{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:36:17Z","timestamp":1794036977880,"version":"4.8.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11-12","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272734"],"award-info":[{"award-number":["82272734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272734"],"award-info":[{"award-number":["82272734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272734"],"award-info":[{"award-number":["82272734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272734"],"award-info":[{"award-number":["82272734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]},{"name":"Research Project of Xinjiang Uygur Autonomous Region Health Commission","award":["2025001QNKYXM653217152"],"award-info":[{"award-number":["2025001QNKYXM653217152"]}]},{"name":"Research Project of Xinjiang Uygur Autonomous Region Health Commission","award":["2025001QNKYXM653217152"],"award-info":[{"award-number":["2025001QNKYXM653217152"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10495-025-02187-w","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:27:50Z","timestamp":1760009270000},"page":"3009-3025","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["AIM2 regulated by JAK3\/STAT1 pathway promotes PANoptosis in intestinal barrier dysfunction caused by concomitant radiation and PD-1 Blockade"],"prefix":"10.1007","volume":"30","author":[{"given":"Jingru","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengmin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"2187_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11121011","author":"Q Lu","year":"2023","unstructured":"Lu Q, Liang Y, Tian S, Jin J, Zhao Y, Fan H (2023) Radiation-Induced intestinal injury: injury mechanism and potential treatment strategies. Toxics. https:\/\/doi.org\/10.3390\/toxics11121011","journal-title":"Toxics"},{"key":"2187_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1409300","author":"G Dagar","year":"2024","unstructured":"Dagar G, Gupta A, Shankar A et al (2024) The future of cancer treatment: combining radiotherapy with immunotherapy. Front Mol Biosci. https:\/\/doi.org\/10.3389\/fmolb.2024.1409300","journal-title":"Front Mol Biosci"},{"key":"2187_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.189008","author":"Y Luo","year":"2023","unstructured":"Luo Y, Zeng Z, Liu Y, Liu A (2023) Reflecting on the cardiac toxicity in non-small cell lung cancer in the era of immune checkpoint inhibitors therapy combined with thoracic radiotherapy. Biochim Biophys Acta Rev Cancer. https:\/\/doi.org\/10.1016\/j.bbcan.2023.189008","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"2187_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116767","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Li K, Adelson DL (2024) An unmet need for pharmacology: treatments for radiation-induced Gastrointestinal mucositis. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2024.116767","journal-title":"Biomed Pharmacother"},{"key":"2187_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102348","author":"R Karki","year":"2023","unstructured":"Karki R, Kanneganti TD (2023) PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis. Curr Opin Immunol. https:\/\/doi.org\/10.1016\/j.coi.2023.102348","journal-title":"Curr Opin Immunol"},{"key":"2187_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13279","author":"X Sun","year":"2024","unstructured":"Sun X, Yang Y, Meng X, Li J, Liu X, Liu H (2024) PANoptosis: Mechanisms, biology, and role in disease. Immunol Rev. https:\/\/doi.org\/10.1111\/imr.13279","journal-title":"Immunol Rev"},{"key":"2187_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01107-9","author":"S Oh","year":"2023","unstructured":"Oh S, Lee J, Oh J et al (2023) Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis. Cell Mol Immunol. https:\/\/doi.org\/10.1038\/s41423-023-01107-9","journal-title":"Cell Mol Immunol"},{"key":"2187_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1452","author":"L Chen","year":"2023","unstructured":"Chen L, Wang Z, Wu J et al (2023) Released dsDNA-triggered inflammasomes serve as intestinal radioprotective targets. Clin Transl Immunol. https:\/\/doi.org\/10.1002\/cti2.1452","journal-title":"Clin Transl Immunol"},{"key":"2187_CR9","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7532","author":"B Hu","year":"2016","unstructured":"Hu B, Jin C, Li HB et al (2016) The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science. https:\/\/doi.org\/10.1126\/science.aaf7532","journal-title":"Science"},{"key":"2187_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2195-8","author":"J Gao","year":"2019","unstructured":"Gao J, Peng S, Shan X et al (2019) Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell Death Dis. https:\/\/doi.org\/10.1038\/s41419-019-2195-8","journal-title":"Cell Death Dis"},{"key":"2187_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2174-3","author":"CR Lammert","year":"2020","unstructured":"Lammert CR, Frost EL, Bellinger CE et al (2020) AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. Nature. https:\/\/doi.org\/10.1038\/s41586-020-2174-3","journal-title":"Nature"},{"issue":"12 Suppl 2","key":"2187_CR12","doi-asserted-by":"publisher","first-page":"S276","DOI":"10.1093\/infdis\/jiaa700","volume":"223","author":"Y Gerardin","year":"2021","unstructured":"Gerardin Y, Timberlake S, Allegretti JR, Smith MB, Kassam Z (2021) Beyond fecal microbiota transplantation: developing drugs from the Microbiome. J Infect Dis 223(12 Suppl 2):S276\u2013S282. https:\/\/doi.org\/10.1093\/infdis\/jiaa700","journal-title":"J Infect Dis"},{"issue":"1","key":"2187_CR13","doi-asserted-by":"publisher","first-page":"1968257","DOI":"10.1080\/19490976.2021.1968257","volume":"13","author":"G Li","year":"2021","unstructured":"Li G, Lin J, Zhang C et al (2021) Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease. Gut Microbes 13(1):1968257. https:\/\/doi.org\/10.1080\/19490976.2021.1968257","journal-title":"Gut Microbes"},{"issue":"4","key":"2187_CR14","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1042\/CS20210778","volume":"136","author":"L Liang","year":"2022","unstructured":"Liang L, Liu L, Zhou W et al (2022) Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage\/WNT\/ERK signaling pathway. Clin Sci (Lond) 136(4):291\u2013307. https:\/\/doi.org\/10.1042\/CS20210778","journal-title":"Clin Sci (Lond)"},{"issue":"9237","key":"2187_CR15","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/s0140-6736(00)02787-2","volume":"356","author":"P Vernia","year":"2000","unstructured":"Vernia P, Fracasso PL, Casale V et al (2000) Topical butyrate for acute radiation proctitis: randomised, crossover trial. Lancet 356(9237):1232\u20131235. https:\/\/doi.org\/10.1016\/s0140-6736(00)02787-2","journal-title":"Lancet"},{"issue":"7","key":"2187_CR16","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1007\/s11095-006-0255-0","volume":"23","author":"CI Grainger","year":"2006","unstructured":"Grainger CI, Greenwell LL, Lockley DJ, Martin GP, Forbes B (2006) Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. Pharm Res 23(7):1482\u20131490. https:\/\/doi.org\/10.1007\/s11095-006-0255-0","journal-title":"Pharm Res"},{"issue":"9","key":"2187_CR17","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1073\/pnas.0903923107","volume":"107","author":"MS Buzza","year":"2010","unstructured":"Buzza MS, Netzel-Arnett S, Shea-Donohue T et al (2010) Membrane-anchored Serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A 107(9):4200\u20134205. https:\/\/doi.org\/10.1073\/pnas.0903923107","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2187_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cells13181531","author":"MM Elbrashy","year":"2024","unstructured":"Elbrashy MM, Metwally H, Sakakibara S, Kishimoto T (2024) Threonine phosphorylation and the Yin and Yang of STAT1: phosphorylation-Dependent spectrum of STAT1 functionality in inflammatory contexts. Cells. https:\/\/doi.org\/10.3390\/cells13181531","journal-title":"Cells"},{"key":"2187_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115845","author":"L Guo","year":"2023","unstructured":"Guo L, Chen Q, Gao Y et al (2023) CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease. Biochem Pharmacol. https:\/\/doi.org\/10.1016\/j.bcp.2023.115845","journal-title":"Biochem Pharmacol"},{"key":"2187_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117031","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Zhang Y, Jin S, Lv J, Li M, Feng N (2024) The gut microbiota derived metabolite trimethylamine N-oxide: its important role in cancer and other diseases. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2024.117031","journal-title":"Biomed Pharmacother"},{"key":"2187_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.854730","author":"Y Wang","year":"2022","unstructured":"Wang Y, Duan M, Peng Z et al (2022) Advances of DNA damage Repair-Related drugs and combination with immunotherapy in tumor treatment. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2022.854730","journal-title":"Front Immunol"},{"key":"2187_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.809304","author":"S Yu","year":"2022","unstructured":"Yu S, Wang Y, He P et al (2022) Effective combinations of immunotherapy and radiotherapy for cancer treatment. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.809304","journal-title":"Front Oncol"},{"key":"2187_CR23","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019190036","author":"KR Kalisz","year":"2019","unstructured":"Kalisz KR, Ramaiya NH, Laukamp KR, Gupta A (2019) Immune checkpoint inhibitor Therapy-related pneumonitis: patterns and management. Radiographics. https:\/\/doi.org\/10.1148\/rg.2019190036","journal-title":"Radiographics"},{"key":"2187_CR24","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-21-0839","author":"B Yan","year":"2023","unstructured":"Yan B, Hooper DC, Yuan Z, Wang C, Chen Y, Lu B (2023) Autoantibodies drive heart damage caused by concomitant radiation and PD-1 Blockade. Cancer Immunol Res. https:\/\/doi.org\/10.1158\/2326-6066.CIR-21-0839","journal-title":"Cancer Immunol Res"},{"key":"2187_CR25","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69431","author":"EK Robinson","year":"2021","unstructured":"Robinson EK, Jagannatha P, Covarrubias S et al (2021) Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2. Elife. https:\/\/doi.org\/10.7554\/eLife.69431","journal-title":"Elife"},{"key":"2187_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02025-2","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Ma Y, Pei J, Zhao X, Jiang Y, Liu Q (2024) Exploring Pyroptosis-related signature genes and potential drugs in ulcerative colitis by transcriptome data and animal experimental validation. Inflammation. https:\/\/doi.org\/10.1007\/s10753-024-02025-2","journal-title":"Inflammation"},{"key":"2187_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114746","author":"H Xu","year":"2024","unstructured":"Xu H, Xiao H, Tang Q (2024) Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease. Exp Neurol. https:\/\/doi.org\/10.1016\/j.expneurol.2024.114746","journal-title":"Exp Neurol"},{"key":"2187_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304781","author":"C Pu","year":"2024","unstructured":"Pu C, Li Y, Fu Y et al (2024) Low-Dose chemotherapy preferentially shapes the ileal Microbiome and augments the response to immune checkpoint Blockade by activating AIM2 inflammasome in ileal epithelial cells. Adv Sci (Weinh). https:\/\/doi.org\/10.1002\/advs.202304781","journal-title":"Adv Sci (Weinh)"},{"key":"2187_CR29","doi-asserted-by":"publisher","unstructured":"Wang Z, Wang Q, Gong L et al (2022) The NF-\u03baB-Regulated miR-221\/222\/Syndecan-1 Axis and Intestinal Mucosal Barrier Function in Radiation Enteritis [published correction appears in Int J Radiat Oncol Biol Phys. ;114(1):175. https:\/\/doi.org\/10.1016\/j.ijrobp.2022.05.019]. Int J Radiat Oncol Biol Phys. 2022;doi:10.1016\/j.ijrobp.2022.01.006","DOI":"10.1016\/j.ijrobp.2022.05.019]"},{"key":"2187_CR30","doi-asserted-by":"publisher","DOI":"10.1039\/d4fo01141d","author":"Y Shang","year":"2024","unstructured":"Shang Y, Cui P, Chen Y et al (2024) Study on the mechanism of mitigating radiation damage by improving the hematopoietic system and intestinal barrier with tenebrio molitor peptides. Food Funct. https:\/\/doi.org\/10.1039\/d4fo01141d","journal-title":"Food Funct"},{"key":"2187_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/nu16203494","author":"A Matar","year":"2024","unstructured":"Matar A, Damianos JA, Jencks KJ, Camilleri M (2024) Intestinal barrier Impairment, Preservation, and repair: an update. Nutrients. https:\/\/doi.org\/10.3390\/nu16203494","journal-title":"Nutrients"},{"key":"2187_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2024.102072","author":"T Shu","year":"2024","unstructured":"Shu T, Zhang J, Hu R et al (2024) Qi Huang Fang improves intestinal barrier function and intestinal microbes in septic mice through NLRP3 inflammasome-mediated cellular pyroptosis. Transpl Immunol. https:\/\/doi.org\/10.1016\/j.trim.2024.102072","journal-title":"Transpl Immunol"},{"key":"2187_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155223","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Zuo L, Song X et al (2024) Arjunolic acid protects the intestinal epithelial barrier, ameliorating crohn\u2019s disease-like colitis by restoring gut microbiota composition and inactivating TLR4 signalling. Phytomedicine. https:\/\/doi.org\/10.1016\/j.phymed.2023.155223","journal-title":"Phytomedicine"},{"issue":"3","key":"2187_CR34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/ecco-jcc\/jjaa182","volume":"15","author":"MR Spalinger","year":"2021","unstructured":"Spalinger MR, Sayoc-Becerra A, Ordookhanian C et al (2021) The JAK inhibitor Tofacitinib rescues intestinal barrier defects caused by disrupted Epithelial-macrophage interactions. J Crohns Colitis 15(3):471\u2013484. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaa182","journal-title":"J Crohns Colitis"},{"issue":"5","key":"2187_CR35","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1053\/j.gastro.2019.07.031","volume":"157","author":"C G\u00fcnther","year":"2019","unstructured":"G\u00fcnther C, Ruder B, Stolzer I et al (2019) Interferon lambda promotes Paneth cell death via STAT1 signaling in mice and is increased in inflamed ileal tissues of patients with crohn\u2019s disease. Gastroenterology 157(5):1310\u20131322e13. https:\/\/doi.org\/10.1053\/j.gastro.2019.07.031","journal-title":"Gastroenterology"},{"key":"2187_CR36","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14289","author":"Z Wang","year":"2019","unstructured":"Wang Z, Wang Q, Wang X et al (2019) Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy. J Cell Mol Med. https:\/\/doi.org\/10.1111\/jcmm.14289","journal-title":"J Cell Mol Med"},{"key":"2187_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087261","author":"N Kunika, Frey","year":"2023","unstructured":"Kunika, Frey N, Rangrez AY (2023) Exploring the involvement of gut microbiota in cancer Therapy-Induced cardiotoxicity. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24087261","journal-title":"Int J Mol Sci"},{"key":"2187_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.165","author":"SJ O\u2019Keefe","year":"2016","unstructured":"O\u2019Keefe SJ (2016) Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol. https:\/\/doi.org\/10.1038\/nrgastro.2016.165","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2187_CR39","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313414","author":"X Zhang","year":"2020","unstructured":"Zhang X, Li Y, Yang P et al (2020) Trimethylamine-N-Oxide promotes vascular calcification through activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) inflammasome and NF-\u03baB (Nuclear factor \u03baB) signals. Arterioscler Thromb Vasc Biol. https:\/\/doi.org\/10.1161\/ATVBAHA.119.313414","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2187_CR40","doi-asserted-by":"publisher","DOI":"10.1159\/000519603","author":"Y Lai","year":"2022","unstructured":"Lai Y, Tang H, Zhang X et al (2022) Trimethylamine-N-Oxide aggravates kidney injury via activation of p38\/MAPK signaling and upregulation of HuR. Kidney Blood Press Res. https:\/\/doi.org\/10.1159\/000519603","journal-title":"Kidney Blood Press Res"},{"key":"2187_CR41","doi-asserted-by":"publisher","first-page":"151390","DOI":"10.1016\/j.bbrc.2025.151390","volume":"750","author":"X Yang","year":"2025","unstructured":"Yang X, Wang Y, Feng Y, Wang F, Gao L, Wang Y (2025) Trimethylamine oxide promotes myocardial fibrosis through activating JAK2-STAT3 pathway. Biochem Biophys Res Commun 750:151390. https:\/\/doi.org\/10.1016\/j.bbrc.2025.151390","journal-title":"Biochem Biophys Res Commun"},{"key":"2187_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01181-z","author":"L Hoyles","year":"2021","unstructured":"Hoyles L, Pontifex MG, Rodriguez-Ramiro I et al (2021) Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. Microbiome. https:\/\/doi.org\/10.1186\/s40168-021-01181-z","journal-title":"Microbiome"},{"key":"2187_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00950-4","author":"V S\u00e1nchez","year":"2024","unstructured":"S\u00e1nchez V, Baumann A, Kromm F et al (2024) Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD). Mol Med. https:\/\/doi.org\/10.1186\/s10020-024-00950-4","journal-title":"Mol Med"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02187-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02187-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02187-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:08:12Z","timestamp":1764587292000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02187-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":43,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2187"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02187-w","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"assertion":[{"value":"26 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College (Approval no. IRM\/2-IACUC-2409-091).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}