{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:23:44Z","timestamp":1789388624391,"version":"build-2803163510"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172438 and 82372473"],"award-info":[{"award-number":["82172438 and 82372473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10495-025-02231-9","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:39:39Z","timestamp":1768037979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["DDIT3 drives nucleus pulposus cell PANoptosis and intervertebral disc degeneration progression"],"prefix":"10.1007","volume":"31","author":[{"given":"Kun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"issue":"4","key":"2231_CR1","doi-asserted-by":"publisher","first-page":"e1033","DOI":"10.1002\/jsp2.1033","volume":"1","author":"CME Rustenburg","year":"2018","unstructured":"Rustenburg CME, Emanuel KS, Peeters M, Lems WF, Vergroesen PA, Smit TH (2018) Osteoarthritis and intervertebral disc degeneration: quite different, quite similar. JOR Spine 1(4):e1033. https:\/\/doi.org\/10.1002\/jsp2.1033","journal-title":"JOR Spine"},{"issue":"9","key":"2231_CR2","doi-asserted-by":"publisher","first-page":"e13448","DOI":"10.1111\/cpr.13448","volume":"56","author":"Y Wang","year":"2023","unstructured":"Wang Y, Cheng H, Wang T, Zhang K, Zhang Y, Kang X (2023) Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment. Cell Prolif 56(9):e13448. https:\/\/doi.org\/10.1111\/cpr.13448","journal-title":"Cell Prolif"},{"issue":"7","key":"2231_CR3","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.amjmed.2023.03.024","volume":"136","author":"AS Zhang","year":"2023","unstructured":"Zhang AS, Xu A, Ansari K, Hardacker K, Anderson G, Alsoof D et al (2023) Lumbar disc herniation: diagnosis and management. Am J Med 136(7):645\u2013651. https:\/\/doi.org\/10.1016\/j.amjmed.2023.03.024","journal-title":"Am J Med"},{"issue":"6","key":"2231_CR4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s40291-024-00729-7","volume":"28","author":"N Elmounedi","year":"2024","unstructured":"Elmounedi N, Bahloul W, Keskes H (2024) Current therapeutic strategies of intervertebral disc regenerative medicine. Mol Diagn Ther 28(6):745\u2013775. https:\/\/doi.org\/10.1007\/s40291-024-00729-7","journal-title":"Mol Diagn Ther"},{"key":"2231_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bioactmat.2023.05.005","volume":"28","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Yu Q, Li H, Han F, Guo Q, Sun H et al (2023) Vanillin-based functionalization strategy to construct multifunctional microspheres for treating inflammation and regenerating intervertebral disc. Bioact Mater 28:167\u2013182. https:\/\/doi.org\/10.1016\/j.bioactmat.2023.05.005","journal-title":"Bioact Mater"},{"key":"2231_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jot.2022.10.009","volume":"37","author":"F Yang","year":"2022","unstructured":"Yang F, Liu W, Huang Y, Yang S, Shao Z, Cai X et al (2022) Regulated cell death: implications for intervertebral disc degeneration and therapy. J Orthop Translat 37:163\u2013172. https:\/\/doi.org\/10.1016\/j.jot.2022.10.009","journal-title":"J Orthop Translat"},{"issue":"1","key":"2231_CR7","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1186\/s12967-024-05943-9","volume":"22","author":"B Qiu","year":"2024","unstructured":"Qiu B, Xie X, Xi Y (2024) Mitochondrial quality control: the real dawn of intervertebral disc degeneration? J Transl Med 22(1):1126. https:\/\/doi.org\/10.1186\/s12967-024-05943-9","journal-title":"J Transl Med"},{"issue":"2","key":"2231_CR8","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41401-024-01376-8","volume":"46","author":"YP You","year":"2025","unstructured":"You YP, Yan L, Ke HY, Li YP, Shi ZJ, Zhou ZY et al (2025) Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages. Acta Pharmacol Sin 46(2):430\u2013447. https:\/\/doi.org\/10.1038\/s41401-024-01376-8","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"2231_CR9","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41401-023-01182-8","volume":"45","author":"FL Shi","year":"2024","unstructured":"Shi FL, Li Q, Xu R, Yuan LS, Chen Y, Shi ZJ et al (2024) Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis. Acta Pharmacol Sin 45(3):594\u2013608. https:\/\/doi.org\/10.1038\/s41401-023-01182-8","journal-title":"Acta Pharmacol Sin"},{"key":"2231_CR10","doi-asserted-by":"publisher","first-page":"102489","DOI":"10.1016\/j.coi.2024.102489","volume":"91","author":"V Nadella","year":"2024","unstructured":"Nadella V, Kanneganti TD (2024) Inflammasomes and their role in PANoptosomes. Curr Opin Immunol 91:102489. https:\/\/doi.org\/10.1016\/j.coi.2024.102489","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"2231_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","volume":"30","author":"A Pandeya","year":"2024","unstructured":"Pandeya A, Kanneganti TD (2024) Therapeutic potential of panoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes. Trends Mol Med 30(1):74\u201388. https:\/\/doi.org\/10.1016\/j.molmed.2023.10.001","journal-title":"Trends Mol Med"},{"issue":"7","key":"2231_CR12","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s12272-024-01506-0","volume":"47","author":"H Bae","year":"2024","unstructured":"Bae H, Jang Y, Karki R, Han JH (2024) Implications of inflammatory cell death-PANoptosis in health and disease. Arch Pharm Res 47(7):617\u2013631. https:\/\/doi.org\/10.1007\/s12272-024-01506-0","journal-title":"Arch Pharm Res"},{"issue":"4","key":"2231_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1136\/jcp-2023-208963","volume":"77","author":"JA Diaz-Perez","year":"2024","unstructured":"Diaz-Perez JA, Kerr DA (2024) Gene of the month: DDIT3. J Clin Pathol 77(4):211\u2013216. https:\/\/doi.org\/10.1136\/jcp-2023-208963","journal-title":"J Clin Pathol"},{"issue":"1","key":"2231_CR14","doi-asserted-by":"publisher","first-page":"113418","DOI":"10.1016\/j.yexcr.2022.113418","volume":"422","author":"A Osman","year":"2023","unstructured":"Osman A, Lind\u00e9n M, \u00d6sterlund T, Vannas C, Andersson L, Escobar M et al (2023) Identification of genomic binding sites and direct target genes for the transcription factor DDIT3\/CHOP. Exp Cell Res 422(1):113418. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113418","journal-title":"Exp Cell Res"},{"issue":"2","key":"2231_CR15","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41418-024-01385-4","volume":"32","author":"R Ni","year":"2025","unstructured":"Ni R, Cao T, Ji X, Peng A, Zhang Z, Fan GC et al (2025) DNA damage-inducible transcript 3 positively regulates RIPK1-mediated necroptosis. Cell Death Differ 32(2):306\u2013319. https:\/\/doi.org\/10.1038\/s41418-024-01385-4","journal-title":"Cell Death Differ"},{"key":"2231_CR16","doi-asserted-by":"crossref","unstructured":"Yang C, Dong W, Wang Y, Dong X, Xu X, Yu X et al (2024) DDIT3 aggravates TMJOA cartilage degradation via Nrf2\/HO-1\/NLRP3-mediated autophagy. Osteoarthritis and Cartilage","DOI":"10.1016\/j.joca.2024.04.017"},{"issue":"1","key":"2231_CR17","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/21505594.2022.2044667","volume":"13","author":"S Wang","year":"2022","unstructured":"Wang S, Ma X, Guo J, Li F, Chen T, Ma W et al (2022) DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway. Virulence 13(1):514\u2013529. https:\/\/doi.org\/10.1080\/21505594.2022.2044667","journal-title":"Virulence"},{"key":"2231_CR18","doi-asserted-by":"publisher","first-page":"100834","DOI":"10.1016\/j.bbrep.2020.100834","volume":"24","author":"Y Nomura","year":"2020","unstructured":"Nomura Y, Sylvester CF, Nguyen LO, Kandeel M, Hirata Y, Mungrue IN et al (2020) Characterization of the 5\u2019-flanking region of the human and mouse CHAC1 genes. Biochem Biophys Rep 24:100834. https:\/\/doi.org\/10.1016\/j.bbrep.2020.100834","journal-title":"Biochem Biophys Rep"},{"issue":"4","key":"2231_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/ijc.20893","volume":"115","author":"M G\u00f6ransson","year":"2005","unstructured":"G\u00f6ransson M, Elias E, St\u00e5hlberg A, Olofsson A, Andersson C, Aman P (2005) Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C\/EBP beta-mediated Interleukin 6 expression. Int J Cancer 115(4):556\u2013560. https:\/\/doi.org\/10.1002\/ijc.20893","journal-title":"Int J Cancer"},{"issue":"2","key":"2231_CR20","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.jds.2023.12.011","volume":"19","author":"MY Ng","year":"2024","unstructured":"Ng MY, Lin T, Chen SH, Liao YW, Liu CM, Yu CC (2024) Er:YAG laser suppresses pro-inflammatory cytokines expression and inflammasome in human periodontal ligament fibroblasts with Porphyromonas gingivalis-lipopolysaccharide stimulation. J Dent Sci 19(2):1135\u20131142. https:\/\/doi.org\/10.1016\/j.jds.2023.12.011","journal-title":"J Dent Sci"},{"issue":"5","key":"2231_CR21","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1302\/2046-3758.95.Bjr-2019-0230.R1","volume":"9","author":"X Peng","year":"2020","unstructured":"Peng X, Zhang C, Bao JP, Zhu L, Shi R, Xie ZY et al (2020) A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. Bone Joint Res 9(5):225\u2013235. https:\/\/doi.org\/10.1302\/2046-3758.95.Bjr-2019-0230.R1","journal-title":"Bone Joint Res"},{"issue":"5","key":"2231_CR22","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s13258-022-01343-9","volume":"45","author":"X Peng","year":"2023","unstructured":"Peng X, Zhang C, Gao JW, Wang F, Bao JP, Zhou ZM et al (2023) A20 ameliorates disc degeneration by suppressing mTOR\/BNIP3 axis-mediated mitophagy. Genes Genomics 45(5):657\u2013671. https:\/\/doi.org\/10.1007\/s13258-022-01343-9","journal-title":"Genes Genomics"},{"issue":"1","key":"2231_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41413-025-00402-7","volume":"13","author":"H Xu","year":"2025","unstructured":"Xu H, Wei K, Ni J, Deng X, Wang Y, Xiang T et al (2025) Matrix stiffness regulates nucleus pulposus cell Glycolysis by MRTF-A-dependent mechanotransduction. Bone Res 13(1):23. https:\/\/doi.org\/10.1038\/s41413-025-00402-7","journal-title":"Bone Res"},{"issue":"4","key":"2231_CR24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1158\/1541-7786.Mcr-09-0454","volume":"8","author":"SY Shin","year":"2010","unstructured":"Shin SY, Kim JH, Baker A, Lim Y, Lee YH (2010) Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha. Mol Cancer Research: MCR 8(4):507\u2013519. https:\/\/doi.org\/10.1158\/1541-7786.Mcr-09-0454","journal-title":"Mol Cancer Research: MCR"},{"issue":"10","key":"2231_CR25","doi-asserted-by":"publisher","first-page":"e1422","DOI":"10.1002\/ctm2.1422","volume":"13","author":"RJ Liu","year":"2023","unstructured":"Liu RJ, Xu ZP, Huang X, Xu B, Chen M (2023) Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non-canonical WNT pathway (FYN\/STAT3). Clin Translational Med 13(10):e1422. https:\/\/doi.org\/10.1002\/ctm2.1422","journal-title":"Clin Translational Med"},{"issue":"2","key":"2231_CR26","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.18632\/oncotarget.23299","volume":"9","author":"C Zhang","year":"2018","unstructured":"Zhang C, Wang F, Xie Z, Chen L, Sinkemani A, Yu H et al (2018) Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence. Oncotarget 9(2):2175\u20132192. https:\/\/doi.org\/10.18632\/oncotarget.23299","journal-title":"Oncotarget"},{"key":"2231_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14226","author":"D Zhou","year":"2024","unstructured":"Zhou D, Mei Y, Song C, Cheng K, Cai W, Guo D et al (2024) Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells. Eur J Clin Invest e14226. https:\/\/doi.org\/10.1111\/eci.14226","journal-title":"Eur J Clin Invest e14226"},{"issue":"6","key":"2231_CR28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2011.03.001","volume":"36","author":"U Woehlbier","year":"2011","unstructured":"Woehlbier U, Hetz C (2011) Modulating stress responses by the uprosome: a matter of life and death. Trends Biochem Sci 36(6):329\u2013337. https:\/\/doi.org\/10.1016\/j.tibs.2011.03.001","journal-title":"Trends Biochem Sci"},{"key":"2231_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.034","author":"B Sundaram","year":"2024","unstructured":"Sundaram B, Pandian N, Kim HJ, Abdelaal HM, Mall R, Indari O et al (2024) NLRC5 senses NAD(+) depletion, forming a PANoptosome and driving PANoptosis and inflammation. Cell. https:\/\/doi.org\/10.1016\/j.cell.2024.05.034","journal-title":"Cell"},{"issue":"1","key":"2231_CR30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/imr.13279","volume":"321","author":"X Sun","year":"2024","unstructured":"Sun X, Yang Y, Meng X, Li J, Liu X, Liu H (2024) PANoptosis: Mechanisms, biology, and role in disease. Immunol Rev 321(1):246\u2013262. https:\/\/doi.org\/10.1111\/imr.13279","journal-title":"Immunol Rev"},{"issue":"1","key":"2231_CR31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.molcel.2023.11.040","volume":"84","author":"Y Ai","year":"2024","unstructured":"Ai Y, Meng Y, Yan B, Zhou Q, Wang X (2024) The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death. Mol Cell 84(1):170\u2013179. https:\/\/doi.org\/10.1016\/j.molcel.2023.11.040","journal-title":"Mol Cell"},{"key":"2231_CR32","doi-asserted-by":"publisher","first-page":"101832","DOI":"10.1016\/j.smim.2023.101832","volume":"70","author":"J Pang","year":"2023","unstructured":"Pang J, Vince JE (2023) The role of caspase-8 in inflammatory signalling and pyroptotic cell death. Semin Immunol 70:101832. https:\/\/doi.org\/10.1016\/j.smim.2023.101832","journal-title":"Semin Immunol"},{"issue":"6","key":"2231_CR33","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.immuni.2020.04.002","volume":"52","author":"R Schwarzer","year":"2020","unstructured":"Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M (2020) FADD and Caspase-8 regulate gut homeostasis and inflammation by controlling MLKL- and GSDMD-Mediated death of intestinal epithelial cells. Immunity 52(6):978\u201393e6. https:\/\/doi.org\/10.1016\/j.immuni.2020.04.002","journal-title":"Immunity"},{"issue":"4","key":"2231_CR34","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.cell.2009.04.052","volume":"137","author":"M B\u00e9k\u00e9s","year":"2009","unstructured":"B\u00e9k\u00e9s M, Salvesen GS (2009) The cult of caspase-8 ubiquitination. Cell 137(4):604\u2013606. https:\/\/doi.org\/10.1016\/j.cell.2009.04.052","journal-title":"Cell"},{"key":"2231_CR35","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.3389\/fimmu.2017.01612","volume":"8","author":"Y Yang","year":"2017","unstructured":"Yang Y, Liu L, Naik I, Braunstein Z, Zhong J, Ren B (2017) Transcription factor C\/EBP homologous protein in health and diseases. Front Immunol 8:1612. https:\/\/doi.org\/10.3389\/fimmu.2017.01612","journal-title":"Front Immunol"},{"key":"2231_CR36","doi-asserted-by":"publisher","unstructured":"Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F et al (2017) DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress. Sci Signal 10(468). https:\/\/doi.org\/10.1126\/scisignal.aaf5967","DOI":"10.1126\/scisignal.aaf5967"},{"issue":"6","key":"2231_CR37","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/s41419-021-03899-y","volume":"12","author":"L P\u00e9rez-Sisqu\u00e9s","year":"2021","unstructured":"P\u00e9rez-Sisqu\u00e9s L, Sancho-Balsells A, Solana-Balaguer J, Campoy-Campos G, Vives-Isern M, Soler-Palaz\u00f3n F et al (2021) RTP801\/REDD1 contributes to neuroinflammation severity and memory impairments in alzheimer\u2019s disease. Cell Death Dis 12(6):616. https:\/\/doi.org\/10.1038\/s41419-021-03899-y","journal-title":"Cell Death Dis"},{"issue":"9","key":"2231_CR38","doi-asserted-by":"publisher","first-page":"e372","DOI":"10.1038\/emm.2017.125","volume":"49","author":"J Kim","year":"2017","unstructured":"Kim J, Song H, Heo HR, Kim JW, Kim HR, Hong Y et al (2017) Cadmium-induced ER stress and inflammation are mediated through C\/EBP-DDIT3 signaling in human bronchial epithelial cells. Exp Mol Med 49(9):e372. https:\/\/doi.org\/10.1038\/emm.2017.125","journal-title":"Exp Mol Med"},{"key":"2231_CR39","doi-asserted-by":"publisher","first-page":"112950","DOI":"10.1016\/j.intimp.2024.112950","volume":"141","author":"X Zhang","year":"2024","unstructured":"Zhang X, Han Y, Fan C, Jiang Y, Jiang W, Zheng C (2024) Epigallocatechin gallate induces apoptosis in multiple myeloma cells through Endoplasmic reticulum stress induction and cytoskeletal disruption. Int Immunopharmacol 141:112950. https:\/\/doi.org\/10.1016\/j.intimp.2024.112950","journal-title":"Int Immunopharmacol"},{"key":"2231_CR40","doi-asserted-by":"publisher","first-page":"960327122115024","DOI":"10.1177\/09603271221150247","volume":"42","author":"J Yu","year":"2023","unstructured":"Yu J, Li S, Shen S, Zhou Q, Yin J, Zhao R et al (2023) The transcript NR 134251.1 of LncRNA APTR with an opposite function to all transcripts inhibits proliferation and induces apoptosis by regulating proliferation and apoptosis-related genes. Hum Exp Toxicol 42:9603271221150247. https:\/\/doi.org\/10.1177\/09603271221150247","journal-title":"Hum Exp Toxicol"},{"issue":"15","key":"2231_CR41","doi-asserted-by":"publisher","first-page":"e2415992122","DOI":"10.1073\/pnas.2415992122","volume":"122","author":"JJP Shaw","year":"2025","unstructured":"Shaw JJP, Guy C, Tummers B, Green DR (2025) FLIP(L) permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization. Proc Natl Acad Sci U S A 122(15):e2415992122. https:\/\/doi.org\/10.1073\/pnas.2415992122","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2231_CR42","doi-asserted-by":"crossref","unstructured":"Yang C, Xu X, Dong X, Yang B, Dong W, Luo Y et al (2021) DDIT3\/CHOP promotes autophagy in chondrocytes via SIRT1-AKT pathway. Biochi et biophys Acta (BBA) Mol Cell Res 1868(9):119074","DOI":"10.1016\/j.bbamcr.2021.119074"},{"issue":"9","key":"2231_CR43","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s00011-023-01790-4","volume":"72","author":"YH Han","year":"2023","unstructured":"Han YH, Liu XD, Jin MH, Sun HN, Kwon T (2023) Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases. Inflamm Res 72(9):1839\u20131859. https:\/\/doi.org\/10.1007\/s00011-023-01790-4","journal-title":"Inflamm Res"},{"issue":"12","key":"2231_CR44","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1080\/15548627.2016.1238554","volume":"12","author":"G Miao","year":"2016","unstructured":"Miao G, Zhao YG, Zhao H, Ji C, Sun H, Chen Y et al (2016) Mice deficient in the Vici syndrome gene Epg5 exhibit features of retinitis pigmentosa. Autophagy 12(12):2263\u20132270. https:\/\/doi.org\/10.1080\/15548627.2016.1238554","journal-title":"Autophagy"},{"issue":"1","key":"2231_CR45","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s13046-024-03089-6","volume":"43","author":"L Gao","year":"2024","unstructured":"Gao L, Shay C, Teng Y (2024) Cell death shapes cancer immunity: spotlighting PANoptosis. J Exp Clin Cancer Res 43(1):168. https:\/\/doi.org\/10.1186\/s13046-024-03089-6","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"2231_CR46","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s12967-024-05913-1","volume":"23","author":"W Zhao","year":"2025","unstructured":"Zhao W, Liu Y, Hu Y, Zhang G (2025) SOX4 accelerates intervertebral disc degeneration via EZH2\/NRF2 pathway in response to mitochondrial ROS-dependent NLRP3 inflammasome activation in nucleus pulposus cells. J Transl Med 23(1):395. https:\/\/doi.org\/10.1186\/s12967-024-05913-1","journal-title":"J Transl Med"},{"issue":"4","key":"2231_CR47","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.3892\/ijmm.2019.4105","volume":"43","author":"L Lu","year":"2019","unstructured":"Lu L, Hu J, Wu Q, An Y, Cui W, Wang J et al (2019) Berberine prevents human nucleus pulposus cells from IL\u20131\u03b2\u2013induced extracellular matrix degradation and apoptosis by inhibiting the NF\u2013\u03baB pathway. Int J Mol Med 43(4):1679\u20131686. https:\/\/doi.org\/10.3892\/ijmm.2019.4105","journal-title":"Int J Mol Med"},{"issue":"9","key":"2231_CR48","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/s41401-019-0349-y","volume":"41","author":"JQ Song","year":"2020","unstructured":"Song JQ, Jiang LY, Fu CP, Wu X, Liu ZL, Xie L et al (2020) Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway. Acta Pharmacol Sin 41(9):1197\u20131207. https:\/\/doi.org\/10.1038\/s41401-019-0349-y","journal-title":"Acta Pharmacol Sin"},{"key":"2231_CR49","doi-asserted-by":"publisher","first-page":"e80327","DOI":"10.7554\/eLife.80327","volume":"12","author":"K Lu","year":"2023","unstructured":"Lu K, Zhang M, Wei G, Xiao G, Tong L, Chen D (2023) Multiple cullin-associated E3 ligases regulate Cyclin D1 protein stability. Elife 12:e80327. https:\/\/doi.org\/10.7554\/eLife.80327","journal-title":"Elife"},{"issue":"17","key":"2231_CR50","doi-asserted-by":"publisher","first-page":"e2320934121","DOI":"10.1073\/pnas.2320934121","volume":"121","author":"L Gu","year":"2024","unstructured":"Gu L, Du Y, Chen J, Hasan MN, Clayton YD, Matye DJ et al (2024) Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance. Proc Natl Acad Sci U S A 121(17):e2320934121. https:\/\/doi.org\/10.1073\/pnas.2320934121","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"2231_CR51","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1111\/febs.13759","volume":"283","author":"J Wang","year":"2016","unstructured":"Wang J, Zhu ZH, Yang HB, Zhang Y, Zhao XN, Zhang M et al (2016) Cullin 3 targets methionine adenosyltransferase II\u03b1 for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation. Febs J 283(13):2390\u20132402. https:\/\/doi.org\/10.1111\/febs.13759","journal-title":"Febs J"},{"key":"2231_CR52","doi-asserted-by":"publisher","first-page":"0350","DOI":"10.34133\/research.0350","volume":"7","author":"D Zhu","year":"2024","unstructured":"Zhu D, Liang H, Du Z, Liu Q, Li G, Zhang W et al (2024) Altered metabolism and inflammation driven by post-translational modifications in intervertebral disc degeneration. Research 7:0350. https:\/\/doi.org\/10.34133\/research.0350","journal-title":"Research"},{"key":"2231_CR53","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.freeradbiomed.2023.06.010","volume":"205","author":"J Wang","year":"2023","unstructured":"Wang J, Barwick SR, Xiao H, Smith SB (2023) Evaluation of the role of Sigma 1 receptor and cullin3 in retinal photoreceptor cells. Free Radic Biol Med 205:214\u2013223. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.06.010","journal-title":"Free Radic Biol Med"},{"issue":"14","key":"2231_CR54","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.7150\/thno.33638","volume":"9","author":"Z Liao","year":"2019","unstructured":"Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K et al (2019) Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics 9(14):4084\u20134100. https:\/\/doi.org\/10.7150\/thno.33638","journal-title":"Theranostics"},{"issue":"4","key":"2231_CR55","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.cell.2009.03.015","volume":"137","author":"Z Jin","year":"2009","unstructured":"Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR et al (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137(4):721\u2013735","journal-title":"Cell"},{"issue":"2","key":"2231_CR56","doi-asserted-by":"publisher","first-page":"188357","DOI":"10.1016\/j.bbcan.2020.188357","volume":"1873","author":"R Mandal","year":"2020","unstructured":"Mandal R, Barr\u00f3n JC, Kostova I, Becker S, Strebhardt K (2020) Caspase-8: the double-edged sword. Biochim Biophys Acta Rev Cancer 1873(2):188357. https:\/\/doi.org\/10.1016\/j.bbcan.2020.188357","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"2","key":"2231_CR57","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1080\/15548627.2023.2258701","volume":"20","author":"T Hattori","year":"2024","unstructured":"Hattori T, Fundora KA, Hamamoto K, Opozda DM, Liang X, Liu X et al (2024) ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis. Autophagy 20(2):349\u2013364. https:\/\/doi.org\/10.1080\/15548627.2023.2258701","journal-title":"Autophagy"},{"issue":"Pt 1","key":"2231_CR58","doi-asserted-by":"publisher","first-page":"125137","DOI":"10.1016\/j.envpol.2024.125137","volume":"363","author":"C Luo","year":"2024","unstructured":"Luo C, Zhang Q, Wang D, Xie H, Zheng S, Huang W et al (2024) Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae. Environ Pollut 363(Pt 1):125137. https:\/\/doi.org\/10.1016\/j.envpol.2024.125137","journal-title":"Environ Pollut"},{"issue":"5","key":"2231_CR59","doi-asserted-by":"publisher","first-page":"zqad034","DOI":"10.1093\/function\/zqad034","volume":"4","author":"G Kumar","year":"2023","unstructured":"Kumar G, Fang S, Golosova D, Lu KT, Brozoski DT, Vazirabad I et al (2023) Structure and function of RhoBTB1 required for substrate specificity and Cullin-3 ubiquitination. Function (Oxf) 4(5):zqad034. https:\/\/doi.org\/10.1093\/function\/zqad034","journal-title":"Function (Oxf)"},{"issue":"10","key":"2231_CR60","doi-asserted-by":"publisher","first-page":"e005270","DOI":"10.1136\/jitc-2022-005270","volume":"10","author":"M Dong","year":"2022","unstructured":"Dong M, Qian M, Ruan Z (2022) CUL3\/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein. J Immunother Cancer 10(10):e005270 https:\/\/doi.org\/10.1136\/jitc-2022-005270","journal-title":"J Immunother Cancer"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02231-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-025-02231-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-025-02231-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:34:09Z","timestamp":1773999249000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-025-02231-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2231"],"URL":"https:\/\/doi.org\/10.1007\/s10495-025-02231-9","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"3 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All clinical investigations were conducted with approval from the Medical Ethics Committee of Henan Provincial People\u2019s Hospital (No. 2023\u2009\u2212\u2009148) in compliance with the Declaration of Helsinki. The requirement for informed consent was waived for retrospective analysis of anonymized patient data. Animal experiments were performed under protocols approved by the Animal Experimental Ethics Committee of Southeast University (No. 20210907001), following ARRIVE 2.0 guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"25"}}