{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:04:19Z","timestamp":1787763859533,"version":"build-2784847793"},"reference-count":194,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32570850"],"award-info":[{"award-number":["32570850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10495-026-02309-y","type":"journal-article","created":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:14:42Z","timestamp":1775981682000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pyroptosis as a double-edged sword in colorectal cancer: Molecular mechanisms and therapeutic opportunities"],"prefix":"10.1007","volume":"31","author":[{"given":"Han-Xi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yuan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Shen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ge","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"issue":"9","key":"2309_CR1","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3390\/cancers13092025","volume":"13","author":"T Sawicki","year":"2021","unstructured":"Sawicki T, Ruszkowska M, Danielewicz A, Nied\u017awiedzka E, Ar\u0142ukowicz T, Przyby\u0142owicz KE (2021) A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers 13(9):2025","journal-title":"Cancers"},{"issue":"1","key":"2309_CR2","first-page":"12","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. CA Cancer J Clin 74(1):12\u201349","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"2309_CR3","first-page":"308","volume":"75","author":"NS Wagle","year":"2025","unstructured":"Wagle NS, Nogueira L, Devasia TP, Mariotto AB, Yabroff KR, Islami F et al (2025) Cancer treatment and survivorship statistics, 2025. CA Cancer J Clin 75(4):308\u2013340","journal-title":"CA Cancer J Clin"},{"issue":"10","key":"2309_CR4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s11912-025-01707-w","volume":"27","author":"KAM Al Kamzari","year":"2025","unstructured":"Al Kamzari KAM, Constantinou C (2025) Navigating the colorectal cancer maze: unveiling pathways to diagnosis, management, pathophysiology and prevention. Curr Oncol Rep 27(10):1115\u20131130","journal-title":"Curr Oncol Rep"},{"issue":"1","key":"2309_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12943-025-02327-5","volume":"24","author":"HJ Boka","year":"2025","unstructured":"Boka HJ, Engel RM, Georges C, McMurrick PJ, Abud HE (2025) Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer. Mol Cancer 24(1):130","journal-title":"Mol Cancer"},{"issue":"21","key":"2309_CR6","doi-asserted-by":"publisher","first-page":"10248","DOI":"10.1021\/acs.chemrev.5c00041","volume":"125","author":"JX Kee","year":"2025","unstructured":"Kee JX, Yau JNN, Kumar Muthuramalingam RP, Wang X, Chng WH, Lopez-Sanchez A et al (2025) Colorectal cancer at the crossroads: the good, the bad, and the future of platinum-based drugs. Chem Rev 125(21):10248\u201310341","journal-title":"Chem Rev"},{"key":"2309_CR7","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1007\/s10495-025-02186-x","volume":"30","author":"M Zhang","year":"2025","unstructured":"Zhang M, Zhao X, Cai T, Wang F (2025) PANoptosis: potential new targets and therapeutic prospects in digestive diseases. Apoptosis 30:2745\u20132760","journal-title":"Apoptosis"},{"key":"2309_CR8","doi-asserted-by":"publisher","first-page":"114931","DOI":"10.1016\/j.intimp.2025.114931","volume":"159","author":"L Qi","year":"2025","unstructured":"Qi L, Lan B, Zhao Z, Ma Y, Song J, Jia Q et al (2025) Research advances of PANoptosis in gastrointestinal tumors. Int Immunopharmacol 159:114931","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"2309_CR9","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","volume":"35","author":"P Broz","year":"2025","unstructured":"Broz P (2025) Pyroptosis: molecular mechanisms and roles in disease. Cell Res 35(5):334\u2013344","journal-title":"Cell Res"},{"issue":"4","key":"2309_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F (2017) Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci 42(4):245\u2013254","journal-title":"Trends Biochem Sci"},{"issue":"9","key":"2309_CR11","doi-asserted-by":"publisher","first-page":"4310","DOI":"10.7150\/thno.71086","volume":"12","author":"Z Rao","year":"2022","unstructured":"Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C et al (2022) Pyroptosis in inflammatory diseases and cancer. Theranostics 12(9):4310\u20134329","journal-title":"Theranostics"},{"issue":"1","key":"2309_CR12","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","volume":"6","author":"P Yu","year":"2021","unstructured":"Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X (2021) Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther 6(1):128","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"2309_CR13","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.biotechadv.2014.03.006","volume":"32","author":"C Cerella","year":"2014","unstructured":"Cerella C, Teiten MH, Radogna F, Dicato M, Diederich M (2014) From nature to bedside: pro-survival and cell death mechanisms as therapeutic targets in cancer treatment. Biotechnol Adv 32(6):1111\u20131122","journal-title":"Biotechnol Adv"},{"issue":"6494","key":"2309_CR14","doi-asserted-by":"publisher","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","volume":"368","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y et al (2020) Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science 368(6494):eaaz7548","journal-title":"Science"},{"key":"2309_CR15","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.critrevonc.2016.11.003","volume":"108","author":"SC Chang","year":"2016","unstructured":"Chang SC, Yang WV (2016) Hyperglycemia, tumorigenesis, and chronic inflammation. Crit Rev Oncol Hematol 108:146\u2013153","journal-title":"Crit Rev Oncol Hematol"},{"issue":"9255","key":"2309_CR16","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","volume":"357","author":"F Balkwill","year":"2001","unstructured":"Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539\u2013545","journal-title":"Lancet"},{"issue":"10","key":"2309_CR17","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1038\/s41401-022-00887-6","volume":"43","author":"F Yang","year":"2022","unstructured":"Yang F, Bettadapura SN, Smeltzer MS, Zhu H, Wang S (2022) Pyroptosis and pyroptosis-inducing cancer drugs. Acta Pharmacol Sin 43(10):2462\u20132473","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"2309_CR18","doi-asserted-by":"publisher","first-page":"151884","DOI":"10.1016\/j.imbio.2019.11.019","volume":"225","author":"W Gong","year":"2020","unstructured":"Gong W, Shi Y, Ren J (2020) Research progresses of molecular mechanism of pyroptosis and its related diseases. Immunobiology 225(2):151884","journal-title":"Immunobiology"},{"issue":"1","key":"2309_CR19","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1186\/s12964-024-01932-z","volume":"22","author":"Z Liu","year":"2024","unstructured":"Liu Z, Xu S, Chen L, Gong J, Wang M (2024) The role of pyroptosis in cancer: key components and therapeutic potential. Cell Commun Signal 22(1):548","journal-title":"Cell Commun Signal"},{"issue":"9","key":"2309_CR20","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","volume":"19","author":"X Wei","year":"2022","unstructured":"Wei X, Xie F, Zhou XX, Wu YC, Yan HY, Liu T et al (2022) Role of pyroptosis in inflammation and cancer. Cell Mol Immunol 19(9):971\u2013992","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"2309_CR21","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","volume":"27","author":"SB Kovacs","year":"2017","unstructured":"Kovacs SB, Miao EA (2017) Gasdermins: effectors of pyroptosis. Trends Cell Biol 27(9):673\u2013684","journal-title":"Trends Cell Biol"},{"issue":"7","key":"2309_CR22","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41417-024-00796-2","volume":"31","author":"J Chen","year":"2024","unstructured":"Chen J, Singh N, Ye X, Theune EV, Wang K (2024) Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis. Cancer Gene Ther 31(7):1007\u20131017","journal-title":"Cancer Gene Ther"},{"key":"2309_CR23","doi-asserted-by":"publisher","first-page":"2515525","DOI":"10.1155\/2022\/2515525","volume":"2022","author":"H Wu","year":"2022","unstructured":"Wu H, Qian D, Bai X, Sun S (2022) Targeted pyroptosis is a potential therapeutic strategy for cancer. J Oncol 2022:2515525","journal-title":"J Oncol"},{"issue":"1","key":"2309_CR24","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s10103-025-04595-5","volume":"40","author":"DY Zhang","year":"2025","unstructured":"Zhang DY, Gu Z, Shi L, Li Z, Du X, Li Y (2025) 5-ALA mediated PDT induces pyroptosis in colorectal cancer cells by targeting the caspase-1\/GSDMD pathway. Lasers Med Sci 40(1):344","journal-title":"Lasers Med Sci"},{"issue":"21-22","key":"2309_CR25","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1080\/17520363.2024.2416886","volume":"18","author":"A Mo","year":"2024","unstructured":"Mo A, Wang H (2024) WTAP-mediated m6A modification regulates NLRP3\/Caspase-1\/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer. Biomark Med 18(21\u201322):945\u2013955","journal-title":"Biomark Med"},{"issue":"5","key":"2309_CR26","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1002\/ddr.21939","volume":"83","author":"T Chen","year":"2022","unstructured":"Chen T, Wang Z, Zhong J, Zhang L, Zhang H, Zhang D et al (2022) Secoisolariciresinol diglucoside induces pyroptosis by activating caspase-1 to cleave GSDMD in colorectal cancer cells. Drug Dev Res 83(5):1152\u20131166","journal-title":"Drug Dev Res"},{"issue":"1","key":"2309_CR27","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s12967-023-04187-3","volume":"21","author":"WQ Feng","year":"2023","unstructured":"Feng WQ, Zhang YC, Xu ZQ, Yu SY, Huo JT, Tuersun A et al (2023) IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8\u2009+\u2009T-cell tumour infiltration. J Transl Med 21(1):335","journal-title":"J Transl Med"},{"issue":"47","key":"2309_CR28","doi-asserted-by":"publisher","first-page":"5092","DOI":"10.1038\/s41388-022-02503-7","volume":"41","author":"X Peng","year":"2022","unstructured":"Peng X, Na R, Zhou W, Meng X, Yang Y, Amini S et al (2022) Nuclear translocation of gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner. Oncogene 41(47):5092\u20135106","journal-title":"Oncogene"},{"issue":"9","key":"2309_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00262-025-04104-1","volume":"74","author":"M Gu","year":"2025","unstructured":"Gu M, Chen W, Ding S, Lin Z, Qian L, Xiao W et al (2025) Deletion of gasdermin D promotes granulocytic myeloid-derived suppressor cell differentiation by decreased release of mitochondrial DNA to promote tumor escape. Cancer Immunol Immunother 74(9):277","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"2309_CR30","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1186\/s12967-024-05984-0","volume":"22","author":"Y Li","year":"2024","unstructured":"Li Y, Chen J, Liang H, Du Q, Shen J, Wang X (2024) Gasdermin D regulates the activation of EGFR in colorectal cancer. J Transl Med 22(1):1170","journal-title":"J Transl Med"},{"issue":"1","key":"2309_CR31","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41420-025-02516-7","volume":"11","author":"N Miao","year":"2025","unstructured":"Miao N, Kang Z, Wang Z, Yu W, Liu T, Kong LZ et al (2025) Mitochondrial reactive oxygen species promote cancer metastasis and tumor microenvironment immunosuppression through gasdermin D. Cell Death Discov 11(1):219","journal-title":"Cell Death Discov"},{"key":"2309_CR32","doi-asserted-by":"publisher","first-page":"6223","DOI":"10.2147\/JIR.S338584","volume":"14","author":"J Wang","year":"2021","unstructured":"Wang J, Kang Y, Li Y, Sun L, Zhang J, Qian S et al (2021) Gasdermin D in different subcellular locations predicts diverse progression, immune microenvironment and prognosis in colorectal cancer. J Inflamm Res 14:6223\u20136235","journal-title":"J Inflamm Res"},{"issue":"1","key":"2309_CR33","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12957-022-02697-w","volume":"20","author":"J Hu","year":"2022","unstructured":"Hu J, Tian C, Zhao Y, Guo Y, Chen S (2022) Prognostic prediction of systemic immune-inflammation status for patients with colorectal cancer: a novel pyroptosis-related model. World J Surg Oncol 20(1):234","journal-title":"World J Surg Oncol"},{"issue":"20","key":"2309_CR34","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1080\/15384101.2022.2088570","volume":"21","author":"J Guo","year":"2022","unstructured":"Guo J, Yu J, Mu M, Chen Z, Xu Z, Zhao C et al (2022) DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1\/2 signaling pathways via upregulation of DEPTOR. Cell Cycle 21(20):2165\u20132178","journal-title":"Cell Cycle"},{"issue":"1","key":"2309_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12935-022-02483-4","volume":"22","author":"M Mu","year":"2022","unstructured":"Mu M, Yu Q, Zhang Q, Guo J, Wang X, Sun X et al (2022) A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins. Cancer Cell Int 22(1):80","journal-title":"Cancer Cell Int"},{"issue":"13","key":"2309_CR36","doi-asserted-by":"publisher","first-page":"14008","DOI":"10.1021\/acs.jmedchem.5c01106","volume":"68","author":"L Guan","year":"2025","unstructured":"Guan L, Tao S, Lu X, Jiang Y, Xu K, Peng J et al (2025) A lysosome-targeted iridium(III) complex inducing pyroptosis for enhanced sonodynamic therapy of colorectal cancer. J Med Chem 68(13):14008\u201314018","journal-title":"J Med Chem"},{"key":"2309_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bbrc.2021.02.043","volume":"548","author":"J Guo","year":"2021","unstructured":"Guo J, Zheng J, Mu M, Chen Z, Xu Z, Zhao C et al (2021) GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis. Biochem Biophys Res Commun 548:60\u201366","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"2309_CR38","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.3390\/cancers14225505","volume":"14","author":"H Xu","year":"2022","unstructured":"Xu H, Zhang D, Wei R, Zhou Y, Dai G, Li J et al (2022) Gambogic acid induces pyroptosis of colorectal cancer cells through the GSDME-dependent pathway and elicits an antitumor immune response. Cancers 14(22):5505","journal-title":"Cancers"},{"issue":"1","key":"2309_CR39","doi-asserted-by":"publisher","first-page":"18049","DOI":"10.1038\/s41598-025-02901-3","volume":"15","author":"T Zhang","year":"2025","unstructured":"Zhang T, Zou Y, Zhang SH, Wang YY, He S, Yuan W et al (2025) Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC\/AKT\/mTOR axis inhibition. Sci Rep 15(1):18049","journal-title":"Sci Rep"},{"key":"2309_CR40","doi-asserted-by":"publisher","first-page":"101097","DOI":"10.1016\/j.drup.2024.101097","volume":"76","author":"J Lin","year":"2024","unstructured":"Lin J, Lyu Z, Feng H, Xie H, Peng J, Zhang W et al (2024) CircPDIA3\/miR-449a\/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer. Drug Resist Updat 76:101097","journal-title":"Drug Resist Updat"},{"issue":"1","key":"2309_CR41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40364-024-00606-9","volume":"12","author":"B Luo","year":"2024","unstructured":"Luo B, Zhang S, Yu X, Tan D, Wang Y, Wang M (2024) Gasdermin E benefits CD8(+)T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferon\u03b2 axis in colorectal cancer. Biomark Res 12(1):59","journal-title":"Biomark Res"},{"issue":"26","key":"2309_CR42","doi-asserted-by":"publisher","first-page":"e2503138","DOI":"10.1002\/adma.202503138","volume":"37","author":"T Li","year":"2025","unstructured":"Li T, Zhang Y, Li C, Song Y, Jiang T, Yin Y et al (2025) Microbial photosynthetic oxygenation and radiotherapeutic sensitization enables pyroptosis induction for combinatorial cancer therapy. Adv Mater 37(26):e2503138","journal-title":"Adv Mater"},{"issue":"1","key":"2309_CR43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13045-020-00985-0","volume":"13","author":"G Tan","year":"2020","unstructured":"Tan G, Huang C, Chen J, Zhi F (2020) HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1\/2 pathway. J Hematol Oncol 13(1):149","journal-title":"J Hematol Oncol"},{"issue":"2","key":"2309_CR44","doi-asserted-by":"publisher","first-page":"e010000","DOI":"10.1136\/jitc-2024-010000","volume":"13","author":"L Li","year":"2025","unstructured":"Li L, Zhao L, Zhou D, Yu Y, Zhang P, Zheng J et al (2025) Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer. J Immunother Cancer 13(2):e010000","journal-title":"J Immunother Cancer"},{"issue":"3","key":"2309_CR45","doi-asserted-by":"publisher","first-page":"e008054","DOI":"10.1136\/jitc-2023-008054","volume":"12","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Zhang W, Wang B, Wang P, Li D, Cao T et al (2024) Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer. J Immunother Cancer 12(3):e008054","journal-title":"J Immunother Cancer"},{"issue":"16","key":"2309_CR46","doi-asserted-by":"publisher","first-page":"8320","DOI":"10.7150\/thno.112209","volume":"15","author":"Z Chen","year":"2025","unstructured":"Chen Z, Yang Z, Rao Z, Luo Y, Liu W, Qiao C et al (2025) A pyroptosis proportion tunable nano-modulator for cancer immunotherapy. Theranostics 15(16):8320\u20138336","journal-title":"Theranostics"},{"issue":"1","key":"2309_CR47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tcb.2022.06.006","volume":"33","author":"AI Ivanov","year":"2023","unstructured":"Ivanov AI, Rana N, Privitera G, Pizarro TT (2023) The enigmatic roles of epithelial gasdermin B: recent discoveries and controversies. Trends Cell Biol 33(1):48\u201359","journal-title":"Trends Cell Biol"},{"issue":"1","key":"2309_CR48","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1186\/s12885-024-12605-y","volume":"24","author":"J Yang","year":"2024","unstructured":"Yang J, Ding X, Fang Z, Wu S, Yuan M, Chen R et al (2024) Association of CD8(+)TILs co-expressing granzyme A and interferon-\u03b3 with colon cancer cells in the tumor microenvironment. BMC Cancer 24(1):869","journal-title":"BMC Cancer"},{"issue":"30","key":"2309_CR49","doi-asserted-by":"publisher","first-page":"e2303908","DOI":"10.1002\/advs.202303908","volume":"10","author":"W Lin","year":"2023","unstructured":"Lin W, Zhang Y, Yang Y, Lin B, Zhu M, Xu J et al (2023) Anti-PD-1\/Her2 bispecific antibody IBI315 enhances the treatment effect of Her2-positive gastric cancer through gasdermin B-cleavage induced pyroptosis. Adv Sci 10(30):e2303908","journal-title":"Adv Sci"},{"issue":"1","key":"2309_CR50","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1186\/s12885-024-12326-2","volume":"24","author":"L Sun","year":"2024","unstructured":"Sun L, Wang J, Li Y, Kang Y, Jiang Y, Zhang J et al (2024) Correlation of gasdermin B staining patterns with prognosis, progression, and immune response in colorectal cancer. BMC Cancer 24(1):567","journal-title":"BMC Cancer"},{"issue":"20","key":"2309_CR51","doi-asserted-by":"publisher","first-page":"e2411375","DOI":"10.1002\/advs.202411375","volume":"12","author":"H Gao","year":"2025","unstructured":"Gao H, Yao Y, Li W, Xu Z, Hu W, Luo K et al (2025) Caspase-6\/Gasdermin C-mediated tumor cell pyroptosis promotes colorectal cancer progression through CXCL2-dependent recruitment of myeloid-derived suppressor cells. Adv Sci 12(20):e2411375","journal-title":"Adv Sci"},{"issue":"1","key":"2309_CR52","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12929-023-00983-7","volume":"30","author":"V Arr\u00e8","year":"2023","unstructured":"Arr\u00e8 V, Scialpi R, Centonze M, Giannelli G, Scavo MP, Negro R (2023) The \u2018speck\u2019-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis. J Biomed Sci 30(1):90","journal-title":"J Biomed Sci"},{"issue":"11","key":"2309_CR53","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1002\/eji.201848070","volume":"49","author":"BR Sharma","year":"2019","unstructured":"Sharma BR, Karki R, Kanneganti TD (2019) Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol 49(11):1998\u20132011","journal-title":"Eur J Immunol"},{"key":"2309_CR54","doi-asserted-by":"publisher","first-page":"100858","DOI":"10.1016\/j.mam.2020.100858","volume":"76","author":"JD Tupik","year":"2020","unstructured":"Tupik JD, Nagai-Singer MA, Allen IC (2020) To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease. Mol Aspects Med 76:100858","journal-title":"Mol Aspects Med"},{"issue":"1","key":"2309_CR55","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/imr.12906","volume":"297","author":"C Kay","year":"2020","unstructured":"Kay C, Wang RL, Kirkby M, Man SM (2020) Molecular mechanisms activating the NAIP-NLRC4 inflammasome: implications in infectious disease, autoinflammation, and cancer. Immunol Rev 297(1):67\u201382","journal-title":"Immunol Rev"},{"issue":"1","key":"2309_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbcan.2019.05.001","volume":"1872","author":"CB Zhou","year":"2019","unstructured":"Zhou CB, Fang JY (2019) The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection. Biochim Biophys Acta Rev Cancer 1872(1):1\u201310","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"4","key":"2309_CR57","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41568-019-0123-y","volume":"19","author":"R Karki","year":"2019","unstructured":"Karki R, Kanneganti TD (2019) Diverging inflammasome signals in tumorigenesis and potential targeting. Nat Rev Cancer 19(4):197\u2013214","journal-title":"Nat Rev Cancer"},{"key":"2309_CR58","doi-asserted-by":"publisher","first-page":"114054","DOI":"10.1016\/j.intimp.2025.114054","volume":"148","author":"Y Yao","year":"2025","unstructured":"Yao Y, Chen Y, Yao T, Li C, Li S, Wang N (2025) Anticancer effects of OSW-1 on colorectal cancer cells via the ROS\/NLRP3\/Caspase-1 pyroptosis signaling pathway. Int Immunopharmacol 148:114054","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2309_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/bph.17352","volume":"182","author":"N Pazhouhesh Far","year":"2025","unstructured":"Pazhouhesh Far N, Hajiheidari Varnousafaderani M, Faghihkhorasani F, Etemad S, Abdulwahid ARR, Bakhtiarinia N et al (2025) Breaking the barriers: overcoming cancer resistance by targeting the NLRP3 inflammasome. Br J Pharmacol 182(1):3\u201325","journal-title":"Br J Pharmacol"},{"key":"2309_CR60","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3389\/fimmu.2020.01444","volume":"11","author":"S Hamarsheh","year":"2020","unstructured":"Hamarsheh S, Zeiser R (2020) NLRP3 inflammasome activation in cancer: a double-edged sword. Front Immunol 11:1444","journal-title":"Front Immunol"},{"issue":"1","key":"2309_CR61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13046-025-03358-y","volume":"44","author":"S Wang","year":"2025","unstructured":"Wang S, Kong L, Wang L, Zhuang Y, Guo C, Zhang Y et al (2025) Viral expression of NE\/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory\/effector CD8(+) T cell infiltration. J Exp Clin Cancer Res 44(1):97","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"2309_CR62","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/eji.201545839","volume":"46","author":"SM Man","year":"2016","unstructured":"Man SM, Karki R, Kanneganti TD (2016) AIM2 inflammasome in infection, cancer, and autoimmunity: role in DNA sensing, inflammation, and innate immunity. Eur J Immunol 46(2):269\u2013280","journal-title":"Eur J Immunol"},{"issue":"12","key":"2309_CR63","doi-asserted-by":"publisher","first-page":"e2409769","DOI":"10.1002\/advs.202409769","volume":"12","author":"W Duan","year":"2025","unstructured":"Duan W, Hosea R, Wang L, Ruan C, Zhao F, Liu J et al (2025) Chromosome missegregation triggers tumor cell pyroptosis and enhances anti-tumor immunotherapy in colorectal cancer. Adv Sci 12(12):e2409769","journal-title":"Adv Sci"},{"key":"2309_CR64","doi-asserted-by":"publisher","first-page":"107079","DOI":"10.1016\/j.phrs.2024.107079","volume":"200","author":"JZ Cui","year":"2024","unstructured":"Cui JZ, Chew ZH, Lim LHK (2024) New insights into nucleic acid sensor AIM2: the potential benefit in targeted therapy for cancer. Pharmacol Res 200:107079","journal-title":"Pharmacol Res"},{"key":"2309_CR65","doi-asserted-by":"publisher","first-page":"588278","DOI":"10.3389\/fcell.2021.588278","volume":"9","author":"S Shah","year":"2021","unstructured":"Shah S, Qin S, Luo Y, Huang Y, Jing R, Shah JN et al (2021) AIM2 inhibits BRAF-mutant colorectal cancer growth in a caspase-1-dependent manner. Front Cell Dev Biol 9:588278","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2309_CR66","doi-asserted-by":"publisher","first-page":"157","DOI":"10.7150\/jca.101473","volume":"16","author":"L Sui","year":"2025","unstructured":"Sui L, Xi Y, Zheng S, Xiao Q, Liu Z (2025) The role of AIM2 in cancer development: inflammasomes and beyond. J Cancer 16(1):157\u2013170","journal-title":"J Cancer"},{"issue":"50","key":"2309_CR67","doi-asserted-by":"publisher","first-page":"21635","DOI":"10.1073\/pnas.1016814108","volume":"107","author":"B Hu","year":"2010","unstructured":"Hu B, Elinav E, Huber S, Booth CJ, Strowig T, Jin C et al (2010) Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A 107(50):21635\u201321640","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2309_CR68","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.4161\/cc.10.12.16008","volume":"10","author":"B Hu","year":"2011","unstructured":"Hu B, Elinav E, Flavell RA (2011) Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation. Cell Cycle 10(12):1936\u20131939","journal-title":"Cell Cycle"},{"issue":"11","key":"2309_CR69","doi-asserted-by":"publisher","DOI":"10.1172\/JCI166085","volume":"134","author":"C Domblides","year":"2024","unstructured":"Domblides C, Crampton S, Liu H, Bartleson JM, Nguyen A, Champagne C et al (2024) Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration. J Clin Invest 134(11):e166085","journal-title":"J Clin Invest"},{"key":"2309_CR70","doi-asserted-by":"publisher","first-page":"5425","DOI":"10.2147\/IJGM.S353380","volume":"15","author":"L Peng","year":"2022","unstructured":"Peng L, Zhu N, Wang D, Zhou Y, Liu Y (2022) Comprehensive analysis of prognostic value and immune infiltration of NLRC4 and CASP1 in colorectal cancer. Int J Gen Med 15:5425\u20135440","journal-title":"Int J Gen Med"},{"issue":"22","key":"2309_CR71","doi-asserted-by":"publisher","first-page":"13757","DOI":"10.3390\/ijms232213757","volume":"23","author":"JS Baik","year":"2022","unstructured":"Baik JS, Seo YN, Lee YC, Yi JM, Rhee MH, Park MT et al (2022) Involvement of the p38 MAPK-NLRC4-caspase-1 pathway in ionizing radiation-enhanced macrophage IL-1\u03b2 production. Int J Mol Sci 23(22):13757","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2309_CR72","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1158\/2326-6066.CIR-16-0269","volume":"5","author":"R Karki","year":"2017","unstructured":"Karki R, Man SM, Kanneganti TD (2017) Inflammasomes and cancer. Cancer Immunol Res 5(2):94\u201399","journal-title":"Cancer Immunol Res"},{"issue":"7661","key":"2309_CR73","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang Y, Gao W, Shi X, Ding J, Liu W, He H et al (2017) Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547(7661):99\u2013103","journal-title":"Nature"},{"issue":"3","key":"2309_CR74","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41419-019-1441-4","volume":"10","author":"J Yu","year":"2019","unstructured":"Yu J, Li S, Qi J, Chen Z, Wu Y, Guo J et al (2019) Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells. Cell Death Dis 10(3):193","journal-title":"Cell Death Dis"},{"key":"2309_CR75","doi-asserted-by":"publisher","first-page":"139345","DOI":"10.1016\/j.ijbiomac.2024.139345","volume":"294","author":"Y Shi","year":"2025","unstructured":"Shi Y, Zhao J, Xu S, Zhu H, Wang Y, Zhao B et al (2025) A sodium alginate-based injectable hydrogel system for locoregional treatment of colorectal cancer by eliciting pyroptosis and apoptosis. Int J Biol Macromol 294:139345","journal-title":"Int J Biol Macromol"},{"issue":"12","key":"2309_CR76","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s41419-023-06382-y","volume":"14","author":"Y Hu","year":"2023","unstructured":"Hu Y, Liu Y, Zong L, Zhang W, Liu R, Xing Q et al (2023) The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles. Cell Death Dis 14(12):836","journal-title":"Cell Death Dis"},{"issue":"1","key":"2309_CR77","doi-asserted-by":"publisher","first-page":"18363","DOI":"10.1038\/s41598-024-69436-x","volume":"14","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Yang M, Fu R, Liu W, Cai Z, Lin H et al (2024) Interleukin-17F suppressed colon cancer by enhancing caspase 4 mediated pyroptosis of endothelial cells. Sci Rep 14(1):18363","journal-title":"Sci Rep"},{"key":"2309_CR78","doi-asserted-by":"publisher","first-page":"116348","DOI":"10.1016\/j.bcp.2024.116348","volume":"226","author":"YG Long","year":"2024","unstructured":"Long YG, Jia XY, Chu L (2024) Insight into the structure, function and the tumor suppression effect of gasdermin E. Biochem Pharmacol 226:116348","journal-title":"Biochem Pharmacol"},{"issue":"12","key":"2309_CR79","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"WT He","year":"2015","unstructured":"He WT, Wan H, Hu L, Chen P, Wang X, Huang Z et al (2015) Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion. Cell Res 25(12):1285\u20131298","journal-title":"Cell Res"},{"issue":"2","key":"2309_CR80","doi-asserted-by":"publisher","first-page":"640","DOI":"10.7150\/thno.91814","volume":"14","author":"DKW Ocansey","year":"2024","unstructured":"Ocansey DKW, Qian F, Cai P, Ocansey S, Amoah S, Qian Y et al (2024) Current evidence and therapeutic implication of PANoptosis in cancer. Theranostics 14(2):640\u2013661","journal-title":"Theranostics"},{"issue":"12","key":"2309_CR81","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/s41419-023-06370-2","volume":"14","author":"L Wang","year":"2023","unstructured":"Wang L, Zhu Y, Zhang L, Guo L, Wang X, Pan Z et al (2023) Mechanisms of PANoptosis and relevant small-molecule compounds for fighting diseases. Cell Death Dis 14(12):851","journal-title":"Cell Death Dis"},{"issue":"3","key":"2309_CR82","doi-asserted-by":"publisher","first-page":"109858","DOI":"10.1016\/j.celrep.2021.109858","volume":"37","author":"R Karki","year":"2021","unstructured":"Karki R, Sundaram B, Sharma BR, Lee S, Malireddi RKS, Nguyen LN et al (2021) ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell Rep 37(3):109858","journal-title":"Cell Rep"},{"issue":"12","key":"2309_CR83","doi-asserted-by":"publisher","first-page":"e136720","DOI":"10.1172\/jci.insight.136720","volume":"5","author":"R Karki","year":"2020","unstructured":"Karki R, Sharma BR, Lee E, Banoth B, Malireddi RKS, Samir P et al (2020) Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI Insight 5(12):e136720","journal-title":"JCI Insight"},{"key":"2309_CR84","doi-asserted-by":"publisher","first-page":"217254","DOI":"10.1016\/j.canlet.2024.217254","volume":"604","author":"YT Tan","year":"2024","unstructured":"Tan YT, Li T, Wang RB, Liu ZK, Ma MY, Huang RZ et al (2024) WTAP weakens oxaliplatin chemosensitivity of colorectal cancer by preventing PANoptosis. Cancer Lett 604:217254","journal-title":"Cancer Lett"},{"issue":"44","key":"2309_CR85","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1038\/s41388-025-03570-2","volume":"44","author":"P Lin","year":"2025","unstructured":"Lin P, Lin C, Teng Z, Liu S, Lin X, He R et al (2025) USP10-mediated Ku70\/80 stabilization inhibits PANoptosis and promotes chemoresistance in colorectal cancer. Oncogene 44(44):4239\u20134253","journal-title":"Oncogene"},{"issue":"10","key":"2309_CR86","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/cells14100730","volume":"14","author":"G M\u0171zes","year":"2025","unstructured":"M\u0171zes G, Sipos F (2025) Panoptosis as a two-edged sword in colorectal cancer: a pathogenic mechanism and therapeutic opportunity. Cells 14(10):730","journal-title":"Cells"},{"issue":"2","key":"2309_CR87","doi-asserted-by":"publisher","first-page":"717","DOI":"10.7150\/ijbs.64350","volume":"18","author":"Z Liu","year":"2022","unstructured":"Liu Z, Li Y, Zhu Y, Li N, Li W, Shang C et al (2022) Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway. Int J Biol Sci 18(2):717\u2013730","journal-title":"Int J Biol Sci"},{"issue":"4","key":"2309_CR88","doi-asserted-by":"publisher","first-page":"e202401873","DOI":"10.1002\/cbdv.202401873","volume":"22","author":"F Dai","year":"2025","unstructured":"Dai F, Cao Y, Zhu C, Li Y, Ma X, Wang S et al (2025) Design, synthesis, and biological evaluation of naphthalimide-polyamine conjugate as a potential anti-colorectal cancer agent. Chem Biodivers 22(4):e202401873","journal-title":"Chem Biodivers"},{"key":"2309_CR89","doi-asserted-by":"publisher","first-page":"1059520","DOI":"10.3389\/fonc.2023.1059520","volume":"13","author":"H Liang","year":"2023","unstructured":"Liang H, He X, Tong Y, Bai N, Pu Y, Han K et al (2023) Ferroptosis open a new door for colorectal cancer treatment. Front Oncol 13:1059520","journal-title":"Front Oncol"},{"issue":"2","key":"2309_CR90","first-page":"101016","volume":"20","author":"W Cao","year":"2025","unstructured":"Cao W, Zhang X, Chen J, Sun L, He H, Yu F (2025) Codelivery of apigenin, FdUMP and CD276 antibody synergistic inhibit colorectal cancer by ferroptosis-apoptosis-pyroptosis and CD276 blockade. Asian J Pharm Sci 20(2):101016","journal-title":"Asian J Pharm Sci"},{"issue":"4","key":"2309_CR91","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3724\/abbs.2023068","volume":"55","author":"Y Wu","year":"2023","unstructured":"Wu Y, Pi D, Zhou S, Yi Z, Dong Y, Wang W et al (2023) Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3\/p53\/NRF2 axis in colorectal cancer cells. Acta Biochim Biophys Sin 55(4):587\u2013600","journal-title":"Acta Biochim Biophys Sin"},{"issue":"6","key":"2309_CR92","doi-asserted-by":"publisher","first-page":"e2409875","DOI":"10.1002\/smll.202409875","volume":"21","author":"JE Cun","year":"2025","unstructured":"Cun JE, He Z, Fan X, Pan Q, Luo K, He B et al (2025) Copper-based bio-coordination nanoparticle for enhanced pyroptosis-cuproptosis cancer immunotherapy through redox modulation and glycolysis inhibition. Small 21(6):e2409875","journal-title":"Small"},{"issue":"27","key":"2309_CR93","doi-asserted-by":"publisher","first-page":"e01675","DOI":"10.1002\/adhm.202501675","volume":"14","author":"Y Wang","year":"2025","unstructured":"Wang Y, Pi W, Shao Y, Tan X, Wang P, Yu H (2025) Natural small molecule self-assembled hydrogel inhibited colorectal cancer progression by regulating cuproptosis and PANoptosis. Adv Healthc Mater 14(27):e01675","journal-title":"Adv Healthc Mater"},{"issue":"3","key":"2309_CR94","doi-asserted-by":"publisher","first-page":"2300164","DOI":"10.1002\/smsc.202300164","volume":"4","author":"W Xiao","year":"2024","unstructured":"Xiao W, Qu K, Zhang W, Lai L, He L, Cheng F et al (2024) High immunogenic cuproptosis evoked by Insitu sulfidation-activated pyroptosis for tumor-targeted immunotherapy of colorectal cancer. Small Sci 4(3):2300164","journal-title":"Small Sci"},{"issue":"1","key":"2309_CR95","doi-asserted-by":"publisher","first-page":"14359","DOI":"10.1038\/s41598-023-41490-x","volume":"13","author":"Y Huang","year":"2023","unstructured":"Huang Y, Yang W, Yang L, Wang T, Li C, Yu J et al (2023) Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis. Sci Rep 13(1):14359","journal-title":"Sci Rep"},{"issue":"6","key":"2309_CR96","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1007\/s00210-023-02855-1","volume":"397","author":"D Hu","year":"2024","unstructured":"Hu D, Cui L, Zhang S, He S, Zhuo Y, Li D et al (2024) Antitumor effect of tubeimoside-I on murine colorectal cancers through PKM2-dependent pyroptosis and immunomodulation. Naunyn Schmiedebergs Arch Pharmacol 397(6):4069\u20134087","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2309_CR97","doi-asserted-by":"publisher","first-page":"118065","DOI":"10.1016\/j.lfs.2020.118065","volume":"257","author":"Z Tang","year":"2020","unstructured":"Tang Z, Ji L, Han M, Xie J, Zhong F, Zhang X et al (2020) Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer. Life Sci 257:118065","journal-title":"Life Sci"},{"key":"2309_CR98","doi-asserted-by":"publisher","first-page":"101833","DOI":"10.1016\/j.smim.2023.101833","volume":"70","author":"J Hou","year":"2023","unstructured":"Hou J, Li T, Hsu JM, Zhang X, Hung MC (2023) Gasdermins and cancers. Semin Immunol 70:101833","journal-title":"Semin Immunol"},{"key":"2309_CR99","doi-asserted-by":"publisher","first-page":"766503","DOI":"10.3389\/fcell.2021.766503","volume":"9","author":"J Rao","year":"2021","unstructured":"Rao J, Li W, Chen C (2021) Pyroptosis-mediated molecular subtypes and tumor microenvironment infiltration characterization in colon cancer. Front Cell Dev Biol 9:766503","journal-title":"Front Cell Dev Biol"},{"key":"2309_CR100","doi-asserted-by":"publisher","first-page":"1626311","DOI":"10.3389\/fimmu.2025.1626311","volume":"16","author":"G Kahaer","year":"2025","unstructured":"Kahaer G, Pan S, Yang C, Xie W, Lu Y (2025) Dual function of Gasdermin E: pyroptosis-mediated pan-cancer suppression versus HCC-specific oncogenic activity. Front Immunol 16:1626311","journal-title":"Front Immunol"},{"issue":"45","key":"2309_CR101","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202506362","volume":"35","author":"N Yang","year":"2025","unstructured":"Yang N, Feng XL, Yin LX, Bi HJ, Fu ZR, Shao XY et al (2025) Multipath synergistic immune activation of hydrogels delivering STING agonist and siXkr8 for long-lasting colorectal cancer therapy. Adv Funct Mater 35(45):2506362","journal-title":"Adv Funct Mater"},{"issue":"43","key":"2309_CR102","doi-asserted-by":"publisher","first-page":"e2403201","DOI":"10.1002\/smll.202403201","volume":"20","author":"Q Chen","year":"2024","unstructured":"Chen Q, Peng B, Lin L, Chen J, Jiang Z, Luo Y et al (2024) Chondroitin sulfate-modified hydroxyapatite for caspase-1 activated induced pyroptosis through Ca overload\/ER stress\/STING\/IRF3 pathway in colorectal cancer. Small 20(43):e2403201","journal-title":"Small"},{"issue":"1","key":"2309_CR103","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1186\/s12951-024-02970-y","volume":"22","author":"J Peng","year":"2024","unstructured":"Peng J, Yang Q, Lei R, Wang Y, Liu G, Qian Z (2024) Preferential activation of type I interferon-mediated antitumor inflammatory signaling by CuS\/MnO(2)\/diAMP nanoparticles enhances anti-PD-1 therapy for sporadic colorectal cancer. J Nanobiotechnology 22(1):699","journal-title":"J Nanobiotechnology"},{"issue":"4","key":"2309_CR104","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/ibd\/izab217","volume":"28","author":"W Gong","year":"2022","unstructured":"Gong W, Liu P, Zhao F, Liu J, Hong Z, Ren H et al (2022) STING-mediated Syk signaling attenuates tumorigenesis of colitis-associated colorectal cancer through enhancing intestinal epithelium pyroptosis. Inflamm Bowel Dis 28(4):572\u2013585","journal-title":"Inflamm Bowel Dis"},{"issue":"16","key":"2309_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26168003","volume":"26","author":"D Yin","year":"2025","unstructured":"Yin D, Chen H, Lin S, Sun Y, Jing X, Chang R et al (2025) Recent advances in the application of cucurbitacin B as an anticancer agent. Int J Mol Sci 26(16):8003","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2309_CR106","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.4251\/wjgo.v16.i9.3781","volume":"16","author":"YK Zhang","year":"2024","unstructured":"Zhang YK, Shi R, Meng RY, Lin SL, Zheng M (2024) Erythropoietin-induced hepatocyte receptor A2 regulates effect of pyroptosis on gastrointestinal colorectal cancer occurrence and metastasis resistance. World J Gastrointest Oncol 16(9):3781\u20133797","journal-title":"World J Gastrointest Oncol"},{"issue":"1","key":"2309_CR107","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1080\/10717544.2022.2069302","volume":"29","author":"R Sala","year":"2022","unstructured":"Sala R, Rioja-Blanco E, Serna N, S\u00e1nchez-Garc\u00eda L, \u00c1lamo P, Alba-Castell\u00f3n L et al (2022) GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. Drug Deliv 29(1):1384\u20131397","journal-title":"Drug Deliv"},{"key":"2309_CR108","doi-asserted-by":"publisher","first-page":"156194","DOI":"10.1016\/j.phymed.2024.156194","volume":"135","author":"G Zhang","year":"2024","unstructured":"Zhang G, Yao Y, Zhang Z, Xiao J, Yu H, Zhao J et al (2024) Regulation of NLRP3 inflammasome and Caspase-3\/4\/11 by 2\u2032,4\u2032-dihydroxychalcone contributes to anti-colorectal cancer. Phytomedicine 135:156194","journal-title":"Phytomedicine"},{"issue":"1","key":"2309_CR109","doi-asserted-by":"publisher","first-page":"e1602","DOI":"10.1038\/cddis.2014.532","volume":"6","author":"C Chen","year":"2015","unstructured":"Chen C, Wang B, Sun J, Na H, Chen Z, Zhu Z et al (2015) DAC can restore expression of NALP1 to suppress tumor growth in colon cancer. Cell Death Dis 6(1):e1602","journal-title":"Cell Death Dis"},{"issue":"12","key":"2309_CR110","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/s41575-018-0054-1","volume":"15","author":"SM Man","year":"2018","unstructured":"Man SM (2018) Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis. Nat Rev Gastroenterol Hepatol 15(12):721\u2013737","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"2309_CR111","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","volume":"22","author":"BR Sharma","year":"2021","unstructured":"Sharma BR, Kanneganti TD (2021) NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol 22(5):550\u2013559","journal-title":"Nat Immunol"},{"issue":"3","key":"2309_CR112","doi-asserted-by":"publisher","first-page":"e13739","DOI":"10.1016\/j.heliyon.2023.e13739","volume":"9","author":"X Ma","year":"2023","unstructured":"Ma X, Wang D, Liu Y, Liu B, Feng X, Yang W (2023) Transcriptomics and experimental validation-based approach to understand the effect and mechanism of Huangqin tang interfeience with colitis associated colorectal cancer. Heliyon 9(3):e13739","journal-title":"Heliyon"},{"issue":"1","key":"2309_CR113","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12964-023-01235-9","volume":"21","author":"A Shadab","year":"2023","unstructured":"Shadab A, Mahjoor M, Abbasi-Kolli M, Afkhami H, Moeinian P, Safdarian AR (2023) Divergent functions of NLRP3 inflammasomes in cancer: a review. Cell Commun Signal 21(1):232","journal-title":"Cell Commun Signal"},{"key":"2309_CR114","doi-asserted-by":"publisher","first-page":"108545","DOI":"10.1016\/j.pharmthera.2023.108545","volume":"251","author":"IW Tengesdal","year":"2023","unstructured":"Tengesdal IW, Dinarello CA, Marchetti C (2023) NLRP3 and cancer: pathogenesis and therapeutic opportunities. Pharmacol Ther 251:108545","journal-title":"Pharmacol Ther"},{"issue":"24","key":"2309_CR115","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.3390\/cells11244106","volume":"11","author":"M Jiang","year":"2022","unstructured":"Jiang M, Cui H, Liu Z, Zhou X, Zhang L, Cao L et al (2022) The role of amino acid metabolism of tumor associated macrophages in the development of colorectal cancer. Cells 11(24):4106","journal-title":"Cells"},{"issue":"1","key":"2309_CR116","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s12964-024-01890-6","volume":"22","author":"H Gao","year":"2024","unstructured":"Gao H, Li W, Xu S, Xu Z, Hu W, Pan L et al (2024) Gasdermin D promotes development of intestinal tumors through regulating IL-1\u03b2 release and gut microbiota composition. Cell Commun Signal 22(1):511","journal-title":"Cell Commun Signal"},{"issue":"1","key":"2309_CR117","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12943-024-02183-9","volume":"23","author":"H Wang","year":"2024","unstructured":"Wang H, Wang T, Yan S, Tang J, Zhang Y, Wang L et al (2024) Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication. Mol Cancer 23(1):268","journal-title":"Mol Cancer"},{"issue":"6","key":"2309_CR118","first-page":"1310","volume":"54","author":"M Ghiyasvand","year":"2025","unstructured":"Ghiyasvand M, Hesampour A, Dabiri H, Arasteh J (2025) Anticancer effects of Escherichia coli-derived outer membrane vesicles against colorectal cancer cells through regulation of apoptosis. Iran J Public Health 54(6):1310\u20131319","journal-title":"Iran J Public Health"},{"issue":"1","key":"2309_CR119","doi-asserted-by":"publisher","first-page":"2333790","DOI":"10.1080\/19490976.2024.2333790","volume":"16","author":"N Wang","year":"2024","unstructured":"Wang N, Zhang L, Leng XX, Xie YL, Kang ZR, Zhao LC et al (2024) Fusobacterium nucleatum induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway. Gut Microbes 16(1):2333790","journal-title":"Gut Microbes"},{"issue":"1","key":"2309_CR120","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12935-021-01886-z","volume":"21","author":"M Ranjbar","year":"2021","unstructured":"Ranjbar M, Salehi R, Haghjooy Javanmard S, Rafiee L, Faraji H, Jafarpor S et al (2021) The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences? A systematic review. Cancer Cell Int 21(1):194","journal-title":"Cancer Cell Int"},{"issue":"1","key":"2309_CR121","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12943-024-01977-1","volume":"23","author":"S Yang","year":"2024","unstructured":"Yang S, Hu C, Chen X, Tang Y, Li J, Yang H et al (2024) Crosstalk between metabolism and cell death in tumorigenesis. Mol Cancer 23(1):71","journal-title":"Mol Cancer"},{"key":"2309_CR122","doi-asserted-by":"publisher","first-page":"114301","DOI":"10.1016\/j.biopha.2023.114301","volume":"159","author":"W Yang","year":"2023","unstructured":"Yang W, Wang Y, Huang Y, Yu J, Wang T, Li C et al (2023) 4-octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer. Biomed Pharmacother 159:114301","journal-title":"Biomed Pharmacother"},{"key":"2309_CR123","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12645-024-00259-1","volume":"15","author":"DD Li","year":"2024","unstructured":"Li DD, Jin JC, Liu XW, Liu SY, Ji FJ, Liu T (2024) Nanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer. Cancer Nanotechnol 15:23","journal-title":"Cancer Nanotechnol"},{"issue":"30","key":"2309_CR124","doi-asserted-by":"publisher","first-page":"e2420445","DOI":"10.1002\/adma.202420445","volume":"37","author":"S Ma","year":"2025","unstructured":"Ma S, Zhu W, Ji X, Liu C, Chen N, Guo D et al (2025) Multiplex methionine modulating hydrogel for cancer metabolic therapy. Adv Mater 37(30):e2420445","journal-title":"Adv Mater"},{"issue":"7-9","key":"2309_CR125","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1089\/ars.2023.0253","volume":"39","author":"X Zhang","year":"2023","unstructured":"Zhang X, Ma L, Wang J (2023) Cross-regulation between redox and epigenetic systems in tumorigenesis: molecular mechanisms and clinical applications. Antioxid Redox Signal 39(7\u20139):445\u2013471","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2309_CR126","doi-asserted-by":"publisher","first-page":"2491316","DOI":"10.1080\/15592294.2025.2491316","volume":"20","author":"S Roy","year":"2025","unstructured":"Roy S, Deka D, Kondaveeti SB, Ayyadurai P, Siripragada S, Philip N et al (2025) An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update. Epigenetics 20(1):2491316","journal-title":"Epigenetics"},{"issue":"9","key":"2309_CR127","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41419-019-1883-8","volume":"10","author":"X Xia","year":"2019","unstructured":"Xia X, Wang X, Cheng Z, Qin W, Lei L, Jiang J et al (2019) The role of pyroptosis in cancer: pro-cancer or pro-\u201chost\u201d? Cell Death Dis 10(9):650","journal-title":"Cell Death Dis"},{"issue":"1","key":"2309_CR128","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00889-0","volume":"7","author":"JF Lin","year":"2022","unstructured":"Lin JF, Hu PS, Wang YY, Tan YT, Yu K, Liao K et al (2022) Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis. Signal Transduct Target Ther 7(1):54","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"2309_CR129","doi-asserted-by":"publisher","first-page":"e1692","DOI":"10.1002\/ctm2.1692","volume":"14","author":"X Guan","year":"2024","unstructured":"Guan X, Liu R, Wang B, Xiong R, Cui L, Liao Y et al (2024) Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3\/GSDMD-mediated pyroptosis in colorectal cancer. Clin Transl Med 14(6):e1692","journal-title":"Clin Transl Med"},{"key":"2309_CR130","doi-asserted-by":"publisher","first-page":"144888","DOI":"10.1016\/j.ijbiomac.2025.144888","volume":"318","author":"M Chen","year":"2025","unstructured":"Chen M, Zhao P, Chou J, Zhou L, Feng Z, Hao X et al (2025) Non-coding RNAs regulating programmed cell death and its implications in cancer chemotherapy resistance. Int J Biol Macromol 318:144888","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"2309_CR131","doi-asserted-by":"publisher","first-page":"114439","DOI":"10.1016\/j.yexcr.2025.114439","volume":"446","author":"SO Rab","year":"2025","unstructured":"Rab SO, Zwamel AH, Oghenemaro EF, Chandra M, Kaur I, Rani B et al (2025) Cell death-associated lncRNAs in cancer immunopathogenesis: an exploration of molecular mechanisms and signaling pathways. Exp Cell Res 446(1):114439","journal-title":"Exp Cell Res"},{"key":"2309_CR132","doi-asserted-by":"publisher","first-page":"862563","DOI":"10.3389\/fcell.2022.862563","volume":"10","author":"J Li","year":"2022","unstructured":"Li J, Sun J, Liu Z, Zeng Z, Ouyang S, Zhang Z et al (2022) The roles of non-coding RNAs in radiotherapy of gastrointestinal carcinoma. Front Cell Dev Biol 10:862563","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"2309_CR133","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3892\/ijo.2021.5259","volume":"59","author":"F Su","year":"2021","unstructured":"Su F, Duan J, Zhu J, Fu H, Zheng X, Ge C (2021) Long non-coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation-induced pyroptosis via microRNA-448\/gasdermin E in colorectal cancer cells. Int J Oncol 59(4):79","journal-title":"Int J Oncol"},{"issue":"5","key":"2309_CR134","first-page":"2648","volume":"40","author":"Y Ma","year":"2018","unstructured":"Ma Y, Chen Y, Lin C, Hu G (2018) Biological functions and clinical significance of the newly identified long non\u2011coding RNA RP1\u201185F18.6 in colorectal cancer. Oncol Rep 40(5):2648\u20132658","journal-title":"Oncol Rep"},{"issue":"18","key":"2309_CR135","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.7150\/jca.99462","volume":"15","author":"WY Feng","year":"2024","unstructured":"Feng WY, Zeng JX, Chen YR, Fang ZP, Gao Y, Zhou WJ (2024) siRNAs targeting non-human species-specific lncRNAs trigger cell death in human colorectal cancer cells. J Cancer 15(18):5956\u20135967","journal-title":"J Cancer"},{"issue":"1","key":"2309_CR136","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41423-022-00950-6","volume":"20","author":"C Chauvin","year":"2023","unstructured":"Chauvin C, Retnakumar SV, Bayry J (2023) Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1\u03b2. Cell Mol Immunol 20(1):8\u201310","journal-title":"Cell Mol Immunol"},{"key":"2309_CR137","doi-asserted-by":"publisher","first-page":"806680","DOI":"10.3389\/fcimb.2021.806680","volume":"11","author":"G Privitera","year":"2021","unstructured":"Privitera G, Rana N, Scaldaferri F, Armuzzi A, Pizarro TT (2021) Novel insights into the interactions between the gut microbiome, inflammasomes, and gasdermins during colorectal cancer. Front Cell Infect Microbiol 11:806680","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"2309_CR138","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.7150\/ijbs.81824","volume":"19","author":"H Chen","year":"2023","unstructured":"Chen H, Ye C, Wu C, Zhang J, Xu L, Wang X et al (2023) Berberine inhibits high fat diet-associated colorectal cancer through modulation of the gut microbiota-mediated lysophosphatidylcholine. Int J Biol Sci 19(7):2097\u20132113","journal-title":"Int J Biol Sci"},{"issue":"8","key":"2309_CR139","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.chom.2024.07.001","volume":"32","author":"P Huang","year":"2024","unstructured":"Huang P, Ji F, Cheung AH, Fu K, Zhou Q, Ding X et al (2024) Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK. Cell Host Microbe 32(8):1365\u201379.e10","journal-title":"Cell Host Microbe"},{"issue":"3","key":"2309_CR140","first-page":"481","volume":"92","author":"A Pandey","year":"2019","unstructured":"Pandey A, Shen C, Man SM (2019) Inflammasomes in colitis and colorectal cancer: mechanism of action and therapies. Yale J Biol Med 92(3):481\u2013498","journal-title":"Yale J Biol Med"},{"issue":"5","key":"2309_CR141","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-025-04004-4","volume":"74","author":"D Tang","year":"2025","unstructured":"Tang D, Mao Z, Chen S, Su M, Lan S, Yan R et al (2025) MS275 induces tumor immunosuppression by upregulating PD-L1 and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer. Cancer Immunol Immunother 74(5):150","journal-title":"Cancer Immunol Immunother"},{"key":"2309_CR142","first-page":"e68351","volume":"221","author":"Y Feng","year":"2025","unstructured":"Feng Y, Yuan Q, Zuniga A, Islam S, Avram D, Guryanova OA (2025) Optimized mouse model to induce colitis-associated colon cancer using azoxymethane and dextran sulfate sodium for tumor immunology and therapy studies. J Vis Exp 221:e68351","journal-title":"J Vis Exp"},{"key":"2309_CR143","doi-asserted-by":"publisher","first-page":"116553","DOI":"10.1016\/j.jpba.2024.116553","volume":"253","author":"D Wang","year":"2025","unstructured":"Wang D, Zhu L, Liu H, Feng X, Zhang C, Liu B et al (2025) Altered gut metabolites and metabolic reprogramming involved in the pathogenesis of colitis-associated colorectal cancer and the transition of colon \u201cinflammation to cancer.\u201d J Pharm Biomed Anal 253:116553","journal-title":"J Pharm Biomed Anal"},{"issue":"9","key":"2309_CR144","doi-asserted-by":"publisher","first-page":"4404","DOI":"10.3390\/ijms26094404","volume":"26","author":"A Niechcial","year":"2025","unstructured":"Niechcial A, Schwarzfischer M, Wawrzyniak P, Determann M, P\u00f6hlmann D, Wawrzyniak M et al (2025) Probiotic administration modulates gut microbiota and suppresses tumor growth in murine models of colorectal cancer. Int J Mol Sci 26(9):4404","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2309_CR145","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1158\/2159-8290.CD-20-0789","volume":"11","author":"E Koren","year":"2021","unstructured":"Koren E, Fuchs Y (2021) Modes of regulated cell death in cancer. Cancer Discov 11(2):245\u2013265","journal-title":"Cancer Discov"},{"issue":"5","key":"2309_CR146","doi-asserted-by":"publisher","first-page":"820","DOI":"10.3390\/biom13050820","volume":"13","author":"P Zhou","year":"2023","unstructured":"Zhou P, Zhang S, Wang M, Zhou J (2023) The induction mechanism of ferroptosis, necroptosis, and pyroptosis in inflammatory bowel disease, colorectal cancer, and intestinal injury. Biomolecules 13(5):820","journal-title":"Biomolecules"},{"issue":"18","key":"2309_CR147","doi-asserted-by":"publisher","first-page":"4520","DOI":"10.3390\/cancers15184520","volume":"15","author":"H Clar-Marmaneu","year":"2023","unstructured":"Clar-Marmaneu H, Garc\u00eda-Fern\u00e1ndez AE, Garc\u00eda-Fern\u00e1ndez FJ (2023) Time-tested strategies in modern context: a bibliometric study of chemotherapy\u2019s continued importance in colorectal cancer treatment. Cancers 15(18):4520","journal-title":"Cancers"},{"issue":"10207","key":"2309_CR148","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","volume":"394","author":"E Dekker","year":"2019","unstructured":"Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB (2019) Colorectal cancer. Lancet 394(10207):1467\u20131480","journal-title":"Lancet"},{"issue":"4","key":"2309_CR149","first-page":"1322","volume":"6","author":"D Salonga","year":"2000","unstructured":"Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD et al (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6(4):1322\u20131327","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2309_CR150","doi-asserted-by":"publisher","first-page":"bgaf041","DOI":"10.1093\/carcin\/bgaf041","volume":"46","author":"Z He","year":"2025","unstructured":"He Z, Yang J, Zhang Y, Zhang T, Guo T, Jin L et al (2025) FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer. Carcinogenesis 46(3):bgaf041","journal-title":"Carcinogenesis"},{"issue":"23","key":"2309_CR151","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.3390\/molecules27238367","volume":"27","author":"A Naeem","year":"2022","unstructured":"Naeem A, Hu P, Yang M, Zhang J, Liu Y, Zhu W et al (2022) Natural products as anticancer agents: current status and future perspectives. Molecules 27(23):8367","journal-title":"Molecules"},{"issue":"5","key":"2309_CR152","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1002\/ptr.8456","volume":"39","author":"Y Wu","year":"2025","unstructured":"Wu Y, Yin M, Xia W, Dou B, Liu X, Sun R (2025) Enhancing NK cell antitumor activity with natural compounds: research advances and molecular mechanisms. Phytother Res 39(5):1905\u20131929","journal-title":"Phytother Res"},{"key":"2309_CR153","doi-asserted-by":"publisher","first-page":"110170","DOI":"10.1016\/j.cbi.2022.110170","volume":"368","author":"MR Islam","year":"2022","unstructured":"Islam MR, Akash S, Rahman MM, Nowrin FT, Akter T, Shohag S et al (2022) Colon cancer and colorectal cancer: prevention and treatment by potential natural products. Chem Biol Interact 368:110170","journal-title":"Chem Biol Interact"},{"issue":"4","key":"2309_CR154","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.tips.2023.01.003","volume":"44","author":"AE Shin","year":"2023","unstructured":"Shin AE, Giancotti FG, Rustgi AK (2023) Metastatic colorectal cancer: mechanisms and emerging therapeutics. Trends Pharmacol Sci 44(4):222\u2013236","journal-title":"Trends Pharmacol Sci"},{"issue":"4","key":"2309_CR155","doi-asserted-by":"publisher","first-page":"883","DOI":"10.55730\/1300-0144.5652","volume":"53","author":"Z Dal","year":"2023","unstructured":"Dal Z, Aru B (2023) The role of curcumin on apoptosis and NLRP3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. Turk J Med Sci 53(4):883\u2013893","journal-title":"Turk J Med Sci"},{"key":"2309_CR156","doi-asserted-by":"publisher","first-page":"105748","DOI":"10.1016\/j.phrs.2021.105748","volume":"170","author":"R Yuan","year":"2021","unstructured":"Yuan R, Zhao W, Wang QQ, He J, Han S, Gao H et al (2021) Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4\/NLRP3\/GSDMD-dependent pyroptosis. Pharmacol Res 170:105748","journal-title":"Pharmacol Res"},{"key":"2309_CR157","doi-asserted-by":"publisher","first-page":"9110704","DOI":"10.1155\/2022\/9110704","volume":"2022","author":"J Yan","year":"2022","unstructured":"Yan J, Tang Y, Yu W, Jiang L, Liu C, Li Q et al (2022) Validation of the anticolitis efficacy of the Jian-Wei-Yu-Yang formula. Evid Based Complement Alternat Med 2022:9110704","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"2309_CR158","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3892\/ol.2022.13369","volume":"24","author":"W Han","year":"2022","unstructured":"Han W, Xing W, Wang K, Wang B, Bai K (2022) Alisol A attenuates malignant phenotypes of colorectal cancer cells by inactivating PI3K\/Akt signaling. Oncol Lett 24(2):249","journal-title":"Oncol Lett"},{"key":"2309_CR159","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.2147\/IJN.S455158","volume":"19","author":"M Li","year":"2024","unstructured":"Li M, Wang Y, Liu H, Huang X, Peng H, Yang Y et al (2024) Staphylococcus aureus membrane vesicles kill tumor cells through a caspase-1-dependent pyroptosis pathway. Int J Nanomedicine 19:4007\u20134019","journal-title":"Int J Nanomedicine"},{"key":"2309_CR160","doi-asserted-by":"publisher","first-page":"5545","DOI":"10.2147\/IJN.S457309","volume":"19","author":"F Ji","year":"2024","unstructured":"Ji F, Shi C, Shu Z, Li Z (2024) Nanomaterials enhance pyroptosis-based tumor immunotherapy. Int J Nanomedicine 19:5545\u20135579","journal-title":"Int J Nanomedicine"},{"key":"2309_CR161","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.2147\/IJN.S499192","volume":"20","author":"LM Carrasco-D\u00edaz","year":"2025","unstructured":"Carrasco-D\u00edaz LM, Gallardo A, Volt\u00e0-Dur\u00e1n E, Virgili AC, P\u00e1ez D, Villaverde A et al (2025) A targeted nanotoxin inhibits colorectal cancer growth through local tumor pyroptosis and eosinophil infiltration and degranulation. Int J Nanomedicine 20:2445\u20132460","journal-title":"Int J Nanomedicine"},{"issue":"14","key":"2309_CR162","doi-asserted-by":"publisher","first-page":"e2501542","DOI":"10.1002\/advs.202501542","volume":"12","author":"J Li","year":"2025","unstructured":"Li J, Lv W, Han Z, Li Y, Deng J, Huang Y et al (2025) Mitoxantrone-encapsulated ZIF-8 enhances chemo-immunotherapy via amplified immunogenic cell death. Adv Sci 12(14):e2501542","journal-title":"Adv Sci"},{"issue":"1","key":"2309_CR163","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3390\/cancers16010066","volume":"16","author":"D Aebisher","year":"2023","unstructured":"Aebisher D, Wo\u017anicki P, Dynarowicz K, Kawczyk-Krupka A, Cie\u015blar G, Bartusik-Aebisher D (2023) Photodynamic therapy and immunological view in gastrointestinal tumors. Cancers 16(1):66","journal-title":"Cancers"},{"issue":"24","key":"2309_CR164","doi-asserted-by":"publisher","first-page":"e2101840","DOI":"10.1002\/advs.202101840","volume":"8","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Zhang T, Ma X, Yang QC, Yang LL, Yang SC et al (2021) Microenvironment-responsive prodrug-induced pyroptosis boosts cancer immunotherapy. Adv Sci 8(24):e2101840","journal-title":"Adv Sci"},{"key":"2309_CR165","doi-asserted-by":"publisher","first-page":"153303382412775","DOI":"10.1177\/15330338241277584","volume":"23","author":"L Li","year":"2024","unstructured":"Li L, Li Y, Lin J, Pang W (2024) A pyroptosis-related gene signature predicts prognosis and tumor immune microenvironment in colorectal cancer. Technol Cancer Res Treat 23:15330338241277584","journal-title":"Technol Cancer Res Treat"},{"key":"2309_CR166","doi-asserted-by":"publisher","first-page":"925338","DOI":"10.3389\/fgene.2022.925338","volume":"13","author":"Z Li","year":"2022","unstructured":"Li Z, Liu Y, Lin B, Yan W, Yi H, Wang H et al (2022) Pyroptosis-related signature as potential biomarkers for predicting prognosis and therapy response in colorectal cancer patients. Front Genet 13:925338","journal-title":"Front Genet"},{"issue":"6","key":"2309_CR167","first-page":"bbaf639","volume":"26","author":"A Sengupta","year":"2025","unstructured":"Sengupta A, Kar SS, Kumar R (2025) Non-apoptotic regulated cell death based prognostic risk model for colorectal cancer using machine learning guided two-step framework. Brief Bioinform 26(6):bbaf639","journal-title":"Brief Bioinform"},{"issue":"13","key":"2309_CR168","doi-asserted-by":"publisher","first-page":"e2417022","DOI":"10.1002\/advs.202417022","volume":"12","author":"Q Gao","year":"2025","unstructured":"Gao Q, Sheng Q, Yang Z, Zhu Z, Li L, Xu L et al (2025) Honokiol-magnolol-baicalin possesses synergistic anticancer potential and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer by triggering GSDME-dependent pyroptosis. Adv Sci 12(13):e2417022","journal-title":"Adv Sci"},{"key":"2309_CR169","doi-asserted-by":"publisher","first-page":"10397","DOI":"10.2147\/CMAR.S244374","volume":"12","author":"LS Wu","year":"2020","unstructured":"Wu LS, Liu Y, Wang XW, Xu B, Lin YL, Song Y et al (2020) LPS enhances the chemosensitivity of oxaliplatin in HT29 cells via GSDMD-mediated pyroptosis. Cancer Manag Res 12:10397\u201310409","journal-title":"Cancer Manag Res"},{"issue":"1","key":"2309_CR170","doi-asserted-by":"publisher","first-page":"114184","DOI":"10.3748\/wjg.v32.i1.114184","volume":"32","author":"DK Maurya","year":"2026","unstructured":"Maurya DK (2026) Peroxiredoxin 1, pyroptosis, and the emerging frontier in colorectal cancer therapy. World J Gastroenterol 32(1):114184","journal-title":"World J Gastroenterol"},{"issue":"6","key":"2309_CR171","doi-asserted-by":"publisher","first-page":"8783","DOI":"10.3934\/mbe.2021433","volume":"18","author":"C Zheng","year":"2021","unstructured":"Zheng C, Tan Z (2021) A novel identified pyroptosis-related prognostic signature of colorectal cancer. Math Biosci Eng 18(6):8783\u20138796","journal-title":"Math Biosci Eng"},{"key":"2309_CR172","doi-asserted-by":"publisher","first-page":"1531695","DOI":"10.3389\/fimmu.2025.1531695","volume":"16","author":"S He","year":"2025","unstructured":"He S, Huang Q, Cheng J (2025) The conflicting role highlights the complexity of GSDMs in cancer. Front Immunol 16:1531695","journal-title":"Front Immunol"},{"issue":"15","key":"2309_CR173","doi-asserted-by":"publisher","first-page":"7590","DOI":"10.3390\/ijms26157590","volume":"26","author":"DO Moon","year":"2025","unstructured":"Moon DO (2025) Curcumin as a dual modulator of pyroptosis: mechanistic insights and therapeutic potential. Int J Mol Sci 26(15):7590","journal-title":"Int J Mol Sci"},{"issue":"23","key":"2309_CR174","doi-asserted-by":"publisher","first-page":"13058","DOI":"10.3390\/ijms252313058","volume":"25","author":"V Scalavino","year":"2024","unstructured":"Scalavino V, Piccinno E, Giannelli G, Serino G (2024) Inflammasomes in intestinal disease: mechanisms of activation and therapeutic strategies. Int J Mol Sci 25(23):13058","journal-title":"Int J Mol Sci"},{"key":"2309_CR175","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fphar.2020.00123","volume":"11","author":"W Tian","year":"2020","unstructured":"Tian W, Wang Z, Tang NN, Li JT, Liu Y, Chu WF et al (2020) Ascorbic acid sensitizes colorectal carcinoma to the cytotoxicity of arsenic trioxide via promoting reactive oxygen species-dependent apoptosis and pyroptosis. Front Pharmacol 11:123","journal-title":"Front Pharmacol"},{"issue":"1","key":"2309_CR176","doi-asserted-by":"publisher","first-page":"2427094","DOI":"10.1080\/08916934.2024.2427094","volume":"57","author":"P Zhao","year":"2024","unstructured":"Zhao P, Ning J, Huang J, Huang X (2024) Mechanism of resveratrol on LPS\/ATP-induced pyroptosis and inflammatory response in HT29 cells. Autoimmunity 57(1):2427094","journal-title":"Autoimmunity"},{"key":"2309_CR177","doi-asserted-by":"publisher","first-page":"1601591","DOI":"10.3389\/fimmu.2025.1601591","volume":"16","author":"B Wu","year":"2025","unstructured":"Wu B, Su S, Wang X, Li Y, Mei Z, Lou F et al (2025) Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of TSG-6. Front Immunol 16:1601591","journal-title":"Front Immunol"},{"issue":"13","key":"2309_CR178","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3390\/cells13131140","volume":"13","author":"Z Liu","year":"2024","unstructured":"Liu Z, Mou S, Li L, Chen Q, Yang R, Guo S et al (2024) The barrier disruption and pyroptosis of intestinal epithelial cells caused by Perfringolysin O (PFO) from Clostridium perfringens. Cells 13(13):1140","journal-title":"Cells"},{"key":"2309_CR179","doi-asserted-by":"publisher","first-page":"5341247","DOI":"10.1155\/2020\/5341247","volume":"2020","author":"Z Xu","year":"2020","unstructured":"Xu Z, Liu R, Huang L, Xu Y, Su M, Chen J et al (2020) CD147 aggravated inflammatory bowel disease by triggering NF-\u03baB-mediated pyroptosis. Biomed Res Int 2020:5341247","journal-title":"Biomed Res Int"},{"key":"2309_CR180","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.3389\/fimmu.2018.02566","volume":"9","author":"L Mao","year":"2018","unstructured":"Mao L, Kitani A, Strober W, Fuss IJ (2018) The role of NLRP3 and IL-1\u03b2 in the pathogenesis of inflammatory bowel disease. Front Immunol 9:2566","journal-title":"Front Immunol"},{"key":"2309_CR181","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1038\/ncomms14128","volume":"8","author":"C Rogers","year":"2017","unstructured":"Rogers C, Fernandes-Alnemri T, Mayes L, Alnemri D, Cingolani G, Alnemri ES (2017) Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death. Nat Commun 8:14128","journal-title":"Nat Commun"},{"issue":"1","key":"2309_CR182","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13046-021-01959-x","volume":"40","author":"Y Tan","year":"2021","unstructured":"Tan Y, Chen Q, Li X, Zeng Z, Xiong W, Li G et al (2021) Pyroptosis: a new paradigm of cell death for fighting against cancer. J Exp Clin Cancer Res 40(1):153","journal-title":"J Exp Clin Cancer Res"},{"issue":"7","key":"2309_CR183","doi-asserted-by":"publisher","first-page":"e70071","DOI":"10.1002\/jcp.70071","volume":"240","author":"S Jeong","year":"2025","unstructured":"Jeong S, Park S, Lee D, Heo G, Lee Y, Rhee SH et al (2025) ATP mediates pyroptosis in the intestinal mucosal system during colitis. J Cell Physiol 240(7):e70071","journal-title":"J Cell Physiol"},{"issue":"2","key":"2309_CR184","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1021\/acsnano.1c08913","volume":"16","author":"Y Chen","year":"2022","unstructured":"Chen Y, Luo R, Li J, Wang S, Ding J, Zhao K et al (2022) Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis. ACS Nano 16(2):2429\u20132441","journal-title":"ACS Nano"},{"issue":"5","key":"2309_CR185","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3390\/biomedicines12050989","volume":"12","author":"J Li","year":"2024","unstructured":"Li J, Wu H, Zhou J, Jiang R, Zhuo Z, Yang Q et al (2024) Ruscogenin attenuates ulcerative colitis in mice by inhibiting caspase-1-dependent pyroptosis via the TLR4\/NF-\u03baB signaling pathway. Biomedicines 12(5):989","journal-title":"Biomedicines"},{"issue":"23","key":"2309_CR186","doi-asserted-by":"publisher","first-page":"5764","DOI":"10.3390\/cancers14235764","volume":"14","author":"K Li","year":"2022","unstructured":"Li K, Qiu J, Pan J, Pan JP (2022) Pyroptosis and its role in cervical cancer. Cancers 14(23):5764","journal-title":"Cancers"},{"key":"2309_CR187","doi-asserted-by":"publisher","first-page":"1209156","DOI":"10.3389\/fonc.2023.1209156","volume":"13","author":"X Tang","year":"2023","unstructured":"Tang X, Yan Z, Miao Y, Ha W, Li Z, Yang L et al (2023) Copper in cancer: from limiting nutrient to therapeutic target. Front Oncol 13:1209156","journal-title":"Front Oncol"},{"key":"2309_CR188","doi-asserted-by":"publisher","first-page":"1322305","DOI":"10.3389\/fcell.2023.1322305","volume":"11","author":"Z Wang","year":"2023","unstructured":"Wang Z, Wang M, Zeng X, Yue X, Wei P (2023) Nanomaterial-induced pyroptosis: a cell type-specific perspective. Front Cell Dev Biol 11:1322305","journal-title":"Front Cell Dev Biol"},{"issue":"43","key":"2309_CR189","doi-asserted-by":"publisher","first-page":"111358","DOI":"10.3748\/wjg.v31.i43.111358","volume":"31","author":"WW Dong","year":"2025","unstructured":"Dong WW, Liu T, He LX, He WT (2025) Targeting pyroptosis in inflammatory bowel disease: a potentially effective therapeutic approach. World J Gastroenterol 31(43):111358","journal-title":"World J Gastroenterol"},{"key":"2309_CR190","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.2147\/JIR.S498703","volume":"18","author":"J Fang","year":"2025","unstructured":"Fang J, Zhu W, Yu D, Zhu L, Zha H, Tang J et al (2025) From inflammasomes to pyroptosis: molecular mechanisms in chronic intestinal diseases\u2014opportunity or challenge? J Inflamm Res 18:3349\u20133360","journal-title":"J Inflamm Res"},{"issue":"39","key":"2309_CR191","doi-asserted-by":"publisher","first-page":"18570","DOI":"10.1039\/D4NR01497A","volume":"16","author":"F Cheng","year":"2024","unstructured":"Cheng F, He L, Wang J, Lai L, Ma L, Qu K et al (2024) Synergistic immunotherapy with a calcium-based nanoinducer: evoking pyroptosis and remodeling tumor-associated macrophages for enhanced antitumor immune response. Nanoscale 16(39):18570\u201318583","journal-title":"Nanoscale"},{"issue":"23","key":"2309_CR192","doi-asserted-by":"publisher","first-page":"2213425","DOI":"10.1002\/adfm.202213425","volume":"33","author":"GH Wang","year":"2023","unstructured":"Wang GH, Li B, Tian H, Xie LS, Yan J, Sang W et al (2023) A metal-phenolic nanocoordinator launches radiotherapeutic cancer pyroptosis through an epigenetic mechanism. Adv Funct Mater 33(23):2213425","journal-title":"Adv Funct Mater"},{"issue":"5","key":"2309_CR193","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1002\/cam4.2103","volume":"8","author":"J Ibrahim","year":"2019","unstructured":"Ibrahim J, de Op Beeck K, Fransen E, Croes L, Beyens M, Suls A et al (2019) Methylation analysis of gasdermin E shows great promise as a biomarker for colorectal cancer. Cancer Med 8(5):2133\u20132145","journal-title":"Cancer Med"},{"issue":"28","key":"2309_CR194","doi-asserted-by":"publisher","first-page":"44505","DOI":"10.18632\/oncotarget.9887","volume":"7","author":"S Alzoubi","year":"2016","unstructured":"Alzoubi S, Brody L, Rahman S, Mahul-Mellier AL, Mercado N, Ito K et al (2016) Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer. Oncotarget 7(28):44505\u201344521","journal-title":"Oncotarget"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02309-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02309-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02309-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:03:58Z","timestamp":1777633438000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02309-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":194,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2309"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02309-y","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"8 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"123"}}