{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:25:49Z","timestamp":1792783549541,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Outstanding Youth Foundation of Hunan Province","award":["2022JJ20092"],"award-info":[{"award-number":["2022JJ20092"]}]},{"name":"Youth Research Project of Shanxi Natural Science Foundation","award":["202303021212349"],"award-info":[{"award-number":["202303021212349"]}]},{"name":"Wisdom Gathering and Talent Cultivating Program from the Third Xiangya Hospital","award":["YX202211"],"award-info":[{"award-number":["YX202211"]}],"id":[{"id":"https:\/\/ror.org\/05akvb491","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81802940"],"award-info":[{"award-number":["81802940"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10495-025-02218-6","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:19:09Z","timestamp":1767953949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Downregulation of NFIA facilitates glycolysis, histone lactylation, and activation of the FN1\u2013integrin \u03b15\u03b21 pathway in pancreatic cancer"],"prefix":"10.1007","volume":"31","author":[{"given":"Xi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"issue":"8","key":"2218_CR1","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","volume":"186","author":"CJ Halbrook","year":"2023","unstructured":"Halbrook CJ et al (2023) Pancreatic cancer: advances and challenges. Cell 186(8):1729\u20131754","journal-title":"Cell"},{"key":"2218_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-073995","volume":"383","author":"M Del Chiaro","year":"2023","unstructured":"Del Chiaro M et al (2023) Advances in the management of pancreatic cancer. BMJ 383:e073995","journal-title":"BMJ"},{"issue":"7592","key":"2218_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nature16965","volume":"531","author":"P Bailey","year":"2016","unstructured":"Bailey P et al (2016) Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 531(7592):47\u201352","journal-title":"Nature"},{"issue":"8","key":"2218_CR4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/s41568-021-00375-9","volume":"21","author":"SA Kerk","year":"2021","unstructured":"Kerk SA et al (2021) Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment. Nat Rev Cancer 21(8):510\u2013525","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"2218_CR5","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/ng.3398","volume":"47","author":"RA Moffitt","year":"2015","unstructured":"Moffitt RA et al (2015) Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet 47(10):1168\u20131178","journal-title":"Nat Genet"},{"issue":"10","key":"2218_CR6","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/nn.3790","volume":"17","author":"SM Glasgow","year":"2014","unstructured":"Glasgow SM et al (2014) Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci 17(10):1322\u20131329","journal-title":"Nat Neurosci"},{"issue":"18","key":"2218_CR7","first-page":"2245","volume":"141","author":"MR Piqu\u00e9-Borr\u00e0s","year":"2023","unstructured":"Piqu\u00e9-Borr\u00e0s MR et al (2023) The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53. Blood 141(18):2245\u20132260","journal-title":"Blood"},{"key":"2218_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.canlet.2017.09.015","volume":"410","author":"KS Chen","year":"2017","unstructured":"Chen KS et al (2017) The convergent roles of the nuclear factor I transcription factors in development and cancer. Cancer Lett 410:124\u2013138","journal-title":"Cancer Lett"},{"issue":"15","key":"2218_CR9","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.1016\/j.cell.2024.06.026","volume":"187","author":"SM Fendt","year":"2024","unstructured":"Fendt SM (2024) 100 years of the Warburg effect: a cancer metabolism endeavor. Cell 187(15):3824\u20133828","journal-title":"Cell"},{"issue":"1","key":"2218_CR10","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s13046-020-01765-x","volume":"39","author":"L Cao","year":"2020","unstructured":"Cao L et al (2020) Glycometabolic rearrangements\u2013aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications. J Exp Clin Cancer Res 39(1):267","journal-title":"J Exp Clin Cancer Res"},{"issue":"7779","key":"2218_CR11","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","volume":"574","author":"D Zhang","year":"2019","unstructured":"Zhang D et al (2019) Metabolic regulation of gene expression by histone lactylation. Nature 574(7779):575\u2013580","journal-title":"Nature"},{"key":"2218_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217117","volume":"598","author":"X Wang","year":"2024","unstructured":"Wang X et al (2024) Histone lactylation dynamics: unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer. Cancer Lett 598:217117","journal-title":"Cancer Lett"},{"issue":"21","key":"2218_CR13","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1158\/0008-5472.CAN-24-2860","volume":"84","author":"ES Carpenter","year":"2024","unstructured":"Carpenter ES et al (2024) Pancreatic cancer-associated fibroblasts: where do we go from here? Cancer Res 84(21):3505\u20133508","journal-title":"Cancer Res"},{"issue":"4","key":"2218_CR14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1158\/1078-0432.CCR-23-0493","volume":"30","author":"PM Galbo Jr.","year":"2024","unstructured":"Galbo PM Jr. et al (2024) Functional contribution and clinical implication of cancer-associated fibroblasts in glioblastoma. Clin Cancer Res 30(4):865\u2013876","journal-title":"Clin Cancer Res"},{"issue":"11","key":"2218_CR15","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1083\/jcb.201704053","volume":"216","author":"B Erdogan","year":"2017","unstructured":"Erdogan B et al (2017) Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J Cell Biol 216(11):3799\u20133816","journal-title":"J Cell Biol"},{"issue":"3","key":"2218_CR16","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20162024","volume":"214","author":"D \u00d6hlund","year":"2017","unstructured":"\u00d6hlund D et al (2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med 214(3):579\u2013596","journal-title":"J Exp Med"},{"key":"2218_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119462","volume":"277","author":"J Tan","year":"2021","unstructured":"Tan J et al (2021) Over-expressed RHEB promotes the progression of pancreatic adenocarcinoma. Life Sci 277:119462","journal-title":"Life Sci"},{"key":"2218_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118131","volume":"257","author":"J Zhang","year":"2020","unstructured":"Zhang J et al (2020) Systematic analysis of the ABC transporter family in hepatocellular carcinoma reveals the importance of ABCB6 in regulating ferroptosis. Life Sci 257:118131","journal-title":"Life Sci"},{"issue":"1","key":"2218_CR19","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1038\/s41467-022-30342-3","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y et al (2022) Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nat Commun 13(1):2669","journal-title":"Nat Commun"},{"issue":"1","key":"2218_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.molcel.2017.09.015","volume":"68","author":"JZ Huang","year":"2017","unstructured":"Huang JZ et al (2017) A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth. Mol Cell 68(1):171-184.e6","journal-title":"Mol Cell"},{"issue":"1","key":"2218_CR21","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41467-022-28341-5","volume":"13","author":"H G\u00f6\u00f6s","year":"2022","unstructured":"G\u00f6\u00f6s H et al (2022) Human transcription factor protein interaction networks. Nat Commun 13(1):766","journal-title":"Nat Commun"},{"issue":"2","key":"2218_CR22","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41375-022-01801-z","volume":"37","author":"N Rastogi","year":"2023","unstructured":"Rastogi N et al (2023) Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia 37(2):276\u2013287","journal-title":"Leukemia"},{"issue":"2","key":"2218_CR23","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.cell.2016.05.052","volume":"166","author":"SK Denny","year":"2016","unstructured":"Denny SK et al (2016) Nfib promotes metastasis through a widespread increase in chromatin accessibility. Cell 166(2):328\u2013342","journal-title":"Cell"},{"issue":"4","key":"2218_CR24","first-page":"524","volume":"19","author":"J Lee","year":"2017","unstructured":"Lee J, Hoxha E, Song HR (2017) A novel NFIA-NF\u03baB feed-forward loop contributes to glioblastoma cell survival. Neuro Oncol 19(4):524\u2013534","journal-title":"Neuro Oncol"},{"issue":"1","key":"2218_CR25","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1038\/s41467-023-39291-x","volume":"14","author":"I Cobo","year":"2023","unstructured":"Cobo I et al (2023) NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun 14(1):3761","journal-title":"Nat Commun"},{"issue":"1","key":"2218_CR26","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1186\/s12935-020-01669-y","volume":"20","author":"L Ye","year":"2020","unstructured":"Ye L et al (2020) MAFG-AS1 aggravates the progression of pancreatic cancer by sponging miR-3196 to boost NFIX. Cancer Cell Int 20(1):591","journal-title":"Cancer Cell Int"},{"issue":"2","key":"2218_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1136\/gutjnl-2021-325564","volume":"72","author":"M Alonso-Nocelo","year":"2023","unstructured":"Alonso-Nocelo M et al (2023) Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma. Gut 72(2):345\u2013359","journal-title":"Gut"},{"issue":"1","key":"2218_CR28","doi-asserted-by":"publisher","first-page":"6730","DOI":"10.1038\/s41467-024-50987-6","volume":"15","author":"Y Gu","year":"2024","unstructured":"Gu Y et al (2024) SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis. Nat Commun 15(1):6730","journal-title":"Nat Commun"},{"issue":"6","key":"2218_CR29","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.21037\/jgo-21-819","volume":"12","author":"Y Ruan","year":"2021","unstructured":"Ruan Y et al (2021) REXO4 acts as a biomarker and promotes hepatocellular carcinoma progression. J Gastrointest Oncol 12(6):3093\u20133106","journal-title":"J Gastrointest Oncol"},{"issue":"1","key":"2218_CR30","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13046-021-01908-8","volume":"40","author":"S Spada","year":"2021","unstructured":"Spada S et al (2021) Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology. J Exp Clin Cancer Res 40(1):102","journal-title":"J Exp Clin Cancer Res"},{"issue":"11","key":"2218_CR31","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1083\/jcb.201702033","volume":"216","author":"Y Attieh","year":"2017","unstructured":"Attieh Y et al (2017) Cancer-associated fibroblasts lead tumor invasion through integrin-\u03b23-dependent fibronectin assembly. J Cell Biol 216(11):3509\u20133520","journal-title":"J Cell Biol"},{"key":"2218_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103209","volume":"74","author":"X Gu","year":"2024","unstructured":"Gu X et al (2024) Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression. Redox Biol 74:103209","journal-title":"Redox Biol"},{"issue":"15","key":"2218_CR33","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1038\/s41388-021-01740-6","volume":"40","author":"A Mart\u00ednez-Ordo\u00f1ez","year":"2021","unstructured":"Mart\u00ednez-Ordo\u00f1ez A et al (2021) POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation. Oncogene 40(15):2725\u20132740","journal-title":"Oncogene"},{"issue":"6","key":"2218_CR34","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1097\/HJH.0000000000003129","volume":"40","author":"X Li","year":"2022","unstructured":"Li X et al (2022) Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia. J Hypertens 40(6):1189\u20131198","journal-title":"J Hypertens"},{"issue":"1","key":"2218_CR35","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12943-024-02008-9","volume":"23","author":"F Li","year":"2024","unstructured":"Li F et al (2024) Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma. Mol Cancer 23(1):90","journal-title":"Mol Cancer"},{"issue":"1","key":"2218_CR36","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","volume":"22","author":"J Yu","year":"2021","unstructured":"Yu J et al (2021) Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma. Genome Biol 22(1):85","journal-title":"Genome Biol"},{"issue":"2","key":"2218_CR37","first-page":"309","volume":"25","author":"C Wu","year":"2023","unstructured":"Wu C et al (2023) Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation. Nat Cell Biol 25(2):309\u2013322","journal-title":"Nat Cell Biol"},{"key":"2218_CR38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.canlet.2020.11.013","volume":"501","author":"CPR Xavier","year":"2021","unstructured":"Xavier CPR et al (2021) Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine. Cancer Lett 501:210\u2013223","journal-title":"Cancer Lett"},{"issue":"4","key":"2218_CR39","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.7150\/thno.50613","volume":"11","author":"C Zhong","year":"2021","unstructured":"Zhong C et al (2021) Remodeling cancer stemness by collagen\/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma. Theranostics 11(4):1991\u20132005","journal-title":"Theranostics"},{"issue":"4","key":"2218_CR40","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41419-023-05788-y","volume":"14","author":"XG Mao","year":"2023","unstructured":"Mao XG et al (2023) CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR\/PI3K pathway. Cell Death Dis 14(4):269","journal-title":"Cell Death Dis"},{"issue":"1","key":"2218_CR41","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1158\/0008-5472.CAN-05-2367","volume":"66","author":"S Han","year":"2006","unstructured":"Han S, Khuri FR, Roman J (2006) Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt\/mammalian target of rapamycin\/S6 kinase and inactivation of LKB1\/AMP-activated protein kinase signal pathways. Cancer Res 66(1):315\u2013323","journal-title":"Cancer Res"},{"issue":"11","key":"2218_CR42","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/s41419-020-03138-w","volume":"11","author":"Z Zhu","year":"2020","unstructured":"Zhu Z et al (2020) MiRNA-671-5p promotes prostate cancer development and metastasis by targeting NFIA\/CRYAB axis. Cell Death Dis 11(11):949","journal-title":"Cell Death Dis"},{"issue":"11","key":"2218_CR43","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/nn.4638","volume":"20","author":"SM Glasgow","year":"2017","unstructured":"Glasgow SM et al (2017) Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci 20(11):1520\u20131528","journal-title":"Nat Neurosci"},{"issue":"4","key":"2218_CR44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41389-020-0223-2","volume":"9","author":"Z Liu","year":"2020","unstructured":"Liu Z et al (2020) Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin. Oncogenesis 9(4):39","journal-title":"Oncogenesis"},{"issue":"1","key":"2218_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2024.100890","volume":"24","author":"D Malaymar Pinar","year":"2024","unstructured":"Malaymar Pinar D et al (2024) Nuclear factor I family members are key transcription factors regulating gene expression. Mol Cell Proteomics 24(1):100890","journal-title":"Mol Cell Proteomics"},{"issue":"13","key":"2218_CR46","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1016\/j.celrep.2018.11.078","volume":"25","author":"MA Scavuzzo","year":"2018","unstructured":"Scavuzzo MA et al (2018) Pancreatic cell fate determination relies on Notch ligand trafficking by NFIA. Cell Rep 25(13):3811-3827.e7","journal-title":"Cell Rep"},{"issue":"20","key":"2218_CR47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2210991120","volume":"120","author":"R Raviram","year":"2023","unstructured":"Raviram R et al (2023) Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proc Natl Acad Sci U S A 120(20):e2210991120","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"2218_CR48","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neo.2018.08.007","volume":"20","author":"M Brun","year":"2018","unstructured":"Brun M et al (2018) Nuclear factor I represses the Notch effector HEY1 in glioblastoma. Neoplasia 20(10):1023\u20131037","journal-title":"Neoplasia"},{"issue":"4","key":"2218_CR49","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/cjp2.316","volume":"9","author":"R de Alwis","year":"2023","unstructured":"de Alwis R et al (2023) Identification and validation of NFIA as a novel prognostic marker in renal cell carcinoma. J Pathol Clin Res 9(4):261\u2013272","journal-title":"J Pathol Clin Res"},{"issue":"9","key":"2218_CR50","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/s41419-022-05213-w","volume":"13","author":"K Cai","year":"2022","unstructured":"Cai K et al (2022) FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis. Cell Death Dis 13(9):765","journal-title":"Cell Death Dis"},{"issue":"1","key":"2218_CR51","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41419-025-07399-1","volume":"16","author":"D Zheng","year":"2025","unstructured":"Zheng D et al (2025) CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance. Cell Death Dis 16(1):68","journal-title":"Cell Death Dis"},{"issue":"21","key":"2218_CR52","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1158\/0008-5472.CAN-23-3513","volume":"84","author":"C Zhang","year":"2024","unstructured":"Zhang C et al (2024) H3K18 lactylation potentiates immune escape of non-small cell lung cancer. Cancer Res 84(21):3589\u20133601","journal-title":"Cancer Res"},{"issue":"5","key":"2218_CR53","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1172\/JCI66715","volume":"123","author":"SC Hanna","year":"2013","unstructured":"Hanna SC et al (2013) HIF1\u03b1 and HIF2\u03b1 independently activate SRC to promote melanoma metastases. J Clin Invest 123(5):2078\u20132093","journal-title":"J Clin Invest"},{"key":"2218_CR54","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407134","author":"W Sun","year":"2024","unstructured":"Sun W et al (2024) Fatty acid oxidation-glycolysis metabolic transition affects ECM homeostasis in silica-induced pulmonary fibrosis. Adv Sci. https:\/\/doi.org\/10.1002\/advs.202407134","journal-title":"Adv Sci"},{"issue":"1","key":"2218_CR55","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13046-021-01946-2","volume":"40","author":"M Kemper","year":"2021","unstructured":"Kemper M et al (2021) Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression. J Exp Clin Cancer Res 40(1):214","journal-title":"J Exp Clin Cancer Res"},{"issue":"5","key":"2218_CR56","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1053\/j.gastro.2017.12.014","volume":"154","author":"W Zhao","year":"2018","unstructured":"Zhao W et al (2018) Galectin-3 mediates tumor cell-stroma interactions by activating pancreatic stellate cells to produce cytokines via integrin signaling. Gastroenterology 154(5):1524-1537.e6","journal-title":"Gastroenterology"},{"issue":"5","key":"2218_CR57","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s41568-021-00340-6","volume":"21","author":"JC Dawson","year":"2021","unstructured":"Dawson JC et al (2021) Targeting FAK in anticancer combination therapies. Nat Rev Cancer 21(5):313\u2013324","journal-title":"Nat Rev Cancer"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02218-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02218-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02218-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:01:25Z","timestamp":1774000885000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02218-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2218"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02218-6","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"25 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No authors declare that they have known competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The retrospective clinical study adhered strictly to the ethical standards established by the Declaration of Helsinki. Ethical approval was granted by the Ethics Committee of Shanxi Provincial People\u2019s Hospital (Ethical Approval Number: 2021-196). All animal procedures were approved by the Biomedical Ethics Committee of Zhoukou Normal University (Ethical approval number: ZKNU-2023021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"4"}}