134_CR73","doi-asserted-by":"publisher","first-page":"16579","DOI":"10.18632\/aging.103846","volume":"12","author":"JY Song","year":"2020","unstructured":"Song JY, Fan B, Che L, Pan YR, Zhang SM, Wang Y et al (2020) Suppressing Endoplasmic reticulum stress-related autophagy attenuates retinal light injury. Aging 12(16):16579\u201316596. https:\/\/doi.org\/10.18632\/aging.103846","journal-title":"Aging"},{"issue":"3","key":"2134_CR74","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/ICU.0000000000000043","volume":"25","author":"ND Chinskey","year":"2014","unstructured":"Chinskey ND, Besirli CG, Zacks DN (2014) Retinal cell death and current strategies in retinal neuroprotection. Curr Opin Ophthalmol 25(3):228\u2013233.","journal-title":"Curr Opin Ophthalmol"},{"key":"2134_CR75","doi-asserted-by":"publisher","first-page":"108492","DOI":"10.1016\/j.exer.2021.108492","volume":"205","author":"J Xiao","year":"2021","unstructured":"Xiao J, Yao J, Jia L, Ferguson TA, Weber S, Sundstrom JM et al (2021) Autophagy activation and photoreceptor survival in retinal detachment. Exp Eye Res 205:108492. https:\/\/doi.org\/10.1016\/j.exer.2021.108492","journal-title":"Exp Eye Res"},{"issue":"7","key":"2134_CR76","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1080\/02713683.2019.1588331","volume":"44","author":"J Ding","year":"2019","unstructured":"Ding J, Yang N, Yan Y, Wang Y, Wang X, Lu L, Dong K (2019) Rapamycin inhibited photoreceptor necroptosis and protected the retina by activation of autophagy in experimental retinal detachment. Curr Eye Res 44(7):739\u2013745. https:\/\/doi.org\/10.1080\/02713683.2019.1588331","journal-title":"Curr Eye Res"},{"key":"2134_CR77","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.exer.2015.06.016","volume":"137","author":"SJ Shelby","year":"2015","unstructured":"Shelby SJ, Angadi PS, Zheng QD, Yao J, Jia L, Zacks DN (2015) Hypoxia inducible factor 1alpha contributes to regulation of autophagy in retinal detachment. Exp Eye Res 137:84\u201393. https:\/\/doi.org\/10.1016\/j.exer.2015.06.016","journal-title":"Exp Eye Res"},{"issue":"4","key":"2134_CR78","doi-asserted-by":"publisher","first-page":"AMD41","DOI":"10.1167\/iovs.18-24289","volume":"59","author":"CR Fisher","year":"2018","unstructured":"Fisher CR, Ferrington DA (2018) Perspective on AMD pathobiology: a bioenergetic crisis in the RPE. Invest Ophthalmol Vis Sci 59(4):AMD41\u2013AMD7. https:\/\/doi.org\/10.1167\/iovs.18-24289","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2134_CR79","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","volume":"60","author":"S Datta","year":"2017","unstructured":"Datta S, Cano M, Ebrahimi K, Wang L, Handa JT (2017) The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Prog Retin Eye Res 60:201\u2013218. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.03.002","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"2134_CR80","doi-asserted-by":"publisher","first-page":"2896036","DOI":"10.1155\/2020\/2896036","volume":"2020","author":"ZY Zhang","year":"2020","unstructured":"Zhang ZY, Bao XL, Cong YY, Fan B, Li GY (2020) Autophagy in Age-Related macular degeneration: a regulatory mechanism of oxidative stress. Oxid Med Cell Longev 2020(1):2896036. https:\/\/doi.org\/10.1155\/2020\/2896036","journal-title":"Oxid Med Cell Longev"},{"key":"2134_CR81","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2016.02.027","volume":"94","author":"F Ye","year":"2016","unstructured":"Ye F, Kaneko H, Hayashi Y, Takayama K, Hwang SJ, Nishizawa Y et al (2016) Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration. Free Radic Biol Med 94:121\u2013134. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.02.027","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"2134_CR82","doi-asserted-by":"publisher","first-page":"e2537","DOI":"10.1038\/cddis.2016.453","volume":"8","author":"N Golestaneh","year":"2018","unstructured":"Golestaneh N, Chu Y, Xiao Y-Y, Stoleru GL, Theos AC (2018) Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration. Cell Death Dis 8(1):e2537\u2013e","journal-title":"Cell Death Dis"},{"issue":"1","key":"2134_CR83","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/s41598-020-59244-4","volume":"10","author":"M Zhang","year":"2020","unstructured":"Zhang M, Jiang N, Chu Y, Postnikova O, Varghese R, Horvath A et al (2020) Dysregulated metabolic pathways in age-related macular degeneration. Sci Rep 10(1):2464. https:\/\/doi.org\/10.1038\/s41598-020-59244-4","journal-title":"Sci Rep"},{"key":"2134_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-018-1434-6","volume":"16","author":"G Inana","year":"2018","unstructured":"Inana G, Murat C, An W, Yao X, Harris IR, Cao J (2018) RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells. J Translational Med 16:1\u201315","journal-title":"J Translational Med"},{"issue":"11","key":"2134_CR85","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.3390\/genes11111318","volume":"11","author":"JJ Paterno","year":"2020","unstructured":"Paterno JJ, Koskela A, Hyttinen JMT, Vattulainen E, Synowiec E, Tuuminen R et al (2020) Autophagy genes for wet age-related macular degeneration in a Finnish case-control study. Genes (Basel) 11(11):1318. https:\/\/doi.org\/10.3390\/genes11111318","journal-title":"Genes (Basel)"},{"issue":"10","key":"2134_CR86","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1080\/15548627.2016.1208889","volume":"12","author":"M Pajares","year":"2016","unstructured":"Pajares M, Jimenez-Moreno N, Garcia-Yague AJ, Escoll M, de Ceballos ML, Van Leuven F et al (2016) Transcription factor NFE2L2\/NRF2 is a regulator of macroautophagy genes. Autophagy 12(10):1902\u20131916. https:\/\/doi.org\/10.1080\/15548627.2016.1208889","journal-title":"Autophagy"},{"issue":"1","key":"2134_CR87","doi-asserted-by":"publisher","first-page":"11023","DOI":"10.1038\/s41598-017-11262-5","volume":"7","author":"S Dayalan Naidu","year":"2017","unstructured":"Dayalan Naidu S, Dikovskaya D, Gaurilcikaite E, Knatko EV, Healy ZR, Mohan H et al (2017) Transcription factors NRF2 and HSF1 have opposing functions in autophagy. Sci Rep 7(1):11023. https:\/\/doi.org\/10.1038\/s41598-017-11262-5","journal-title":"Sci Rep"},{"key":"2134_CR88","doi-asserted-by":"publisher","first-page":"108404","DOI":"10.1016\/j.exer.2020.108404","volume":"203","author":"SPS Pandi","year":"2021","unstructured":"Pandi SPS, Ratnayaka JA, Lotery AJ, Teeling JL (2021) Progress in developing rodent models of age-related macular degeneration (AMD). Exp Eye Res 203:108404","journal-title":"Exp Eye Res"},{"issue":"4","key":"2134_CR89","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1167\/iovs.16-21255","volume":"58","author":"G Chowers","year":"2017","unstructured":"Chowers G, Cohen M, Marks-Ohana D, Stika S, Eijzenberg A, Banin E, Obolensky A (2017) Course of sodium Iodate-Induced retinal degeneration in albino and pigmented mice. Invest Ophthalmol Vis Sci 58(4):2239\u20132249. https:\/\/doi.org\/10.1167\/iovs.16-21255","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"2134_CR90","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1089\/jop.2017.0073","volume":"34","author":"YC Lin","year":"2018","unstructured":"Lin YC, Horng LY, Sung HC, Wu RT (2018) Sodium iodate disrupted the mitochondrial-lysosomal axis in cultured retinal pigment epithelial cells. J Ocul Pharmacol Ther 34(7):500\u2013511. https:\/\/doi.org\/10.1089\/jop.2017.0073","journal-title":"J Ocul Pharmacol Ther"},{"key":"2134_CR91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-018-0495-4","volume":"26","author":"C-M Chan","year":"2019","unstructured":"Chan C-M, Huang D-Y, Sekar P, Hsu S-H, Lin W-W (2019) Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death. J Biomed Sci 26:1\u201311","journal-title":"J Biomed Sci"},{"key":"2134_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.redox.2018.09.011","volume":"20","author":"S Felszeghy","year":"2019","unstructured":"Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M et al (2019) Loss of NRF-2 and PGC-1alpha genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration. Redox Biol 20:1\u201312. https:\/\/doi.org\/10.1016\/j.redox.2018.09.011","journal-title":"Redox Biol"},{"key":"2134_CR93","doi-asserted-by":"crossref","unstructured":"Sridevi Gurubaran I, Viiri J, Koskela A, Hyttinen JMT, Paterno JJ, Kis G et al (2020) Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2\/PGC-1alpha(-\/-) Mouse Model. Int J Mol Sci;21(6):1976.","DOI":"10.3390\/ijms21061976"},{"issue":"9","key":"2134_CR94","doi-asserted-by":"publisher","first-page":"12502","DOI":"10.1096\/fj.202000612R","volume":"34","author":"YM Go","year":"2020","unstructured":"Go YM, Zhang J, Fernandes J, Litwin C, Chen R, Wensel TG et al (2020) MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. FASEB J 34(9):12502\u201312520. https:\/\/doi.org\/10.1096\/fj.202000612R","journal-title":"FASEB J"},{"issue":"4","key":"2134_CR95","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.7150\/thno.26281","volume":"9","author":"J Huang","year":"2019","unstructured":"Huang J, Gu S, Chen M, Zhang SJ, Jiang Z, Chen X et al (2019) Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration. Theranostics 9(4):1170\u20131180. https:\/\/doi.org\/10.7150\/thno.26281","journal-title":"Theranostics"},{"issue":"48","key":"2134_CR96","doi-asserted-by":"publisher","first-page":"29035","DOI":"10.1074\/jbc.M115.682310","volume":"290","author":"L Perusek","year":"2015","unstructured":"Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ et al (2015) Di-retinoid-pyridinium-ethanolamine (A2E) accumulation and the maintenance of the visual cycle are independent of Atg7-mediated autophagy in the retinal pigmented epithelium. J Biol Chem 290(48):29035\u201329044. https:\/\/doi.org\/10.1074\/jbc.M115.682310","journal-title":"J Biol Chem"},{"issue":"5","key":"2134_CR97","doi-asserted-by":"publisher","first-page":"jcs222984","DOI":"10.1242\/jcs.222984","volume":"132","author":"BL Heckmann","year":"2019","unstructured":"Heckmann BL, Green DR (2019) LC3-associated phagocytosis at a glance. J Cell Sci 132(5):jcs222984","journal-title":"J Cell Sci"},{"issue":"47","key":"2134_CR98","doi-asserted-by":"publisher","first-page":"23724","DOI":"10.1073\/pnas.1906643116","volume":"116","author":"S Notomi","year":"2019","unstructured":"Notomi S, Ishihara K, Efstathiou NE, Lee JJ, Hisatomi T, Tachibana T et al (2019) Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. Proc Natl Acad Sci USA 116(47):23724\u201323734. https:\/\/doi.org\/10.1073\/pnas.1906643116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1568","key":"2134_CR99","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1098\/rstb.2010.0302","volume":"366","author":"S Bassnett","year":"2011","unstructured":"Bassnett S, Shi Y, Vrensen GF (2011) Biological glass: structural determinants of eye lens transparency. Philos Trans R Soc Lond B Biol Sci 366(1568):1250\u20131264. https:\/\/doi.org\/10.1098\/rstb.2010.0302","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"2","key":"2134_CR100","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.exer.2008.08.017","volume":"88","author":"S Bassnett","year":"2009","unstructured":"Bassnett S (2009) On the mechanism of organelle degradation in the vertebrate lens. Exp Eye Res 88(2):133\u2013139. https:\/\/doi.org\/10.1016\/j.exer.2008.08.017","journal-title":"Exp Eye Res"},{"issue":"12","key":"2134_CR101","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.3109\/02713689208999548","volume":"11","author":"S Bassnett","year":"1992","unstructured":"Bassnett S (1992) Mitochondrial dynamics in differentiating fiber cells of the mammalian lens. Curr Eye Res 11(12):1227\u20131232. https:\/\/doi.org\/10.3109\/02713689208999548","journal-title":"Curr Eye Res"},{"issue":"6952","key":"2134_CR102","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature01895","volume":"424","author":"S Nishimoto","year":"2003","unstructured":"Nishimoto S, Kawane K, Watanabe-Fukunaga R, Fukuyama H, Ohsawa Y, Uchiyama Y et al (2003) Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens. Nature 424(6952):1071\u20131074. https:\/\/doi.org\/10.1038\/nature01895","journal-title":"Nature"},{"issue":"12","key":"2134_CR103","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1111\/j.1742-4658.2007.05836.x","volume":"274","author":"M Nakahara","year":"2007","unstructured":"Nakahara M, Nagasaka A, Koike M, Uchida K, Kawane K, Uchiyama Y, Nagata S (2007) Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens. FEBS J 274(12):3055\u20133064. https:\/\/doi.org\/10.1111\/j.1742-4658.2007.05836.x","journal-title":"FEBS J"},{"issue":"12","key":"2134_CR104","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1167\/iovs.07-0782","volume":"48","author":"A De Maria","year":"2007","unstructured":"De Maria A, Bassnett S (2007) DNase IIbeta distribution and activity in the mouse lens. Invest Ophthalmol Vis Sci 48(12):5638\u20135646. https:\/\/doi.org\/10.1167\/iovs.07-0782","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2134_CR105","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.biochi.2014.07.025","volume":"106","author":"A Iida","year":"2014","unstructured":"Iida A, Tabata Y, Baba Y, Fujii T, Watanabe S (2014) Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish. Biochimie 106:68\u201374. https:\/\/doi.org\/10.1016\/j.biochi.2014.07.025","journal-title":"Biochimie"},{"issue":"5","key":"2134_CR106","doi-asserted-by":"publisher","first-page":"165724","DOI":"10.1016\/j.bbadis.2020.165724","volume":"1866","author":"J Zhang","year":"2020","unstructured":"Zhang J, Cui WW, Du C, Huang Y, Pi X, Guo W et al (2020) Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish. Biochim Biophys Acta Mol Basis Dis 1866(5):165724. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165724","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2134_CR107","doi-asserted-by":"crossref","unstructured":"Chaffee BR, Shang F, Chang ML, Clement TM, Eddy EM, Wagner BD et al (2014) Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development;141(17):3388-98.","DOI":"10.1242\/dev.106005"},{"key":"2134_CR108","doi-asserted-by":"publisher","unstructured":"He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL et al (2016) Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development;143(11):1937-47.https:\/\/doi.org\/10.1242\/dev.135285","DOI":"10.1242\/dev.135285"},{"key":"2134_CR109","doi-asserted-by":"publisher","unstructured":"Imai F, Yoshizawa A, Fujimori-Tonou N, Kawakami K, Masai I (2010) The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish. Development;137(19):3257-68.https:\/\/doi.org\/10.1242\/dev.053124","DOI":"10.1242\/dev.053124"},{"issue":"10","key":"2134_CR110","doi-asserted-by":"publisher","first-page":"e3082","DOI":"10.1038\/cddis.2017.478","volume":"8","author":"M Gao","year":"2017","unstructured":"Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S et al (2017) HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death Dis 8(10):e3082. https:\/\/doi.org\/10.1038\/cddis.2017.478","journal-title":"Cell Death Dis"},{"issue":"21","key":"2134_CR111","doi-asserted-by":"publisher","first-page":"4297","DOI":"10.1038\/sj.emboj.7600435","volume":"23","author":"M Fujimoto","year":"2004","unstructured":"Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S et al (2004) HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J 23(21):4297\u20134306. https:\/\/doi.org\/10.1038\/sj.emboj.7600435","journal-title":"EMBO J"},{"issue":"4","key":"2134_CR112","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/gene.20087","volume":"40","author":"JN Min","year":"2004","unstructured":"Min JN, Zhang Y, Moskophidis D, Mivechi NF (2004) Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis 40(4):205\u2013217. https:\/\/doi.org\/10.1002\/gene.20087","journal-title":"Genesis"},{"issue":"4","key":"2134_CR113","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.bbalip.2014.10.002","volume":"1851","author":"H Kuhn","year":"2015","unstructured":"Kuhn H, Banthiya S, van Leyen K (2015) Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta 1851(4):308\u2013330. https:\/\/doi.org\/10.1016\/j.bbalip.2014.10.002","journal-title":"Biochim Biophys Acta"},{"issue":"39","key":"2134_CR114","doi-asserted-by":"publisher","first-page":"24055","DOI":"10.1074\/jbc.271.39.24055","volume":"271","author":"D Sun","year":"1996","unstructured":"Sun D, Funk CD (1996) Disruption of 12\/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem 271(39):24055\u201324062","journal-title":"J Biol Chem"},{"key":"2134_CR115","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.exer.2015.08.019","volume":"144","author":"H Morishita","year":"2016","unstructured":"Morishita H, Mizushima N (2016) Autophagy in the lens. Exp Eye Res 144:22\u201328. https:\/\/doi.org\/10.1016\/j.exer.2015.08.019","journal-title":"Exp Eye Res"},{"key":"2134_CR116","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.exer.2018.06.003","volume":"174","author":"LA Brennan","year":"2018","unstructured":"Brennan LA, McGreal-Estrada R, Logan CM, Cvekl A, Menko AS, Kantorow M (2018) BNIP3L\/NIX is required for elimination of mitochondria, endoplasmic reticulum and golgi apparatus during eye lens organelle-free zone formation. Exp Eye Res 174:173\u2013184. https:\/\/doi.org\/10.1016\/j.exer.2018.06.003","journal-title":"Exp Eye Res"},{"issue":"7","key":"2134_CR117","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.4161\/auto.28768","volume":"10","author":"S Basu","year":"2014","unstructured":"Basu S, Rajakaruna S, Reyes B, Van Bockstaele E, Menko AS (2014) Suppression of MAPK\/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells. Autophagy 10(7):1193\u20131211. https:\/\/doi.org\/10.4161\/auto.28768","journal-title":"Autophagy"},{"key":"2134_CR118","doi-asserted-by":"publisher","first-page":"108129","DOI":"10.1016\/j.exer.2020.108129","volume":"198","author":"L Brennan","year":"2020","unstructured":"Brennan L, Disatham J, Kantorow M (2020) Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a. Exp Eye Res 198:108129. https:\/\/doi.org\/10.1016\/j.exer.2020.108129","journal-title":"Exp Eye Res"},{"issue":"2","key":"2134_CR119","doi-asserted-by":"publisher","first-page":"113043","DOI":"10.1016\/j.yexcr.2022.113043","volume":"412","author":"R Gheyas","year":"2022","unstructured":"Gheyas R, Ortega-Alvarez R, Chauss D, Kantorow M, Menko AS (2022) Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone. Exp Cell Res 412(2):113043. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113043","journal-title":"Exp Cell Res"},{"issue":"9","key":"2134_CR120","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1080\/15548627.2021.1950372","volume":"17","author":"H Morishita","year":"2021","unstructured":"Morishita H, Eguchi T, Mizushima N (2021) A new insight into the lens: cytosolic PLAAT phospholipases degrade organelles to make the lens transparent. Autophagy 17(9):2645\u20132647. https:\/\/doi.org\/10.1080\/15548627.2021.1950372","journal-title":"Autophagy"},{"issue":"2","key":"2134_CR121","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.bbrc.2005.11.044","volume":"339","author":"M Matsui","year":"2006","unstructured":"Matsui M, Yamamoto A, Kuma A, Ohsumi Y, Mizushima N (2006) Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun 339(2):485\u2013489","journal-title":"Biochem Biophys Res Commun"},{"issue":"7855","key":"2134_CR122","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s41586-021-03439-w","volume":"592","author":"H Morishita","year":"2021","unstructured":"Morishita H, Eguchi T, Tsukamoto S, Sakamaki Y, Takahashi S, Saito C et al (2021) Organelle degradation in the lens by PLAAT phospholipases. Nature 592(7855):634\u2013638. https:\/\/doi.org\/10.1038\/s41586-021-03439-w","journal-title":"Nature"},{"issue":"18","key":"2134_CR123","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1002\/1873-3468.12787","volume":"591","author":"T Uyama","year":"2017","unstructured":"Uyama T, Tsuboi K, Ueda N (2017) An involvement of phospholipase a\/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism. FEBS Lett 591(18):2745\u20132760. https:\/\/doi.org\/10.1002\/1873-3468.12787","journal-title":"FEBS Lett"},{"key":"2134_CR124","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12929-015-0210-7","volume":"22","author":"EB Mardian","year":"2015","unstructured":"Mardian EB, Bradley RM, Duncan RE (2015) The HRASLS (PLA\/AT) subfamily of enzymes. J Biomed Sci 22:99. https:\/\/doi.org\/10.1186\/s12929-015-0210-7","journal-title":"J Biomed Sci"},{"key":"2134_CR125","first-page":"1491","volume":"20","author":"TV Hoang","year":"2014","unstructured":"Hoang TV, Kumar PK, Sutharzan S, Tsonis PA, Liang C, Robinson ML (2014) Comparative transcriptome analysis of epithelial and fiber cells in newborn mouse lenses with RNA sequencing. Mol Vis 20:1491\u20131517","journal-title":"Mol Vis"},{"key":"2134_CR126","doi-asserted-by":"publisher","first-page":"108535","DOI":"10.1016\/j.exer.2021.108535","volume":"206","author":"DR Farnsworth","year":"2021","unstructured":"Farnsworth DR, Posner M, Miller AC (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Exp Eye Res 206:108535. https:\/\/doi.org\/10.1016\/j.exer.2021.108535","journal-title":"Exp Eye Res"},{"key":"2134_CR127","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.biocel.2018.10.003","volume":"105","author":"X Cui","year":"2018","unstructured":"Cui X, Han J, Li J, Cui WW, Wu DD, Liu S et al (2018) Downregulation of heat shock factor 4 transcription activity via MAPKinase phosphorylation at Serine 299. Int J Biochem Cell Biol 105:61\u201369. https:\/\/doi.org\/10.1016\/j.biocel.2018.10.003","journal-title":"Int J Biochem Cell Biol"},{"issue":"8","key":"2134_CR128","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.bbadis.2013.03.007","volume":"1832","author":"X Cui","year":"2013","unstructured":"Cui X, Wang L, Zhang J, Du R, Liao S, Li D et al (2013) HSF4 regulates DLAD expression and promotes lens de-nucleation. Biochim Biophys Acta 1832(8):1167\u20131172. https:\/\/doi.org\/10.1016\/j.bbadis.2013.03.007","journal-title":"Biochim Biophys Acta"},{"key":"2134_CR129","doi-asserted-by":"crossref","unstructured":"Cicinelli MV, Buchan JC, Nicholson M, Varadaraj V, Khanna RC (2023) Cataracts. Lancet 401(10374):377\u2013\u200989.","DOI":"10.1016\/S0140-6736(22)01839-6"},{"key":"2134_CR130","unstructured":"Nizami AA, Gurnani B, Gulani AC, Cataract (2024) StatPearls [Internet]: StatPearls Publishing"},{"issue":"1","key":"2134_CR131","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.survophthal.2023.08.002","volume":"69","author":"TJ Ferguson","year":"2024","unstructured":"Ferguson TJ, Randleman JB (2024) Cataract surgery following refractive surgery: principles to achieve optical success and patient satisfaction. Surv Ophthalmol 69(1):140\u2013159. https:\/\/doi.org\/10.1016\/j.survophthal.2023.08.002","journal-title":"Surv Ophthalmol"},{"issue":"7","key":"2134_CR132","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jfo.2019.11.009","volume":"43","author":"M Delbarre","year":"2020","unstructured":"Delbarre M, Froussart-Maille F (2020) [Signs, symptoms, and clinical forms of cataract in adults]. J Fr Ophtalmol 43(7):653\u2013659. https:\/\/doi.org\/10.1016\/j.jfo.2019.11.009","journal-title":"J Fr Ophtalmol"},{"issue":"22","key":"2134_CR133","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.21037\/atm-20-3033","volume":"8","author":"D Bremond-Gignac","year":"2020","unstructured":"Bremond-Gignac D, Daruich A, Robert MP, Valleix S (2020) Recent developments in the management of congenital cataract. Ann Transl Med 8(22):1545. https:\/\/doi.org\/10.21037\/atm-20-3033","journal-title":"Ann Transl Med"},{"issue":"3","key":"2134_CR134","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1086\/519980","volume":"81","author":"A Shiels","year":"2007","unstructured":"Shiels A, Bennett TM, Knopf HL, Yamada K, Yoshiura K, Niikawa N et al (2007) CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q. Am J Hum Genet 81(3):596\u2013606. https:\/\/doi.org\/10.1086\/519980","journal-title":"Am J Hum Genet"},{"key":"2134_CR138","doi-asserted-by":"publisher","first-page":"974393","DOI":"10.1155\/2014\/974393","volume":"2014","author":"AP Sagona","year":"2014","unstructured":"Sagona AP, Nezis IP, Stenmark H (2014) Association of CHMP4B and autophagy with micronuclei: implications for cataract formation. Biomed Res Int 2014:974393. https:\/\/doi.org\/10.1155\/2014\/974393","journal-title":"Biomed Res Int"},{"key":"2134_CR139","first-page":"471","volume":"24","author":"XH Zhang","year":"2018","unstructured":"Zhang XH, Da Wang J, Jia HY, Zhang JS, Li Y, Xiong Y et al (2018) Mutation profiles of congenital cataract genes in 21 Northern Chinese families. Mol Vis 24:471\u2013477","journal-title":"Mol Vis"},{"key":"2134_CR140","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.diff.2019.07.003","volume":"109","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Bennett TM, Shiels A (2019) A charged multivesicular body protein (CHMP4B) is required for lens growth and differentiation. Differentiation 109:16\u201327. https:\/\/doi.org\/10.1016\/j.diff.2019.07.003","journal-title":"Differentiation"},{"issue":"6384","key":"2134_CR141","doi-asserted-by":"publisher","first-page":"eaar5078","DOI":"10.1126\/science.aar5078","volume":"360","author":"ML Skowyra","year":"2018","unstructured":"Skowyra ML, Schlesinger PH, Naismith TV, Hanson PI (2018) Triggered recruitment of ESCRT machinery promotes endolysosomal repair. Science 360(6384):eaar5078.","journal-title":"Science"},{"issue":"21","key":"2134_CR142","doi-asserted-by":"publisher","first-page":"e99753","DOI":"10.15252\/embj.201899753","volume":"37","author":"M Radulovic","year":"2018","unstructured":"Radulovic M, Schink KO, Wenzel EM, Nahse V, Bongiovanni A, Lafont F, Stenmark H (2018) ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival. EMBO J 37(21):e99753. https:\/\/doi.org\/10.15252\/embj.201899753","journal-title":"EMBO J"},{"issue":"1","key":"2134_CR143","doi-asserted-by":"publisher","first-page":"5058","DOI":"10.1038\/s41467-019-12991-z","volume":"10","author":"M Loi","year":"2019","unstructured":"Loi M, Raimondi A, Morone D, Molinari M (2019) ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress. Nat Commun 10(1):5058. https:\/\/doi.org\/10.1038\/s41467-019-12991-z","journal-title":"Nat Commun"},{"key":"2134_CR144","doi-asserted-by":"crossref","unstructured":"Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW et al (2020) ESCRT-mediated phagophore sealing during mitophagy. Autophagy;16(5):826\u2013\u200941.","DOI":"10.1080\/15548627.2019.1639301"},{"issue":"6573","key":"2134_CR145","doi-asserted-by":"publisher","first-page":"eabk0410","DOI":"10.1126\/science.abk0410","volume":"374","author":"F Gulluni","year":"2021","unstructured":"Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT et al (2021) PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science 374(6573):eabk0410. https:\/\/doi.org\/10.1126\/science.abk0410","journal-title":"Science"},{"issue":"6","key":"2134_CR146","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.ajhg.2011.05.008","volume":"88","author":"J Chen","year":"2011","unstructured":"Chen J, Ma Z, Jiao X, Fariss R, Kantorow WL, Kantorow M et al (2011) Mutations in FYCO1 cause autosomal-recessive congenital cataracts. Am J Hum Genet 88(6):827\u2013838. https:\/\/doi.org\/10.1016\/j.ajhg.2011.05.008","journal-title":"Am J Hum Genet"},{"issue":"4","key":"2134_CR147","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1167\/iovs.17-21469","volume":"58","author":"J Chen","year":"2017","unstructured":"Chen J, Wang Q, Cabrera PE, Zhong Z, Sun W, Jiao X et al (2017) Molecular genetic analysis of Pakistani families with autosomal recessive congenital cataracts by homozygosity screening. Invest Ophthalmol Vis Sci 58(4):2207\u20132217. https:\/\/doi.org\/10.1167\/iovs.17-21469","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"2134_CR148","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/s41431-021-00833-w","volume":"29","author":"NA Barashkov","year":"2021","unstructured":"Barashkov NA, Konovalov FA, Borisova TV, Teryutin FM, Solovyev AV, Pshennikova VG et al (2021) Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene. Eur J Hum Genet 29(6):965\u2013976. https:\/\/doi.org\/10.1038\/s41431-021-00833-w","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"2134_CR149","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1083\/jcb.200907015","volume":"188","author":"S Pankiv","year":"2010","unstructured":"Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A et al (2010) FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol 188(2):253\u2013269. https:\/\/doi.org\/10.1083\/jcb.200907015","journal-title":"J Cell Biol"},{"issue":"1","key":"2134_CR151","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41392-021-00543-1","volume":"6","author":"W Xiao","year":"2021","unstructured":"Xiao W, Yeerken D, Li J, Li Z, Jiang L, Li D et al (2021) Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. Signal Transduct Target Ther 6(1):152.","journal-title":"Signal Transduct Target Ther"},{"issue":"15","key":"2134_CR152","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1016\/j.cub.2021.05.052","volume":"31","author":"JL Nieto-Torres","year":"2021","unstructured":"Nieto-Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S et al (2021) LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Curr Biol 31(15):3440\u20133449. https:\/\/doi.org\/10.1016\/j.cub.2021.05.052","journal-title":"Curr Biol"},{"issue":"49","key":"2134_CR153","doi-asserted-by":"publisher","first-page":"29361","DOI":"10.1074\/jbc.M115.686915","volume":"290","author":"HL Olsvik","year":"2015","unstructured":"Olsvik HL, Lamark T, Takagi K, Larsen KB, Evjen G, Overvatn A et al (2015) FYCO1 contains a C-terminally extended, LC3A\/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy. J Biol Chem 290(49):29361\u201329374. https:\/\/doi.org\/10.1074\/jbc.M115.686915","journal-title":"J Biol Chem"},{"issue":"8","key":"2134_CR154","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1080\/15548627.2016.1185590","volume":"12","author":"X Cheng","year":"2016","unstructured":"Cheng X, Wang Y, Gong Y, Li F, Guo Y, Hu S et al (2016) Structural basis of FYCO1 and MAP1LC3A interaction reveals a novel binding mode for Atg8-family proteins. Autophagy 12(8):1330\u20131339. https:\/\/doi.org\/10.1080\/15548627.2016.1185590","journal-title":"Autophagy"},{"issue":"12","key":"2134_CR155","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1083\/jcb.201611073","volume":"216","author":"Z Hong","year":"2017","unstructured":"Hong Z, Pedersen NM, Wang L, Torgersen ML, Stenmark H, Raiborg C (2017) PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol 216(12):4217\u20134233. https:\/\/doi.org\/10.1083\/jcb.201611073","journal-title":"J Cell Biol"},{"issue":"1","key":"2134_CR156","doi-asserted-by":"publisher","first-page":"13771","DOI":"10.1038\/s41598-021-93110-1","volume":"11","author":"K Satoh","year":"2021","unstructured":"Satoh K, Takemura Y, Satoh M, Ozaki K, Kubota S (2021) Loss of FYCO1 leads to cataract formation. Sci Rep 11(1):13771. https:\/\/doi.org\/10.1038\/s41598-021-93110-1","journal-title":"Sci Rep"},{"issue":"9","key":"2134_CR157","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1080\/15548627.2022.2025570","volume":"18","author":"SY Khan","year":"2022","unstructured":"Khan SY, Ali M, Kabir F, Na CH, Delannoy M, Ma Y et al (2022) The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Autophagy 18(9):2198\u20132215. https:\/\/doi.org\/10.1080\/15548627.2022.2025570","journal-title":"Autophagy"},{"issue":"6","key":"2134_CR158","doi-asserted-by":"publisher","first-page":"e1006090","DOI":"10.1371\/journal.pgen.1006090","volume":"12","author":"JH Chen","year":"2016","unstructured":"Chen JH, Huang C, Zhang B, Yin S, Liang J, Xu C et al (2016) Mutations of raga GTPase in mTORC1 pathway are associated with autosomal dominant cataracts. PLoS Genet 12(6):e1006090. https:\/\/doi.org\/10.1371\/journal.pgen.1006090","journal-title":"PLoS Genet"},{"issue":"1","key":"2134_CR159","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1177\/0300060513504702","volume":"42","author":"C Zheng","year":"2014","unstructured":"Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (2014) RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract. J Int Med Res 42(1):153\u2013163. https:\/\/doi.org\/10.1177\/0300060513504702","journal-title":"J Int Med Res"},{"issue":"5","key":"2134_CR160","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1038\/gim.2017.130","volume":"21","author":"YQ Tan","year":"2019","unstructured":"Tan YQ, Tu C, Meng L, Yuan S, Sjaarda C, Luo A et al (2019) Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans. Genet Med 21(5):1209\u20131217. https:\/\/doi.org\/10.1038\/gim.2017.130","journal-title":"Genet Med"},{"issue":"11","key":"2134_CR161","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1080\/15548627.2021.1894058","volume":"17","author":"C Tu","year":"2021","unstructured":"Tu C, Li H, Liu X, Wang Y, Li W, Meng L et al (2021) TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation. Autophagy 17(11):3848\u20133864. https:\/\/doi.org\/10.1080\/15548627.2021.1894058","journal-title":"Autophagy"},{"issue":"6","key":"2134_CR162","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.ajhg.2013.10.011","volume":"93","author":"RP Liegel","year":"2013","unstructured":"Liegel RP, Handley MT, Ronchetti A, Brown S, Langemeyer L, Linford A et al (2013) Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet 93(6):1001\u20131014.","journal-title":"Am J Hum Genet"},{"issue":"10","key":"2134_CR163","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1080\/15548627.2016.1199300","volume":"12","author":"DJ Sidjanin","year":"2016","unstructured":"Sidjanin DJ, Park AK, Ronchetti A, Martins J, Jackson WT (2016) TBC1D20 mediates autophagy as a key regulator of autophagosome maturation. Autophagy 12(10):1759\u20131775.","journal-title":"Autophagy"},{"issue":"Pt 3","key":"2134_CR164","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/brain\/awv393","volume":"139","author":"S Byrne","year":"2016","unstructured":"Byrne S, Jansen L, JM UK-I, Siddiqui A, Lidov HG, Bodi I et al (2016) EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy. Brain 139(Pt 3):765\u2013781. https:\/\/doi.org\/10.1093\/brain\/awv393","journal-title":"Brain"},{"issue":"6","key":"2134_CR165","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.ajhg.2020.10.012","volume":"107","author":"C Rodger","year":"2020","unstructured":"Rodger C, Flex E, Allison RJ, Sanchis-Juan A, Hasenahuer MA, Cecchetti S et al (2020) De Novo VPS4A mutations cause multisystem disease with abnormal neurodevelopment. Am J Hum Genet 107(6):1129\u20131148. https:\/\/doi.org\/10.1016\/j.ajhg.2020.10.012","journal-title":"Am J Hum Genet"},{"issue":"6","key":"2134_CR166","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.ajhg.2020.10.013","volume":"107","author":"KG Seu","year":"2020","unstructured":"Seu KG, Trump LR, Emberesh S, Lorsbach RB, Johnson C, Meznarich J et al (2020) VPS4A mutations in humans cause syndromic congenital dyserythropoietic Anemia due to cytokinesis and trafficking defects. Am J Hum Genet 107(6):1149\u20131156. https:\/\/doi.org\/10.1016\/j.ajhg.2020.10.013","journal-title":"Am J Hum Genet"},{"key":"2134_CR167","doi-asserted-by":"crossref","unstructured":"Ping X, Liang J, Shi K, Bao J, Wu J, Yu X et al (2021) Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish. Autophagy 17(11):3323-37.","DOI":"10.1080\/15548627.2021.1872188"},{"issue":"3","key":"2134_CR168","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3390\/cells12030475","volume":"12","author":"L Brennan","year":"2023","unstructured":"Brennan L, Costello MJ, Hejtmancik JF, Menko AS, Riazuddin SA, Shiels A, Kantorow M (2023) Autophagy requirements for eye Lens differentiation and transparency. Cells 12(3):475. https:\/\/doi.org\/10.3390\/cells12030475","journal-title":"Cells"},{"key":"2134_CR169","doi-asserted-by":"publisher","first-page":"110180","DOI":"10.1016\/j.abb.2024.110180","volume":"761","author":"S Chen","year":"2024","unstructured":"Chen S, Zhao W, Chen R, Sheng F, Gu Y, Hao S et al (2024) FYCO1 regulates autophagy and senescence via PAK1\/p21 in cataract. Arch Biochem Biophys 761:110180. https:\/\/doi.org\/10.1016\/j.abb.2024.110180","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"2134_CR170","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1080\/02713683.2021.2021586","volume":"47","author":"D Dong","year":"2022","unstructured":"Dong D, Wu J, Sheng L, Gong X, Zhang Z, Yu C (2022) FUNDC1 induces apoptosis and autophagy under oxidative stress via PI3K\/Akt\/mTOR pathway in cataract Lens cells. Curr Eye Res 47(4):547\u2013554. https:\/\/doi.org\/10.1080\/02713683.2021.2021586","journal-title":"Curr Eye Res"},{"issue":"5","key":"2134_CR171","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00109-016-1502-4","volume":"95","author":"H Liu","year":"2017","unstructured":"Liu H, Smith AJ, Ball SS, Bao Y, Bowater RP, Wang N, Michael Wormstone I (2017) Sulforaphane promotes ER stress, autophagy, and cell death: implications for cataract surgery. J Mol Med (Berl) 95(5):553\u2013564. https:\/\/doi.org\/10.1007\/s00109-016-1502-4","journal-title":"J Mol Med (Berl)"},{"issue":"4","key":"2134_CR172","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1080\/02713683.2021.2009516","volume":"47","author":"J Li","year":"2022","unstructured":"Li J, Sun Q, Qiu X, Zhang J, Zheng Y, Luo L, Tan X (2022) Downregulation of AMPK dependent FOXO3 and TFEB involves in the Inhibition of autophagy in diabetic cataract. Curr Eye Res 47(4):555\u2013564. https:\/\/doi.org\/10.1080\/02713683.2021.2009516","journal-title":"Curr Eye Res"},{"key":"2134_CR173","doi-asserted-by":"publisher","first-page":"112827","DOI":"10.1016\/j.intimp.2024.112827","volume":"140","author":"WN Liu","year":"2024","unstructured":"Liu WN, Huang HL, Lan Y, Li L, Yang ZL, Jiang L (2024) Hyperhomocysteine promotes cataract development through mTOR-mediated Inhibition of autophagy and connexins expression. Int Immunopharmacol 140:112827. https:\/\/doi.org\/10.1016\/j.intimp.2024.112827","journal-title":"Int Immunopharmacol"},{"key":"2134_CR174","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.exer.2013.06.026","volume":"115","author":"JA Wignes","year":"2013","unstructured":"Wignes JA, Goldman JW, Weihl CC, Bartley MG, Andley UP (2013) p62 expression and autophagy in \u03b1B-crystallin R120G mutant knock-in mouse model of hereditary cataract. Exp Eye Res 115:263\u2013273. https:\/\/doi.org\/10.1016\/j.exer.2013.06.026","journal-title":"Exp Eye Res"},{"key":"2134_CR175","doi-asserted-by":"crossref","unstructured":"Cui Y, Yu X, Bao J, Ping X, Shi S, Huang Y et al (2024) Lens autophagy protein ATG16L1: a potential target for cataract treatment. Theranostics 14(10):3984-96.","DOI":"10.7150\/thno.93864"},{"issue":"6","key":"2134_CR176","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1167\/iovs.63.6.26","volume":"63","author":"Y Sun","year":"2022","unstructured":"Sun Y, Wang X, Chen B, Huang M, Ma P, Xiong L et al (2022) TFEB-Mediated lysosomal restoration alleviates high Glucose-Induced cataracts via attenuating oxidative stress. Invest Ophthalmol Vis Sci 63(6):26. https:\/\/doi.org\/10.1167\/iovs.63.6.26","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2134_CR177","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s10020-022-00540-2","volume":"28","author":"J Ma","year":"2022","unstructured":"Ma J, Ye W, Yang Y, Wu T, Wang Y, Li J et al (2022) The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD\/ULK1 is involved in the formation of diabetic cataracts. Mol Med 28(1):116. https:\/\/doi.org\/10.1186\/s10020-022-00540-2","journal-title":"Mol Med"},{"issue":"4","key":"2134_CR178","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.65.4.4","volume":"65","author":"AK Boateng","year":"2024","unstructured":"Boateng AK, Joseph R, Srivastava OP (2024) Dysregulation of autophagy occurs during congenital cataract development in betaA3DeltaG91 mice. Invest Ophthalmol Vis Sci 65(4):4. https:\/\/doi.org\/10.1167\/iovs.65.4.4","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"2134_CR179","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/ncb2934","volume":"16","author":"E Bejarano","year":"2014","unstructured":"Bejarano E, Yuste A, Patel B, Stout RF Jr., Spray DC, Cuervo AM (2014) Connexins modulate autophagosome biogenesis. Nat Cell Biol 16(5):401\u2013414. https:\/\/doi.org\/10.1038\/ncb2934","journal-title":"Nat Cell Biol"},{"issue":"1","key":"2134_CR180","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12860-016-0093-9","volume":"17","author":"J Iyyathurai","year":"2016","unstructured":"Iyyathurai J, Decuypere JP, Leybaert L, D\u2019Hondt C, Bultynck G (2016) Connexins: substrates and regulators of autophagy. BMC Cell Biol 17(1):20. https:\/\/doi.org\/10.1186\/s12860-016-0093-9","journal-title":"BMC Cell Biol"},{"issue":"Pt 6","key":"2134_CR181","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1242\/jcs.073072","volume":"124","author":"A Lichtenstein","year":"2011","unstructured":"Lichtenstein A, Minogue PJ, Beyer EC, Berthoud VM (2011) Autophagy: a pathway that contributes to connexin degradation. J Cell Sci 124(Pt 6):910\u2013920. https:\/\/doi.org\/10.1242\/jcs.073072","journal-title":"J Cell Sci"},{"issue":"11","key":"2134_CR182","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1091\/mbc.E11-10-0844","volume":"23","author":"E Bejarano","year":"2012","unstructured":"Bejarano E, Girao H, Yuste A, Patel B, Marques C, Spray DC et al (2012) Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol Biol Cell 23(11):2156\u20132169. https:\/\/doi.org\/10.1091\/mbc.E11-10-0844","journal-title":"Mol Biol Cell"},{"issue":"44","key":"2134_CR183","doi-asserted-by":"publisher","first-page":"77360","DOI":"10.18632\/oncotarget.20483","volume":"8","author":"L Zhang","year":"2017","unstructured":"Zhang L, Cheng R, Huang Y (2017) MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. Oncotarget 8(44):77360\u201377368. https:\/\/doi.org\/10.18632\/oncotarget.20483","journal-title":"Oncotarget"},{"issue":"9","key":"2134_CR184","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1080\/02713683.2021.1900273","volume":"46","author":"Y Cao","year":"2021","unstructured":"Cao Y, Li P, Zhang G, Kang L, Zhou T, Wu J et al (2021) MicroRNA Let-7c-5p-Mediated regulation of ERCC6 disrupts autophagic flux in age-related cataract via the binding to VCP. Curr Eye Res 46(9):1353\u20131362. https:\/\/doi.org\/10.1080\/02713683.2021.1900273","journal-title":"Curr Eye Res"},{"issue":"1","key":"2134_CR185","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41419-021-04489-8","volume":"13","author":"J Huang","year":"2022","unstructured":"Huang J, Yu W, He Q, He X, Yang M, Chen W, Han W (2022) Autophagy facilitates age-related cell apoptosis-a new insight from senile cataract. Cell Death Dis 13(1):37. https:\/\/doi.org\/10.1038\/s41419-021-04489-8","journal-title":"Cell Death Dis"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02134-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02134-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02134-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:03:52Z","timestamp":1758913432000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02134-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":181,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2134"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02134-9","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"6 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}