{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:22Z","timestamp":1792783582116,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Guizhou Provincial Science and Technology Fund Project","award":["Qiankehe Jichu-2k [2023] General 378"],"award-info":[{"award-number":["Qiankehe Jichu-2k [2023] General 378"]}]},{"name":"Science and Technology Fund Project of Guizhou Provincial Health Commission","award":["gzwkj2023-026"],"award-info":[{"award-number":["gzwkj2023-026"]}],"id":[{"id":"https:\/\/ror.org\/027yzwq33","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260145"],"award-info":[{"award-number":["82260145"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Natural Science Foundation of China Cultivation Project at Guizhou Medical University Affiliated Hospital","award":["gyfynsfc[2024]-03"],"award-info":[{"award-number":["gyfynsfc[2024]-03"]}],"id":[{"id":"https:\/\/ror.org\/035y7a716","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10495-026-02267-5","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:48:04Z","timestamp":1775562484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease"],"prefix":"10.1007","volume":"31","author":[{"given":"Yingchun","family":"Jian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"2267_CR1","first-page":"109119","volume":"183","author":"S Hong","year":"2021","unstructured":"Hong S, Pouya S, Suvi K et al (2021) IDF Diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract 183:109119","journal-title":"Diabetes Res Clin Pract"},{"key":"2267_CR2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41419-024-06833-0","volume":"15","author":"F Xiaoting","year":"2024","unstructured":"Xiaoting F, Meilin Y, Yating L et al (2024) Mitochondrial metabolic reprogramming in diabetic kidney disease. Cell Death Dis 15:442","journal-title":"Cell Death Dis"},{"key":"2267_CR3","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"Boris Bikbov","year":"2020","unstructured":"Bikbov Boris, Purcell Caroline A, Levey Andrew S, Smith Mari, Abdoli Amir, Abebe Molla, Adebayo Oladimeji M et al (2020) Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the global Burden of Disease Study 2017. Lancet 395:709\u2013733","journal-title":"Lancet"},{"key":"2267_CR4","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","volume":"380","author":"P Vlado","year":"2019","unstructured":"Vlado P, Meg JJ, Bruce N et al (2019) Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med 380:2295\u20132306","journal-title":"N Engl J Med"},{"key":"2267_CR5","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.cmet.2020.10.019","volume":"32","author":"F Yi","year":"2020","unstructured":"Yi F, Yu S, Mei W et al (2020) Elevation of JAML promotes diabetic Kidney disease by modulating podocyte lipid metabolism. Cell Metab 32:1052\u20131062","journal-title":"Cell Metab"},{"key":"2267_CR6","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.cmet.2017.01.004","volume":"25","author":"F Annelie","year":"2017","unstructured":"Annelie F, Annika M, Isolde P et al (2017) Reducing VEGF-B signaling ameliorates renal lipotoxicity and protects against diabetic kidney disease. Cell Metab 25:713\u2013726","journal-title":"Cell Metab"},{"key":"2267_CR7","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2337\/db22-0680","volume":"72","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Liu L, Jin B et al (2023) Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy. Diabetes 72:611\u2013626","journal-title":"Diabetes"},{"key":"2267_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104778","volume":"156","author":"K Su","year":"2020","unstructured":"Su K, Yi B, Yao BQ et al (2020) Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis. Pharmacol Res 156:104778","journal-title":"Pharmacol Res"},{"key":"2267_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114465","volume":"161","author":"L Ren","year":"2023","unstructured":"Ren L, Cui H, Wang Y et al (2023) The role of lipotoxicity in kidney disease: from molecular mechanisms to therapeutic prospects. Biomed Pharmacother 161:114465","journal-title":"Biomed Pharmacother"},{"key":"2267_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41392-025-02216-9","volume":"10","author":"W Xiaohong","year":"2025","unstructured":"Xiaohong W, Tao C, Sizhe C et al (2025) STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation. Signal Transduct Target Ther 10:136","journal-title":"Signal Transduct Target Ther"},{"key":"2267_CR11","doi-asserted-by":"publisher","first-page":"103576","DOI":"10.1016\/j.autrev.2024.103576","volume":"23","author":"J Xueqian","year":"2024","unstructured":"Xueqian J, Lifu Z, Qixing Z, Jiaxiang Z (2024) The role of mitochondrial dysfunction in kidney injury and disease. Autoimmun Rev 23:103576","journal-title":"Autoimmun Rev"},{"key":"2267_CR12","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.7150\/ijbs.85674","volume":"19","author":"F Qi","year":"2023","unstructured":"Qi F, Yang Y, Kaidi R et al (2023) Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases. Int J Biol Sci 19:3726","journal-title":"Int J Biol Sci"},{"key":"2267_CR13","first-page":"807","volume":"42","author":"Z Yuexin","year":"2024","unstructured":"Yuexin Z, Changqing D, Zhiheng X et al (2024) Human umbilical cord mesenchymal stem cells alleviate diabetic nephropathy by inhibiting ferroptosis via the JNK\/KEAP1\/NRF2 signaling pathway. Antioxid Redox Signal 42:807\u2013826","journal-title":"Antioxid Redox Signal"},{"key":"2267_CR14","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu Y, Li Z, Zhang S, Zhang T, Liu Y, Zhang L (2023) Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics 13:736\u2013766","journal-title":"Theranostics"},{"key":"2267_CR15","first-page":"651","volume":"26","author":"G Petra","year":"2024","unstructured":"Petra G (2024) Mitophagy protects against ferroptosis. Nat Cell Biol 26:651\u2013661","journal-title":"Nat Cell Biol"},{"key":"2267_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102906","volume":"67","author":"C Chu","year":"2023","unstructured":"Chu C, Wang X, Yang C et al (2023) Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy. Redox Biol 67:102906","journal-title":"Redox Biol"},{"key":"2267_CR17","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.7150\/ijbs.80775","volume":"19","author":"Q Lin","year":"2023","unstructured":"Lin Q, Li S, Jin H et al (2023) Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis. Int J Biol Sci 19:1192\u20131210","journal-title":"Int J Biol Sci"},{"key":"2267_CR18","doi-asserted-by":"publisher","first-page":"7819","DOI":"10.2147\/JIR.S488655","volume":"17","author":"C Huixin","year":"2024","unstructured":"Huixin C, Xuehan W, Juyi Y, Chunbo Y, Jian L (2024) Mitophagy and ferroptosis in sepsis-induced ALI\/ARDS: molecular mechanisms, interactions and therapeutic prospects of medicinal plants. J Inflamm Res 17:7819\u20137835","journal-title":"J Inflamm Res"},{"key":"2267_CR19","first-page":"77","volume":"8","author":"LP Singh","year":"2021","unstructured":"Singh LP, Yumnamcha T, Devi TS (2021) Mitophagy, ferritinophagy and ferroptosis in retinal pigment epithelial cells under high glucose conditions: implications for diabetic retinopathy and age-related retinal diseases. JOJ Ophthalmol 8:77\u201385","journal-title":"JOJ Ophthalmol"},{"key":"2267_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jare.2023.02.012","volume":"55","author":"Y Bi","year":"2024","unstructured":"Bi Y, Liu S, Qin X et al (2024) FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner. J Adv Res 55:45\u201360","journal-title":"J Adv Res"},{"key":"2267_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831168","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang Y, Liu Y, Wang Y et al (2022) Regulation of SIRT1 and its roles in inflammation. Front Immunol 13:831168","journal-title":"Front Immunol"},{"key":"2267_CR22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11255-024-04162-x","volume":"57","author":"W Wang","year":"2025","unstructured":"Wang W, Hu Y, Ding N, Wei J, Li C (2025) The role of SIRT1 in kidney diseases. Int Urol Nephrol 57:147\u2013158","journal-title":"Int Urol Nephrol"},{"key":"2267_CR23","first-page":"1232","volume":"90","author":"Y Liu","year":"2025","unstructured":"Liu Y, Zhou F, Zhao H et al (2025) Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis. J Adv Res. 90:1232","journal-title":"J Adv Res."},{"key":"2267_CR24","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","volume":"157","author":"F Evandro Fei","year":"2014","unstructured":"Evandro Fei F, Morten S-K, Lear EB et al (2014) Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction. Cell 157:882\u2013896","journal-title":"Cell"},{"key":"2267_CR25","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.3390\/foods14122115","volume":"14","author":"L Na","year":"2025","unstructured":"Na L, Hu L, Duo F et al (2025) Anti-diabetic effect of soy-whey dual-protein on mice with type 2 diabetes mellitus through INS\/IRS1\/PI3K signaling pathway. Foods 14:2115","journal-title":"Foods"},{"key":"2267_CR26","first-page":"S1931","volume":"282","author":"W Yinghui","year":"2025","unstructured":"Yinghui W, Qingqing Z, Shasha L et al (2025) PHGDH alleviates DKD by regulating YB1\/SLC7A11-mediated ferroptosis in podocytes. Transl Res 282:S1931-5244","journal-title":"Transl Res"},{"key":"2267_CR27","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.kint.2022.02.038","volume":"102","author":"X Yifan","year":"2022","unstructured":"Yifan X, Jing E, Hong C et al (2022) Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells. Kidney Int 102:293\u2013306","journal-title":"Kidney Int"},{"key":"2267_CR28","first-page":"48","volume":"14","author":"A Kengo","year":"2017","unstructured":"Kengo A, Susan BG, Thomas MC (2017) Modelling diabetic nephropathy in mice. Nat Rev Nephrol 14:48\u201356","journal-title":"Nat Rev Nephrol"},{"key":"2267_CR29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.2147\/DMSO.S289624","volume":"14","author":"Z Langen","year":"2021","unstructured":"Langen Z, Ziwei W, Xiaolei H, Qingqing Y, Xiaoyan P, Guoxi J (2021) CircHIPK3 alleviates high glucose toxicity to human renal tubular epithelial HK-2 Cells through regulation of miR-326\/miR-487a-3p\/SIRT1. Diabetes Metab Syndr Obes 14:729\u2013740","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2267_CR30","doi-asserted-by":"publisher","first-page":"639165","DOI":"10.3389\/fendo.2021.639165","volume":"12","author":"G Jun","year":"2021","unstructured":"Jun G, Rong W, Donghai L (2021) Bone marrow-derived mesenchymal stem cells ameliorate sepsis-induced acute kidney injury by promoting mitophagy of renal tubular epithelial cells via the SIRT1\/parkin axis. Front Endocrinol (Lausanne) 12:639165","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2267_CR31","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12772","author":"J Xie","year":"2022","unstructured":"Xie J, Ye Z, Li L et al (2022) Ferrostatin\u20111 alleviates oxalate\u2011induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis. Mol Med Rep. https:\/\/doi.org\/10.3892\/mmr.2022.12772","journal-title":"Mol Med Rep"},{"key":"2267_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102260","volume":"50","author":"L Liu","year":"2022","unstructured":"Liu L, Bai F, Song H et al (2022) Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. Redox Biol 50:102260","journal-title":"Redox Biol"},{"key":"2267_CR33","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.7150\/thno.80435","volume":"13","author":"J Xinrong","year":"2023","unstructured":"Xinrong J, Xingyue L, Xuetong Q et al (2023) Integration of metabolomics and peptidomics reveals distinct molecular landscape of human diabetic kidney disease. Theranostics 13:3188","journal-title":"Theranostics"},{"key":"2267_CR34","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1186\/s12872-023-03603-2","volume":"23","author":"L Yunfei","year":"2023","unstructured":"Yunfei L, Ben K, Xiaoyan L, Jianjun X, Yongbing W (2023) Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1\/Parkin signaling pathway. BMC Cardiovasc Disord 23:582","journal-title":"BMC Cardiovasc Disord"},{"key":"2267_CR35","first-page":"118390","volume":"292","author":"Z Yi","year":"2021","unstructured":"Yi Z, Hui-Xin L, Yu L, Jia-Gen C, Milton T, Jin-Long L (2021) Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1\/PINK1\/mitophagy axis and mitochondrial unfolded protein response. Environ Pollut 292:118390","journal-title":"Environ Pollut"},{"key":"2267_CR36","first-page":"1879","volume":"18","author":"Y Jingyue","year":"2021","unstructured":"Jingyue Y, Jubo W, Ye X et al (2021) CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma. Autophagy 18:1879\u20131897","journal-title":"Autophagy"},{"key":"2267_CR37","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.cmet.2025.01.016","volume":"37","author":"J Jie","year":"2025","unstructured":"Jie J, Yuqing G, Jiang W et al (2025) Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism. Cell Metab 37:1119\u20131136","journal-title":"Cell Metab"},{"key":"2267_CR38","doi-asserted-by":"publisher","first-page":"2413255","DOI":"10.1002\/advs.202413255","volume":"12","author":"Z Yangfei","year":"2025","unstructured":"Yangfei Z, Mingyue G, Ting P et al (2025) \u03b1-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal \u03b2-Oxidation and Reducing Lipophagy in Chicken Hepatocyte. Adv Sci (Weinh) 12:2413255","journal-title":"Adv Sci (Weinh)"},{"key":"2267_CR39","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/cells14110794","volume":"14","author":"P Nikola","year":"2025","unstructured":"Nikola P, Marinela K, Marko K, Katarina V, Jo\u0161ko B (2025) Mitochondrial dysfunction: the silent catalyst of kidney disease progression. Cells 14:794","journal-title":"Cells"},{"key":"2267_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s10020-024-00783-1","volume":"30","author":"Y Hao","year":"2024","unstructured":"Hao Y, Daojing G, Zhen L et al (2024) \u03b1-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice. Mol Med 30:15","journal-title":"Mol Med"},{"key":"2267_CR41","first-page":"718","volume":"47","author":"J Hongfei","year":"2023","unstructured":"Hongfei J, Yanyan Z, Xiaojun M et al (2023) Upregulation of UHRF1 promotes PINK1-mediated mitophagy to alleviates ferroptosis in diabetic nephropathy. Inflammation 47:718\u2013732","journal-title":"Inflammation"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02267-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02267-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02267-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:47:49Z","timestamp":1777592869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02267-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2267"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02267-5","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Allexperiments involving human renal biopsy samples were approved by the EthicsCommittee of the Affiliated Hospital of GuizhouMedical University (ApprovalNo: 2025 Lun Shen 286). All animal experiments were approved by theInstitutional Animal EthicsCommittee of Guizhou Medical University (ApprovalNo: 2403717).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval andconsent to participate"}},{"value":"Informed consent was obtained from all patients prior to the collection of renal biopsy samples.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"121"}}