{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:05:08Z","timestamp":1774987508836,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s10495-026-02304-3","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T09:33:39Z","timestamp":1772876019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Superenhancer-driven SMC4 promotes myeloma growth by epigenetically enhancing IFI16-dependent STING signaling"],"prefix":"10.1007","volume":"31","author":[{"given":"Jiayun","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenfeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze King","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee-Joo","family":"Chng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiang","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"issue":"8","key":"2304_CR1","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/ajh.26590","volume":"97","author":"VS Rajkumar","year":"2022","unstructured":"Rajkumar VS (2022) Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol 97(8):1086\u20131107","journal-title":"Am J Hematol"},{"issue":"5","key":"2304_CR2","doi-asserted-by":"publisher","first-page":"e207","DOI":"10.1038\/bcj.2014.29","volume":"4","author":"K Dimopoulos","year":"2014","unstructured":"Dimopoulos K, Gimsing P, Gr\u00f8nb\u00e6k K (2014) The role of epigenetics in the biology of multiple myeloma. Blood Cancer J 4(5):e207\u2013e207","journal-title":"Blood Cancer J"},{"issue":"9","key":"2304_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0119-y","volume":"8","author":"H Ohguchi","year":"2018","unstructured":"Ohguchi H, Hideshima T, Anderson CK (2018) The biological significance of histone modifiers in multiple myeloma: clinical applications. Blood Cancer J 8(9):83","journal-title":"Blood Cancer J"},{"issue":"1","key":"2304_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02033-8","volume":"23","author":"S Liu","year":"2024","unstructured":"Liu S, Dai W, Jin B et al (2024) Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets. Mol Cancer 23(1):122","journal-title":"Mol Cancer"},{"issue":"1","key":"2304_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/ng.3167","volume":"47","author":"S Pott","year":"2015","unstructured":"Pott S, Lieb DJ (2015) What are super-enhancers? Nat Genet 47(1):8\u201312","journal-title":"Nat Genet"},{"issue":"4","key":"2304_CR6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.trecan.2017.03.006","volume":"3","author":"S Sengupta","year":"2017","unstructured":"Sengupta S, George ER (2017) Super-enhancer-driven transcriptional dependencies in cancer. Trends Cancer 3(4):269\u2013281","journal-title":"Trends Cancer"},{"issue":"1","key":"2304_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0757-y","volume":"12","author":"Y Jia","year":"2019","unstructured":"Jia Y, Chng JW, Zhou J (2019) Super-enhancers: critical roles and therapeutic targets in hematologic malignancies. J Hematol Oncol 12(1):77","journal-title":"J Hematol Oncol"},{"issue":"3","key":"2304_CR8","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1158\/0008-5472.CAN-21-0921","volume":"82","author":"Y Jia","year":"2022","unstructured":"Jia Y, Zhou J, Tan KT et al (2022) Super enhancer-mediated upregulation of HJURP promotes growth and survival of t (4; 14)-positive multiple myeloma. Cancer Res 82(3):406\u2013418","journal-title":"Cancer Res"},{"issue":"2","key":"2304_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00421-7","volume":"11","author":"Y Jia","year":"2021","unstructured":"Jia Y, Zhou J, Tan KT et al (2021) Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma. Blood Cancer J 11(2):32","journal-title":"Blood Cancer J"},{"issue":"8","key":"2304_CR10","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/j.celrep.2016.01.063","volume":"14","author":"MJ Eeftens","year":"2016","unstructured":"Eeftens MJ, Katan JA, Kschonsak M et al (2016) Condensin Smc2-Smc4 dimers are flexible and dynamic. Cell Rep 14(8):1813\u20131818","journal-title":"Cell Rep"},{"issue":"9","key":"2304_CR11","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.cmet.2023.07.005","volume":"35","author":"X Sun","year":"2023","unstructured":"Sun X, He L, Liu H et al (2023) The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity. Cell Metab 35(9):1563-1579. e8","journal-title":"Cell Metab"},{"key":"2304_CR12","doi-asserted-by":"publisher","first-page":"1117642","DOI":"10.3389\/fonc.2023.1117642","volume":"13","author":"Z Zhao","year":"2023","unstructured":"Zhao Z, Wang X, Ding Y et al (2023) SMC4, a novel tumor prognostic marker and potential tumor therapeutic target. Front Oncol 13:1117642","journal-title":"Front Oncol"},{"issue":"1","key":"2304_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1756-9966-33-55","volume":"33","author":"B Zhou","year":"2014","unstructured":"Zhou B, Chen H, Wei D et al (2014) A novel miR-219-SMC4-JAK2\/Stat3 regulatory pathway in human hepatocellular carcinoma. J Exp Clin Cancer Res 33(1):55","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"2304_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","volume":"19","author":"FA Wolf","year":"2018","unstructured":"Wolf FA, Angerer P, Theis FJ (2018) SCANPY: large-scale single-cell gene expression data analysis. Genome Biol 19(1):15","journal-title":"Genome Biol"},{"issue":"5","key":"2304_CR15","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ccell.2021.02.015","volume":"39","author":"K Bi","year":"2021","unstructured":"Bi K, He MX, Bakouny Z, Kanodia A, Napolitano S, Wu J et al (2021) Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma. Cancer Cell 39(5):649-661.e5","journal-title":"Cancer Cell"},{"issue":"5","key":"2304_CR16","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R (2018) Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol 36(5):411\u2013420","journal-title":"Nat Biotechnol"},{"issue":"1","key":"2304_CR17","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH et al (2021) Inference and analysis of cell-cell communication using Cell Chat. Nat Commun 12(1):1088","journal-title":"Nat Commun"},{"issue":"7","key":"2304_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","volume":"37","author":"AM Newman","year":"2019","unstructured":"Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F et al (2019) Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol 37(7):773\u2013782","journal-title":"Nat Biotechnol"},{"issue":"4","key":"2304_CR19","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s12276-024-01246-7","volume":"56","author":"MH Han","year":"2024","unstructured":"Han MH, Park J, Park M (2024) Advances in the multimodal analysis of the 3D chromatin structure and gene regulation. Exp Mol Med 56(4):763\u2013771","journal-title":"Exp Mol Med"},{"issue":"6400","key":"2304_CR20","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3958","volume":"361","author":"BR Sabari","year":"2018","unstructured":"Sabari BR, Dall\u2019Agnese A, Boija A et al (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science 361(6400):eaar3958","journal-title":"Science"},{"issue":"6","key":"2304_CR21","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","volume":"146","author":"JE Delmore","year":"2011","unstructured":"Delmore JE, Issa GC, Lemieux ME et al (2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146(6):904\u2013917","journal-title":"Cell"},{"issue":"3","key":"2304_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.molcel.2019.07.009","volume":"75","author":"K Shrinivas","year":"2019","unstructured":"Shrinivas K, Sabari BR, Coffey EL et al (2019) Enhancer features that drive formation of transcriptional condensates. Mol Cell 75(3):549-561. e7","journal-title":"Mol Cell"},{"issue":"11","key":"2304_CR23","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni.1932","volume":"11","author":"L Unterholzner","year":"2010","unstructured":"Unterholzner L, Keating SE, Baran M et al (2010) IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11(11):997\u20131004","journal-title":"Nat Immunol"},{"issue":"1","key":"2304_CR24","doi-asserted-by":"publisher","first-page":"14391","DOI":"10.1038\/ncomms14391","volume":"8","author":"KL J\u00f8nsson","year":"2017","unstructured":"J\u00f8nsson KL, Laustsen A, Krapp C et al (2017) IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun 8(1):14391","journal-title":"Nat Commun"},{"issue":"3","key":"2304_CR25","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1038\/oncsis.2017.8","volume":"6","author":"L Jiang","year":"2017","unstructured":"Jiang L, Zhou J, Zhong D et al (2017) Overexpression of SMC4 activates TGF\u03b2\/Smad signaling and promotes aggressive phenotype in glioma cells. Oncogenesis 6(3):e301\u2013e301","journal-title":"Oncogenesis"},{"key":"2304_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.761693","volume":"11","author":"Y Wang","year":"2021","unstructured":"Wang Y, Wu Z (2021) The clinical significance and transcription regulation of a DNA damage repair gene, SMC4, in low-grade glioma via integrated bioinformatic analysis. Front Oncol 11:761693","journal-title":"Front Oncol"},{"issue":"6","key":"2304_CR27","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1007\/s13577-021-00603-2","volume":"34","author":"H He","year":"2021","unstructured":"He H, Zheng C, Tang Y (2021) Overexpression of SMC4 predicts a poor prognosis in cervical cancer and facilitates cancer cell malignancy phenotype by activating NF-\u03baB pathway. Hum Cell 34(6):1888\u20131898","journal-title":"Hum Cell"},{"issue":"5","key":"2304_CR28","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.molcel.2018.07.034","volume":"71","author":"G Dunphy","year":"2018","unstructured":"Dunphy G, Flannery SM, Almine JF et al (2018) Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-\u03baB signaling after nuclear DNA damage. Mol Cell 71(5):745-760. e5","journal-title":"Mol Cell"},{"issue":"1","key":"2304_CR29","doi-asserted-by":"publisher","first-page":"14392","DOI":"10.1038\/ncomms14392","volume":"8","author":"JF Almine","year":"2017","unstructured":"Almine JF, O\u2019Hare CAJ, Dunphy G et al (2017) IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun 8(1):14392","journal-title":"Nat Commun"},{"issue":"1","key":"2304_CR30","doi-asserted-by":"publisher","first-page":"14391","DOI":"10.1038\/ncomms14391","volume":"8","author":"KL J\u00f8nsson","year":"2017","unstructured":"J\u00f8nsson KL, Laustsen A, Krapp C et al (2017) IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun 8(1):14391","journal-title":"Nat Commun"},{"issue":"5","key":"2304_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1158\/2643-3230.BCD-23-0211","volume":"5","author":"R Mulet-Lazaro","year":"2024","unstructured":"Mulet-Lazaro R, Delwel R (2024) Oncogenic enhancers in leukemia. Blood Cancer Discov 5(5):303\u2013317","journal-title":"Blood Cancer Discov"},{"issue":"7572","key":"2304_CR32","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nature14904","volume":"526","author":"HE Pelish","year":"2015","unstructured":"Pelish HE, Liau BB, Nitulescu II et al (2015) Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature 526(7572):273\u2013276","journal-title":"Nature"},{"issue":"1","key":"2304_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02428-9","volume":"41","author":"F Fang","year":"2022","unstructured":"Fang F, Lu J, Sang X et al (2022) Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia[J]. J Exp Clin Cancer Res 41(1):225","journal-title":"J Exp Clin Cancer Res"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02304-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02304-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02304-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:26:21Z","timestamp":1774985181000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02304-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2304"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02304-3","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"6 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The collection of primary multiple myeloma plasma cells and age-matched normal plasma cells was approved by the Institutional Review Board (IRB), and written informed consent was obtained from all participants in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"92"}}