{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:13:33Z","timestamp":1784052813079,"version":"3.55.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]},{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]},{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]},{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]},{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]},{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]},{"name":"Wuhan Municipal Health Commission - Clinical Medical Research Project (Western Medicine Category) - Major General Program","award":["Project Number: wx20B26"],"award-info":[{"award-number":["Project Number: wx20B26"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10495-026-02353-8","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:25:54Z","timestamp":1781616354000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zinc regulates the balance of specific gut microbiota through MTF1\/Nrf2 and mitigates ferroptosis through activation of PINK1\/Parkin\/mitophagy via the gut-kidney axis in sepsis-associated acute kidney injury in pregnant mice"],"prefix":"10.1007","volume":"31","author":[{"given":"Xingfeng","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"issue":"2","key":"2353_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/ACO.0000000000000963","volume":"34","author":"P Arina","year":"2021","unstructured":"Arina P, Singer M (2021) Pathophysiology of sepsis. Curr Opin Anaesthesiol 34(2):77\u201384","journal-title":"Curr Opin Anaesthesiol"},{"issue":"11","key":"2353_CR2","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","volume":"54","author":"T van der Poll","year":"2021","unstructured":"van der Poll T, Shankar-Hari M, Wiersinga WJ (2021) The immunology of sepsis. Immunity 54(11):2450\u20132464","journal-title":"Immunity"},{"issue":"10141","key":"2353_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","volume":"392","author":"M Cecconi","year":"2018","unstructured":"Cecconi M et al (2018) Sepsis and septic shock. Lancet 392(10141):75\u201387","journal-title":"Lancet"},{"issue":"4","key":"2353_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/OGX.0000000000001108","volume":"78","author":"S Giouleka","year":"2023","unstructured":"Giouleka S et al (2023) Sepsis in pregnancy and the puerperium: a comparative review of major guidelines. Obstet Gynecol Surv 78(4):237\u2013248","journal-title":"Obstet Gynecol Surv"},{"issue":"1","key":"2353_CR5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13613-024-01377-0","volume":"14","author":"A Borges","year":"2024","unstructured":"Borges A, Bento L (2024) Organ crosstalk and dysfunction in sepsis. Ann Intensive Care 14(1):147","journal-title":"Ann Intensive Care"},{"issue":"5","key":"2353_CR6","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","volume":"96","author":"S Peerapornratana","year":"2019","unstructured":"Peerapornratana S et al (2019) Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int 96(5):1083\u20131099","journal-title":"Kidney Int"},{"key":"2353_CR7","doi-asserted-by":"publisher","first-page":"k4891","DOI":"10.1136\/bmj.k4891","volume":"364","author":"JT Poston","year":"2019","unstructured":"Poston JT, Koyner JL (2019) Sepsis associated acute kidney injury. BMJ 364:k4891","journal-title":"BMJ"},{"issue":"3","key":"2353_CR8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1177\/00494755231157109","volume":"53","author":"D Kharkongor","year":"2023","unstructured":"Kharkongor D et al (2023) Acute kidney injury in obstetrics: hospital-based cohort study. Trop Doct 53(3):356\u2013361","journal-title":"Trop Doct"},{"issue":"21","key":"2353_CR9","doi-asserted-by":"publisher","first-page":"5388","DOI":"10.3390\/ijms20215388","volume":"20","author":"O Greer","year":"2019","unstructured":"Greer O et al (2019) Sepsis: precision-based medicine for pregnancy and the puerperium. Int J Mol Sci 20(21):5388","journal-title":"Int J Mol Sci"},{"key":"2353_CR10","doi-asserted-by":"publisher","first-page":"1176894","DOI":"10.3389\/fphys.2023.1176894","volume":"14","author":"S Ai","year":"2023","unstructured":"Ai S et al (2023) Bibliometric visualization analysis of gut-kidney axis from 2003 to 2022. Front Physiol 14:1176894","journal-title":"Front Physiol"},{"key":"2353_CR11","doi-asserted-by":"publisher","first-page":"620102","DOI":"10.3389\/fmed.2020.620102","volume":"7","author":"E Stavropoulou","year":"2020","unstructured":"Stavropoulou E et al (2020) Focus on the gut-kidney axis in health and disease. Front Med 7:620102","journal-title":"Front Med"},{"issue":"1","key":"2353_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/diagnostics15010021","volume":"15","author":"K Tsuji","year":"2024","unstructured":"Tsuji K et al (2024) The gut-kidney axis in chronic kidney diseases. Diagnostics 15(1):21","journal-title":"Diagnostics"},{"key":"2353_CR13","doi-asserted-by":"publisher","first-page":"1207132","DOI":"10.3389\/fmicb.2023.1207132","volume":"14","author":"H Zhao","year":"2023","unstructured":"Zhao H et al (2023) The roles of gut microbiota and its metabolites in diabetic nephropathy. Front Microbiol 14:1207132","journal-title":"Front Microbiol"},{"issue":"6","key":"2353_CR14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/lam.13333","volume":"72","author":"S Ahlawat","year":"2021","unstructured":"Ahlawat S, Asha, Sharma KK (2021) Gut-organ axis: a microbial outreach and networking. Lett Appl Microbiol 72(6):636\u2013668","journal-title":"Lett Appl Microbiol"},{"issue":"3","key":"2353_CR15","first-page":"329","volume":"35","author":"L Zhang","year":"2023","unstructured":"Zhang L, Wang Y, Yu X (2023) Research progress of sepsis-associated acute kidney injury based on Gut-Kidney axis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 35(3):329\u2013333","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"1","key":"2353_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13054-018-2040-y","volume":"22","author":"J Zhang","year":"2018","unstructured":"Zhang J et al (2018) Gut-kidney crosstalk in septic acute kidney injury. Crit Care 22(1):117","journal-title":"Crit Care"},{"issue":"5","key":"2353_CR17","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s00204-020-02702-9","volume":"94","author":"CT Chasapis","year":"2020","unstructured":"Chasapis CT et al (2020) Recent aspects of the effects of zinc on human health. Arch Toxicol 94(5):1443\u20131460","journal-title":"Arch Toxicol"},{"issue":"8","key":"2353_CR18","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3390\/nu10080976","volume":"10","author":"W Alker","year":"2018","unstructured":"Alker W, Haase H (2018) Zinc and sepsis. Nutrients 10(8):976","journal-title":"Nutrients"},{"issue":"7","key":"2353_CR19","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s12098-021-03748-y","volume":"88","author":"N Banupriya","year":"2021","unstructured":"Banupriya N, Bhat BV, Sridhar MG (2021) Role of zinc in neonatal sepsis. Indian J Pediatr 88(7):696\u2013702","journal-title":"Indian J Pediatr"},{"issue":"5","key":"2353_CR20","doi-asserted-by":"publisher","first-page":"e0176069","DOI":"10.1371\/journal.pone.0176069","volume":"12","author":"J Hoeger","year":"2017","unstructured":"Hoeger J et al (2017) Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study. PLoS ONE 12(5):e0176069","journal-title":"PLoS ONE"},{"key":"2353_CR21","doi-asserted-by":"publisher","first-page":"894572","DOI":"10.3389\/fnut.2022.894572","volume":"9","author":"W Xia","year":"2022","unstructured":"Xia W et al (2022) The impact of zinc supplementation on critically Ill patients with acute kidney injury: a propensity score matching analysis. Front Nutr 9:894572","journal-title":"Front Nutr"},{"issue":"2","key":"2353_CR22","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1039\/D4FO04200J","volume":"16","author":"X Yu","year":"2025","unstructured":"Yu X et al (2025) Glycosylation of oyster peptides by COS ameliorates zinc deficiency-induced syndromes: intestinal inflammation and imbalance of the gut microbiota in vivo. Food Funct 16(2):640\u2013656","journal-title":"Food Funct"},{"issue":"3","key":"2353_CR23","doi-asserted-by":"publisher","first-page":"491","DOI":"10.18388\/abp.2015_1038","volume":"62","author":"A Grzywacz","year":"2015","unstructured":"Grzywacz A et al (2015) Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level. Acta Biochim Pol 62(3):491\u2013498","journal-title":"Acta Biochim Pol"},{"key":"2353_CR24","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD (2019) NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107","journal-title":"Redox Biol"},{"issue":"6","key":"2353_CR25","doi-asserted-by":"publisher","first-page":"166752","DOI":"10.1016\/j.bbadis.2023.166752","volume":"1869","author":"CC Zhong","year":"2023","unstructured":"Zhong CC et al (2023) Copper induces liver lipotoxicity disease by up-regulating Nrf2 expression via the activation of MTF-1 and inhibition of SP1\/Fyn pathway. Biochim Biophys Acta Mol Basis Dis 1869(6):166752","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"7","key":"2353_CR26","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41419-021-03952-w","volume":"12","author":"S Gumeni","year":"2021","unstructured":"Gumeni S et al (2021) Nrf2 activation induces mitophagy and reverses Parkin\/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes. Cell Death Dis 12(7):671","journal-title":"Cell Death Dis"},{"issue":"2","key":"2353_CR27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang D et al (2021) Ferroptosis: molecular mechanisms and health implications. Cell Res 31(2):107\u2013125","journal-title":"Cell Res"},{"issue":"7","key":"2353_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41419-024-06826-z","volume":"15","author":"T Li","year":"2024","unstructured":"Li T et al (2024) Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury. Cell Death Dis 15(7):473","journal-title":"Cell Death Dis"},{"issue":"3","key":"2353_CR29","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0002-8223(01)00078-5","volume":"101","author":"P Trumbo","year":"2001","unstructured":"Trumbo P et al (2001) Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc 101(3):294\u2013301","journal-title":"J Am Diet Assoc"},{"issue":"2","key":"2353_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/0976-0105.177703","volume":"7","author":"AB Nair","year":"2016","unstructured":"Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7(2):27\u201331","journal-title":"J Basic Clin Pharm"},{"key":"2353_CR31","doi-asserted-by":"publisher","first-page":"1407091","DOI":"10.3389\/fmicb.2024.1407091","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y et al (2024) Protective effect of zinc gluconate on intestinal mucosal barrier injury in antibiotics and LPS-induced mice. Front Microbiol 15:1407091","journal-title":"Front Microbiol"},{"issue":"3","key":"2353_CR32","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ajpath.2022.11.008","volume":"193","author":"YY Cao","year":"2023","unstructured":"Cao YY et al (2023) The polo-like Kinase 1-mammalian target of rapamycin axis regulates autophagy to prevent intestinal barrier dysfunction during sepsis. Am J Pathol 193(3):296\u2013312","journal-title":"Am J Pathol"},{"key":"2353_CR33","doi-asserted-by":"publisher","first-page":"e15786","DOI":"10.7717\/peerj.15786","volume":"11","author":"Y Zhao","year":"2023","unstructured":"Zhao Y et al (2023) Ferrostatin-1 post-treatment attenuates acute kidney injury in mice by inhibiting ferritin production and regulating iron uptake-related proteins. PeerJ 11:e15786","journal-title":"PeerJ"},{"issue":"4","key":"2353_CR34","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1097\/CCM.0b013e31819cefe4","volume":"37","author":"DL Knoell","year":"2009","unstructured":"Knoell DL et al (2009) Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit Care Med 37(4):1380\u20131388","journal-title":"Crit Care Med"},{"issue":"4","key":"2353_CR35","doi-asserted-by":"publisher","first-page":"258","DOI":"10.4103\/0971-4065.202406","volume":"27","author":"J Prakash","year":"2017","unstructured":"Prakash J, Ganiger VC (2017) Acute kidney injury in pregnancy-specific disorders. Indian J Nephrol 27(4):258\u2013270","journal-title":"Indian J Nephrol"},{"issue":"7","key":"2353_CR36","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3390\/biom12070900","volume":"12","author":"Y Wan","year":"2022","unstructured":"Wan Y, Zhang B (2022) The impact of zinc and zinc homeostasis on the intestinal mucosal barrier and intestinal diseases. Biomolecules 12(7):900","journal-title":"Biomolecules"},{"issue":"1","key":"2353_CR37","doi-asserted-by":"publisher","first-page":"G105","DOI":"10.1152\/ajpgi.00405.2015","volume":"311","author":"Y Miyoshi","year":"2016","unstructured":"Miyoshi Y, Tanabe S, Suzuki T (2016) Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression. Am J Physiol Gastrointest Liver Physiol 311(1):G105\u2013G116","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2353_CR38","doi-asserted-by":"publisher","first-page":"116111","DOI":"10.1016\/j.ecoenv.2024.116111","volume":"272","author":"C Xiao","year":"2024","unstructured":"Xiao C et al (2024) Zinc glycinate alleviates LPS-induced inflammation and intestinal barrier disruption in chicken embryos by regulating zinc homeostasis and TLR4\/NF-kappaB pathway. Ecotoxicol Environ Saf 272:116111","journal-title":"Ecotoxicol Environ Saf"},{"issue":"12","key":"2353_CR39","doi-asserted-by":"publisher","first-page":"101462","DOI":"10.1016\/j.psj.2021.101462","volume":"100","author":"Y Xie","year":"2021","unstructured":"Xie Y et al (2021) Effect of zinc supplementation on growth performance, intestinal development, and intestinal barrier function in Pekin ducks with lipopolysaccharide challenge. Poult Sci 100(12):101462","journal-title":"Poult Sci"},{"key":"2353_CR40","doi-asserted-by":"publisher","first-page":"968045","DOI":"10.3389\/fpubh.2022.968045","volume":"10","author":"S Jin","year":"2022","unstructured":"Jin S, Hu C, Zheng Y (2022) Maternal serum zinc level is associated with risk of preeclampsia: a systematic review and meta-analysis. Front Public Health 10:968045","journal-title":"Front Public Health"},{"issue":"24","key":"2353_CR41","first-page":"4690","volume":"19","author":"PJ Shen","year":"2015","unstructured":"Shen PJ et al (2015) Four trace elements in pregnant women and their relationships with adverse pregnancy outcomes. Eur Rev Med Pharmacol Sci 19(24):4690\u20134697","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"2353_CR42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12291-022-01043-x","volume":"38","author":"Sairoz","year":"2023","unstructured":"Sairoz et al (2023) Maternal serum zinc, copper, magnesium, and iron in spontaneous abortions. Indian J Clin Biochem 38(1):128\u2013131","journal-title":"Indian J Clin Biochem"},{"issue":"2","key":"2353_CR43","doi-asserted-by":"publisher","first-page":"317e5","DOI":"10.1016\/j.jcrc.2013.12.003","volume":"29","author":"JY Jang","year":"2014","unstructured":"Jang JY et al (2014) Serum selenium and zinc levels in critically ill surgical patients. J Crit Care 29(2):317e5\u2013317e8","journal-title":"J Crit Care"},{"issue":"4","key":"2353_CR44","doi-asserted-by":"publisher","first-page":"e94934","DOI":"10.1371\/journal.pone.0094934","volume":"9","author":"MJ Liu","year":"2014","unstructured":"Liu MJ et al (2014) Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling. PLoS ONE 9(4):e94934","journal-title":"PLoS ONE"},{"issue":"0","key":"2353_CR45","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.5604\/17322693.1229074","volume":"70","author":"M Wolonciej","year":"2016","unstructured":"Wolonciej M, Milewska E, Roszkowska-Jakimiec W (2016) Trace elements as an activator of antioxidant enzymes. Postepy Hig Med Dosw (Online) 70(0):1483\u20131498","journal-title":"Postepy Hig Med Dosw (Online)"},{"issue":"12","key":"2353_CR46","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.3390\/antiox11122456","volume":"11","author":"Y Wang","year":"2022","unstructured":"Wang Y et al (2022) Impact of maternal and offspring dietary Zn supplementation on growth performance and antioxidant and immune function of offspring broilers. Antioxid 11(12):2456","journal-title":"Antioxid"},{"issue":"10","key":"2353_CR47","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1139\/apnm-2018-0070","volume":"43","author":"NM Aziz","year":"2018","unstructured":"Aziz NM et al (2018) Antioxidant, anti-inflammatory, and anti-apoptotic effects of zinc supplementation in testes of rats with experimentally induced diabetes. Appl Physiol Nutr Metab 43(10):1010\u20131018","journal-title":"Appl Physiol Nutr Metab"},{"issue":"3","key":"2353_CR48","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ekir.2018.10.015","volume":"4","author":"K Wiles","year":"2019","unstructured":"Wiles K et al (2019) Serum creatinine in pregnancy: a systematic review. Kidney Int Rep 4(3):408\u2013419","journal-title":"Kidney Int Rep"},{"issue":"5","key":"2353_CR49","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1262\/jrd.2019-052","volume":"65","author":"L Lei","year":"2019","unstructured":"Lei L et al (2019) Role of endoplasmic reticulum stress in lipopolysaccharide-inhibited mouse granulosa cell estradiol production. J Reprod Dev 65(5):459\u2013465","journal-title":"J Reprod Dev"},{"key":"2353_CR50","doi-asserted-by":"publisher","first-page":"14277","DOI":"10.1038\/srep14277","volume":"5","author":"Y Li","year":"2015","unstructured":"Li Y et al (2015) Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells. Sci Rep 5:14277","journal-title":"Sci Rep"},{"issue":"25","key":"2353_CR51","doi-asserted-by":"publisher","first-page":"7627","DOI":"10.1080\/10408398.2022.2048292","volume":"63","author":"S Yin","year":"2023","unstructured":"Yin S et al (2023) Zinc homeostasis and regulation: zinc transmembrane transport through transporters. Crit Rev Food Sci Nutr 63(25):7627\u20137637","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2353_CR52","doi-asserted-by":"publisher","first-page":"1510372","DOI":"10.3389\/fphar.2025.1510372","volume":"16","author":"D Li","year":"2025","unstructured":"Li D et al (2025) Zinc regulates microglial polarization and inflammation through IKBalpha after spinal cord injury and promotes neuronal repair and motor function recovery in mice. Front Pharmacol 16:1510372","journal-title":"Front Pharmacol"},{"issue":"3","key":"2353_CR53","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3390\/biom13030416","volume":"13","author":"S Liu","year":"2023","unstructured":"Liu S et al (2023) Zinc homeostasis: an emerging therapeutic target for neuroinflammation related diseases. Biomolecules 13(3):416","journal-title":"Biomolecules"},{"issue":"10","key":"2353_CR54","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/antiox13101211","volume":"13","author":"A Loser","year":"2024","unstructured":"Loser A, Schwarz M, Kipp AP (2024) NRF2 and thioredoxin reductase 1 as modulators of interactions between zinc and selenium. Antioxidants 13(10):1211","journal-title":"Antioxidants"},{"issue":"4","key":"2353_CR55","doi-asserted-by":"publisher","first-page":"fuad046","DOI":"10.1093\/femsre\/fuad046","volume":"47","author":"CG Lee","year":"2023","unstructured":"Lee CG et al (2023) Exploring probiotic effector molecules and their mode of action in gut-immune interactions. FEMS Microbiol Rev 47(4):fuad046","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"2353_CR56","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/mi.2016.75","volume":"10","author":"MY Zeng","year":"2017","unstructured":"Zeng MY, Inohara N, Nunez G (2017) Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunol 10(1):18\u201326","journal-title":"Mucosal Immunol"},{"issue":"1","key":"2353_CR57","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/nu15010054","volume":"15","author":"Q Chen","year":"2022","unstructured":"Chen Q et al (2022) Zinc laurate protects against intestinal barrier dysfunction and inflammation induced by ETEC in a mice model. Nutrients 15(1):54","journal-title":"Nutrients"},{"issue":"2","key":"2353_CR58","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1007\/s12011-022-03207-5","volume":"201","author":"L Wang","year":"2023","unstructured":"Wang L et al (2023) Dietary zinc glycine supplementation improves tibia quality of meat ducks by modulating the intestinal barrier and bone resorption. Biol Trace Elem Res 201(2):888\u2013903","journal-title":"Biol Trace Elem Res"},{"issue":"14","key":"2353_CR59","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.7150\/ijms.45980","volume":"18","author":"SY Su","year":"2021","unstructured":"Su SY, Tang QQ (2021) Altered intestinal microflora and barrier injury in severe acute pancreatitis can be changed by zinc. Int J Med Sci 18(14):3050\u20133058","journal-title":"Int J Med Sci"},{"issue":"3","key":"2353_CR60","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/imm.13896","volume":"174","author":"T Kido","year":"2025","unstructured":"Kido T, Yanagisawa H, Suka M (2025) Zinc deficiency reduces intestinal secretory immunoglobulin a and induces inflammatory responses via the gut-liver axis. Immunology 174(3):363\u2013373","journal-title":"Immunology"},{"key":"2353_CR61","doi-asserted-by":"publisher","first-page":"101916","DOI":"10.1016\/j.redox.2021.101916","volume":"41","author":"C Hubner","year":"2021","unstructured":"Hubner C, Haase H (2021) Interactions of zinc- and redox-signaling pathways. Redox Biol 41:101916","journal-title":"Redox Biol"},{"key":"2353_CR62","doi-asserted-by":"publisher","first-page":"101767","DOI":"10.1016\/j.redox.2020.101767","volume":"38","author":"Y Wang","year":"2021","unstructured":"Wang Y et al (2021) The PINK1\/PARK2\/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury. Redox Biol 38:101767","journal-title":"Redox Biol"},{"key":"2353_CR63","doi-asserted-by":"publisher","first-page":"112527","DOI":"10.1016\/j.intimp.2024.112527","volume":"138","author":"X Lei","year":"2024","unstructured":"Lei X et al (2024) Micheliolide ameliorates lipopolysaccharide-induced acute kidney injury through suppression of NLRP3 activation by promoting mitophagy via Nrf2\/PINK1\/Parkin axis. Int Immunopharmacol 138:112527","journal-title":"Int Immunopharmacol"},{"key":"2353_CR64","doi-asserted-by":"publisher","first-page":"7819","DOI":"10.2147\/JIR.S488655","volume":"17","author":"H Cheng","year":"2024","unstructured":"Cheng H et al (2024) Mitophagy and ferroptosis in sepsis-induced ALI\/ARDS: molecular mechanisms, interactions and therapeutic prospects of medicinal plants. J Inflamm Res 17:7819\u20137835","journal-title":"J Inflamm Res"},{"issue":"3","key":"2353_CR65","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.ekir.2025.01.015","volume":"10","author":"S Jesudason","year":"2025","unstructured":"Jesudason S, Lightstone L (2025) Pregnancy as a window to current and future kidney health-an opportunity. Kidney Int Rep 10(3):645\u2013649","journal-title":"Kidney Int Rep"},{"issue":"9","key":"2353_CR66","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3109\/0886022X.2015.1074493","volume":"37","author":"N Gopalakrishnan","year":"2015","unstructured":"Gopalakrishnan N et al (2015) Acute kidney injury in pregnancy: a single center experience. Ren Fail 37(9):1476\u20131480","journal-title":"Ren Fail"},{"issue":"6","key":"2353_CR67","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3390\/nu9060624","volume":"9","author":"NZ Gammoh","year":"2017","unstructured":"Gammoh NZ, Rink L (2017) Zinc in infection and inflammation. Nutrients 9(6):624","journal-title":"Nutrients"},{"issue":"5","key":"2353_CR68","doi-asserted-by":"publisher","first-page":"100408","DOI":"10.1016\/j.advnut.2025.100408","volume":"16","author":"L Huang","year":"2025","unstructured":"Huang L, Wong CP, Ho E (2025) Zinc. Adv Nutr 16(5):100408","journal-title":"Adv Nutr"},{"key":"2353_CR69","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.freeradbiomed.2024.07.019","volume":"223","author":"B Dai","year":"2024","unstructured":"Dai B et al (2024) LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: induction of Metallothionein-1 and suppression of tubular ferroptosis. Free Radic Biol Med 223:42\u201352","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"2353_CR70","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s12951-023-02224-3","volume":"21","author":"J Guo","year":"2023","unstructured":"Guo J et al (2023) Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis. J Nanobiotechnol 21(1):448","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"2353_CR71","doi-asserted-by":"publisher","first-page":"F184","DOI":"10.1152\/ajprenal.00337.2023","volume":"327","author":"J Guo","year":"2024","unstructured":"Guo J, Yuan Z, Wang R (2024) Zn(2+) improves sepsis-induced acute kidney injury by upregulating SIRT7-mediated Parkin acetylation. Am J Physiol Ren Physiol 327(1):F184\u2013F197","journal-title":"Am J Physiol Ren Physiol"},{"key":"2353_CR72","doi-asserted-by":"publisher","first-page":"04240","DOI":"10.7189\/jogh.14.04240","volume":"14","author":"V Bonnell","year":"2024","unstructured":"Bonnell V, White M, Connor K (2024) Do nutritional interventions before or during pregnancy affect placental phenotype? Findings from a systematic review of human clinical trials. J Glob Health 14:04240","journal-title":"J Glob Health"},{"issue":"8","key":"2353_CR73","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.3390\/biom10081176","volume":"10","author":"K Grzeszczak","year":"2020","unstructured":"Grzeszczak K, Kwiatkowski S, Kosik-Bogacka D (2020) The role of Fe, Zn, and Cu in pregnancy. Biomolecules 10(8):1176","journal-title":"Biomolecules"},{"issue":"2","key":"2353_CR74","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/ajcn\/51.2.225","volume":"51","author":"GJ Fosmire","year":"1990","unstructured":"Fosmire GJ (1990) Zinc toxicity. Am J Clin Nutr 51(2):225\u2013227","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"2353_CR75","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.3390\/ijerph7041342","volume":"7","author":"LM Plum","year":"2010","unstructured":"Plum LM, Rink L, Haase H (2010) The essential toxin: impact of zinc on human health. Int J Environ Res Public Health 7(4):1342\u20131365","journal-title":"Int J Environ Res Public Health"},{"key":"2353_CR76","unstructured":"Organization WH (2001) Zinc. Environmental Health Criteria 221, FIRST Draft Prepared"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02353-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02353-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02353-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:02:11Z","timestamp":1784052131000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02353-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":76,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2353"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02353-8","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"assertion":[{"value":"29 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interests.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Animal Care and Use Committee of Huazhong University of Science and Technology ([2025] IACUC Number: 4576). The procedures were performed in accordance with the guidelines established by the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals (8th Edition, 2011), ensuring humane treatment of animals and minimizing their pain and discomfort.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"171"}}