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The collection of samples and the handling of animals in this study were thoroughly reviewed and approved by the Xiangya Hospital of Central South University (Ethics Approval No. 2022111388). The animal trials received approval from the Institutional Animal Care and Use Committee at Central South University (CSU-2022-0001-0234).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests exist.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"155"}}