{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:10:56Z","timestamp":1774008656561,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Taizhou School of Clinical Medicine, Nanjing Medical University","award":["TZKY20230308, TZKY20230102"],"award-info":[{"award-number":["TZKY20230308, TZKY20230102"]}]},{"name":"Yanzhen Talent Program for Emerging Academic Leaders","award":["YZ-HBDTR-SJ-2025"],"award-info":[{"award-number":["YZ-HBDTR-SJ-2025"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82300609"],"award-info":[{"award-number":["82300609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changzhou Sci&Tech Program","award":["2022CZBJ066, CJ20245024"],"award-info":[{"award-number":["2022CZBJ066, CJ20245024"]}]},{"name":"Changzhou Medical Center of Nanjing Medical University Program","award":["CMC2024PY17"],"award-info":[{"award-number":["CMC2024PY17"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10495-025-02228-4","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:33:24Z","timestamp":1768037604000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RNF168 promotes chronic colitis through ANXA7-mediated autophagy and NLRP3-driven pyroptosis"],"prefix":"10.1007","volume":"31","author":[{"given":"Honggang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"issue":"1","key":"2228_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","volume":"6","author":"G Roda","year":"2020","unstructured":"Roda G, Chien Ng S, Kotze PG et al (2020) Crohn\u2019s disease. Nat Rev Dis Primers 6(1):22","journal-title":"Nat Rev Dis Primers"},{"issue":"10114","key":"2228_CR2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N et al (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet 390(10114):2769\u20132778","journal-title":"Lancet"},{"key":"2228_CR3","unstructured":"GBD 2017 Inflammatory Bowel Disease Collaborators (2020) The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 5(1):17\u201330"},{"issue":"1","key":"2228_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13062-020-00280-5","volume":"15","author":"L Petagna","year":"2020","unstructured":"Petagna L, Antonelli A, Ganini C et al (2020) Pathophysiology of Crohn\u2019s disease inflammation and recurrence. Biol Direct 15(1):23","journal-title":"Biol Direct"},{"issue":"5","key":"2228_CR5","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","volume":"160","author":"D Turner","year":"2021","unstructured":"Turner D, Ricciuto A, Lewis A et al (2021) STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology 160(5):1570\u20131583","journal-title":"Gastroenterology"},{"issue":"5","key":"2228_CR6","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3748\/wjg.v18.i5.412","volume":"18","author":"SA Naser","year":"2012","unstructured":"Naser SA, Arce M, Khaja A et al (2012) Role of ATG16L, NOD2 and IL23R in Crohn\u2019s disease pathogenesis. World J Gastroenterol 18(5):412\u2013424","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2228_CR7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1080\/15548627.2019.1635384","volume":"16","author":"A Larabi","year":"2020","unstructured":"Larabi A, Barnich N, Nguyen H (2020) New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy 16(1):38\u201351","journal-title":"Autophagy"},{"issue":"9","key":"2228_CR8","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s41419-022-05226-5","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao J, Sun Y, Yang H et al (2022) PLGA-microspheres-carried circGMCL1 protects against Crohn\u2019s colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy. Cell Death Dis 13(9):782","journal-title":"Cell Death Dis"},{"issue":"1","key":"2228_CR9","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/s41467-024-45954-0","volume":"15","author":"V Gerke","year":"2024","unstructured":"Gerke V, Gavins F, Geisow M et al (2024) Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics. Nat Commun 15(1):1574","journal-title":"Nat Commun"},{"issue":"4","key":"2228_CR10","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/0016-5085(90)90613-6","volume":"99","author":"P Rutgeerts","year":"1990","unstructured":"Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M (1990) Predictability of the postoperative course of Crohn\u2019s disease. Gastroenterology 99(4):956\u2013963","journal-title":"Gastroenterology"},{"issue":"3","key":"2228_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","volume":"70","author":"WR Best","year":"1976","unstructured":"Best WR, Becktel JM, Singleton JW, Kern F Jr. (1976) Development of a Crohn\u2019s disease activity index. National Cooperative Crohn\u2019s Disease Study. Gastroenterology 70(3):439\u2013444","journal-title":"Gastroenterology"},{"issue":"4","key":"2228_CR12","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0016-5107(04)01878-4","volume":"60","author":"M Daperno","year":"2004","unstructured":"Daperno M, D\u2019Haens G, Van Assche G et al (2004) Development and validation of a new, simplified endoscopic activity score for Crohn\u2019s disease: the SES-CD. Gastrointest Endosc 60(4):505\u2013512","journal-title":"Gastrointest Endosc"},{"issue":"7","key":"2228_CR13","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/nprot.2017.044","volume":"12","author":"S Wirtz","year":"2017","unstructured":"Wirtz S, Popp V, Kindermann M et al (2017) Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc 12(7):1295\u20131309","journal-title":"Nat Protoc"},{"issue":"3","key":"2228_CR14","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nprot.2007.41","volume":"2","author":"S Wirtz","year":"2007","unstructured":"Wirtz S, Neufert C, Weigmann B, Neurath MF (2007) Chemically induced mouse models of intestinal inflammation. Nat Protoc 2(3):541\u2013546","journal-title":"Nat Protoc"},{"issue":"1","key":"2228_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13059-023-02991-0","volume":"24","author":"S Huang","year":"2023","unstructured":"Huang S, Xie Z, Han J et al (2023) Protocadherin 20 maintains intestinal barrier function to protect against Crohn\u2019s disease by targeting ATF6. Genome Biol 24(1):159","journal-title":"Genome Biol"},{"issue":"3","key":"2228_CR16","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.4049\/jimmunol.171.3.1401","volume":"171","author":"UP Singh","year":"2003","unstructured":"Singh UP, Singh S, Taub DD, Lillard JW Jr (2003) Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-\/- mice. J Immunol 171(3):1401\u20131406","journal-title":"J Immunol"},{"issue":"1","key":"2228_CR17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-024-02042-5","volume":"9","author":"X Jiang","year":"2024","unstructured":"Jiang X, Wang J, Lin L et al (2024) Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity. Signal Transduct Target Ther 9(1):352","journal-title":"Signal Transduct Target Ther"},{"issue":"D1","key":"2228_CR18","doi-asserted-by":"publisher","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","volume":"50","author":"JA Castro-Mondragon","year":"2022","unstructured":"Castro-Mondragon JA, Riudavets-Puig R, Rauluseviciute I et al (2022) JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Res 50(D1):D165\u2013D173","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"2228_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1136\/gutjnl-2023-329628","volume":"73","author":"MT Chiriac","year":"2024","unstructured":"Chiriac MT, Hracsko Z, G\u00fcnther C et al (2024) IL-20 controls resolution of experimental colitis by regulating epithelial IFN\/STAT2 signalling. Gut 73(2):282\u2013297","journal-title":"Gut"},{"issue":"8","key":"2228_CR20","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/ecco-jcc\/jjy046","volume":"12","author":"M Yu","year":"2018","unstructured":"Yu M, Luo Y, Cong Z, Mu Y, Qiu Y, Zhong M (2018) MicroRNA-590-5p inhibits intestinal inflammation by targeting YAP. J Crohns Colitis 12(8):993\u20131004","journal-title":"J Crohns Colitis"},{"issue":"1","key":"2228_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/gut.2008.150888","volume":"58","author":"MC Arrieta","year":"2009","unstructured":"Arrieta MC, Madsen K, Doyle J, Meddings J (2009) Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58(1):41\u201348","journal-title":"Gut"},{"issue":"4","key":"2228_CR22","doi-asserted-by":"publisher","first-page":"G621","DOI":"10.1152\/ajpgi.00274.2010","volume":"300","author":"M van Looijer- Langen","year":"2011","unstructured":"van Looijer- Langen M, Hotte N, Dieleman LA, Albert E, Mulder C, Madsen KL (2011) Estrogen receptor-\u03b2 signaling modulates epithelial barrier function. Am J Physiol Gastrointest Liver Physiol 300(4):G621\u2013G626","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"2228_CR23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/19490976.2019.1629235","volume":"11","author":"M Stephens","year":"2020","unstructured":"Stephens M, von der Weid PY (2020) Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner. Gut Microbes 11(3):421\u2013432","journal-title":"Gut Microbes"},{"issue":"1","key":"2228_CR24","doi-asserted-by":"publisher","first-page":"5125","DOI":"10.1038\/s41598-017-04989-8","volume":"7","author":"R Ahmad","year":"2017","unstructured":"Ahmad R, Rah B, Bastola D, Dhawan P, Singh AB (2017) Obesity-induces organ and tissue specific tight junction restructuring and barrier deregulation by claudin switching. Sci Rep 7(1):5125","journal-title":"Sci Rep"},{"issue":"9","key":"2228_CR25","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.ccell.2021.07.003","volume":"39","author":"B Seong","year":"2021","unstructured":"Seong B, Dharia NV, Lin S et al (2021) TRIM8 modulates the EWS\/FLI oncoprotein to promote survival in Ewing sarcoma. Cancer Cell 39(9):1262-1278.e7","journal-title":"Cancer Cell"},{"issue":"50","key":"2228_CR26","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1038\/s41388-023-02879-0","volume":"42","author":"L Wang","year":"2023","unstructured":"Wang L, Li H, Huang A et al (2023) Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination. Oncogene 42(50):3708\u20133718","journal-title":"Oncogene"},{"issue":"5","key":"2228_CR27","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM (2014) Mechanisms and functions of inflammasomes. Cell 157(5):1013\u20131022","journal-title":"Cell"},{"issue":"6","key":"2228_CR28","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1080\/15548627.2019.1569916","volume":"15","author":"Y Xia","year":"2019","unstructured":"Xia Y, Liu N, Xie X et al (2019) The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy 15(6):960\u2013975","journal-title":"Autophagy"},{"issue":"10080","key":"2228_CR29","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","volume":"389","author":"J Torres","year":"2017","unstructured":"Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L (2017) Crohn\u2019s disease. Lancet 389(10080):1741\u20131755","journal-title":"Lancet"},{"issue":"3","key":"2228_CR30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.molcel.2018.11.018","volume":"73","author":"S Mehto","year":"2019","unstructured":"Mehto S, Jena KK, Nath P et al (2019) The Crohn\u2019s disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy. Mol Cell 73(3):429-445.e7","journal-title":"Mol Cell"},{"issue":"1","key":"2228_CR31","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/imr.12613","volume":"281","author":"M Takahama","year":"2018","unstructured":"Takahama M, Akira S, Saitoh T (2018) Autophagy limits activation of the inflammasomes. Immunol Rev 281(1):62\u201373","journal-title":"Immunol Rev"},{"key":"2228_CR32","doi-asserted-by":"publisher","first-page":"110591","DOI":"10.1016\/j.biopha.2020.110591","volume":"130","author":"Y Xi","year":"2020","unstructured":"Xi Y, Ju R, Wang Y (2020) Roles of annexin A protein family in autophagy regulation and therapy. Biomed Pharmacother 130:110591","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"2228_CR33","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1159\/000505910","volume":"38","author":"S Reischl","year":"2020","unstructured":"Reischl S, Troger J, Jesinghaus M et al (2020) Annexin A1 expression capacity as a determinant for disease severity in Crohn\u2019s disease. Dig Dis 38(5):398\u2013407","journal-title":"Dig Dis"},{"key":"2228_CR34","doi-asserted-by":"publisher","first-page":"714138","DOI":"10.3389\/fimmu.2021.714138","volume":"12","author":"M de Paula-Silva","year":"2021","unstructured":"de Paula-Silva M, da Rocha G, Broering MF et al (2021) Formyl peptide receptors and annexin A1: complementary mechanisms to Infliximab in murine experimental colitis and Crohn\u2019s disease. Front Immunol 12:714138","journal-title":"Front Immunol"},{"issue":"9","key":"2228_CR35","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1111\/febs.15857","volume":"289","author":"J Kelliher","year":"2022","unstructured":"Kelliher J, Ghosal G, Leung J (2022) New answers to the old RIDDLE: RNF168 and the DNA damage response pathway. FEBS J 289(9):2467\u20132480","journal-title":"FEBS J"},{"issue":"3","key":"2228_CR36","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3390\/molecules28031417","volume":"28","author":"T Xie","year":"2023","unstructured":"Xie T, Qin H, Yuan Z, Zhang Y, Li X, Zheng L (2023) Emerging roles of RNF168 in tumor progression. Molecules 28(3):1417","journal-title":"Molecules"},{"issue":"8","key":"2228_CR37","doi-asserted-by":"publisher","first-page":"e252","DOI":"10.1038\/oncsis.2016.57","volume":"5","author":"M Kongsema","year":"2016","unstructured":"Kongsema M, Zona S, Karunarathna U et al (2016) RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment. Oncogenesis 5(8):e252","journal-title":"Oncogenesis"},{"issue":"22","key":"2228_CR38","doi-asserted-by":"publisher","first-page":"15028","DOI":"10.1021\/acs.jmedchem.2c00432","volume":"65","author":"FC Wang","year":"2022","unstructured":"Wang FC, Peng B, Ren TT et al (2022) A 1,2,3-triazole derivative of quinazoline exhibits antitumor activity by tethering RNF168 to SQSTM1\/P62. J Med Chem 65(22):15028\u201315047","journal-title":"J Med Chem"},{"issue":"2","key":"2228_CR39","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.immuni.2023.01.002","volume":"56","author":"L Kong","year":"2023","unstructured":"Kong L, Pokatayev V, Lefkovith A et al (2023) The landscape of immune dysregulation in Crohn\u2019s disease revealed through single-cell transcriptomic profiling in the ileum and colon. Immunity 56(2):444-458.e5","journal-title":"Immunity"},{"issue":"6","key":"2228_CR40","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1007\/s13577-022-00789-z","volume":"35","author":"J Wang","year":"2022","unstructured":"Wang J, Luo J, Wu X, Li Z (2022) ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression. Hum Cell 35(6):1961\u20131975","journal-title":"Hum Cell"},{"key":"2228_CR41","doi-asserted-by":"publisher","first-page":"106272","DOI":"10.1016\/j.intimp.2020.106272","volume":"81","author":"H Guo","year":"2020","unstructured":"Guo H, Lei H, Zhang BG, Xu ZC, Dong C, Hao YQ (2020) c-Jun NH2-terminal kinase (JNK)\/stress-activated protein kinase-associated protein 1 is a critical regulator for arthritis progression by mediating inflammation in mice model. Int Immunopharmacol 81:106272","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"2228_CR42","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/j.1582-4934.2010.01065.x","volume":"15","author":"R Al-Sadi","year":"2011","unstructured":"Al-Sadi R, Ye D, Said HM, Ma TY (2011) Cellular and molecular mechanism of interleukin-1\u03b2 modulation of Caco-2 intestinal epithelial tight junction barrier. J Cell Mol Med 15(4):970\u2013982","journal-title":"J Cell Mol Med"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02228-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02228-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02228-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:02:44Z","timestamp":1774000964000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02228-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2228"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02228-4","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"27 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Consent to participate is not applicable in this study. The clinical study was approved by the ethics committee of The First Affiliated Hospital of Nanjing Medical University (No. 2023-SR-115). All the experimental protocols were approved by the Ethics Committee of the Laboratory Animal Center of Nantong University (NO.S20200323-289) according to the guidelines by the Chinese Council on Animal Care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"27"}}